NO952677L - Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparater - Google Patents
Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparaterInfo
- Publication number
- NO952677L NO952677L NO952677A NO952677A NO952677L NO 952677 L NO952677 L NO 952677L NO 952677 A NO952677 A NO 952677A NO 952677 A NO952677 A NO 952677A NO 952677 L NO952677 L NO 952677L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- radical
- cycloalkyl
- phenyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Abstract
Det beskrives forbindelser med den generelle formel (I): O) R, hvor: - Rx er valgt fra hydrogen, alkyl, alkenyl, cyanoalkyl og arylalkyl, Rg W er valgt fra gruppene ¿A-R., and -(AJ^CH^N X Ra er valgt fra alkyl, cykloalkyl, cykloalkylalkyl, fenyl, fenylalkyl, naftyl og naftylalkyl, R, og R4 er valgt, hver uavhengig av den andre, fra hydrogen, alkyl, fenyl, fenylalkyl, cyclokalkyl og cykloalkylalkyl, eller de danner sammmen med nitrogenatomet som bærer dem, et hetero- cyklisk system valgt fra: ¿N ¿ CH og hvor: a representerer et heltall på fra O til 4, b representerer l eller 2, c, d, e og f representerer et heltall på fra O til 4, g representerer 4 eller 5, Z representerer O, S eller N-R,, hvor R7 representerer et hydrogenatom, eller en alkyl-, fenyl-fenylalkyl-, cyklo- alkyl-, cykloalkylalkyl-, benzhydryl-, naftyl-, pyridyl- eller pyrimidylgruppe, n representerer et heltall fra l til 4 inklusive, m representererr O eller l, O OH \\ l A er valgt fra gruppen ~ C ~ og gruppen ¿ CH ¿, Y representerer et oksygenatom eller en gruppe hvor Rs og R« begge er valgt, uavhengig av hverandre, fra hydrogen, et alkylradikal, et cykloalkylradikal, et cyloalkyl- alkylradikal, et fenylradikal og et benzylradikal, deres eventuelle geometriske og/eller optiske isomerer, i ren form eller i form av en blanding, og deres farmasøytisk akseptable addi- sjonssalter med en syre eller en base.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9408418A FR2722195B1 (fr) | 1994-07-07 | 1994-07-07 | Nouveaux derives de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2(3h)-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR9408419A FR2722196B1 (fr) | 1994-07-07 | 1994-07-07 | Nouveaux derives amines de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2 (3h)-ones, leur procede de preparation et les compositions pharmaceutique qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
NO952677D0 NO952677D0 (no) | 1995-07-06 |
NO952677L true NO952677L (no) | 1996-01-08 |
Family
ID=26231276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO952677A NO952677L (no) | 1994-07-07 | 1995-07-06 | Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparater |
Country Status (9)
Country | Link |
---|---|
US (2) | US5618819A (no) |
EP (1) | EP0691339A1 (no) |
JP (1) | JPH0853447A (no) |
CN (1) | CN1127254A (no) |
AU (1) | AU683167B2 (no) |
CA (1) | CA2153294A1 (no) |
FI (1) | FI953327A (no) |
NO (1) | NO952677L (no) |
NZ (1) | NZ272516A (no) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5618819A (en) * | 1994-07-07 | 1997-04-08 | Adir Et Compagnie | 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds |
US6166274A (en) * | 1999-12-15 | 2000-12-26 | Atofina Chemicals, Inc. | Catalyzed liquid phase fluorination of 1230za |
CN101087789B (zh) * | 2004-10-27 | 2011-01-12 | 詹森药业有限公司 | 用作黄体酮受体调节剂的吡啶并咪唑类和氮杂吲哚类化合物 |
DE102005007694A1 (de) * | 2005-02-18 | 2006-09-21 | Henkel Kgaa | Mittel zum Färben von keratinhaltigen Fasern |
MY145694A (en) * | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
MY158766A (en) * | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
AR053713A1 (es) * | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
AU2007254179B2 (en) * | 2006-05-18 | 2013-03-21 | Pharmacyclics Llc | Intracellular kinase inhibitors |
CA2666143A1 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
BRPI0719210A2 (pt) * | 2006-10-12 | 2015-05-05 | Xenon Pharmaceuticals Inc | Uso de compostos espiro-oxindol como agentes terapêuticos |
EP2076518A1 (en) * | 2006-10-12 | 2009-07-08 | Xenon Pharmaceuticals Inc. | Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents |
WO2009025265A1 (ja) * | 2007-08-21 | 2009-02-26 | Shionogi & Co., Ltd. | ピペラジン誘導体 |
CA2741024A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
CN102256983B (zh) | 2008-10-17 | 2017-04-05 | 泽农医药公司 | 螺羟吲哚化合物及其作为治疗剂的用途 |
EP2379561B1 (en) | 2008-11-25 | 2015-11-04 | University Of Rochester | Mlk inhibitors and methods of use |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
AU2010306768B2 (en) | 2009-10-14 | 2016-08-04 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
EP2538919B1 (en) | 2010-02-26 | 2017-07-12 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
JP6086326B2 (ja) | 2010-05-24 | 2017-03-01 | ユニヴァーシティー オブ ロチェスター | 二環式ヘテロアリールキナーゼ阻害剤および使用方法 |
EP2707373A1 (de) | 2011-05-10 | 2014-03-19 | Bayer Intellectual Property GmbH | Bicyclische (thio)carbonylamidine |
BR112014004595A2 (pt) * | 2011-09-01 | 2017-03-21 | Dsm Ip Assets Bv | processo para a carbonilação de alquenos opcionalmente funcionalizados |
WO2014085795A1 (en) | 2012-11-30 | 2014-06-05 | University Of Rochester | Mixed lineage kinase inhibitors for hiv/aids therapies |
MA41169A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2244507A1 (en) * | 1973-06-26 | 1975-04-18 | Inst Nat Sante Rech Med | Chalcones and analogues - analgesics having low toxicity |
US4038396A (en) * | 1975-02-24 | 1977-07-26 | Merck & Co., Inc. | Anti-inflammatory oxazole[4,5-b]pyridines |
JPS6015635B2 (ja) * | 1976-05-28 | 1985-04-20 | 久光製薬株式会社 | 新規なオキサゾロ〔4,5−b〕ピリジン誘導体 |
US4866074A (en) * | 1987-05-08 | 1989-09-12 | Rorer Pharmaceutical Corporation | Naphtheridinone- and pyridooxazinone-pyridone compounds, cardiotonic compositions including same, and their uses |
FR2650591B1 (fr) * | 1989-08-07 | 1991-11-15 | Science Organisation | Nouveaux derives d'oxazolo pyridines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2652085A1 (fr) * | 1989-09-20 | 1991-03-22 | Science Organisation | Nouveau procede de synthese de derives d'oxazolopyridines. |
WO1991009598A1 (en) * | 1990-01-05 | 1991-07-11 | Pfizer Inc. | Azaoxindole derivatives |
FR2663929A1 (fr) * | 1990-06-29 | 1992-01-03 | Adir | Nouveaux derives d'oxazolo pyridines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2669336B1 (fr) * | 1990-11-20 | 1993-01-22 | Adir | Nouveaux derives d'oxazolo pyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
US5618819A (en) * | 1994-07-07 | 1997-04-08 | Adir Et Compagnie | 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds |
-
1995
- 1995-07-03 US US08/497,524 patent/US5618819A/en not_active Expired - Fee Related
- 1995-07-04 AU AU24827/95A patent/AU683167B2/en not_active Ceased
- 1995-07-05 CA CA002153294A patent/CA2153294A1/fr not_active Abandoned
- 1995-07-05 EP EP95401608A patent/EP0691339A1/fr not_active Ceased
- 1995-07-06 FI FI953327A patent/FI953327A/fi unknown
- 1995-07-06 NO NO952677A patent/NO952677L/no unknown
- 1995-07-06 NZ NZ272516A patent/NZ272516A/en unknown
- 1995-07-07 JP JP7171778A patent/JPH0853447A/ja active Pending
- 1995-07-07 CN CN95109180A patent/CN1127254A/zh active Pending
-
1996
- 1996-11-05 US US08/743,948 patent/US5767128A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI953327A (fi) | 1996-01-08 |
EP0691339A1 (fr) | 1996-01-10 |
AU2482795A (en) | 1996-01-18 |
US5618819A (en) | 1997-04-08 |
JPH0853447A (ja) | 1996-02-27 |
FI953327A0 (fi) | 1995-07-06 |
NZ272516A (en) | 1996-10-28 |
NO952677D0 (no) | 1995-07-06 |
CN1127254A (zh) | 1996-07-24 |
AU683167B2 (en) | 1997-10-30 |
CA2153294A1 (fr) | 1996-01-08 |
US5767128A (en) | 1998-06-16 |
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