NO891381L - Fremgangsmaate for fremstilling av nye fluorfosfonatnukleotidderivater. - Google Patents
Fremgangsmaate for fremstilling av nye fluorfosfonatnukleotidderivater.Info
- Publication number
- NO891381L NO891381L NO89891381A NO891381A NO891381L NO 891381 L NO891381 L NO 891381L NO 89891381 A NO89891381 A NO 89891381A NO 891381 A NO891381 A NO 891381A NO 891381 L NO891381 L NO 891381L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- new
- fluorphosphonate
- procedure
- nucleotide derivatives
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002015 acyclic group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6521—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Nye forbindelser av én av formlene. eller farmasøytisk akseptable salter derav hvori n er null, én eller to, og hvori B er en base av strukturformel. hvori X, X,, x2, X3, X,, x5, X5., y. har forskjellig» betydninger og & betegner en acyklisk eller cyklisk gruppe, og hvor de øvrige substituen-ter er som angitt i beskrivelsen, utviser terapeutisk aktivitet. Fremstilling av forbindelsene er beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP88400806A EP0339161A1 (en) | 1988-04-01 | 1988-04-01 | Novel fluorophosphonate nucleotide derivatives |
EP89400773A EP0335770B1 (en) | 1988-04-01 | 1989-03-20 | Novel fluorophosphonate nucleotide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
NO891381D0 NO891381D0 (no) | 1989-03-31 |
NO891381L true NO891381L (no) | 1989-10-02 |
Family
ID=26117598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO89891381A NO891381L (no) | 1988-04-01 | 1989-03-31 | Fremgangsmaate for fremstilling av nye fluorfosfonatnukleotidderivater. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0335770B1 (no) |
JP (1) | JPH0272192A (no) |
CN (1) | CN1036578A (no) |
AU (2) | AU614128B2 (no) |
DK (1) | DK157389A (no) |
FI (1) | FI891462A (no) |
HU (1) | HU204535B (no) |
IL (1) | IL89771A0 (no) |
NO (1) | NO891381L (no) |
NZ (1) | NZ228492A (no) |
PT (1) | PT90179B (no) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0465297B1 (en) * | 1990-07-04 | 1996-01-31 | Merrell Dow Pharmaceuticals Inc. | 9-Purinyl phosphonic acid derivatives |
US5349018A (en) * | 1991-01-17 | 1994-09-20 | Tomoegawa Paper Co., Ltd. | Polyamide-hydrogenated polybutadiene-acrylonitrile copolymers |
US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
KR100386685B1 (ko) * | 1993-09-17 | 2003-12-31 | 길리애드 사이언시즈, 인코포레이티드 | 뉴클레오타이드동족체류 |
JP5049067B2 (ja) * | 2007-07-31 | 2012-10-17 | 東ソ−・エフテック株式会社 | 含フッ素非環状n,o−アセタール化合物の製造方法 |
CN102079760A (zh) * | 2010-12-24 | 2011-06-01 | 南京师范大学 | α-二氟亚甲基膦内酯的合成方法 |
EP3292912B1 (de) * | 2016-09-09 | 2019-12-25 | Loesche GmbH | Verfahren zum betrieb eines multizyklons zum trennen von fein- und feinstkorn sowie multizyklon |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU729196A1 (ru) * | 1976-11-26 | 1980-04-25 | Московский Ордена Ленина И Ордена Трудового Красного Знамени Государственный Университет Им.М.В.Ломоносова | Способ получени фосфонатных эфиров нуклеозидов |
US4266282A (en) * | 1979-03-12 | 1981-05-05 | International Business Machines Corporation | Vertical semiconductor integrated circuit chip packaging |
US4452790A (en) * | 1982-06-23 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
CS263951B1 (en) * | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
DE3790883T1 (no) * | 1987-01-20 | 1988-12-08 | ||
GB8921469D0 (en) * | 1989-09-22 | 1989-11-08 | Erba Carlo Spa | 5'-alkylphosphonylnucleosides as antivirals |
-
1989
- 1989-03-20 EP EP89400773A patent/EP0335770B1/en not_active Expired - Lifetime
- 1989-03-28 IL IL89771A patent/IL89771A0/xx unknown
- 1989-03-28 FI FI891462A patent/FI891462A/fi not_active Application Discontinuation
- 1989-03-29 NZ NZ228492A patent/NZ228492A/en unknown
- 1989-03-31 DK DK157389A patent/DK157389A/da not_active IP Right Cessation
- 1989-03-31 JP JP1078743A patent/JPH0272192A/ja active Pending
- 1989-03-31 PT PT90179A patent/PT90179B/pt not_active IP Right Cessation
- 1989-03-31 NO NO89891381A patent/NO891381L/no unknown
- 1989-03-31 HU HU891608A patent/HU204535B/hu not_active IP Right Cessation
- 1989-04-01 CN CN89101905A patent/CN1036578A/zh active Pending
- 1989-04-03 AU AU32410/89A patent/AU614128B2/en not_active Ceased
-
1991
- 1991-06-14 AU AU78366/91A patent/AU631319B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
HUT49627A (en) | 1989-10-30 |
HU204535B (en) | 1992-01-28 |
DK157389D0 (da) | 1989-03-31 |
NZ228492A (en) | 1991-07-26 |
FI891462A0 (fi) | 1989-03-28 |
NO891381D0 (no) | 1989-03-31 |
AU7836691A (en) | 1991-09-12 |
IL89771A0 (en) | 1989-09-28 |
CN1036578A (zh) | 1989-10-25 |
EP0335770A2 (en) | 1989-10-04 |
EP0335770A3 (en) | 1990-12-27 |
AU631319B2 (en) | 1992-11-19 |
EP0335770B1 (en) | 1997-01-15 |
PT90179A (pt) | 1989-11-10 |
DK157389A (da) | 1989-10-02 |
PT90179B (pt) | 1994-06-30 |
AU3241089A (en) | 1989-10-05 |
AU614128B2 (en) | 1991-08-22 |
JPH0272192A (ja) | 1990-03-12 |
FI891462A (fi) | 1989-10-02 |
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