NO950970L - Fremgangsmåte for stabilisering av pranoprofen og stabile væskepreparater av pranoprofen - Google Patents

Fremgangsmåte for stabilisering av pranoprofen og stabile væskepreparater av pranoprofen

Info

Publication number
NO950970L
NO950970L NO950970A NO950970A NO950970L NO 950970 L NO950970 L NO 950970L NO 950970 A NO950970 A NO 950970A NO 950970 A NO950970 A NO 950970A NO 950970 L NO950970 L NO 950970L
Authority
NO
Norway
Prior art keywords
pranoprofen
aqueous solution
stabilizing
liquid preparations
stable liquid
Prior art date
Application number
NO950970A
Other languages
English (en)
Other versions
NO950970D0 (no
Inventor
Koji Doi
Hisaka Sawa
Yoshie Ozaki
Original Assignee
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co filed Critical Senju Pharma Co
Publication of NO950970D0 publication Critical patent/NO950970D0/no
Publication of NO950970L publication Critical patent/NO950970L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
    • Y10T428/1393—Multilayer [continuous layer]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Fremgangsmåte for stabilisering av pranoprofen, omfattende plassering av en vandig oppløsning av pranoprofen sammen med en antloksydant, eller plasse- ring av en vandig oppløsning av pranoprofen under betingelser begrenset av oksygentllførsel, og et stabilt vandig preparat av pranoprofen, omfattende pranoprofen og en antioksydant. Dekomponeringen av pranoprofen l en vandig oppløsning av pranoprofen blir bemerkelsesverdig undertrykket. Spesielt blir pranopro- fen stabilt overfor lys, og tillater således langtids- konserverlng <w en vandig oppløsning, spesielt et væskepreparat av pranoprofen.
NO950970A 1994-03-15 1995-03-14 Fremgangsmåte for stabilisering av pranoprofen og stabile væskepreparater av pranoprofen NO950970L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4418494 1994-03-15

Publications (2)

Publication Number Publication Date
NO950970D0 NO950970D0 (no) 1995-03-14
NO950970L true NO950970L (no) 1995-09-18

Family

ID=12684495

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950970A NO950970L (no) 1994-03-15 1995-03-14 Fremgangsmåte for stabilisering av pranoprofen og stabile væskepreparater av pranoprofen

Country Status (19)

Country Link
US (2) US5856345A (no)
EP (2) EP1163906A3 (no)
KR (1) KR100338851B1 (no)
CN (1) CN1091597C (no)
AT (1) ATE297206T1 (no)
AU (1) AU707119B2 (no)
BR (1) BR9501081A (no)
CA (1) CA2144591A1 (no)
DE (1) DE69534258T2 (no)
EE (1) EE9500015A (no)
ES (1) ES2240966T3 (no)
FI (1) FI951190A (no)
HU (1) HUT71245A (no)
LT (1) LT3969B (no)
LV (1) LV10922B (no)
NO (1) NO950970L (no)
PL (1) PL179534B1 (no)
RU (1) RU2148402C1 (no)
TW (1) TW358812B (no)

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US6235781B1 (en) 1998-07-14 2001-05-22 Alcon Laboratories, Inc. Prostaglandin product
CA2359605A1 (en) * 1998-12-02 2000-06-08 Gt Merchandising & Licensing Corp. Gradual hair relaxation composition
BR0313064A (pt) * 2002-07-31 2005-06-28 Pharmacia Corp Forma de dosagem farmacêutica compreendendo um composto de sulfito
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
EP1525884B1 (en) 2002-07-31 2011-10-12 Senju Pharmaceutical Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
JP4500261B2 (ja) 2003-01-21 2010-07-14 千寿製薬株式会社 ２−アミノ−３−（４−ブロモベンゾイル）フェニル酢酸含有水性液剤
AU2003100262B4 (en) * 2003-04-07 2003-09-18 Jurox Pty Ltd Stable carprofen composition
US7125497B1 (en) * 2003-05-22 2006-10-24 Sandia Corporation Reactive formulations for a neutralization of toxic industrial chemicals
US20060188557A1 (en) * 2003-05-23 2006-08-24 Hisamitsu Pharmaceutical Co., Inc. Prepartaion for external percutaneous administration containing non-steroidal anti-inflammatory drug and interleukin-1 alpha production inhibitor
US20060073172A1 (en) * 2004-10-01 2006-04-06 Schneider L W Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
ES2363964B1 (es) 2009-11-20 2012-08-22 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados.
CN104010661B (zh) * 2011-12-27 2017-06-06 千寿制药株式会社 含有二丁基羟基甲苯的制剂及二丁基羟基甲苯的稳定化方法
JP5345743B1 (ja) * 2012-02-27 2013-11-20 ロート製薬株式会社 眼科用組成物キット
JP5687395B2 (ja) * 2013-02-19 2015-03-18 ロート製薬株式会社 網膜疾患の予防、改善、又は治療用粘膜適用剤
JP5340498B1 (ja) * 2013-03-11 2013-11-13 千寿製薬株式会社 ソフトコンタクトレンズ用眼科用組成物
WO2014192737A1 (ja) * 2013-05-30 2014-12-04 千寿製薬株式会社 クロルフェニラミン又はその塩の安定化方法
TWI644663B (zh) * 2014-03-10 2018-12-21 日商千壽製藥股份有限公司 二丁基羥基甲苯的穩定化方法，及含二丁基羥基甲苯之製品(一)
TW201540292A (zh) * 2014-03-10 2015-11-01 Senju Pharma Co 二丁基羥基甲苯的穩定化方法（二）
AR102172A1 (es) 2015-10-05 2017-02-08 Química Luar S R L Una composición farmacéutica bactericida y virucida
KR102478553B1 (ko) * 2018-02-28 2022-12-16 한림제약(주) 벤조피란 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 용액 형태의 점안제
CN115677733A (zh) * 2022-12-20 2023-02-03 济南宣正药业有限公司 一种用于普拉洛芬质量研究的化合物及其制备方法和应用

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US3931295A (en) 1974-07-23 1976-01-06 Universal Oil Products Company Hydroxylation of aromatic compounds
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Also Published As

Publication number Publication date
RU2148402C1 (ru) 2000-05-10
BR9501081A (pt) 1996-06-04
ATE297206T1 (de) 2005-06-15
LV10922B (en) 1996-08-20
NO950970D0 (no) 1995-03-14
EP1163906A2 (en) 2001-12-19
LT95028A (en) 1995-10-25
HUT71245A (en) 1995-11-28
EP0672414A2 (en) 1995-09-20
FI951190A0 (fi) 1995-03-14
DE69534258T2 (de) 2006-05-04
EP0672414A3 (en) 1995-12-13
AU1485295A (en) 1995-09-21
KR100338851B1 (ko) 2002-10-12
PL307671A1 (en) 1995-09-18
EP0672414B1 (en) 2005-06-08
EE9500015A (et) 1995-12-15
TW358812B (en) 1999-05-21
PL179534B1 (pl) 2000-09-29
CA2144591A1 (en) 1995-09-16
DE69534258D1 (de) 2005-07-14
AU707119B2 (en) 1999-07-01
KR950032201A (ko) 1995-12-20
ES2240966T3 (es) 2005-10-16
CN1111510A (zh) 1995-11-15
FI951190A (fi) 1995-09-16
LT3969B (en) 1996-05-27
CN1091597C (zh) 2002-10-02
LV10922A (lv) 1995-12-20
US5856345A (en) 1999-01-05
US5889030A (en) 1999-03-30
HU9500772D0 (en) 1995-04-28
EP1163906A3 (en) 2003-05-21

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