NO933854D0 - Promedikamenter, deres fremstilling og anvendelse som legemiddel - Google Patents
Promedikamenter, deres fremstilling og anvendelse som legemiddelInfo
- Publication number
- NO933854D0 NO933854D0 NO933854A NO933854A NO933854D0 NO 933854 D0 NO933854 D0 NO 933854D0 NO 933854 A NO933854 A NO 933854A NO 933854 A NO933854 A NO 933854A NO 933854 D0 NO933854 D0 NO 933854D0
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- promedices
- medicine
- glycosyl
- prodrugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4236237A DE4236237A1 (de) | 1992-10-27 | 1992-10-27 | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
Publications (3)
Publication Number | Publication Date |
---|---|
NO933854D0 true NO933854D0 (no) | 1993-10-26 |
NO933854L NO933854L (no) | 1994-04-28 |
NO311830B1 NO311830B1 (no) | 2002-02-04 |
Family
ID=6471460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19933854A NO311830B1 (no) | 1992-10-27 | 1993-10-26 | Promedikamenter, samt fremstilling derav |
Country Status (12)
Country | Link |
---|---|
US (2) | US5955100A (no) |
EP (1) | EP0595133B1 (no) |
JP (1) | JP3841311B2 (no) |
KR (1) | KR100297862B1 (no) |
AT (1) | ATE494009T1 (no) |
AU (1) | AU669218B2 (no) |
CA (1) | CA2109259C (no) |
DE (2) | DE4236237A1 (no) |
IL (1) | IL107398A (no) |
NO (1) | NO311830B1 (no) |
NZ (1) | NZ250030A (no) |
ZA (1) | ZA937951B (no) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4417865A1 (de) * | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
US5525606A (en) | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
DE19512484A1 (de) * | 1995-04-04 | 1996-10-17 | Bayer Ag | Kohlenhydratmodifizierte Cytostatika |
DE69533615T2 (de) | 1995-06-27 | 2005-10-13 | Pharmachemie B.V. | Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie |
DE19524515A1 (de) * | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharid-Konjugate |
SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
GB9600471D0 (en) * | 1996-01-10 | 1996-03-13 | Univ London Pharmacy | Drug delivery system |
DK0795334T3 (da) * | 1996-03-12 | 2006-06-06 | Sanofi Aventis Deutschland | Nye prodrugs til behandling af tumorer og betændelsessygdomme |
WO1997038727A1 (fr) | 1996-04-15 | 1997-10-23 | Asahi Kasei Kogyo Kabushiki Kaisha | Composite medicamenteux |
AUPO203996A0 (en) * | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
ES2169429T3 (es) * | 1996-09-30 | 2002-07-01 | Bayer Ag | Glicoconjugados de derivados modificados de la camptotecina (enlace en 20-o). |
DE19640207A1 (de) * | 1996-09-30 | 1998-04-02 | Bayer Ag | Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung) |
WO1998050018A1 (en) * | 1997-05-06 | 1998-11-12 | Xiao Yu Wu | Drug delivery system |
ID23424A (id) * | 1997-05-14 | 2000-04-20 | Bayer Ag | Glikokonjugat dari 20(s)-kamptotesin |
DE19720312A1 (de) * | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
AU2173899A (en) | 1998-02-06 | 1999-08-23 | De Montfort University | Hydroxylation activated prodrugs |
AU2531599A (en) * | 1998-02-12 | 1999-08-30 | De Montfort University | Hydroxylation activated drug release |
GB2334256A (en) | 1998-02-12 | 1999-08-18 | Univ Montfort | Hydroxylation activated prodrugs |
WO2000015766A1 (en) * | 1998-09-16 | 2000-03-23 | Oncopharmaceutical, Inc. | Treatment of oncologic tumors with an injectable formulation of a golgi apparatus disturbing agent |
US20030060425A1 (en) * | 1998-11-24 | 2003-03-27 | Ahlem Clarence N. | Immune modulation method using steroid compounds |
US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
FR2791679B1 (fr) * | 1999-03-31 | 2003-04-11 | Fabre Pierre Dermo Cosmetique | Bioprecurseurs aptes a liberer un derive retinoique par mise a profit de l'activite enzymatique de la surface cutanee et compositions pharmaceutiques et/ou cosmetiques |
KR20020013533A (ko) | 1999-05-04 | 2002-02-20 | 앤드류 맥린 | 안드로겐 글리코사이드와 그것의 안드로겐 활성 |
DE19925810A1 (de) * | 1999-06-07 | 2000-12-14 | Paz Arzneimittelentwicklung | Anwendung von Verapamil und Verapamilderivaten zur Herstellung von Arzneimitteln mit Glucuronidase hemmender Wirkung |
US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
DE10027887A1 (de) | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
US6638312B2 (en) | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
US7220824B1 (en) | 2000-08-28 | 2007-05-22 | Bayer Aktiengesellschaft | Integrin-mediated drug targeting |
US6642205B2 (en) * | 2000-09-25 | 2003-11-04 | Pro-Pharmaceuticals, Inc. | Methods and compositions for reducing side effects in chemotherapeutic treatments |
US6436386B1 (en) | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
US7829074B2 (en) | 2001-10-18 | 2010-11-09 | Nektar Therapeutics | Hydroxypatite-targeting poly(ethylene glycol) and related polymers |
EP1238678A1 (en) * | 2001-03-08 | 2002-09-11 | Bayer Aktiengesellschaft | Enzyme-activated cytostatic conjugates with integrin ligands |
US20030033021A1 (en) | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration scaffold and method |
US7819918B2 (en) | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
AU2002354911B2 (en) | 2001-07-16 | 2007-08-30 | Depuy Products, Inc. | Meniscus regeneration device and method |
WO2003007786A2 (en) | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Porous delivery scaffold and method |
US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US20060014697A1 (en) | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
ES2545393T3 (es) * | 2001-12-03 | 2015-09-10 | Universitätsklinikum Charité Der Humboldt- Universität Zu Berlin | Las podofilotoxinas como agentes antiproliferativos |
DE60235408D1 (de) * | 2001-12-17 | 2010-04-01 | Univ Cardiff | Enzymatische spaltbare reagenzien zum spezifischen targeting von krankheitsherden |
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
NZ537686A (en) * | 2002-06-20 | 2007-01-26 | Nippon Suisan Kaisha Ltd | A beta2 agonist prodrug having reduced side effects |
US20040152769A1 (en) * | 2002-11-09 | 2004-08-05 | Ekwuribe Nnochiri Nkem | Modified carbamate-containing prodrugs and methods of synthesizing same |
WO2004050089A1 (en) * | 2002-12-05 | 2004-06-17 | Schering Ag | Epothilone analogs for site specific delivery in the treatment of proliferative diseases |
DE10256982A1 (de) | 2002-12-05 | 2004-06-24 | Schering Ag | Neue Effektor-Konjugate, Verfahren zu Ihrer Herstellung und Ihre Pharmazeutische Verwendung |
US8133881B2 (en) | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
JP2006515885A (ja) * | 2003-01-17 | 2006-06-08 | スレッシュオールド ファーマシューティカルズ, インコーポレイテッド | 癌の処置のための併用療法 |
US7160867B2 (en) * | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
US20070275911A1 (en) * | 2003-09-05 | 2007-11-29 | Koch Tad H | Targeted Drug-Formaldehyde Conjugates and Methods of Making and Using the Same |
US20050053664A1 (en) | 2003-09-08 | 2005-03-10 | Eliezer Zomer | Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer |
US7534780B2 (en) | 2004-05-21 | 2009-05-19 | Bayer Schering Pharma Aktiengesellschaft | Estradiol prodrugs |
US7825096B2 (en) * | 2004-09-08 | 2010-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs |
JP2008514701A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキン類似体およびそれらの薬学的使用 |
JP2008515886A (ja) | 2004-10-06 | 2008-05-15 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキンおよびそれらの医用薬剤としての有用性 |
TW200631586A (en) * | 2005-03-08 | 2006-09-16 | Phytohealth Corp | A method for preparing a pharmaceutical compound by way of magnetic carbon nanocapsules |
US7569358B2 (en) * | 2005-03-30 | 2009-08-04 | Saladax Biomedical Inc. | Doxorubicin immunoassay |
US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
US20080031866A1 (en) * | 2006-06-20 | 2008-02-07 | Eichenbaum Gary M | Method for modulating the pharmacokinetics and metabolism of a therapeutic agent |
WO2007149827A2 (en) * | 2006-06-20 | 2007-12-27 | Janssen Pharmaceutica, N.V. | Method for modulating the pharmacokinetics and metabolism of a therapeutic agent |
US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
US7792651B2 (en) * | 2007-04-26 | 2010-09-07 | General Electric Company | Methods and systems for computing gear modifications |
WO2008153394A2 (en) * | 2007-06-14 | 2008-12-18 | Academisch Medisch Centrum | Novel anti-inflammatory pro-drugs |
CN101835496B (zh) | 2007-10-23 | 2015-11-25 | 尼克塔治疗公司 | 靶向羟基磷灰石的多臂聚合物以及由其制造的偶联物 |
EP2249921B1 (en) * | 2008-02-25 | 2020-06-17 | Eyegate Pharmaceuticals, Inc. | Enhanced delivery of dexamethasone phosphate to ocular tissues through iontophoresis |
KR20140065017A (ko) * | 2008-07-30 | 2014-05-28 | 닛토덴코 가부시키가이샤 | 약물 담체 |
KR20120103604A (ko) | 2009-11-06 | 2012-09-19 | 첼시 쎄라퓨틱스, 인코포레이티드 | 효소 저해성 화합물 |
KR101253399B1 (ko) | 2010-10-26 | 2013-04-11 | 영남대학교 산학협력단 | 아포지단백질 a-i 및 그 변이체를 포함한 재조합 고밀도지단백질을 이용한 라파마이신 제형 |
EP2468741A1 (en) | 2010-12-16 | 2012-06-27 | Bel/Novamann International s.r.o. | Novel quercetin derivatives, their preparation, pharmaceutical compositions containing them and their use |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
JP6392241B2 (ja) | 2012-12-17 | 2018-09-19 | パリオン・サイエンシィズ・インコーポレーテッド | 3,5−ジアミノ−6−クロロ−n−(n−(4−フェニルブチル)カルバムイミドイル)ピラジン−2−カルボキサミド化合物 |
DK2931713T3 (en) | 2012-12-17 | 2017-01-30 | Parion Sciences Inc | CHLORPYRAZINE CARBOXAMIDE DERIVATIVES USED FOR THE TREATMENT OF DISEASES BENEFITED BY INDEPENDENT MOSPHEREWIN |
US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
CA2938919C (en) | 2014-02-28 | 2020-12-29 | Hangzhou Dac Biotech Co., Ltd | Charged linkers and their uses for conjugation |
JP6759326B2 (ja) | 2015-07-12 | 2020-09-23 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 細胞結合分子の共役のための架橋連結体 |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
WO2018086139A1 (en) | 2016-11-14 | 2018-05-17 | Hangzhou Dac Biotech Co., Ltd | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
CA3086233A1 (en) * | 2017-12-21 | 2019-06-27 | Pharmacytics B.V. | Method for improving the oral bioavailability of a drug |
KR20210100607A (ko) | 2018-11-05 | 2021-08-17 | 바이엘 파마 악티엔게젤샤프트 | 인테그린 리간드를 갖는 세포증식억제 콘쥬게이트 |
CN118556062A (zh) | 2021-10-04 | 2024-08-27 | 文赛克斯制药有限责任公司 | 用于治疗、预防或管理过度增殖病症的化合物、药物组合物和方法 |
EP4412655A1 (en) | 2021-10-04 | 2024-08-14 | Vincerx Pharma GmbH | Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorder |
JP2024536628A (ja) | 2021-10-04 | 2024-10-04 | ヴィンセルクス ファーマ ゲーエムベーハー | 過剰増殖性障害の処置、予防、または管理のための化合物、医薬組成物、および方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541436A (en) * | 1976-02-02 | 1979-02-28 | Searle & Co | Immunological materials |
US4279992A (en) * | 1978-03-13 | 1981-07-21 | Miles Laboratories, Inc. | Specific binding assay employing an enzyme-cleavable substrate as label |
US4481195A (en) * | 1978-10-13 | 1984-11-06 | Adolf Schwimmer | Method for the treatment of tumors with β-glucuronidase activity dependent pharmaceuticals |
US4265885A (en) * | 1978-10-25 | 1981-05-05 | Farmitalia Carlo Erba S.P.A. | Anthracyclines containing branched-chain amino-deoxy sugars |
WO1981001145A1 (en) * | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
DK406686D0 (da) * | 1986-08-26 | 1986-08-26 | Hans Bundgaard | Carboxylsyrederivater |
US5434247A (en) * | 1986-10-10 | 1995-07-18 | Board Of Regents, The University Of Texas System | Peptides for inducing monocyte cytotoxicity in diagnostics |
GB8705477D0 (en) * | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
US4975278A (en) * | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
IL106992A (en) * | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Noble hydrazonic history of anthracycline and methods for their preparation |
DE3842836A1 (de) * | 1988-12-20 | 1990-06-21 | Behringwerke Ag | Rhodomycine mit einer modifizierten kohlenhydrat-einheit |
DK24089D0 (da) * | 1989-01-20 | 1989-01-20 | Hans Bundgaard | Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups |
US5433955A (en) * | 1989-01-23 | 1995-07-18 | Akzo N.V. | Site specific in vivo activation of therapeutic drugs |
DE3924655A1 (de) * | 1989-07-26 | 1991-01-31 | Behringwerke Ag | Anthracyclin-derivate |
DE3928659A1 (de) * | 1989-08-30 | 1991-03-07 | Bayer Ag | Ketophosphamidglycoside, verfahren zu ihrer herstellung sowie ihre verwendung als pharmazeutische wirkstoffe |
DE3935016A1 (de) * | 1989-10-20 | 1991-04-25 | Behringwerke Ag | Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten |
US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
EP0510080A4 (en) * | 1989-12-26 | 1992-12-02 | Nova Pharmaceutical Corporation | Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use |
DE4002888A1 (de) * | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Anthracyclin-glycosyl-prodrugs, verfahren zu ihrer herstellung und ihre verwendung in kombination mit funktionalisierten tumorspezifischen enzymkonjugaten |
US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
GB9017024D0 (en) * | 1990-08-03 | 1990-09-19 | Erba Carlo Spa | New linker for bioactive agents |
CA2089375A1 (en) * | 1990-08-30 | 1992-03-01 | Tatsushi Toyokuni | Inhibition of metastatis potential and invasiveness by oligosaccharides or oligosaccharide antigens or antibodies |
AU649275B2 (en) * | 1990-11-06 | 1994-05-19 | Bristol-Myers Squibb Company | Prodrugs for beta-lactamase and uses thereof |
FR2676058B1 (fr) * | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
-
1992
- 1992-10-27 DE DE4236237A patent/DE4236237A1/de not_active Withdrawn
-
1993
- 1993-10-15 EP EP93116702A patent/EP0595133B1/de not_active Expired - Lifetime
- 1993-10-15 AT AT93116702T patent/ATE494009T1/de active
- 1993-10-15 DE DE59310399T patent/DE59310399D1/de not_active Expired - Lifetime
- 1993-10-22 NZ NZ250030A patent/NZ250030A/en not_active IP Right Cessation
- 1993-10-25 IL IL10739893A patent/IL107398A/en not_active IP Right Cessation
- 1993-10-26 AU AU50225/93A patent/AU669218B2/en not_active Expired
- 1993-10-26 JP JP26697693A patent/JP3841311B2/ja not_active Expired - Lifetime
- 1993-10-26 ZA ZA937951A patent/ZA937951B/xx unknown
- 1993-10-26 CA CA002109259A patent/CA2109259C/en not_active Expired - Lifetime
- 1993-10-26 NO NO19933854A patent/NO311830B1/no not_active IP Right Cessation
- 1993-10-27 KR KR1019930022473A patent/KR100297862B1/ko not_active IP Right Cessation
-
1995
- 1995-05-24 US US08/449,021 patent/US5955100A/en not_active Expired - Lifetime
-
1997
- 1997-05-20 US US08/859,084 patent/US6146658A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NZ250030A (en) | 1994-12-22 |
IL107398A0 (en) | 1994-01-25 |
CA2109259A1 (en) | 1994-04-28 |
ZA937951B (en) | 1995-07-05 |
JPH06293665A (ja) | 1994-10-21 |
AU669218B2 (en) | 1996-05-30 |
NO933854L (no) | 1994-04-28 |
EP0595133A2 (de) | 1994-05-04 |
DE4236237A1 (de) | 1994-04-28 |
EP0595133B1 (de) | 2011-01-05 |
JP3841311B2 (ja) | 2006-11-01 |
ATE494009T1 (de) | 2011-01-15 |
KR100297862B1 (ko) | 2001-10-24 |
EP0595133A3 (de) | 1998-11-04 |
US6146658A (en) | 2000-11-14 |
US5955100A (en) | 1999-09-21 |
IL107398A (en) | 2001-01-28 |
DE59310399D1 (de) | 2011-02-17 |
KR940008685A (ko) | 1994-05-16 |
CA2109259C (en) | 2005-05-24 |
AU5022593A (en) | 1994-05-12 |
NO311830B1 (no) | 2002-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO933854D0 (no) | Promedikamenter, deres fremstilling og anvendelse som legemiddel | |
PT83872A (de) | Arzneimittel | |
NO881164L (no) | Substituerte 9-amino-tetrahydroakridiner og relaterte forbindelser, en fremgangsmaate for deres fremstilling og deres bruk som medikamenter. | |
ATE98480T1 (de) | Arzneimittelformulierungen. | |
DK584089A (da) | Quinuclidiner, deres anvendelse som laegemiddel og fremgangsmaade til deres fremstilling | |
DK0530087T3 (da) | Hidtil ukendte naphthylethylurinstof- og naphthylethylthiourinstofforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
NO934706D0 (no) | Substituerte 4-fenyl-pyridoner og 4-fenyl-2-alkoksypyridiner | |
NO169387C (no) | Nye, substituerte 3-(4-nitrofenoxy)-pyrazoler, herbicide preparater inneholdende dem som aktive bestanddeler, og anvendelse av forbindelsene for bekjempelse av uoensket vegetasjon | |
DK0533516T3 (da) | Hidtil ukendte 1-(alkoxybenzyl)piperazinamidforbindelser, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
DK0511800T3 (da) | Farmaceutisk formulering indeholdende dirithromycin | |
NO890096L (no) | Pyrazol- og indozolpyridinaminer, en fremgangsmaate for fremstilling og anvendelse derav som medikamenter. | |
DK0579939T3 (da) | Phospholipidderivater | |
DK256689A (da) | 1,2-dithiol-3-thion-s-oxid-forbindelser til anven delse som laegemidler | |
DK120889D0 (da) | 3-(2,3,4,5,6-pentafluorphenoxy)-8-azabicyclooe3.2.1aaoctaner, en fremgangsmaade til deres fremstilling og deres anvendelse som medikamenter | |
DE3773322D1 (de) | Pharmazeutische zubereitungen mit heilender aktivitaet. | |
DK322187D0 (da) | Azolderivater, fremgangsmaade til deres fremstilling og landbrugs- og havebrugsmidler indeholdende disse som aktiv bestanddel | |
NO894558L (no) | Substituerte adeninderivater som er anvendbare som terapeutiske midler. | |
DK202085D0 (da) | Terapeutisk aktive, membranstabiliserende forbindelser |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |