NO882558L - Tricykliske pyridonderivater. - Google Patents
Tricykliske pyridonderivater.Info
- Publication number
- NO882558L NO882558L NO882558A NO882558A NO882558L NO 882558 L NO882558 L NO 882558L NO 882558 A NO882558 A NO 882558A NO 882558 A NO882558 A NO 882558A NO 882558 L NO882558 L NO 882558L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- oxo
- phenyl
- pyrido
- lower alkyl
- Prior art date
Links
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 122
- -1 nitro, amino Chemical group 0.000 claims description 106
- 125000000217 alkyl group Chemical group 0.000 claims description 76
- 238000000034 method Methods 0.000 claims description 46
- 239000001257 hydrogen Substances 0.000 claims description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 28
- 125000003545 alkoxy group Chemical group 0.000 claims description 25
- 239000002585 base Substances 0.000 claims description 22
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
- 125000001589 carboacyl group Chemical group 0.000 claims description 20
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 20
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 18
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 17
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical group 0.000 claims description 16
- 229920006395 saturated elastomer Polymers 0.000 claims description 16
- 239000007858 starting material Substances 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 15
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 14
- 239000002253 acid Substances 0.000 claims description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 10
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 229910052717 sulfur Inorganic materials 0.000 claims description 10
- 125000004434 sulfur atom Chemical group 0.000 claims description 10
- 125000002947 alkylene group Chemical group 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 9
- 125000004423 acyloxy group Chemical group 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000005041 acyloxyalkyl group Chemical group 0.000 claims description 7
- 125000003118 aryl group Chemical group 0.000 claims description 7
- 125000004043 oxo group Chemical group O=* 0.000 claims description 7
- 125000005530 alkylenedioxy group Chemical group 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
- 239000001961 anticonvulsive agent Substances 0.000 claims description 5
- 125000005129 aryl carbonyl group Chemical group 0.000 claims description 5
- 235000019253 formic acid Nutrition 0.000 claims description 5
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 5
- 230000004799 sedative–hypnotic effect Effects 0.000 claims description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 5
- LLFKURFIVNYHLX-UHFFFAOYSA-N 10-chloro-1-(morpholine-4-carbonyl)-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazin-4-one Chemical compound C12=CC(Cl)=CC=C2CNN(C2=O)C1=C(C(=O)N1CCOCC1)C=C2C1=CC=CC=C1 LLFKURFIVNYHLX-UHFFFAOYSA-N 0.000 claims description 4
- 239000003158 myorelaxant agent Substances 0.000 claims description 4
- OMURRLFDWHJLNA-UHFFFAOYSA-N 10-chloro-1-(3-methoxyazetidine-1-carbonyl)-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazin-4-one Chemical compound C1C(OC)CN1C(=O)C1=C2C3=CC(Cl)=CC=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 OMURRLFDWHJLNA-UHFFFAOYSA-N 0.000 claims description 3
- QEHVRCCKHYCKDW-UHFFFAOYSA-N 10-chloro-n,n-dimethyl-4-oxo-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazine-1-carboxamide Chemical compound O=C1N2NCC3=CC=C(Cl)C=C3C2=C(C(=O)N(C)C)C=C1C1=CC=CC=C1 QEHVRCCKHYCKDW-UHFFFAOYSA-N 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 239000002249 anxiolytic agent Substances 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- ARNIELYKCHURLY-UHFFFAOYSA-N O=C1N2NCC=3C=CSC=3C2=C(C(=O)N(C)C)C=C1C1=CC=CC=C1 Chemical compound O=C1N2NCC=3C=CSC=3C2=C(C(=O)N(C)C)C=C1C1=CC=CC=C1 ARNIELYKCHURLY-UHFFFAOYSA-N 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 229940125681 anticonvulsant agent Drugs 0.000 claims description 2
- 230000000949 anxiolytic effect Effects 0.000 claims description 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims description 2
- 125000004983 dialkoxyalkyl group Chemical group 0.000 claims description 2
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 229910052702 rhenium Inorganic materials 0.000 claims description 2
- 125000001544 thienyl group Chemical group 0.000 claims description 2
- 102100026933 Myelin-associated neurite-outgrowth inhibitor Human genes 0.000 claims 1
- 239000005554 hypnotics and sedatives Substances 0.000 claims 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 75
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 72
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 71
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 70
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 54
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 45
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 44
- 238000006243 chemical reaction Methods 0.000 description 39
- 239000002904 solvent Substances 0.000 description 36
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 35
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 30
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
- 239000013078 crystal Substances 0.000 description 22
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 17
- 239000011541 reaction mixture Substances 0.000 description 17
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 14
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 12
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 12
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 150000001412 amines Chemical class 0.000 description 11
- 238000009835 boiling Methods 0.000 description 11
- 235000019439 ethyl acetate Nutrition 0.000 description 11
- 150000008282 halocarbons Chemical class 0.000 description 11
- 238000001953 recrystallisation Methods 0.000 description 11
- 238000010992 reflux Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 8
- 239000012442 inert solvent Substances 0.000 description 8
- 239000008096 xylene Substances 0.000 description 8
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 7
- 150000002170 ethers Chemical class 0.000 description 7
- 239000012948 isocyanate Substances 0.000 description 7
- 150000002513 isocyanates Chemical class 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000003960 organic solvent Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 229960000583 acetic acid Drugs 0.000 description 6
- 229910052786 argon Inorganic materials 0.000 description 6
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 6
- 239000000969 carrier Substances 0.000 description 6
- 239000000825 pharmaceutical preparation Substances 0.000 description 6
- 238000007363 ring formation reaction Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 150000003512 tertiary amines Chemical class 0.000 description 6
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 6
- 208000019901 Anxiety disease Diseases 0.000 description 5
- 101100379079 Emericella variicolor andA gene Proteins 0.000 description 5
- 239000012448 Lithium borohydride Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 229910052801 chlorine Inorganic materials 0.000 description 5
- 238000000354 decomposition reaction Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 125000000623 heterocyclic group Chemical group 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 5
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 5
- KXAMIGWVSKHWAR-UHFFFAOYSA-N 7-chloro-2h-phthalazine-1-thione Chemical compound C1=NNC(=S)C2=CC(Cl)=CC=C21 KXAMIGWVSKHWAR-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- 239000003638 chemical reducing agent Substances 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 239000012043 crude product Substances 0.000 description 4
- 230000032050 esterification Effects 0.000 description 4
- 238000005886 esterification reaction Methods 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 230000002140 halogenating effect Effects 0.000 description 4
- 239000005457 ice water Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 4
- IMAKHNTVDGLIRY-UHFFFAOYSA-N methyl prop-2-ynoate Chemical compound COC(=O)C#C IMAKHNTVDGLIRY-UHFFFAOYSA-N 0.000 description 4
- 229920005862 polyol Polymers 0.000 description 4
- 150000003077 polyols Chemical class 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- 229910000104 sodium hydride Inorganic materials 0.000 description 4
- JAZQJMCGJBEKTB-LJQANCHMSA-N 10-chloro-1-[(2r)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazin-4-one Chemical compound COC[C@H]1CCCN1C(=O)C1=C2C3=CC(Cl)=CC=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 JAZQJMCGJBEKTB-LJQANCHMSA-N 0.000 description 3
- RMMYJUUOCPRHCW-UHFFFAOYSA-N 4-oxo-3-phenylpyrido[2,1-a]phthalazine-1-carboxylic acid Chemical compound O=C1N2N=CC3=CC=CC=C3C2=C(C(=O)O)C=C1C1=CC=CC=C1 RMMYJUUOCPRHCW-UHFFFAOYSA-N 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 229940126062 Compound A Drugs 0.000 description 3
- 206010010904 Convulsion Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- 230000001773 anti-convulsant effect Effects 0.000 description 3
- 229960003965 antiepileptics Drugs 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 125000005842 heteroatom Chemical group 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 125000006239 protecting group Chemical group 0.000 description 3
- 229930195734 saturated hydrocarbon Natural products 0.000 description 3
- 239000012312 sodium hydride Substances 0.000 description 3
- RHZHROULVUUCJD-QGZVFWFLSA-N 13-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-7-methyl-11-phenyl-3-thia-8,9-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,7,11-pentaen-10-one Chemical compound COC[C@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3C(C)=NN2C(=O)C(C=2C=CC=CC=2)=C1 RHZHROULVUUCJD-QGZVFWFLSA-N 0.000 description 2
- UNRWOXIUUAREPO-MRXNPFEDSA-N 13-[(3R)-3-methoxypyrrolidine-1-carbonyl]-11-phenyl-3-thia-8,9-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,11-tetraen-10-one Chemical compound C1[C@H](OC)CCN1C(=O)C1=C2C(SC=C3)=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 UNRWOXIUUAREPO-MRXNPFEDSA-N 0.000 description 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- ABFPKTQEQNICFT-UHFFFAOYSA-M 2-chloro-1-methylpyridin-1-ium;iodide Chemical compound [I-].C[N+]1=CC=CC=C1Cl ABFPKTQEQNICFT-UHFFFAOYSA-M 0.000 description 2
- CMLWYJJXQXLJTA-UHFFFAOYSA-N 3-methoxy-1-((7-oxo-8-phenyl-7h-pyrido(1,2-b)thieno(2,3-d)pyridazin-10-yl)carbonyl)azetidine Chemical compound C1C(OC)CN1C(=O)C1=C2C(SC=C3)=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 CMLWYJJXQXLJTA-UHFFFAOYSA-N 0.000 description 2
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 description 2
- XHWWBHDIWZNRDI-UHFFFAOYSA-N 7-nitro-2h-phthalazine-1-thione Chemical compound C1=NNC(=S)C2=CC([N+](=O)[O-])=CC=C21 XHWWBHDIWZNRDI-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 2
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 description 2
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
- 125000004036 acetal group Chemical group 0.000 description 2
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 2
- 150000001241 acetals Chemical class 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 150000008064 anhydrides Chemical class 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229910000085 borane Inorganic materials 0.000 description 2
- 150000001735 carboxylic acids Chemical class 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 238000006352 cycloaddition reaction Methods 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- XXTZHYXQVWRADW-UHFFFAOYSA-N diazomethanone Chemical compound [N]N=C=O XXTZHYXQVWRADW-UHFFFAOYSA-N 0.000 description 2
- 239000008298 dragée Substances 0.000 description 2
- MZMJHXFYLRTLQX-UHFFFAOYSA-N ethenylsulfinylbenzene Chemical compound C=CS(=O)C1=CC=CC=C1 MZMJHXFYLRTLQX-UHFFFAOYSA-N 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 150000002430 hydrocarbons Chemical group 0.000 description 2
- SHFJWMWCIHQNCP-UHFFFAOYSA-M hydron;tetrabutylazanium;sulfate Chemical compound OS([O-])(=O)=O.CCCC[N+](CCCC)(CCCC)CCCC SHFJWMWCIHQNCP-UHFFFAOYSA-M 0.000 description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- UMTHMOIAMHAAAD-UHFFFAOYSA-N methyl 4-oxo-3-phenylpyrido[2,1-a]phthalazine-1-carboxylate Chemical compound O=C1N2N=CC3=CC=CC=C3C2=C(C(=O)OC)C=C1C1=CC=CC=C1 UMTHMOIAMHAAAD-UHFFFAOYSA-N 0.000 description 2
- AVQWCIAHAVZINM-UHFFFAOYSA-N methyl 7-oxo-8-phenyl-7h-pyrido[1,2-b]thieno[2,3-d]pyridazine-10-carboxylate Chemical compound O=C1N2N=CC=3C=CSC=3C2=C(C(=O)OC)C=C1C1=CC=CC=C1 AVQWCIAHAVZINM-UHFFFAOYSA-N 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- LEHBURLTIWGHEM-UHFFFAOYSA-N pyridinium chlorochromate Chemical compound [O-][Cr](Cl)(=O)=O.C1=CC=[NH+]C=C1 LEHBURLTIWGHEM-UHFFFAOYSA-N 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
- 229910052720 vanadium Inorganic materials 0.000 description 2
- 239000002966 varnish Substances 0.000 description 2
- 239000000052 vinegar Substances 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- XXMQQALPYWNQFA-UHFFFAOYSA-N (4,5-dihydro-7-oxo-8-phenyl-7h-pyrido[1,2-b]-thieno[2,3-d]pyridazin-10-yl)methyl-4-morpholinecarboxylate Chemical compound C1COCCN1C(=O)OCC(=C1C=2SC=CC=2CNN1C1=O)C=C1C1=CC=CC=C1 XXMQQALPYWNQFA-UHFFFAOYSA-N 0.000 description 1
- ZYECOAILUNWEAL-NUDFZHEQSA-N (4z)-4-[[2-methoxy-5-(phenylcarbamoyl)phenyl]hydrazinylidene]-n-(3-nitrophenyl)-3-oxonaphthalene-2-carboxamide Chemical compound COC1=CC=C(C(=O)NC=2C=CC=CC=2)C=C1N\N=C(C1=CC=CC=C1C=1)/C(=O)C=1C(=O)NC1=CC=CC([N+]([O-])=O)=C1 ZYECOAILUNWEAL-NUDFZHEQSA-N 0.000 description 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- ZZQCBMLFRABDSI-UHFFFAOYSA-N 1-(3-hydroxyazetidine-1-carbonyl)-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound C1C(O)CN1C(=O)C1=C2C3=CC=CC=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 ZZQCBMLFRABDSI-UHFFFAOYSA-N 0.000 description 1
- GGIDEHNEDOQHCT-UHFFFAOYSA-N 1-(3-methoxyazetidine-1-carbonyl)-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound C1C(OC)CN1C(=O)C1=C2C3=CC=CC=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 GGIDEHNEDOQHCT-UHFFFAOYSA-N 0.000 description 1
- VUMQMGZMZXEVIJ-UHFFFAOYSA-N 1-(morpholine-4-carbonyl)-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound C1=C(C=2C=CC=CC=2)C(=O)N2N=CC3=CC=CC=C3C2=C1C(=O)N1CCOCC1 VUMQMGZMZXEVIJ-UHFFFAOYSA-N 0.000 description 1
- NISGLMGHNJARFJ-LJQANCHMSA-N 1-[(2r)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound COC[C@H]1CCCN1C(=O)C1=C2C3=CC=CC=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 NISGLMGHNJARFJ-LJQANCHMSA-N 0.000 description 1
- RGQUWMQSJLCPBM-GOSISDBHSA-N 1-[(3r)-3-methoxypyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazin-4-one Chemical compound C1[C@H](OC)CCN1C(=O)C1=C2C3=CC=CC=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 RGQUWMQSJLCPBM-GOSISDBHSA-N 0.000 description 1
- XEAAQWCDOLIKAB-UHFFFAOYSA-N 10-(3-cyclopropyl-1,2,4 oxadiazol-5-yl)-7-oxo-8-phenyl-7h-pyrido[1,2-b]thieno[2,3-d]pyridazine Chemical compound C=12C=3SC=CC=3C=NN2C(=O)C(C=2C=CC=CC=2)=CC=1C(ON=1)=NC=1C1CC1 XEAAQWCDOLIKAB-UHFFFAOYSA-N 0.000 description 1
- UDAXRMZYQLFUEY-UHFFFAOYSA-N 10-chloro-1-(3-methoxyazetidine-1-carbonyl)-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound C1C(OC)CN1C(=O)C1=C2C3=CC(Cl)=CC=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 UDAXRMZYQLFUEY-UHFFFAOYSA-N 0.000 description 1
- OGEWBCGUZPQFAL-LJQANCHMSA-N 10-chloro-1-[(2r)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound COC[C@H]1CCCN1C(=O)C1=C2C3=CC(Cl)=CC=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 OGEWBCGUZPQFAL-LJQANCHMSA-N 0.000 description 1
- NREAALCWDQQYOD-SFHVURJKSA-N 10-chloro-1-[(2s)-2-(hydroxymethyl)pyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazin-4-one Chemical compound OC[C@@H]1CCCN1C(=O)C1=C2C3=CC(Cl)=CC=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 NREAALCWDQQYOD-SFHVURJKSA-N 0.000 description 1
- WKALDCVOSAVQSA-SFHVURJKSA-N 10-chloro-1-[(2s)-2-(hydroxymethyl)pyrrolidine-1-carbonyl]-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound OC[C@@H]1CCCN1C(=O)C1=C2C3=CC(Cl)=CC=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 WKALDCVOSAVQSA-SFHVURJKSA-N 0.000 description 1
- JAZQJMCGJBEKTB-IBGZPJMESA-N 10-chloro-1-[(2s)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazin-4-one Chemical compound COC[C@@H]1CCCN1C(=O)C1=C2C3=CC(Cl)=CC=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 JAZQJMCGJBEKTB-IBGZPJMESA-N 0.000 description 1
- OGEWBCGUZPQFAL-IBGZPJMESA-N 10-chloro-1-[(2s)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound COC[C@@H]1CCCN1C(=O)C1=C2C3=CC(Cl)=CC=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 OGEWBCGUZPQFAL-IBGZPJMESA-N 0.000 description 1
- PBCYHOKURCQSAI-GOSISDBHSA-N 10-chloro-1-[(3r)-3-methoxypyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazin-4-one Chemical compound C1[C@H](OC)CCN1C(=O)C1=C2C3=CC(Cl)=CC=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 PBCYHOKURCQSAI-GOSISDBHSA-N 0.000 description 1
- NXKMNLDJTINDJK-GOSISDBHSA-N 10-chloro-1-[(3r)-3-methoxypyrrolidine-1-carbonyl]-3-phenylpyrido[2,1-a]phthalazin-4-one Chemical compound C1[C@H](OC)CCN1C(=O)C1=C2C3=CC(Cl)=CC=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 NXKMNLDJTINDJK-GOSISDBHSA-N 0.000 description 1
- AKJWDABHSPSOGD-UHFFFAOYSA-N 10-chloro-n,n-diethyl-4-oxo-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazine-1-carboxamide Chemical compound O=C1N2NCC3=CC=C(Cl)C=C3C2=C(C(=O)N(CC)CC)C=C1C1=CC=CC=C1 AKJWDABHSPSOGD-UHFFFAOYSA-N 0.000 description 1
- OALVCDVTGWHBQL-UHFFFAOYSA-N 10-chloro-n,n-diethyl-4-oxo-3-phenylpyrido[2,1-a]phthalazine-1-carboxamide Chemical compound O=C1N2N=CC3=CC=C(Cl)C=C3C2=C(C(=O)N(CC)CC)C=C1C1=CC=CC=C1 OALVCDVTGWHBQL-UHFFFAOYSA-N 0.000 description 1
- KOBBSJVNYLPRTB-UHFFFAOYSA-N 10-chloro-n,n-dimethyl-4-oxo-3-phenylpyrido[2,1-a]phthalazine-1-carboxamide Chemical compound O=C1N2N=CC3=CC=C(Cl)C=C3C2=C(C(=O)N(C)C)C=C1C1=CC=CC=C1 KOBBSJVNYLPRTB-UHFFFAOYSA-N 0.000 description 1
- MCQBQZIBMVIZBV-UHFFFAOYSA-N 10-chloro-n-ethyl-n-(2-methoxyethyl)-4-oxo-3-phenyl-6,7-dihydropyrido[2,1-a]phthalazine-1-carboxamide Chemical compound O=C1N2NCC3=CC=C(Cl)C=C3C2=C(C(=O)N(CCOC)CC)C=C1C1=CC=CC=C1 MCQBQZIBMVIZBV-UHFFFAOYSA-N 0.000 description 1
- LCBJPBGIVZDLOB-UHFFFAOYSA-N 10-chloro-n-ethyl-n-(2-methoxyethyl)-4-oxo-3-phenylpyrido[2,1-a]phthalazine-1-carboxamide Chemical compound O=C1N2N=CC3=CC=C(Cl)C=C3C2=C(C(=O)N(CCOC)CC)C=C1C1=CC=CC=C1 LCBJPBGIVZDLOB-UHFFFAOYSA-N 0.000 description 1
- WNNTZLMVRLVEAL-QGZVFWFLSA-N 13-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-11-phenyl-3-thia-8,9-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,11-tetraen-10-one Chemical compound COC[C@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 WNNTZLMVRLVEAL-QGZVFWFLSA-N 0.000 description 1
- GKJUIWOYVPXEEN-QGZVFWFLSA-N 13-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-11-phenyl-3-thia-8,9-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,7,11-pentaen-10-one Chemical compound COC[C@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 GKJUIWOYVPXEEN-QGZVFWFLSA-N 0.000 description 1
- WNNTZLMVRLVEAL-KRWDZBQOSA-N 13-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-11-phenyl-3-thia-8,9-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,11-tetraen-10-one Chemical compound COC[C@@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3CNN2C(=O)C(C=2C=CC=CC=2)=C1 WNNTZLMVRLVEAL-KRWDZBQOSA-N 0.000 description 1
- GKJUIWOYVPXEEN-KRWDZBQOSA-N 13-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-11-phenyl-3-thia-8,9-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,7,11-pentaen-10-one Chemical compound COC[C@@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3C=NN2C(=O)C(C=2C=CC=CC=2)=C1 GKJUIWOYVPXEEN-KRWDZBQOSA-N 0.000 description 1
- FSDLIDQQJKQRNB-SFHVURJKSA-N 13-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-8-methyl-11-phenyl-3-thia-8,9-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,11-tetraen-10-one Chemical compound COC[C@@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3CN(C)N2C(=O)C(C=2C=CC=CC=2)=C1 FSDLIDQQJKQRNB-SFHVURJKSA-N 0.000 description 1
- PVJZBZSCGJAWNG-UHFFFAOYSA-N 2,4,6-trimethylbenzenesulfonyl chloride Chemical compound CC1=CC(C)=C(S(Cl)(=O)=O)C(C)=C1 PVJZBZSCGJAWNG-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- 125000004278 2-oxazolin-2-yl group Chemical group [H]C1([H])OC(*)=NC1([H])[H] 0.000 description 1
- MVPVSDDVDXPOOP-UHFFFAOYSA-N 3-(2-chlorophenyl)oxirane-2,2-dicarbonitrile Chemical compound ClC1=CC=CC=C1C1C(C#N)(C#N)O1 MVPVSDDVDXPOOP-UHFFFAOYSA-N 0.000 description 1
- QHTCMUIWJSESBR-UHFFFAOYSA-N 3-(3-chlorophenyl)oxirane-2,2-dicarbonitrile Chemical compound ClC1=CC=CC(C2C(O2)(C#N)C#N)=C1 QHTCMUIWJSESBR-UHFFFAOYSA-N 0.000 description 1
- TXPQLTJOGXSVGN-UHFFFAOYSA-N 3-(4-chlorophenyl)oxirane-2,2-dicarbonitrile Chemical compound C1=CC(Cl)=CC=C1C1C(C#N)(C#N)O1 TXPQLTJOGXSVGN-UHFFFAOYSA-N 0.000 description 1
- FXQHQOZGEJSOST-UHFFFAOYSA-N 3-phenyloxirane-2,2-dicarbonitrile Chemical compound N#CC1(C#N)OC1C1=CC=CC=C1 FXQHQOZGEJSOST-UHFFFAOYSA-N 0.000 description 1
- ZPJCPQMELXIQBK-UHFFFAOYSA-N 4,5-dihydro-10-(hydroxymethyl)-8-phenyl-7h-pyrido[1,2-b]thieno[2,3-d]pyridazin-7-one Chemical compound O=C1N2NCC=3C=CSC=3C2=C(CO)C=C1C1=CC=CC=C1 ZPJCPQMELXIQBK-UHFFFAOYSA-N 0.000 description 1
- AKPFNWJBXWIFCP-UHFFFAOYSA-N 4-methyl-6h-thieno[2,3-d]pyridazine-7-thione Chemical compound CC1=NNC(=S)C2=C1C=CS2 AKPFNWJBXWIFCP-UHFFFAOYSA-N 0.000 description 1
- RCGMJFIJVKTRAI-UHFFFAOYSA-N 6h-thieno[2,3-d]pyridazine-7-thione Chemical compound S=C1NN=CC2=C1SC=C2 RCGMJFIJVKTRAI-UHFFFAOYSA-N 0.000 description 1
- OOKJRZYVWWMGFI-UHFFFAOYSA-N 7-nitro-2h-phthalazin-1-one Chemical compound C1=NNC(=O)C2=CC([N+](=O)[O-])=CC=C21 OOKJRZYVWWMGFI-UHFFFAOYSA-N 0.000 description 1
- QTWYQVLTDKKSKW-UHFFFAOYSA-N C1=C(C=2C=CC=CC=2)C(=O)N2NCC=3C=CSC=3C2=C1C(=O)N1CCOCC1 Chemical compound C1=C(C=2C=CC=CC=2)C(=O)N2NCC=3C=CSC=3C2=C1C(=O)N1CCOCC1 QTWYQVLTDKKSKW-UHFFFAOYSA-N 0.000 description 1
- FDKVJMMXEGFTMY-UHFFFAOYSA-N C1C(OC)CN1C(=O)C1=C2C(SC=C3)=C3C(C)=NN2C(=O)C(C=2C=CC=CC=2)=C1 Chemical compound C1C(OC)CN1C(=O)C1=C2C(SC=C3)=C3C(C)=NN2C(=O)C(C=2C=CC=CC=2)=C1 FDKVJMMXEGFTMY-UHFFFAOYSA-N 0.000 description 1
- ZGPPTVDHPAVAJL-UHFFFAOYSA-N C1C(OC)CN1C(=O)C1=C2C(SC=C3)=C3C(C)NN2C(=O)C(C=2C=CC=CC=2)=C1 Chemical compound C1C(OC)CN1C(=O)C1=C2C(SC=C3)=C3C(C)NN2C(=O)C(C=2C=CC=CC=2)=C1 ZGPPTVDHPAVAJL-UHFFFAOYSA-N 0.000 description 1
- UZLUBEZVVOLCON-UHFFFAOYSA-N C1C(OC)CN1C(=O)C1=C2C(SC=C3)=C3CN(C)N2C(=O)C(C=2C=CC=CC=2)=C1 Chemical compound C1C(OC)CN1C(=O)C1=C2C(SC=C3)=C3CN(C)N2C(=O)C(C=2C=CC=CC=2)=C1 UZLUBEZVVOLCON-UHFFFAOYSA-N 0.000 description 1
- YFXQGFZEQRCKCQ-UHFFFAOYSA-N C=12C=3SC=CC=3CNN2C(=O)C(C=2C=CC=CC=2)=CC=1C(ON=1)=NC=1C1CC1 Chemical compound C=12C=3SC=CC=3CNN2C(=O)C(C=2C=CC=CC=2)=CC=1C(ON=1)=NC=1C1CC1 YFXQGFZEQRCKCQ-UHFFFAOYSA-N 0.000 description 1
- VQYYODDQSBURHC-UHFFFAOYSA-N CN(C(=O)C=1C=C(C(N2C1C1=CC(=CC=C1C=N2)Cl)=O)C2=CC=CC=C2)C.CNC Chemical compound CN(C(=O)C=1C=C(C(N2C1C1=CC(=CC=C1C=N2)Cl)=O)C2=CC=CC=C2)C.CNC VQYYODDQSBURHC-UHFFFAOYSA-N 0.000 description 1
- NDKHODAKMMAYBP-UHUGOGIASA-N COC[C@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3C(C)N(C)N2C(=O)C(C=2C=CC=CC=2)=C1 Chemical compound COC[C@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3C(C)N(C)N2C(=O)C(C=2C=CC=CC=2)=C1 NDKHODAKMMAYBP-UHUGOGIASA-N 0.000 description 1
- PORXPDQQBPKJJU-OMOCHNIRSA-N COC[C@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3C(C)NN2C(=O)C(C=2C=CC=CC=2)=C1 Chemical compound COC[C@H]1CCCN1C(=O)C1=C2C(SC=C3)=C3C(C)NN2C(=O)C(C=2C=CC=CC=2)=C1 PORXPDQQBPKJJU-OMOCHNIRSA-N 0.000 description 1
- FXIXEGSPOSTAIO-UHFFFAOYSA-N ClC1=CC=C2C=NN3C(C2=C1)=C(C=C(C3=O)C3=CC=CC=C3)C(=O)N3CC(C3)OC.COC3CNC3 Chemical compound ClC1=CC=C2C=NN3C(C2=C1)=C(C=C(C3=O)C3=CC=CC=C3)C(=O)N3CC(C3)OC.COC3CNC3 FXIXEGSPOSTAIO-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 1
- 206010014566 Emprosthotonus Diseases 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010049816 Muscle tightness Diseases 0.000 description 1
- OSAPLVROHUAKTG-UHFFFAOYSA-N O=C1N2N(C)CC=3C=CSC=3C2=C(C(=O)N(C)C)C=C1C1=CC=CC=C1 Chemical compound O=C1N2N(C)CC=3C=CSC=3C2=C(C(=O)N(C)C)C=C1C1=CC=CC=C1 OSAPLVROHUAKTG-UHFFFAOYSA-N 0.000 description 1
- BNWQYDWALZBUET-UHFFFAOYSA-N O=C1N2N=CC=3C=CSC=3C2=C(C(=O)N(CCOC)CC)C=C1C1=CC=CC=C1 Chemical compound O=C1N2N=CC=3C=CSC=3C2=C(C(=O)N(CCOC)CC)C=C1C1=CC=CC=C1 BNWQYDWALZBUET-UHFFFAOYSA-N 0.000 description 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 1
- HVVNJUAVDAZWCB-YFKPBYRVSA-N [(2s)-pyrrolidin-2-yl]methanol Chemical compound OC[C@@H]1CCCN1 HVVNJUAVDAZWCB-YFKPBYRVSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 1
- 229910000102 alkali metal hydride Inorganic materials 0.000 description 1
- 150000008046 alkali metal hydrides Chemical class 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 125000005277 alkyl imino group Chemical group 0.000 description 1
- 150000004791 alkyl magnesium halides Chemical class 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 230000000049 anti-anxiety effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940005530 anxiolytics Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 description 1
- UQUPQEUNHVVNKW-UHFFFAOYSA-N azetidin-1-ium-3-ol;chloride Chemical compound Cl.OC1CNC1 UQUPQEUNHVVNKW-UHFFFAOYSA-N 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 1
- 150000001731 carboxylic acid azides Chemical class 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 150000004292 cyclic ethers Chemical class 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- 125000004990 dihydroxyalkyl group Chemical group 0.000 description 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical group 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000010200 folin Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- HVTICUPFWKNHNG-UHFFFAOYSA-N iodoethane Chemical compound CCI HVTICUPFWKNHNG-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical compound C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- QZQHEIAIHBYMLC-UHFFFAOYSA-N methyl 10-chloro-4-oxo-3-phenylpyrido[2,1-a]phthalazine-1-carboxylate Chemical compound O=C1N2N=CC3=CC=C(Cl)C=C3C2=C(C(=O)OC)C=C1C1=CC=CC=C1 QZQHEIAIHBYMLC-UHFFFAOYSA-N 0.000 description 1
- ULHLMCFTGRDQET-UHFFFAOYSA-N methyl 4,5-dihydro-5-methyl-7-oxo-8-phenyl-7h-pyrido[1,2-b]thieno-[2,3-d]pyridazine-10-carboxylate Chemical compound O=C1N2N(C)CC=3C=CSC=3C2=C(C(=O)OC)C=C1C1=CC=CC=C1 ULHLMCFTGRDQET-UHFFFAOYSA-N 0.000 description 1
- OZYOYHKUJOFXBY-UHFFFAOYSA-N methyl 4,5-dihydro-7-oxo-8-phenyl-7h-pyrido[1,2-b]thieno[2,3-d]pyridazine-10-carboxylate Chemical compound O=C1N2NCC=3C=CSC=3C2=C(C(=O)OC)C=C1C1=CC=CC=C1 OZYOYHKUJOFXBY-UHFFFAOYSA-N 0.000 description 1
- PAKGYWHEXUMFJU-UHFFFAOYSA-N methyl 5-acetyl-4,5-dihydro-7-oxo-8-phenyl-7h-pyrido[1,2-b]thieno[2,3-d]pyridazine-10-carboxylate Chemical compound O=C1N2N(C(C)=O)CC=3C=CSC=3C2=C(C(=O)OC)C=C1C1=CC=CC=C1 PAKGYWHEXUMFJU-UHFFFAOYSA-N 0.000 description 1
- XMWFMEYDRNJSOO-UHFFFAOYSA-N morpholine-4-carbonyl chloride Chemical compound ClC(=O)N1CCOCC1 XMWFMEYDRNJSOO-UHFFFAOYSA-N 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- HSPSCWZIJWKZKD-UHFFFAOYSA-N n-chloroacetamide Chemical compound CC(=O)NCl HSPSCWZIJWKZKD-UHFFFAOYSA-N 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 description 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
- MLGFHJHBQIXXDW-UHFFFAOYSA-N phthalazine-1-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=NN=CC2=C1 MLGFHJHBQIXXDW-UHFFFAOYSA-N 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- SEDZOYHHAIAQIW-UHFFFAOYSA-N trimethylsilyl azide Chemical compound C[Si](C)(C)N=[N+]=[N-] SEDZOYHHAIAQIW-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH220687 | 1987-06-12 | ||
| CH129788 | 1988-04-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO882558D0 NO882558D0 (no) | 1988-06-10 |
| NO882558L true NO882558L (no) | 1988-12-13 |
Family
ID=25687239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO882558A NO882558L (no) | 1987-06-12 | 1988-06-10 | Tricykliske pyridonderivater. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US4889854A (fr) |
| EP (1) | EP0294599A3 (fr) |
| JP (1) | JPS63316779A (fr) |
| KR (1) | KR890000481A (fr) |
| CN (1) | CN88103535A (fr) |
| AU (1) | AU1742788A (fr) |
| DK (1) | DK317388A (fr) |
| FI (1) | FI882750A (fr) |
| HU (1) | HU201069B (fr) |
| IL (1) | IL86639A0 (fr) |
| MC (1) | MC1961A1 (fr) |
| NO (1) | NO882558L (fr) |
| PT (1) | PT87699B (fr) |
| SU (1) | SU1598879A3 (fr) |
| YU (1) | YU108788A (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1317945C (fr) * | 1985-12-13 | 1993-05-18 | Ulf Fischer | Derives de pyridazopyridone tricyclique |
| GB8728314D0 (en) * | 1987-12-03 | 1988-01-06 | May & Baker Ltd | New compositions of matter |
| GB9708945D0 (en) * | 1997-05-01 | 1997-06-25 | Merck Sharp & Dohme | Therapeutic agents |
| UA52804C2 (uk) | 1997-12-02 | 2003-01-15 | Текнікал Графікс Сек'Юріті Продактс, Ллс | Магнітний/металевий захисний пристрій (варіанти), спосіб його виготовлення (варіанти), спосіб встановлення його автентичності і металевий захисний пристрій |
| US7303570B2 (en) * | 1999-07-28 | 2007-12-04 | Cardica, Inc. | Anastomosis tool having a connector holder |
| MXPA05010454A (es) | 2003-04-02 | 2005-11-04 | Valspar Sourcing Inc | Dispersiones y recubrimientos acuosos. |
| US7243951B2 (en) * | 2003-08-19 | 2007-07-17 | Technical Graphics, Inc. | Durable security devices and security articles employing such devices |
| EP1819789B1 (fr) * | 2004-10-20 | 2011-06-15 | Valspar Sourcing, Inc. | Compositions de revetement pour canettes et procedes de revetement |
| US7482345B2 (en) * | 2005-12-05 | 2009-01-27 | Meng-Hsin Chen | P38 kinase inhibiting agents |
| EP3156228B1 (fr) | 2009-04-09 | 2023-11-29 | Swimc Llc | Polymère présentant une fonctionnalité cycloaliphatique insaturée et compositions de revêtement formées à partir de ceux-ci |
| US8486574B2 (en) * | 2009-07-14 | 2013-07-16 | Ford Global Technologies, Llc | Method and system for power control in an automotive vehicle |
| US8754614B2 (en) * | 2009-07-17 | 2014-06-17 | Tesla Motors, Inc. | Fast charging of battery using adjustable voltage control |
| US8747979B2 (en) | 2009-07-17 | 2014-06-10 | Valspar Sourcing, Inc. | Coating compositions and articles coated therewith |
| EP3483195A1 (fr) | 2009-09-18 | 2019-05-15 | Swimc, LLC | Composition de revêtement à base de polyuréthane |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ191763A (en) * | 1978-10-13 | 1984-05-31 | Hoffmann La Roche | 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions |
| US4650804A (en) * | 1984-03-30 | 1987-03-17 | Fujisawa Pharmaceutical Co., Ltd. | Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents |
| ZW17385A1 (en) * | 1984-11-06 | 1986-02-19 | Hoffmann La Roche | Tricyclic pyridine derivatives |
| CA1317945C (fr) * | 1985-12-13 | 1993-05-18 | Ulf Fischer | Derives de pyridazopyridone tricyclique |
-
1988
- 1988-05-09 EP EP88107444A patent/EP0294599A3/fr not_active Withdrawn
- 1988-05-25 US US07/198,535 patent/US4889854A/en not_active Expired - Fee Related
- 1988-06-03 SU SU884355854A patent/SU1598879A3/ru active
- 1988-06-06 YU YU01087/88A patent/YU108788A/xx unknown
- 1988-06-06 AU AU17427/88A patent/AU1742788A/en not_active Abandoned
- 1988-06-06 IL IL86639A patent/IL86639A0/xx unknown
- 1988-06-08 HU HU882955A patent/HU201069B/hu not_active IP Right Cessation
- 1988-06-09 MC MC881984A patent/MC1961A1/fr unknown
- 1988-06-09 PT PT87699A patent/PT87699B/pt not_active IP Right Cessation
- 1988-06-09 FI FI882750A patent/FI882750A/fi not_active IP Right Cessation
- 1988-06-10 NO NO882558A patent/NO882558L/no unknown
- 1988-06-10 DK DK317388A patent/DK317388A/da not_active Application Discontinuation
- 1988-06-10 KR KR1019880006977A patent/KR890000481A/ko not_active Application Discontinuation
- 1988-06-10 CN CN198888103535A patent/CN88103535A/zh active Pending
- 1988-06-11 JP JP63144555A patent/JPS63316779A/ja active Pending
-
1989
- 1989-10-16 US US07/422,197 patent/US5082842A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MC1961A1 (fr) | 1989-06-30 |
| US4889854A (en) | 1989-12-26 |
| PT87699B (pt) | 1992-10-30 |
| KR890000481A (ko) | 1989-03-14 |
| NO882558D0 (no) | 1988-06-10 |
| US5082842A (en) | 1992-01-21 |
| PT87699A (pt) | 1988-07-01 |
| FI882750A0 (fi) | 1988-06-09 |
| HU201069B (en) | 1990-09-28 |
| DK317388A (da) | 1988-12-13 |
| IL86639A0 (en) | 1988-11-30 |
| SU1598879A3 (ru) | 1990-10-07 |
| FI882750A (fi) | 1988-12-13 |
| YU108788A (en) | 1990-04-30 |
| DK317388D0 (da) | 1988-06-10 |
| AU1742788A (en) | 1988-12-15 |
| EP0294599A3 (fr) | 1990-05-09 |
| EP0294599A2 (fr) | 1988-12-14 |
| JPS63316779A (ja) | 1988-12-26 |
| HUT47273A (en) | 1989-02-28 |
| CN88103535A (zh) | 1988-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4690930A (en) | Pyrazolo[4,3-c]quinoline-3-one and imidazo[4,3-c]cinnolin-3-one derivatives and their use as psychotropic agents | |
| CA2931583C (fr) | Derives d'imidazopyridine comme modulateurs de l'activite du tnf | |
| NO882558L (no) | Tricykliske pyridonderivater. | |
| WO2015086498A1 (fr) | Dérivés de tétrahydroimidazopyridine substitués comme modulateurs de l'activité du tnf | |
| NO310620B1 (no) | Nye kinazolinforbindelser, farmasöytisk formulering inneholdende slike forbindelser, anvendelse derav, ogfremgangsmåte for deres fremstilling | |
| IL148932A (en) | Inhibitors of cell adhesion are debated by 2αLβ | |
| AU2011336214B2 (en) | KAT II inhibitors | |
| FI89049B (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara tricykliska pyridinderivat och mellanprodukter | |
| CZ17988A3 (en) | BENZOPYRAN(4,3-c)PYRAZOLE OR BENZOTHIOPYRAN(4,3-c)PYRAZOLE DERIVATIVES, PROCESSES OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE COMPRISED | |
| US7700634B2 (en) | (Indol-3-yl) heterocycle derivatives as agonists of the cannabinoid CB1 receptor | |
| NO129043B (fr) | ||
| NO802326L (no) | Fremgangsmaate ved fremstilling av substituerte tetraazatricyklen | |
| AU597016B2 (en) | Tricyclic pyridazopyridone derivatives | |
| US6528653B2 (en) | Thienopyrrolidinones | |
| AU2001287568A1 (en) | Thienopyrrolidinones | |
| KR930005448B1 (ko) | 트리사이클릭 피리딘 유도체의 제조방법 | |
| KR950007178B1 (ko) | 트리사이클릭 피리다조피리돈 유도체 및 그의 제조방법 | |
| ZA200209971B (en) | Thienopyrrolidinones. | |
| ZA200408060B (en) | 1-oxa-3-aza-deibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the production thereof |