NO854712L - Nitrogenderivater av oksoforbindelser. - Google Patents
Nitrogenderivater av oksoforbindelser.Info
- Publication number
- NO854712L NO854712L NO854712A NO854712A NO854712L NO 854712 L NO854712 L NO 854712L NO 854712 A NO854712 A NO 854712A NO 854712 A NO854712 A NO 854712A NO 854712 L NO854712 L NO 854712L
- Authority
- NO
- Norway
- Prior art keywords
- stands
- lower alkyl
- residues
- group
- oxo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 75
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical class [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims description 63
- -1 3-oxa-1,5-pentylene Chemical group 0.000 claims description 40
- 150000003839 salts Chemical class 0.000 claims description 29
- 239000001257 hydrogen Substances 0.000 claims description 26
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 18
- 125000002947 alkylene group Chemical group 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 150000002367 halogens Chemical class 0.000 claims description 9
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- IFTBVXOIBSEIGP-UHFFFAOYSA-N [(2,2-dimethyl-5-oxo-3,4-dihydrobenzo[h]chromen-6-ylidene)amino]urea Chemical compound C12=CC=CC=C2C(=NNC(N)=O)C(=O)C2=C1OC(C)(C)CC2 IFTBVXOIBSEIGP-UHFFFAOYSA-N 0.000 claims description 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 125000000464 thioxo group Chemical group S=* 0.000 claims description 5
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 4
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 3
- DCRWATIKESMSAG-UHFFFAOYSA-N [(2,2-dimethyl-5-oxo-3,4-dihydrobenzo[h]chromen-6-ylidene)amino]thiourea Chemical compound C12=CC=CC=C2C(=NNC(N)=S)C(=O)C2=C1OC(C)(C)CC2 DCRWATIKESMSAG-UHFFFAOYSA-N 0.000 claims description 2
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- DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 claims description 2
- YSULOORXQBDPCU-UHFFFAOYSA-O (2-hydrazinyl-2-oxoethyl)-trimethylazanium;hydrochloride Chemical compound Cl.C[N+](C)(C)CC(=O)NN YSULOORXQBDPCU-UHFFFAOYSA-O 0.000 claims 1
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- JBFGUBYZMUYYTH-UHFFFAOYSA-N 2-(dimethylamino)-n-[(2,2-dimethyl-5-oxo-3,4-dihydrobenzo[h]chromen-6-ylidene)amino]acetamide Chemical compound C12=CC=CC=C2C(=NNC(=O)CN(C)C)C(=O)C2=C1OC(C)(C)CC2 JBFGUBYZMUYYTH-UHFFFAOYSA-N 0.000 claims 1
- DALNXMAZDJRTPB-UHFFFAOYSA-N 2-(dimethylamino)acetohydrazide Chemical compound CN(C)CC(=O)NN DALNXMAZDJRTPB-UHFFFAOYSA-N 0.000 claims 1
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 7
- PWDRXAGBIBJHNE-UHFFFAOYSA-N 2h-pyran-5,6-dione Chemical compound O=C1OCC=CC1=O PWDRXAGBIBJHNE-UHFFFAOYSA-N 0.000 description 6
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- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 5
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- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 5
- 239000002502 liposome Substances 0.000 description 5
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- QZPQTZZNNJUOLS-UHFFFAOYSA-N beta-lapachone Chemical compound C12=CC=CC=C2C(=O)C(=O)C2=C1OC(C)(C)CC2 QZPQTZZNNJUOLS-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 4
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- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 3
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- 229940093471 ethyl oleate Drugs 0.000 description 1
- LTZZYVWUGIPISL-UHFFFAOYSA-N ethyl(hydroxy)azanium;chloride Chemical compound [Cl-].CC[NH2+]O LTZZYVWUGIPISL-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
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- RGZRSLKIOCHTSI-UHFFFAOYSA-N hydron;n-methylhydroxylamine;chloride Chemical compound Cl.CNO RGZRSLKIOCHTSI-UHFFFAOYSA-N 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
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- 125000002950 monocyclic group Chemical group 0.000 description 1
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
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- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- 239000011975 tartaric acid Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH562984 | 1984-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO854712L true NO854712L (no) | 1985-05-27 |
Family
ID=4296800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO854712A NO854712L (no) | 1984-11-26 | 1985-11-25 | Nitrogenderivater av oksoforbindelser. |
Country Status (20)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962944B2 (en) * | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
| CN116730969B (zh) * | 2023-06-26 | 2024-04-19 | 中国药科大学 | 一种β-拉帕醌-氨基酸缀合物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3154565A (en) * | 1962-03-22 | 1964-10-27 | Merck & Co Inc | Chromenyl compounds and method of preparing |
| AT334896B (de) * | 1973-09-28 | 1977-02-10 | Erba Carlo Spa | Verfahren zum herstellen von neuen 1-oxo-1h-naphtho (2,1-b)pyranderivaten |
| DE2654796A1 (de) * | 1976-12-03 | 1978-06-08 | Hoechst Ag | Polyoxygenierte labdan-derivate |
-
1985
- 1985-11-20 MC MC851804A patent/MC1710A1/xx unknown
- 1985-11-21 EP EP85810555A patent/EP0183649A1/de not_active Withdrawn
- 1985-11-22 MT MT974A patent/MTP974B/xx unknown
- 1985-11-22 AU AU50348/85A patent/AU5034885A/en not_active Abandoned
- 1985-11-22 FI FI854632A patent/FI854632A7/fi not_active Application Discontinuation
- 1985-11-22 MW MW39/85A patent/MW3985A1/xx unknown
- 1985-11-22 MA MA20803A patent/MA20578A1/fr unknown
- 1985-11-25 ZM ZM87/85A patent/ZM8785A1/xx unknown
- 1985-11-25 GR GR852843A patent/GR852843B/el unknown
- 1985-11-25 OA OA58735A patent/OA08542A/xx unknown
- 1985-11-25 DD DD85283220A patent/DD239203A5/de unknown
- 1985-11-25 DK DK544485A patent/DK544485A/da not_active Application Discontinuation
- 1985-11-25 ZW ZW209/85A patent/ZW20985A1/xx unknown
- 1985-11-25 ZA ZA858992A patent/ZA858992B/xx unknown
- 1985-11-25 IL IL77139A patent/IL77139A0/xx unknown
- 1985-11-25 PT PT81554A patent/PT81554B/pt unknown
- 1985-11-25 KR KR1019850008785A patent/KR860004047A/ko not_active Withdrawn
- 1985-11-25 PL PL25644085A patent/PL256440A1/xx unknown
- 1985-11-25 NO NO854712A patent/NO854712L/no unknown
- 1985-11-26 JP JP60263978A patent/JPS61186378A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI854632A0 (fi) | 1985-11-22 |
| PT81554A (en) | 1985-12-01 |
| DK544485A (da) | 1986-05-27 |
| JPS61186378A (ja) | 1986-08-20 |
| DD239203A5 (de) | 1986-09-17 |
| ZM8785A1 (en) | 1986-06-27 |
| PT81554B (en) | 1987-09-21 |
| AU5034885A (en) | 1986-06-05 |
| MC1710A1 (fr) | 1986-09-22 |
| DK544485D0 (da) | 1985-11-25 |
| ZA858992B (en) | 1986-07-30 |
| GR852843B (enrdf_load_stackoverflow) | 1986-03-21 |
| MA20578A1 (fr) | 1986-07-01 |
| MW3985A1 (en) | 1986-12-10 |
| OA08542A (fr) | 1988-09-30 |
| PL256440A1 (en) | 1986-10-07 |
| KR860004047A (ko) | 1986-06-16 |
| MTP974B (en) | 1990-03-30 |
| EP0183649A1 (de) | 1986-06-04 |
| IL77139A0 (en) | 1986-04-29 |
| FI854632A7 (fi) | 1986-05-27 |
| ZW20985A1 (en) | 1986-06-25 |
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