NO841811L - Nye vektorer for interferonekspersjon - Google Patents
Nye vektorer for interferonekspersjonInfo
- Publication number
- NO841811L NO841811L NO841811A NO841811A NO841811L NO 841811 L NO841811 L NO 841811L NO 841811 A NO841811 A NO 841811A NO 841811 A NO841811 A NO 841811A NO 841811 L NO841811 L NO 841811L
- Authority
- NO
- Norway
- Prior art keywords
- interferon
- organism
- yeast
- gene
- temperature
- Prior art date
Links
- 108010050904 Interferons Proteins 0.000 title claims abstract description 51
- 102000014150 Interferons Human genes 0.000 title claims abstract description 48
- 229940079322 interferon Drugs 0.000 title claims abstract description 44
- 239000013598 vector Substances 0.000 title claims description 13
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 12
- 229910052816 inorganic phosphate Inorganic materials 0.000 claims abstract description 8
- 239000001963 growth medium Substances 0.000 claims abstract description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 57
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 40
- 108010051457 Acid Phosphatase Proteins 0.000 claims description 22
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 claims description 21
- 102000013563 Acid Phosphatase Human genes 0.000 claims description 21
- 239000013604 expression vector Substances 0.000 claims description 12
- 108010047761 Interferon-alpha Proteins 0.000 claims description 8
- 102000006992 Interferon-alpha Human genes 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000010367 cloning Methods 0.000 claims description 4
- 239000006166 lysate Substances 0.000 claims description 4
- 230000016396 cytokine production Effects 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 abstract description 15
- 239000013612 plasmid Substances 0.000 description 27
- 239000012634 fragment Substances 0.000 description 23
- 108020004414 DNA Proteins 0.000 description 18
- 230000000694 effects Effects 0.000 description 17
- 239000002609 medium Substances 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 16
- 210000005253 yeast cell Anatomy 0.000 description 11
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 9
- 238000003786 synthesis reaction Methods 0.000 description 9
- 241000276498 Pollachius virens Species 0.000 description 7
- 230000033228 biological regulation Effects 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 238000013518 transcription Methods 0.000 description 7
- 230000035897 transcription Effects 0.000 description 7
- 101100083259 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pho-4 gene Proteins 0.000 description 6
- 230000006698 induction Effects 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108091081024 Start codon Proteins 0.000 description 5
- 101150006914 TRP1 gene Proteins 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 5
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 102000004594 DNA Polymerase I Human genes 0.000 description 3
- 108010017826 DNA Polymerase I Proteins 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 108091008146 restriction endonucleases Proteins 0.000 description 3
- 230000001131 transforming effect Effects 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 108020005029 5' Flanking Region Proteins 0.000 description 2
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 2
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 2
- 101150009006 HIS3 gene Proteins 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 239000013614 RNA sample Substances 0.000 description 2
- 101710167911 Repressible acid phosphatase Proteins 0.000 description 2
- 101100394989 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) hisI gene Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000011543 agarose gel Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940015043 glyoxal Drugs 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 229940047124 interferons Drugs 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229940035893 uracil Drugs 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 1
- 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000908115 Bolivar Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 101000904152 Homo sapiens Transcription factor E2F1 Proteins 0.000 description 1
- 101150017040 I gene Proteins 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241001460678 Napo <wasp> Species 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 108700005075 Regulator Genes Proteins 0.000 description 1
- 101100083263 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PHO80 gene Proteins 0.000 description 1
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 102100024026 Transcription factor E2F1 Human genes 0.000 description 1
- LVTKHGUGBGNBPL-UHFFFAOYSA-N Trp-P-1 Chemical compound N1C2=CC=CC=C2C2=C1C(C)=C(N)N=C2C LVTKHGUGBGNBPL-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 241001105470 Valenzuela Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
- NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 229960004198 guanidine Drugs 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 101150047627 pgk gene Proteins 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000006903 response to temperature Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000013605 shuttle vector Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49167283A | 1983-05-05 | 1983-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO841811L true NO841811L (no) | 1984-11-06 |
Family
ID=23953166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO841811A NO841811L (no) | 1983-05-05 | 1984-05-04 | Nye vektorer for interferonekspersjon |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0124874A3 (hu) |
| JP (1) | JPS60186288A (hu) |
| AU (1) | AU2767684A (hu) |
| DK (1) | DK224684A (hu) |
| ES (2) | ES532173A0 (hu) |
| FI (1) | FI841787A (hu) |
| GR (1) | GR79963B (hu) |
| HU (1) | HUT34239A (hu) |
| IL (1) | IL71745A0 (hu) |
| MC (1) | MC1598A1 (hu) |
| NO (1) | NO841811L (hu) |
| NZ (1) | NZ208046A (hu) |
| PT (1) | PT78552B (hu) |
| ZA (1) | ZA843275B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0214638A3 (en) * | 1985-09-09 | 1988-08-31 | G.D. Searle & Co. | Yeast promoters |
| JPH0655146B2 (ja) * | 1985-12-27 | 1994-07-27 | 財団法人化学及血清療法研究所 | シヤトルベクタ− |
| US5013652A (en) * | 1986-10-14 | 1991-05-07 | Genex Corporation | Composite yeast vectors |
| DE3635867A1 (de) * | 1986-10-22 | 1988-05-11 | Boehringer Ingelheim Int | Neue hefeexpressionsvektoren fuer ifn-omega, verfahren zu ihrer herstellung und deren verwendung |
| KR100374307B1 (ko) * | 1995-07-21 | 2003-07-07 | 주식회사 엘지생명과학 | 재조합효모로부터발현된감마인터페론의정제방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| IE54592B1 (en) * | 1982-03-08 | 1989-12-06 | Genentech Inc | Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby |
| GB2125047B (en) * | 1982-08-09 | 1986-02-19 | Ciba Geigy Ag | Yeast hybrid vectors and their use for the production of polypeptides |
| IL72773A0 (en) * | 1983-08-29 | 1984-11-30 | Meloy Lab | Production of immune interferon and its mrna |
-
1984
- 1984-05-02 ZA ZA843275A patent/ZA843275B/xx unknown
- 1984-05-03 IL IL71745A patent/IL71745A0/xx unknown
- 1984-05-03 EP EP84104967A patent/EP0124874A3/en not_active Withdrawn
- 1984-05-03 NZ NZ208046A patent/NZ208046A/en unknown
- 1984-05-04 AU AU27676/84A patent/AU2767684A/en not_active Abandoned
- 1984-05-04 NO NO841811A patent/NO841811L/no unknown
- 1984-05-04 PT PT78552A patent/PT78552B/pt unknown
- 1984-05-04 MC MC841704A patent/MC1598A1/xx unknown
- 1984-05-04 ES ES532173A patent/ES532173A0/es active Granted
- 1984-05-04 FI FI841787A patent/FI841787A/fi not_active Application Discontinuation
- 1984-05-04 DK DK224684A patent/DK224684A/da not_active Application Discontinuation
- 1984-05-04 GR GR74605A patent/GR79963B/el unknown
- 1984-05-04 HU HU841734A patent/HUT34239A/hu unknown
- 1984-05-07 JP JP59090862A patent/JPS60186288A/ja active Pending
-
1985
- 1985-02-01 ES ES540038A patent/ES8606887A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0124874A2 (en) | 1984-11-14 |
| DK224684D0 (da) | 1984-05-04 |
| MC1598A1 (fr) | 1985-05-09 |
| ES8505411A1 (es) | 1985-06-01 |
| ZA843275B (en) | 1984-12-24 |
| NZ208046A (en) | 1988-04-29 |
| ES532173A0 (es) | 1985-06-01 |
| ES540038A0 (es) | 1986-05-16 |
| FI841787A0 (fi) | 1984-05-04 |
| JPS60186288A (ja) | 1985-09-21 |
| GR79963B (hu) | 1984-10-31 |
| EP0124874A3 (en) | 1987-03-25 |
| FI841787A (fi) | 1984-11-06 |
| PT78552A (en) | 1984-06-01 |
| HUT34239A (en) | 1985-02-28 |
| IL71745A0 (en) | 1984-09-30 |
| ES8606887A1 (es) | 1986-05-16 |
| PT78552B (en) | 1986-09-15 |
| DK224684A (da) | 1984-11-06 |
| AU2767684A (en) | 1984-11-08 |
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