NO337485B1 - Anvendelse av en ikke-neurotoksiske plasminogenaktivatorer fra Desmodus rotundus DSPA-alfa-1, for fremstillingen av et terapeutisk medikament for intravenøst anvendelse ved behandling av cerebralt slag - Google Patents

Anvendelse av en ikke-neurotoksiske plasminogenaktivatorer fra Desmodus rotundus DSPA-alfa-1, for fremstillingen av et terapeutisk medikament for intravenøst anvendelse ved behandling av cerebralt slag Download PDF

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Publication number
NO337485B1
NO337485B1 NO20055692A NO20055692A NO337485B1 NO 337485 B1 NO337485 B1 NO 337485B1 NO 20055692 A NO20055692 A NO 20055692A NO 20055692 A NO20055692 A NO 20055692A NO 337485 B1 NO337485 B1 NO 337485B1
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NO
Norway
Prior art keywords
dspa
stroke
treatment
tissue
plasminogen
Prior art date
Application number
NO20055692A
Other languages
English (en)
Norwegian (no)
Other versions
NO20055692D0 (no
NO20055692L (no
Inventor
Wolf-Dieter Schleuning
Mariola Söhngen
Wolfgang Söhngen
Robert Medcalf
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2003/004729 external-priority patent/WO2004096267A1/de
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of NO20055692D0 publication Critical patent/NO20055692D0/no
Publication of NO20055692L publication Critical patent/NO20055692L/no
Publication of NO337485B1 publication Critical patent/NO337485B1/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20055692A 2003-05-02 2005-12-01 Anvendelse av en ikke-neurotoksiske plasminogenaktivatorer fra Desmodus rotundus DSPA-alfa-1, for fremstillingen av et terapeutisk medikament for intravenøst anvendelse ved behandling av cerebralt slag NO337485B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP03/04608 2003-05-02
PCT/EP2003/004729 WO2004096267A1 (de) 2003-05-02 2003-05-06 Intravenöse injektion nicht-neurotoxischer plasminogen-aktivatoren zur behandlung von schlaganfall
PCT/EP2004/004626 WO2004096268A2 (de) 2003-05-02 2004-04-30 Intravenöse injektion nicht-neurotoxischer plasminogen-aktivatoren zur behandlung von schlaganfall

Publications (3)

Publication Number Publication Date
NO20055692D0 NO20055692D0 (no) 2005-12-01
NO20055692L NO20055692L (no) 2006-01-30
NO337485B1 true NO337485B1 (no) 2016-04-25

Family

ID=35610451

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055692A NO337485B1 (no) 2003-05-02 2005-12-01 Anvendelse av en ikke-neurotoksiske plasminogenaktivatorer fra Desmodus rotundus DSPA-alfa-1, for fremstillingen av et terapeutisk medikament for intravenøst anvendelse ved behandling av cerebralt slag

Country Status (10)

Country Link
EP (1) EP1622639B1 (enExample)
JP (1) JP2006525270A (enExample)
KR (1) KR101212631B1 (enExample)
BR (1) BRPI0409865A (enExample)
CA (1) CA2524573A1 (enExample)
HR (1) HRP20050903B1 (enExample)
NO (1) NO337485B1 (enExample)
NZ (1) NZ543367A (enExample)
PL (1) PL1622639T3 (enExample)
WO (1) WO2004096268A2 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
EA017982B1 (ru) 2005-02-24 2013-04-30 ДИФФЬЮЖН ФАРМАСЬЮТИКАЛЗ ЭлЭлСи Фармацевтическая композиция на основе транскаротиноидов и способы лечения опухоли
EP1897554A1 (en) * 2006-08-25 2008-03-12 PAION Deutschland GmbH Method for the manufacture of a medicament for treating hemorrhagic stroke
WO2008022801A1 (en) * 2006-08-25 2008-02-28 Paion Deutschland Gmbh Method for the manufacture of a medicament for treating hemorrhagic stroke
BRPI0810647A2 (pt) 2007-04-13 2014-11-04 Diffusion Pharmaceuticals Llc " uso de trans carotenóides bipolares como um pré-tratamento e no tratamento de doença vascular periférica ".
DK2440230T3 (da) 2009-06-10 2021-01-18 Nono Inc Behandlingsregimener til behandling af neurologisk sygdom
EP3539542B1 (en) 2009-06-22 2023-04-19 Diffusion Pharmaceuticals LLC Diffusion enhancing compounds and their use with a thrombolytic
US8652476B2 (en) 2009-07-27 2014-02-18 Niigata University Pharmaceutical composition for treating ischemic events
JP5823671B2 (ja) * 2009-07-27 2015-11-25 国立大学法人 新潟大学 免疫製剤を含む脳梗塞治療用医薬品組成物
JP5823672B2 (ja) * 2009-07-27 2015-11-25 国立大学法人 新潟大学 受容体シグナル伝達阻害剤を含む脳梗塞治療用医薬品組成物
ES2654945T3 (es) 2010-06-02 2018-02-15 Diffusion Pharmaceuticals Llc Formulaciones orales de carotenoides trans bipolares
AU2012274910B2 (en) 2011-06-24 2017-05-11 Nono, Inc. Combination therapy with PSD-95 inhibitor for ischemia
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia
EP3432929A4 (en) 2016-03-24 2019-11-27 Diffusion Pharmaceuticals LLC USE OF BIPOLAR TRANSCAROTINOIDS WITH CHEMOTHERAPY AND RADIOTHERAPY FOR THE TREATMENT OF CANCER
US10617756B2 (en) 2017-01-05 2020-04-14 Shimojani, LLC Drug regimen for treatment of cerebral ischemia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0352119A2 (en) * 1988-07-20 1990-01-24 Schering Aktiengesellschaft Vampire bat salivary plasminogen activators
WO2003037363A2 (de) * 2001-11-02 2003-05-08 Paion Gmbh Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8902454A (nl) * 1989-10-03 1991-05-01 Stichting Centraal Lab Mutanten van de humane plasminogeen activator inhibitor 1 (pai-1), hun bereiding en toepassing, en recombinante polynucleotiden die voor deze mutanten coderende genetische informatie omvatten.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0352119A2 (en) * 1988-07-20 1990-01-24 Schering Aktiengesellschaft Vampire bat salivary plasminogen activators
WO2003037363A2 (de) * 2001-11-02 2003-05-08 Paion Gmbh Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall

Also Published As

Publication number Publication date
KR101212631B1 (ko) 2012-12-14
EP1622639B1 (de) 2013-01-16
NO20055692D0 (no) 2005-12-01
EP1622639A2 (de) 2006-02-08
BRPI0409865A (pt) 2006-05-16
HRP20050903B1 (hr) 2013-11-22
PL1622639T3 (pl) 2013-06-28
HRP20050903A2 (en) 2006-08-31
WO2004096268A2 (de) 2004-11-11
KR20060020616A (ko) 2006-03-06
CA2524573A1 (en) 2004-11-11
NZ543367A (en) 2010-06-25
WO2004096268A3 (de) 2005-04-21
NO20055692L (no) 2006-01-30
JP2006525270A (ja) 2006-11-09

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