NO332223B1 - Anvendelse av spesifikke (R,S)-1-arylketonforbindelser for fremstilling av medikamenter til behandling av sykdommer som involverer IL-8-indusert human PMN-kjemotakse og til forebygging og behandling av skader forarsaket av iskemiog reperfusjon, og farmasoytisk sammensetninger inneholdende forbindelsene. - Google Patents

Anvendelse av spesifikke (R,S)-1-arylketonforbindelser for fremstilling av medikamenter til behandling av sykdommer som involverer IL-8-indusert human PMN-kjemotakse og til forebygging og behandling av skader forarsaket av iskemiog reperfusjon, og farmasoytisk sammensetninger inneholdende forbindelsene. Download PDF

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Publication number
NO332223B1
NO332223B1 NO20053086A NO20053086A NO332223B1 NO 332223 B1 NO332223 B1 NO 332223B1 NO 20053086 A NO20053086 A NO 20053086A NO 20053086 A NO20053086 A NO 20053086A NO 332223 B1 NO332223 B1 NO 332223B1
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Norway
Prior art keywords
phenyl
methyl
isobutylphenyl
oxo
oxopentanoate
Prior art date
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NO20053086A
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English (en)
Norwegian (no)
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NO20053086L (no
Inventor
Riccardo Bertini
Cinzia Bizzarri
Marcello Allegretti
Maria Candida Cesta
Francesco Colotta
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Dompe Pha R Ma Spa
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Publication of NO20053086L publication Critical patent/NO20053086L/no
Publication of NO332223B1 publication Critical patent/NO332223B1/no

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    • C07ORGANIC CHEMISTRY
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    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C45/676Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
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NO20053086A 2002-12-10 2005-06-23 Anvendelse av spesifikke (R,S)-1-arylketonforbindelser for fremstilling av medikamenter til behandling av sykdommer som involverer IL-8-indusert human PMN-kjemotakse og til forebygging og behandling av skader forarsaket av iskemiog reperfusjon, og farmasoytisk sammensetninger inneholdende forbindelsene. NO332223B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02027453 2002-12-10
PCT/EP2003/013946 WO2004052830A1 (en) 2002-12-10 2003-12-09 Chiral arylketones in the treatement of neutrophil-dependent inflammatory deseases

Publications (2)

Publication Number Publication Date
NO20053086L NO20053086L (no) 2005-06-23
NO332223B1 true NO332223B1 (no) 2012-07-30

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NO20053086A NO332223B1 (no) 2002-12-10 2005-06-23 Anvendelse av spesifikke (R,S)-1-arylketonforbindelser for fremstilling av medikamenter til behandling av sykdommer som involverer IL-8-indusert human PMN-kjemotakse og til forebygging og behandling av skader forarsaket av iskemiog reperfusjon, og farmasoytisk sammensetninger inneholdende forbindelsene.

Country Status (17)

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US (2) US20060247297A1 (sl)
EP (1) EP1581474B1 (sl)
JP (1) JP5021169B2 (sl)
CN (1) CN100383110C (sl)
AT (1) ATE406343T1 (sl)
AU (1) AU2003289993B8 (sl)
CA (1) CA2507765C (sl)
CY (1) CY1108596T1 (sl)
DE (1) DE60323264D1 (sl)
DK (1) DK1581474T3 (sl)
ES (1) ES2312834T3 (sl)
HK (1) HK1085721A1 (sl)
NO (1) NO332223B1 (sl)
PT (1) PT1581474E (sl)
RU (1) RU2345759C2 (sl)
SI (1) SI1581474T1 (sl)
WO (1) WO2004052830A1 (sl)

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Publication number Priority date Publication date Assignee Title
CN109928868A (zh) * 2019-03-22 2019-06-25 河北科技大学 1,3-双(2,5-二甲基苯基)丙-2-酮的合成方法及其应用
CN115894198B (zh) * 2022-11-04 2024-05-17 浙江永太科技股份有限公司 Qulipta的关键中间体1-(2,3,6-三氟苯基)丙烷-2-酮的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125957C (sl) * 1960-07-26
US3591350A (en) * 1968-06-17 1971-07-06 M & T Chemicals Inc Novel plating process
SE385883B (sv) * 1972-04-10 1976-07-26 Ciba Geigy Ag Forfarande for framstellning av nya pyridinkarbonsyraestrar
JPS5842851B2 (ja) 1976-03-05 1983-09-22 三井東圧化学株式会社 2−(4′−アルキルフエニル)プロピオン酸の製造方法
US4151172A (en) 1977-08-11 1979-04-24 E. R. Squibb & Sons, Inc. Phosphonoacyl prolines and related compounds
JPS5697249A (en) 1979-12-30 1981-08-05 Ota Seiyaku Kk Preparation of 2-arylalkane acid
JP2782359B2 (ja) 1989-06-22 1998-07-30 日本石油化学株式会社 2―(4―イソブチルフエニル)―2―ブテン
AU644281B2 (en) 1991-04-24 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Novel thiazole derivatives
JPH05286902A (ja) * 1992-04-10 1993-11-02 Sumitomo Pharmaceut Co Ltd α−クロロ−β−ケトエステル誘導体の製造方法
IT1303249B1 (it) * 1998-10-23 2000-11-06 Dompe Spa Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
IT1317826B1 (it) * 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.

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Publication number Publication date
JP5021169B2 (ja) 2012-09-05
SI1581474T1 (sl) 2009-02-28
RU2005121554A (ru) 2006-01-20
CY1108596T1 (el) 2014-04-09
CA2507765C (en) 2012-03-20
EP1581474B1 (en) 2008-08-27
DE60323264D1 (de) 2008-10-09
WO2004052830A1 (en) 2004-06-24
ES2312834T3 (es) 2009-03-01
US9328057B2 (en) 2016-05-03
AU2003289993B8 (en) 2008-05-08
EP1581474A1 (en) 2005-10-05
PT1581474E (pt) 2008-12-09
CA2507765A1 (en) 2004-06-24
CN1732145A (zh) 2006-02-08
US20090203652A1 (en) 2009-08-13
AU2003289993B2 (en) 2008-04-24
DK1581474T3 (da) 2008-12-08
CN100383110C (zh) 2008-04-23
HK1085721A1 (en) 2006-09-01
JP2006509022A (ja) 2006-03-16
RU2345759C2 (ru) 2009-02-10
US20060247297A1 (en) 2006-11-02
ATE406343T1 (de) 2008-09-15
NO20053086L (no) 2005-06-23
AU2003289993A1 (en) 2004-06-30

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