NO331779B1 - Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol - Google Patents
Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol Download PDFInfo
- Publication number
- NO331779B1 NO331779B1 NO20014657A NO20014657A NO331779B1 NO 331779 B1 NO331779 B1 NO 331779B1 NO 20014657 A NO20014657 A NO 20014657A NO 20014657 A NO20014657 A NO 20014657A NO 331779 B1 NO331779 B1 NO 331779B1
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- Prior art keywords
- lipg
- cholesterol
- cells
- polypeptide
- lipase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/277,401 US7008776B1 (en) | 1996-12-06 | 1999-03-26 | Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol |
| PCT/US2000/007870 WO2000057837A2 (en) | 1999-03-26 | 2000-03-24 | Compositions and methods for effecting the levels of cholesterol |
Publications (3)
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| NO20014657D0 NO20014657D0 (no) | 2001-09-25 |
| NO20014657L NO20014657L (no) | 2001-11-21 |
| NO331779B1 true NO331779B1 (no) | 2012-03-26 |
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| NO20014657A NO331779B1 (no) | 1999-03-26 | 2001-09-25 | Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol |
| NO20100214A NO331784B1 (no) | 1999-03-26 | 2010-02-11 | Anvendelse av et ribozym for fremstilling av et preparat i stand til a redusere den enzymatiske aktiviteten av LIPG hos en pasient. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20100214A NO331784B1 (no) | 1999-03-26 | 2010-02-11 | Anvendelse av et ribozym for fremstilling av et preparat i stand til a redusere den enzymatiske aktiviteten av LIPG hos en pasient. |
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| Country | Link |
|---|---|
| EP (1) | EP1171078A4 (enExample) |
| JP (1) | JP2002540127A (enExample) |
| KR (2) | KR100887164B1 (enExample) |
| AU (1) | AU776684B2 (enExample) |
| BR (1) | BR0009333A (enExample) |
| CA (1) | CA2363486C (enExample) |
| HK (1) | HK1043309A1 (enExample) |
| IL (2) | IL145526A0 (enExample) |
| MX (1) | MXPA01009727A (enExample) |
| NO (2) | NO331779B1 (enExample) |
| NZ (2) | NZ514350A (enExample) |
| WO (1) | WO2000057837A2 (enExample) |
| ZA (1) | ZA200107598B (enExample) |
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| US7507808B2 (en) * | 2002-12-12 | 2009-03-24 | Isis Pharmaceuticals, Inc. | Modulation of endothelial lipase expression |
| EP1976567B1 (en) | 2005-12-28 | 2020-05-13 | The Scripps Research Institute | Natural antisense and non-coding rna transcripts as drug targets |
| EP2370582B1 (en) | 2008-12-04 | 2017-05-10 | CuRNA, Inc. | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
| CN102317458B (zh) | 2008-12-04 | 2018-01-02 | 库尔纳公司 | 通过红细胞生成素(epo)天然反义转录物的抑制对epo相关疾病的治疗 |
| PT2396038E (pt) | 2009-02-12 | 2016-02-19 | Curna Inc | Tratamento das doenças associadas com o factor neurotrófico derivado do cérebro (bdnf) por inibição do produto antisenso natural da transcrição para bdnf |
| CA2755409C (en) | 2009-03-16 | 2019-04-30 | Joseph Collard | Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2 |
| JP5904935B2 (ja) | 2009-03-17 | 2016-04-20 | クルナ・インコーポレーテッド | デルタ様1ホモログ(dlk1)に対する天然アンチセンス転写物の抑制によるdlk1関連疾患の治療 |
| JP6250930B2 (ja) | 2009-05-06 | 2017-12-20 | クルナ・インコーポレーテッド | トリステトラプロリン(ttp)に対する天然アンチセンス転写物の抑制によるttp関連疾患の治療 |
| EP2427553A4 (en) | 2009-05-06 | 2012-11-07 | Opko Curna Llc | TREATMENT OF LIPID TRANSPORT AND METABOLISM-RELATED DISEASES BY INHIBITING THE NATURAL ANTISENSE TRANSCRIPT AGAINST A LIPID TRANSPORT AND METABOLIC TREATMENT |
| ES2664590T3 (es) | 2009-05-18 | 2018-04-20 | Curna, Inc. | Tratamiento de enfermedades relacionadas con factores de reprogramación por inhibición del tránscrito antisentido natural a un factor de reprogramación |
| CN102549158B (zh) | 2009-05-22 | 2017-09-26 | 库尔纳公司 | 通过抑制针对转录因子e3(tfe3)的天然反义转录物来治疗tfe3和胰岛素受体底物蛋白2(irs2)相关的疾病 |
| CN102695797B (zh) | 2009-06-16 | 2018-05-25 | 库尔纳公司 | 通过抑制针对胶原基因的天然反义转录物来治疗胶原基因相关的疾病 |
| ES2629339T3 (es) | 2009-06-16 | 2017-08-08 | Curna, Inc. | Tratamiento de enfermedades relacionadas con la paraoxonasa 1 (pon1) por inhibición de transcrito antisentido natural a pon1 |
| ES2618894T3 (es) | 2009-06-24 | 2017-06-22 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2 |
| KR101807324B1 (ko) | 2009-06-26 | 2017-12-08 | 큐알엔에이, 인크. | 다운 증후군 유전자에 대한 천연 안티센스 전사체의 억제에 의한 다운 증후군 유전자 관련된 질환의 치료 |
| WO2011011700A2 (en) | 2009-07-24 | 2011-01-27 | Curna, Inc. | Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt) |
| WO2011019815A2 (en) | 2009-08-11 | 2011-02-17 | Curna, Inc. | Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq) |
| US8791087B2 (en) | 2009-08-21 | 2014-07-29 | Curna, Inc. | Treatment of ‘C terminus of HSP70-interacting protein’ (CHIP)related diseases by inhibition of natural antisense transcript to CHIP |
| CN102482671B (zh) | 2009-08-25 | 2017-12-01 | 库尔纳公司 | 通过抑制‘含有iq模体的gtp酶激活蛋白’(iqgap)的天然反义转录物而治疗iqgap相关疾病 |
| CN102791861B (zh) | 2009-09-25 | 2018-08-07 | 库尔纳公司 | 通过调节聚丝蛋白(flg)的表达和活性而治疗flg相关疾病 |
| KR101823702B1 (ko) | 2009-12-16 | 2018-01-30 | 큐알엔에이, 인크. | 막 결합 전사 인자 펩티다제, 부위 1(mbtps1)에 대한 천연 안티센스 전사체의 억제에 의한 mbtps1 관련 질환의 치료 |
| KR101793753B1 (ko) | 2009-12-23 | 2017-11-03 | 큐알엔에이, 인크. | 커플링방지 단백질 2(ucp2)에 대한 천연 안티센스 전사체의 저해에 의한 ucp2 관련 질환의 치료 |
| DK2516648T3 (en) | 2009-12-23 | 2018-02-12 | Curna Inc | TREATMENT OF HEPATOCYTE GROWTH FACTOR (HGF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT AGAINST HGF |
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| WO1999032611A1 (en) * | 1997-12-19 | 1999-07-01 | Progenitor, Inc. | A lipase expressed in endothelial cells and methods for its use |
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- 2000-03-24 KR KR1020017012300A patent/KR100887164B1/ko not_active Expired - Fee Related
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- 2000-03-24 WO PCT/US2000/007870 patent/WO2000057837A2/en not_active Ceased
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| AU776684B2 (en) | 2004-09-16 |
| MXPA01009727A (es) | 2002-07-22 |
| KR20050044812A (ko) | 2005-05-12 |
| IL145526A0 (en) | 2002-06-30 |
| KR20020029651A (ko) | 2002-04-19 |
| CA2363486C (en) | 2012-12-18 |
| EP1171078A2 (en) | 2002-01-16 |
| AU3918700A (en) | 2000-10-16 |
| NO20014657D0 (no) | 2001-09-25 |
| NO20100214L (no) | 2001-11-21 |
| IL145526A (en) | 2010-11-30 |
| NO331784B1 (no) | 2012-03-26 |
| NZ531180A (en) | 2005-06-24 |
| CA2363486A1 (en) | 2000-10-05 |
| WO2000057837A2 (en) | 2000-10-05 |
| WO2000057837A8 (en) | 2001-09-27 |
| HK1043309A1 (zh) | 2002-09-13 |
| NO20014657L (no) | 2001-11-21 |
| BR0009333A (pt) | 2002-01-08 |
| EP1171078A4 (en) | 2002-11-06 |
| JP2002540127A (ja) | 2002-11-26 |
| WO2000057837A9 (en) | 2001-10-18 |
| ZA200107598B (en) | 2003-05-28 |
| NZ514350A (en) | 2004-12-24 |
| WO2000057837A3 (en) | 2001-01-25 |
| KR100887164B1 (ko) | 2009-03-10 |
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