NO329973B1 - Kombretastatin A-4 fosfat mono- og diorganiske aminsalter, mono- og diaminosyresalter, og mono- og diaminosyreestersalter, fremgangsmate for fremstilling derav, farmasoytisk preparat, anvendelse av forbindelsen samt sammensetning og forbindelser - Google Patents

Kombretastatin A-4 fosfat mono- og diorganiske aminsalter, mono- og diaminosyresalter, og mono- og diaminosyreestersalter, fremgangsmate for fremstilling derav, farmasoytisk preparat, anvendelse av forbindelsen samt sammensetning og forbindelser Download PDF

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Publication number
NO329973B1
NO329973B1 NO20022270A NO20022270A NO329973B1 NO 329973 B1 NO329973 B1 NO 329973B1 NO 20022270 A NO20022270 A NO 20022270A NO 20022270 A NO20022270 A NO 20022270A NO 329973 B1 NO329973 B1 NO 329973B1
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NO
Norway
Prior art keywords
amino acid
compound
nitrogen atoms
ca4p
quaternary ammonium
Prior art date
Application number
NO20022270A
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English (en)
Norwegian (no)
Other versions
NO20022270D0 (no
NO20022270L (no
Inventor
John J Venit
Mandar V Dali
Manisha M Dali
Yande Huang
Charles E Dahlheim
Ravindra W Tejwani
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20022270D0 publication Critical patent/NO20022270D0/no
Publication of NO20022270L publication Critical patent/NO20022270L/no
Publication of NO329973B1 publication Critical patent/NO329973B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/12—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20022270A 2000-09-14 2002-05-13 Kombretastatin A-4 fosfat mono- og diorganiske aminsalter, mono- og diaminosyresalter, og mono- og diaminosyreestersalter, fremgangsmate for fremstilling derav, farmasoytisk preparat, anvendelse av forbindelsen samt sammensetning og forbindelser NO329973B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23256800P 2000-09-14 2000-09-14
US25192100P 2000-12-07 2000-12-07
PCT/US2001/028401 WO2002022626A1 (en) 2000-09-14 2001-09-12 Combretastatin a-4 phosphate prodrug salts with nitrogen-containing compounds

Publications (3)

Publication Number Publication Date
NO20022270D0 NO20022270D0 (no) 2002-05-13
NO20022270L NO20022270L (no) 2002-07-01
NO329973B1 true NO329973B1 (no) 2011-01-31

Family

ID=26926130

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022270A NO329973B1 (no) 2000-09-14 2002-05-13 Kombretastatin A-4 fosfat mono- og diorganiske aminsalter, mono- og diaminosyresalter, og mono- og diaminosyreestersalter, fremgangsmate for fremstilling derav, farmasoytisk preparat, anvendelse av forbindelsen samt sammensetning og forbindelser

Country Status (26)

Country Link
US (2) US6670344B2 (es)
EP (1) EP1320534B1 (es)
JP (2) JP4149804B2 (es)
KR (1) KR100858464B1 (es)
CN (1) CN100338077C (es)
AR (1) AR030727A1 (es)
AT (1) ATE293630T1 (es)
AU (2) AU785183B2 (es)
BR (1) BRPI0107210B1 (es)
CA (1) CA2422359C (es)
DE (1) DE60110249T2 (es)
EE (1) EE200200249A (es)
ES (1) ES2241872T3 (es)
HK (1) HK1052356B (es)
HU (1) HU229055B1 (es)
IL (3) IL149601A0 (es)
MX (1) MXPA03002209A (es)
NO (1) NO329973B1 (es)
NZ (1) NZ524926A (es)
PE (1) PE20020445A1 (es)
PT (1) PT1320534E (es)
RS (1) RS50309B (es)
SK (1) SK287117B6 (es)
TW (1) TWI250163B (es)
UY (1) UY26935A1 (es)
WO (1) WO2002022626A1 (es)

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US6670344B2 (en) * 2000-09-14 2003-12-30 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
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EP1696934B1 (en) 2003-12-23 2013-05-29 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
TW200534879A (en) * 2004-03-25 2005-11-01 Bristol Myers Squibb Co Coated tablet formulation and method
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WO2006138427A2 (en) 2005-06-14 2006-12-28 Baylor University Combretastatin analogs with tubulin binding activity
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JP5844028B2 (ja) 2006-04-04 2016-01-13 ケージー アクキュイシチオン エルエルシー 抗血小板薬及び酸阻害薬を含む経口剤形
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SI2178513T1 (sl) * 2007-06-22 2011-05-31 Bristol Myers Squibb Co Tabletni sestavki vsebujoäśi atazanavir
PT2170292E (pt) * 2007-06-22 2014-03-06 Bristol Myers Squibb Holdings Ireland Composições de comprimido contendo atazanavir
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EP2178512B1 (en) * 2007-06-22 2011-03-09 Bristol-Myers Squibb Company Tableted compositions containing atazanavir
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Also Published As

Publication number Publication date
NO20022270D0 (no) 2002-05-13
ATE293630T1 (de) 2005-05-15
AR030727A1 (es) 2003-09-03
IL149601A (en) 2007-06-17
NO20022270L (no) 2002-07-01
HK1052356B (zh) 2008-06-27
HU229055B1 (hu) 2013-07-29
JP4149804B2 (ja) 2008-09-17
US6855702B2 (en) 2005-02-15
YU34802A (sh) 2005-07-19
IL176088A0 (en) 2006-10-05
KR20020063187A (ko) 2002-08-01
WO2002022626A1 (en) 2002-03-21
KR100858464B1 (ko) 2008-09-16
CA2422359C (en) 2008-12-23
SK287117B6 (sk) 2009-12-07
BRPI0107210B1 (pt) 2017-09-26
EP1320534A1 (en) 2003-06-25
PT1320534E (pt) 2005-08-31
US6670344B2 (en) 2003-12-30
DE60110249D1 (de) 2005-05-25
EP1320534B1 (en) 2005-04-20
US20040054212A1 (en) 2004-03-18
JP2004509128A (ja) 2004-03-25
CN100338077C (zh) 2007-09-19
SK6722002A3 (en) 2002-11-06
NZ524926A (en) 2004-10-29
AU2007200218A1 (en) 2007-02-08
IL149601A0 (en) 2002-11-10
AU785183B2 (en) 2006-10-19
ES2241872T3 (es) 2005-11-01
BR0107210A (pt) 2003-02-25
EE200200249A (et) 2003-06-16
HK1052356A1 (en) 2003-09-11
HUP0204423A2 (en) 2003-05-28
MXPA03002209A (es) 2004-03-02
DE60110249T2 (de) 2006-03-02
PE20020445A1 (es) 2002-05-18
CN1392876A (zh) 2003-01-22
RS50309B (sr) 2009-09-08
TWI250163B (en) 2006-03-01
UY26935A1 (es) 2002-04-26
HUP0204423A3 (en) 2005-02-28
WO2002022626A8 (en) 2002-04-18
US20020072507A1 (en) 2002-06-13
AU9077101A (en) 2002-03-26
CA2422359A1 (en) 2002-03-21
JP2008195740A (ja) 2008-08-28

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