NO328960B1 - Fremgangsmate ved semi-syntetisk fremstilling av N-debenzoylpaclitaxel - Google Patents

Fremgangsmate ved semi-syntetisk fremstilling av N-debenzoylpaclitaxel Download PDF

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Publication number
NO328960B1
NO328960B1 NO20044291A NO20044291A NO328960B1 NO 328960 B1 NO328960 B1 NO 328960B1 NO 20044291 A NO20044291 A NO 20044291A NO 20044291 A NO20044291 A NO 20044291A NO 328960 B1 NO328960 B1 NO 328960B1
Authority
NO
Norway
Prior art keywords
formula
compound
nitrobenzenesulfenyl
give
range
Prior art date
Application number
NO20044291A
Other languages
English (en)
Norwegian (no)
Other versions
NO20044291L (no
Inventor
Ezio Bombardelli
Gabriele Fontana
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of NO20044291L publication Critical patent/NO20044291L/no
Publication of NO328960B1 publication Critical patent/NO328960B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20044291A 2002-04-12 2004-10-11 Fremgangsmate ved semi-syntetisk fremstilling av N-debenzoylpaclitaxel NO328960B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000782A ITMI20020782A1 (it) 2002-04-12 2002-04-12 Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
PCT/EP2003/003017 WO2003087077A1 (en) 2002-04-12 2003-03-24 A semi-synthetic process for the preparation of n­ debenzoylpaclitaxel

Publications (2)

Publication Number Publication Date
NO20044291L NO20044291L (no) 2004-10-11
NO328960B1 true NO328960B1 (no) 2010-06-28

Family

ID=11449694

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044291A NO328960B1 (no) 2002-04-12 2004-10-11 Fremgangsmate ved semi-syntetisk fremstilling av N-debenzoylpaclitaxel

Country Status (18)

Country Link
US (1) US7053222B2 (de)
EP (1) EP1495011B1 (de)
JP (2) JP5197908B2 (de)
KR (2) KR101159837B1 (de)
CN (1) CN1310897C (de)
AT (1) ATE314357T1 (de)
AU (1) AU2003219094B2 (de)
CA (1) CA2482131C (de)
DE (1) DE60303023T2 (de)
DK (1) DK1495011T3 (de)
ES (1) ES2254921T3 (de)
HK (1) HK1075661A1 (de)
IL (2) IL164486A0 (de)
IT (1) ITMI20020782A1 (de)
NO (1) NO328960B1 (de)
PL (1) PL209650B1 (de)
RU (1) RU2302415C2 (de)
WO (1) WO2003087077A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20020782A1 (it) * 2002-04-12 2003-10-13 Indena Spa Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
US7446126B2 (en) 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
WO2008074178A1 (fr) * 2006-11-23 2008-06-26 Shanghai Bailing Pharmaceutical Technology Co., Ltd Nouveau procédé de préparation de paclitaxel semi-synthétique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69433297T2 (de) * 1993-02-05 2004-10-21 Bryn Mawr College Bryn Mawr Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
KR20000010861A (ko) * 1996-05-08 2000-02-25 로렌스 티. 마이젠헬더 탁솔의 제조 방법
WO1998008833A1 (en) * 1996-08-26 1998-03-05 Bristol-Myers Squibb Company Sulfenamide taxane derivatives
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
ITMI20020782A1 (it) * 2002-04-12 2003-10-13 Indena Spa Processo semisintetico per la preparazione di n-debenzoilpaclitaxel

Also Published As

Publication number Publication date
DE60303023T2 (de) 2006-09-28
AU2003219094B2 (en) 2008-06-26
CN1310897C (zh) 2007-04-18
IL164486A0 (en) 2005-12-18
CN1646512A (zh) 2005-07-27
CA2482131A1 (en) 2003-10-23
IL164486A (en) 2008-11-26
EP1495011B1 (de) 2005-12-28
DE60303023D1 (de) 2006-02-02
EP1495011A1 (de) 2005-01-12
RU2302415C2 (ru) 2007-07-10
KR20100036394A (ko) 2010-04-07
RU2004130316A (ru) 2005-06-27
CA2482131C (en) 2012-07-17
KR101159837B1 (ko) 2012-06-25
US20050049297A1 (en) 2005-03-03
WO2003087077A1 (en) 2003-10-23
ITMI20020782A1 (it) 2003-10-13
KR20040105795A (ko) 2004-12-16
DK1495011T3 (da) 2006-05-15
JP2010265274A (ja) 2010-11-25
PL371673A1 (en) 2005-06-27
JP5197908B2 (ja) 2013-05-15
ES2254921T3 (es) 2006-06-16
PL209650B1 (pl) 2011-09-30
US7053222B2 (en) 2006-05-30
NO20044291L (no) 2004-10-11
ITMI20020782A0 (it) 2002-04-12
HK1075661A1 (en) 2005-12-23
ATE314357T1 (de) 2006-01-15
AU2003219094A1 (en) 2003-10-27
JP2005530729A (ja) 2005-10-13

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