HK1075661A1 - A semi-synthetic process for the preparation of n debenzoylpaclitavel - Google Patents

A semi-synthetic process for the preparation of n debenzoylpaclitavel

Info

Publication number
HK1075661A1
HK1075661A1 HK05107780A HK05107780A HK1075661A1 HK 1075661 A1 HK1075661 A1 HK 1075661A1 HK 05107780 A HK05107780 A HK 05107780A HK 05107780 A HK05107780 A HK 05107780A HK 1075661 A1 HK1075661 A1 HK 1075661A1
Authority
HK
Hong Kong
Prior art keywords
preparation
debenzoylpaclitavel
semi
synthetic process
formula
Prior art date
Application number
HK05107780A
Other languages
English (en)
Inventor
Ezio Bombardelli
Gabriele Fontana
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of HK1075661A1 publication Critical patent/HK1075661A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK05107780A 2002-04-12 2005-09-05 A semi-synthetic process for the preparation of n debenzoylpaclitavel HK1075661A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000782A ITMI20020782A1 (it) 2002-04-12 2002-04-12 Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
PCT/EP2003/003017 WO2003087077A1 (en) 2002-04-12 2003-03-24 A semi-synthetic process for the preparation of n­ debenzoylpaclitaxel

Publications (1)

Publication Number Publication Date
HK1075661A1 true HK1075661A1 (en) 2005-12-23

Family

ID=11449694

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05107780A HK1075661A1 (en) 2002-04-12 2005-09-05 A semi-synthetic process for the preparation of n debenzoylpaclitavel

Country Status (18)

Country Link
US (1) US7053222B2 (xx)
EP (1) EP1495011B1 (xx)
JP (2) JP5197908B2 (xx)
KR (2) KR20100036394A (xx)
CN (1) CN1310897C (xx)
AT (1) ATE314357T1 (xx)
AU (1) AU2003219094B2 (xx)
CA (1) CA2482131C (xx)
DE (1) DE60303023T2 (xx)
DK (1) DK1495011T3 (xx)
ES (1) ES2254921T3 (xx)
HK (1) HK1075661A1 (xx)
IL (2) IL164486A0 (xx)
IT (1) ITMI20020782A1 (xx)
NO (1) NO328960B1 (xx)
PL (1) PL209650B1 (xx)
RU (1) RU2302415C2 (xx)
WO (1) WO2003087077A1 (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20020782A1 (it) * 2002-04-12 2003-10-13 Indena Spa Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
US7446126B2 (en) 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
WO2008074178A1 (fr) * 2006-11-23 2008-06-26 Shanghai Bailing Pharmaceutical Technology Co., Ltd Nouveau procédé de préparation de paclitaxel semi-synthétique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0682660B1 (en) * 1993-02-05 2003-11-05 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable a-ring side chains
PL329637A1 (en) * 1996-05-08 1999-04-12 Upjohn Co Taxol obtained method
US5821263A (en) * 1996-08-26 1998-10-13 Bristol-Myers Squibb Company Sulfenamide taxane derivatives
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
ITMI20020782A1 (it) * 2002-04-12 2003-10-13 Indena Spa Processo semisintetico per la preparazione di n-debenzoilpaclitaxel

Also Published As

Publication number Publication date
DK1495011T3 (da) 2006-05-15
JP5197908B2 (ja) 2013-05-15
WO2003087077A1 (en) 2003-10-23
CN1646512A (zh) 2005-07-27
ITMI20020782A0 (it) 2002-04-12
EP1495011A1 (en) 2005-01-12
DE60303023D1 (de) 2006-02-02
JP2005530729A (ja) 2005-10-13
KR20040105795A (ko) 2004-12-16
AU2003219094B2 (en) 2008-06-26
RU2004130316A (ru) 2005-06-27
NO20044291L (no) 2004-10-11
PL371673A1 (en) 2005-06-27
IL164486A0 (en) 2005-12-18
KR20100036394A (ko) 2010-04-07
EP1495011B1 (en) 2005-12-28
RU2302415C2 (ru) 2007-07-10
ITMI20020782A1 (it) 2003-10-13
CA2482131C (en) 2012-07-17
US7053222B2 (en) 2006-05-30
ATE314357T1 (de) 2006-01-15
US20050049297A1 (en) 2005-03-03
AU2003219094A1 (en) 2003-10-27
NO328960B1 (no) 2010-06-28
PL209650B1 (pl) 2011-09-30
CA2482131A1 (en) 2003-10-23
CN1310897C (zh) 2007-04-18
DE60303023T2 (de) 2006-09-28
ES2254921T3 (es) 2006-06-16
IL164486A (en) 2008-11-26
JP2010265274A (ja) 2010-11-25
KR101159837B1 (ko) 2012-06-25

Similar Documents

Publication Publication Date Title
NZ330671A (en) 13-Substituted-(Oxazolidin-4-yl)-oxycarbonyl-delta-6,7-taxols
MXPA04006677A (es) Procedimiento para la preparacion de esteres de escopina.
WO2006004898A3 (en) Semi-synthetic conversion of paclitaxel to docetaxel
HU9400803D0 (en) New beta-lactames and process for producing taxane derivatives with them
HK1075661A1 (en) A semi-synthetic process for the preparation of n debenzoylpaclitavel
WO2004033442A3 (en) Novel taxanes and methods related to use and preparation thereof
MXPA03000235A (es) Preparacion de derivados 4-tioalquilbromobenceno.
EA200700064A1 (ru) Способ получения эфиров 4,4-дифтор-3-оксобутановой кислоты
HK1042490A1 (en) A process for the preparation of taxanes from 10-deacetylbaccatin iii
EP2428510A3 (en) Preparation of taxanes from 9-dihydro-13-acetylbaccatin III
CA2142354A1 (en) Process of Converting Taxanes Into Baccatin III and 10-Deacetylbaccatin III
ATE266015T1 (de) Verfahren zur herstellung eines c-4- methylcarbonat-analogons von paclitaxel
WO2001002407A3 (en) Taxane derivatives and processes for the preparation thereof
AU6221596A (en) Method for the preparation of taxol and its derivatives
GB2441840A (en) Process for the synthesis of arylfluorenes and analogues thereof
AU2603797A (en) Process to prepare taxol
MY125378A (en) Pentacyclic taxan compound
ATE499353T1 (de) Verfahren zur herstellung von taxanderivaten
FI956025A (fi) Menetelmä oksatsolidiinikarboksyylihapon valmistamiseksi, joka on hyödyllinen valmistettaessa terapeuttisesti vaikuttavia taksoideja
EP1262476A4 (en) PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES AND THEIR INTERMEDIATES
DE60317487D1 (de) Verfahren zur herstellung von 2,6-dihalogenpurin
DE60236303D1 (de) Verfahren zur herstellung von 14-beta-hydroxybaccatin-iii-1,14-carbonat
IL141304A0 (en) A method for the preparation of c-4 deacetyltaxane derivatives and the enzyme for use therein
SG164282A1 (en) Taxane derivatives functionalized at the 14-position and a process for the preparation thereof
AU2683200A (en) The preparation of chiral (cis)-5-amino-2-cyclopenten-1-ol derivatives

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20230323