NO325655B1 - Merkaptoacetylamidderivater, fremgangsmate for deres fremstilling og deres anvendelse samt farmasoytisk sammensetning og fremgangsmate for fremstilling derav - Google Patents
Merkaptoacetylamidderivater, fremgangsmate for deres fremstilling og deres anvendelse samt farmasoytisk sammensetning og fremgangsmate for fremstilling derav Download PDFInfo
- Publication number
- NO325655B1 NO325655B1 NO20034412A NO20034412A NO325655B1 NO 325655 B1 NO325655 B1 NO 325655B1 NO 20034412 A NO20034412 A NO 20034412A NO 20034412 A NO20034412 A NO 20034412A NO 325655 B1 NO325655 B1 NO 325655B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- compound
- phenyl
- hydrogen
- oxo
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 13
- 230000008569 process Effects 0.000 title claims abstract description 7
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- 239000001257 hydrogen Substances 0.000 claims description 23
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000001151 peptidyl group Chemical group 0.000 description 1
- 230000036581 peripheral resistance Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 150000004728 pyruvic acid derivatives Chemical class 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000011916 stereoselective reduction Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- DUYAAUVXQSMXQP-UHFFFAOYSA-M thioacetate Chemical compound CC([S-])=O DUYAAUVXQSMXQP-UHFFFAOYSA-M 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28330501P | 2001-04-12 | 2001-04-12 | |
| GBGB0119305.1A GB0119305D0 (en) | 2001-04-12 | 2001-08-08 | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| PCT/EP2002/003668 WO2002083671A1 (en) | 2001-04-12 | 2002-04-03 | Mercaptoacetylamide derivatives, a process for their preparation and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20034412D0 NO20034412D0 (no) | 2003-10-02 |
| NO20034412L NO20034412L (no) | 2003-10-02 |
| NO325655B1 true NO325655B1 (no) | 2008-06-30 |
Family
ID=26246410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20034412A NO325655B1 (no) | 2001-04-12 | 2003-10-02 | Merkaptoacetylamidderivater, fremgangsmate for deres fremstilling og deres anvendelse samt farmasoytisk sammensetning og fremgangsmate for fremstilling derav |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1381605B1 (de) |
| JP (1) | JP4392167B2 (de) |
| CN (1) | CN1245404C (de) |
| AT (1) | ATE286898T1 (de) |
| AU (1) | AU2002304804B2 (de) |
| BG (1) | BG66387B1 (de) |
| BR (1) | BR0208889A (de) |
| CA (1) | CA2443488C (de) |
| CZ (1) | CZ299708B6 (de) |
| DE (1) | DE60202602T2 (de) |
| EE (1) | EE05272B1 (de) |
| ES (1) | ES2232752T3 (de) |
| HK (1) | HK1061690A1 (de) |
| HR (1) | HRP20030823B1 (de) |
| HU (1) | HU229612B1 (de) |
| IL (1) | IL158289A0 (de) |
| MA (1) | MA26098A1 (de) |
| MX (1) | MXPA03008613A (de) |
| NO (1) | NO325655B1 (de) |
| NZ (1) | NZ528825A (de) |
| OA (1) | OA12502A (de) |
| PL (1) | PL209338B1 (de) |
| PT (1) | PT1381605E (de) |
| RU (1) | RU2286346C2 (de) |
| SI (1) | SI1381605T1 (de) |
| SK (1) | SK287616B6 (de) |
| WO (1) | WO2002083671A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10229180A1 (de) * | 2002-06-28 | 2004-01-29 | Aventis Pharma Deutschland Gmbh | Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen |
| US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| EP0534363B1 (de) * | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung |
| CN1110865A (zh) * | 1993-06-11 | 1995-10-25 | 卫材株式会社 | 氨基酸衍生物 |
-
2002
- 2002-04-03 SK SK1255-2003A patent/SK287616B6/sk not_active IP Right Cessation
- 2002-04-03 CA CA2443488A patent/CA2443488C/en not_active Expired - Fee Related
- 2002-04-03 IL IL15828902A patent/IL158289A0/xx unknown
- 2002-04-03 NZ NZ528825A patent/NZ528825A/en not_active IP Right Cessation
- 2002-04-03 RU RU2003132875/04A patent/RU2286346C2/ru not_active IP Right Cessation
- 2002-04-03 EP EP02732549A patent/EP1381605B1/de not_active Expired - Lifetime
- 2002-04-03 PL PL363034A patent/PL209338B1/pl unknown
- 2002-04-03 ES ES02732549T patent/ES2232752T3/es not_active Expired - Lifetime
- 2002-04-03 BR BR0208889-4A patent/BR0208889A/pt not_active Application Discontinuation
- 2002-04-03 PT PT02732549T patent/PT1381605E/pt unknown
- 2002-04-03 SI SI200230089T patent/SI1381605T1/xx unknown
- 2002-04-03 MX MXPA03008613A patent/MXPA03008613A/es active IP Right Grant
- 2002-04-03 CN CNB028081005A patent/CN1245404C/zh not_active Expired - Fee Related
- 2002-04-03 OA OA1200300267A patent/OA12502A/fr unknown
- 2002-04-03 JP JP2002581426A patent/JP4392167B2/ja not_active Expired - Fee Related
- 2002-04-03 DE DE60202602T patent/DE60202602T2/de not_active Expired - Lifetime
- 2002-04-03 EE EEP200300500A patent/EE05272B1/xx not_active IP Right Cessation
- 2002-04-03 AU AU2002304804A patent/AU2002304804B2/en not_active Ceased
- 2002-04-03 AT AT02732549T patent/ATE286898T1/de active
- 2002-04-03 WO PCT/EP2002/003668 patent/WO2002083671A1/en active IP Right Grant
- 2002-04-03 CZ CZ20032722A patent/CZ299708B6/cs not_active IP Right Cessation
- 2002-04-03 HU HU0303482A patent/HU229612B1/hu not_active IP Right Cessation
-
2003
- 2003-09-16 MA MA27312A patent/MA26098A1/fr unknown
- 2003-09-26 BG BG108203A patent/BG66387B1/bg unknown
- 2003-10-02 NO NO20034412A patent/NO325655B1/no not_active IP Right Cessation
- 2003-10-10 HR HR20030823A patent/HRP20030823B1/xx not_active IP Right Cessation
-
2004
- 2004-07-02 HK HK04104739A patent/HK1061690A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |