NO324941B1 - Forlopere til NMDA-reseptor-ligander, preparater inneholdende slike forbindelser, fremgangsmate for fremstilling av slike, slike forbindelser for behandling av sykdommer samt anvendelse av disse for fremstilling av preparater for behandling av sykdommer - Google Patents
Forlopere til NMDA-reseptor-ligander, preparater inneholdende slike forbindelser, fremgangsmate for fremstilling av slike, slike forbindelser for behandling av sykdommer samt anvendelse av disse for fremstilling av preparater for behandling av sykdommer Download PDFInfo
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- NO324941B1 NO324941B1 NO20030781A NO20030781A NO324941B1 NO 324941 B1 NO324941 B1 NO 324941B1 NO 20030781 A NO20030781 A NO 20030781A NO 20030781 A NO20030781 A NO 20030781A NO 324941 B1 NO324941 B1 NO 324941B1
- Authority
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- Norway
- Prior art keywords
- compound
- formula
- ethanesulfonyl
- benzyl
- hydroxy
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 150000002823 nitrates Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- RQKYHDHLEMEVDR-UHFFFAOYSA-N oxo-bis(phenylmethoxy)phosphanium Chemical compound C=1C=CC=CC=1CO[P+](=O)OCC1=CC=CC=C1 RQKYHDHLEMEVDR-UHFFFAOYSA-N 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00117918 | 2000-08-21 | ||
| PCT/EP2001/009561 WO2002016321A1 (en) | 2000-08-21 | 2001-08-20 | Prodrugs to nmda receptor ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20030781L NO20030781L (no) | 2003-02-19 |
| NO20030781D0 NO20030781D0 (no) | 2003-02-19 |
| NO324941B1 true NO324941B1 (no) | 2008-01-07 |
Family
ID=8169594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030781A NO324941B1 (no) | 2000-08-21 | 2003-02-19 | Forlopere til NMDA-reseptor-ligander, preparater inneholdende slike forbindelser, fremgangsmate for fremstilling av slike, slike forbindelser for behandling av sykdommer samt anvendelse av disse for fremstilling av preparater for behandling av sykdommer |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6407235B1 (sh) |
| EP (1) | EP1313703B1 (sh) |
| JP (1) | JP4162991B2 (sh) |
| KR (1) | KR100589991B1 (sh) |
| CN (1) | CN1227230C (sh) |
| AR (1) | AR030373A1 (sh) |
| AT (1) | ATE386022T1 (sh) |
| AU (2) | AU2001285894B2 (sh) |
| BR (1) | BR0113348A (sh) |
| CA (1) | CA2419279C (sh) |
| CY (1) | CY1107937T1 (sh) |
| CZ (1) | CZ303319B6 (sh) |
| DE (1) | DE60132782T2 (sh) |
| DK (1) | DK1313703T3 (sh) |
| EC (1) | ECSP034489A (sh) |
| EG (1) | EG24293A (sh) |
| ES (1) | ES2299508T3 (sh) |
| HK (1) | HK1059083A1 (sh) |
| HR (1) | HRP20030125B1 (sh) |
| HU (1) | HU229802B1 (sh) |
| IL (1) | IL154254A0 (sh) |
| JO (1) | JO2289B1 (sh) |
| MA (1) | MA26947A1 (sh) |
| MX (1) | MXPA03001311A (sh) |
| MY (1) | MY136065A (sh) |
| NO (1) | NO324941B1 (sh) |
| NZ (1) | NZ523990A (sh) |
| PA (1) | PA8525601A1 (sh) |
| PE (1) | PE20020291A1 (sh) |
| PL (1) | PL204215B1 (sh) |
| PT (1) | PT1313703E (sh) |
| RS (1) | RS51467B (sh) |
| RU (1) | RU2272027C2 (sh) |
| SI (1) | SI1313703T1 (sh) |
| WO (1) | WO2002016321A1 (sh) |
| ZA (1) | ZA200300894B (sh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL151125A0 (en) * | 2000-03-21 | 2003-04-10 | Procter & Gamble | Heterocyclic side chain containing, n-substituted metalloprotease inhibitors |
| US6713490B2 (en) | 2002-04-26 | 2004-03-30 | Pfizer, Inc. | 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists |
| CA2633010A1 (en) * | 2005-12-19 | 2007-06-28 | Methylgene Inc. | Histone deacetylase inhibitors for enhancing activity of antifungal agents |
| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| JP2010513326A (ja) | 2006-12-19 | 2010-04-30 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ |
| JP6479834B2 (ja) | 2013-11-05 | 2019-03-06 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | Ｎｍｄａアンタゴニストプロドラッグ |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4410822A1 (de) | 1994-03-24 | 1995-09-28 | Schering Ag | Neue Piperidin-Derivate |
| TW498067B (en) | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
| TWI254043B (en) | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
-
2001
- 2001-08-16 US US09/931,431 patent/US6407235B1/en not_active Expired - Lifetime
- 2001-08-16 PA PA20018525601A patent/PA8525601A1/es unknown
- 2001-08-16 PE PE2001000820A patent/PE20020291A1/es not_active Application Discontinuation
- 2001-08-17 AR ARP010103939A patent/AR030373A1/es active IP Right Grant
- 2001-08-17 MY MYPI20013876A patent/MY136065A/en unknown
- 2001-08-19 JO JO2001136A patent/JO2289B1/en active
- 2001-08-20 EG EG20010906A patent/EG24293A/xx active
- 2001-08-20 CA CA002419279A patent/CA2419279C/en not_active Expired - Fee Related
- 2001-08-20 MX MXPA03001311A patent/MXPA03001311A/es active IP Right Grant
- 2001-08-20 DE DE60132782T patent/DE60132782T2/de not_active Expired - Lifetime
- 2001-08-20 EP EP01965201A patent/EP1313703B1/en not_active Expired - Lifetime
- 2001-08-20 JP JP2002521197A patent/JP4162991B2/ja not_active Expired - Fee Related
- 2001-08-20 NZ NZ523990A patent/NZ523990A/en not_active IP Right Cessation
- 2001-08-20 RS YUP-130/03A patent/RS51467B/sr unknown
- 2001-08-20 PL PL361387A patent/PL204215B1/pl unknown
- 2001-08-20 HU HU0301548A patent/HU229802B1/hu not_active IP Right Cessation
- 2001-08-20 BR BR0113348-9A patent/BR0113348A/pt not_active Application Discontinuation
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- 2001-08-20 AU AU2001285894A patent/AU2001285894B2/en not_active Ceased
- 2001-08-20 DK DK01965201T patent/DK1313703T3/da active
- 2001-08-20 CZ CZ20030492A patent/CZ303319B6/cs not_active IP Right Cessation
- 2001-08-20 KR KR1020037002485A patent/KR100589991B1/ko not_active IP Right Cessation
- 2001-08-20 AU AU8589401A patent/AU8589401A/xx active Pending
- 2001-08-20 SI SI200130812T patent/SI1313703T1/sl unknown
- 2001-08-20 ES ES01965201T patent/ES2299508T3/es not_active Expired - Lifetime
- 2001-08-20 WO PCT/EP2001/009561 patent/WO2002016321A1/en active IP Right Grant
- 2001-08-20 AT AT01965201T patent/ATE386022T1/de active
- 2001-08-20 PT PT01965201T patent/PT1313703E/pt unknown
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- 2001-08-20 RU RU2003107572/04A patent/RU2272027C2/ru not_active IP Right Cessation
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2003
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- 2003-02-19 NO NO20030781A patent/NO324941B1/no not_active IP Right Cessation
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- 2003-02-20 EC EC2003004489A patent/ECSP034489A/es unknown
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2004
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Owner name: EVOTEC INTERNATIONAL GMBH, DE |
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