NO324788B1 - Perfluoralkyletere inneholdende polysiloksaner, fremstilling derav og deres anvendelse, polymer omfattende polymerisasjonsproduktet av minst en av nevnte forbindelser samt formlegeme, biomedisinsk artikkel, kornealt implantat og cellevekstsubstrat omfattende denne. - Google Patents
Perfluoralkyletere inneholdende polysiloksaner, fremstilling derav og deres anvendelse, polymer omfattende polymerisasjonsproduktet av minst en av nevnte forbindelser samt formlegeme, biomedisinsk artikkel, kornealt implantat og cellevekstsubstrat omfattende denne. Download PDFInfo
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- NO324788B1 NO324788B1 NO19974584A NO974584A NO324788B1 NO 324788 B1 NO324788 B1 NO 324788B1 NO 19974584 A NO19974584 A NO 19974584A NO 974584 A NO974584 A NO 974584A NO 324788 B1 NO324788 B1 NO 324788B1
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- carbon atoms
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- polymer
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- DQCSJGUXTUJMAA-UHFFFAOYSA-N n,n-dimethylmethanamine;2-hydroxypropyl 2-methylprop-2-enoate;hydrochloride Chemical compound Cl.CN(C)C.CC(O)COC(=O)C(C)=C DQCSJGUXTUJMAA-UHFFFAOYSA-N 0.000 claims description 3
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Mechanical Engineering (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Manufacturing & Machinery (AREA)
- Ophthalmology & Optometry (AREA)
- Plasma & Fusion (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Silicon Polymers (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Eyeglasses (AREA)
- Polyurethanes Or Polyureas (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95810221 | 1995-04-04 | ||
| CH147695 | 1995-05-18 | ||
| US08569816 US5760100B1 (en) | 1994-09-06 | 1995-12-08 | Extended wear ophthalmic lens |
| PCT/EP1996/001255 WO1996031791A1 (en) | 1995-04-04 | 1996-03-22 | Polysiloxane-comprising perfluoroalkyl ethers, and the preparation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO974584D0 NO974584D0 (no) | 1997-10-03 |
| NO974584L NO974584L (no) | 1997-11-26 |
| NO324788B1 true NO324788B1 (no) | 2007-12-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19974584A NO324788B1 (no) | 1995-04-04 | 1997-10-03 | Perfluoralkyletere inneholdende polysiloksaner, fremstilling derav og deres anvendelse, polymer omfattende polymerisasjonsproduktet av minst en av nevnte forbindelser samt formlegeme, biomedisinsk artikkel, kornealt implantat og cellevekstsubstrat omfattende denne. |
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| EP (1) | EP0820601B1 (zh) |
| JP (1) | JP3967377B2 (zh) |
| KR (1) | KR19980703577A (zh) |
| CN (1) | CN1135403C (zh) |
| AT (1) | ATE188041T1 (zh) |
| AU (1) | AU703193B2 (zh) |
| BR (1) | BR9604817A (zh) |
| CA (1) | CA2213357C (zh) |
| CZ (1) | CZ310897A3 (zh) |
| DE (1) | DE69605780T2 (zh) |
| DK (1) | DK0820601T3 (zh) |
| ES (1) | ES2142574T3 (zh) |
| GR (1) | GR3032791T3 (zh) |
| HU (1) | HUP9801570A3 (zh) |
| IL (1) | IL117697A (zh) |
| MX (1) | MX9707554A (zh) |
| NO (1) | NO324788B1 (zh) |
| NZ (1) | NZ304318A (zh) |
| PL (1) | PL322643A1 (zh) |
| PT (1) | PT820601E (zh) |
| TW (1) | TW393498B (zh) |
| WO (1) | WO1996031791A1 (zh) |
| ZA (1) | ZA962655B (zh) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7468398B2 (en) | 1994-09-06 | 2008-12-23 | Ciba Vision Corporation | Extended wear ophthalmic lens |
| US5760100B1 (en) | 1994-09-06 | 2000-11-14 | Ciba Vision Corp | Extended wear ophthalmic lens |
| WO1997035904A1 (en) * | 1996-03-27 | 1997-10-02 | Novartis Ag | Process for manufacture of a porous polymer from a mixture |
| NZ332019A (en) * | 1996-03-27 | 2000-02-28 | Novartis Ag | High water content porous polymer comprising a perfluoropolyether unit |
| AU7533696A (en) | 1996-12-13 | 1998-06-18 | Ciba-Geigy Ag | New materials |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
| WO1999014253A1 (en) * | 1997-09-16 | 1999-03-25 | Novartis Ag | Crosslinkable polyurea polymers |
| JPH11228643A (ja) * | 1998-02-17 | 1999-08-24 | Menicon Co Ltd | 眼用レンズ材料およびその製法 |
| SE9800853D0 (sv) * | 1998-03-16 | 1998-03-16 | Pharmacia & Upjohn Bv | Intraocular lens |
| US6361560B1 (en) * | 1998-12-23 | 2002-03-26 | Anamed, Inc. | Corneal implant and method of manufacture |
| US6450642B1 (en) | 1999-01-12 | 2002-09-17 | California Institute Of Technology | Lenses capable of post-fabrication power modification |
| US6715874B1 (en) * | 1999-02-08 | 2004-04-06 | Novartis Ag | Organic polymers |
| JP4489975B2 (ja) * | 1999-03-30 | 2010-06-23 | ノバルティス アーゲー | 有機化合物 |
| KR100522339B1 (ko) * | 1999-12-16 | 2005-10-20 | 아사히 가세이 아이미 가부시끼가이샤 | 장기간 착용이 가능한 소프트 콘택트 렌즈 |
| JP3929014B2 (ja) | 2000-02-24 | 2007-06-13 | Ｈｏｙａヘルスケア株式会社 | 側鎖にポリシロキサン構造を有するマクロマーからなるコンタクトレンズ材料 |
| US7521519B1 (en) | 2000-03-14 | 2009-04-21 | Novartis Ag | Organic compounds |
| US6814755B2 (en) * | 2000-06-16 | 2004-11-09 | Corneal Industrie | Synthetic cornea |
| FR2810230B1 (fr) * | 2000-06-16 | 2003-06-20 | Corneal Ind | Cornee synthetique |
| CA2421948C (en) | 2000-09-12 | 2009-12-22 | Anamed, Inc. | System for packaging and handling an implant and method of use |
| US8668735B2 (en) | 2000-09-12 | 2014-03-11 | Revision Optics, Inc. | Corneal implant storage and delivery devices |
| US7060288B2 (en) * | 2001-02-28 | 2006-06-13 | Timothy Charles Hughes | Biomedical devices |
| WO2002076338A2 (en) * | 2001-03-21 | 2002-10-03 | Calhoun Vision | Composition and method for producing shapable implants in vivo and implants produced thereby |
| US7120693B2 (en) * | 2001-05-08 | 2006-10-10 | International Business Machines Corporation | Method using two different programs to determine state of a network node to eliminate message response delays in system processing |
| DE10123012C1 (de) * | 2001-05-11 | 2002-07-25 | Pharm Pur Gmbh | Verfahren zur Passivierung einer Intraokularlinse |
| US6815074B2 (en) | 2001-05-30 | 2004-11-09 | Novartis Ag | Polymeric materials for making contact lenses |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US6861149B2 (en) * | 2001-11-27 | 2005-03-01 | 3M Innovative Properties Company | Compositions for aqueous delivery of self-emulsifying fluorinated alkoxysilanes |
| US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
| US7828728B2 (en) | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
| US7497827B2 (en) | 2004-07-13 | 2009-03-03 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20040075039A1 (en) | 2002-08-16 | 2004-04-22 | Dubey Dharmesh K. | Molds for producing contact lenses |
| US7071244B2 (en) * | 2002-12-03 | 2006-07-04 | Staar Surgical Company | High refractive index and optically clear copoly (carbosilane and siloxane) elastomers |
| US20040143327A1 (en) * | 2003-01-17 | 2004-07-22 | Ku David N. | Solid implant |
| EP1648298A4 (en) | 2003-07-25 | 2010-01-13 | Dexcom Inc | OXYGEN-IMPROVED MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US9040090B2 (en) | 2003-12-19 | 2015-05-26 | The University Of North Carolina At Chapel Hill | Isolated and fixed micro and nano structures and methods thereof |
| US7354980B1 (en) | 2004-03-12 | 2008-04-08 | Key Medical Technologies, Inc. | High refractive index polymers for ophthalmic applications |
| US7776086B2 (en) | 2004-04-30 | 2010-08-17 | Revision Optics, Inc. | Aspherical corneal implant |
| US10835371B2 (en) | 2004-04-30 | 2020-11-17 | Rvo 2.0, Inc. | Small diameter corneal inlay methods |
| US8057541B2 (en) | 2006-02-24 | 2011-11-15 | Revision Optics, Inc. | Method of using small diameter intracorneal inlays to treat visual impairment |
| US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
| MXPA06014425A (es) * | 2004-06-08 | 2007-05-23 | Ocularis Pharma Inc | Composiciones oftalmicas hidrofobas y metodo de uso. |
| US20060004165A1 (en) * | 2004-06-30 | 2006-01-05 | Phelan John C | Silicone hydrogels with lathability at room temperature |
| US9248614B2 (en) * | 2004-06-30 | 2016-02-02 | Novartis Ag | Method for lathing silicone hydrogel lenses |
| US9322958B2 (en) | 2004-08-27 | 2016-04-26 | Coopervision International Holding Company, Lp | Silicone hydrogel contact lenses |
| CN102323629B (zh) | 2004-08-27 | 2015-08-19 | 库柏维景国际控股公司 | 硅水凝胶隐形眼镜 |
| US7446157B2 (en) | 2004-12-07 | 2008-11-04 | Key Medical Technologies, Inc. | Nanohybrid polymers for ophthalmic applications |
| US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| MY146558A (en) * | 2005-08-09 | 2012-08-30 | Coopervision Int Holding Co Lp | Compositions and methods for producing silicone hydrogel contact lenses |
| CA2618035A1 (en) | 2005-08-10 | 2007-02-15 | Novartis Ag | Silicone hydrogels |
| JP4809022B2 (ja) | 2005-09-05 | 2011-11-02 | Ｈｏｙａ株式会社 | コンタクトレンズ材料の製造方法およびソフトコンタクトレンズの製造方法 |
| US20070168025A1 (en) * | 2006-01-13 | 2007-07-19 | Sohrab Darougar | Artificial cornea |
| EP1818690A1 (en) | 2006-02-14 | 2007-08-15 | Procornea Holding B.V. | Intraocular lenses essentially free from glistenings |
| US10555805B2 (en) | 2006-02-24 | 2020-02-11 | Rvo 2.0, Inc. | Anterior corneal shapes and methods of providing the shapes |
| US7576159B2 (en) * | 2006-04-28 | 2009-08-18 | Bausch & Lomb Incorporated | Gas-permeable materials and medical devices |
| US20070254000A1 (en) | 2006-04-28 | 2007-11-01 | Xiaoping Guo | Biocompatible self-lubricating polymer compositions and their use in medical and surgical devices |
| US7468397B2 (en) * | 2006-06-30 | 2008-12-23 | Bausch & Lomb Incorporated | Polymerizable siloxane-quaternary amine copolymers |
| EP2129513B1 (en) * | 2007-03-22 | 2016-08-03 | Novartis AG | Prepolymers with dangling polysiloxane-containing polymer chains |
| CN101641615B (zh) * | 2007-03-22 | 2012-06-06 | 诺瓦提斯公司 | 具有悬挂的亲水性聚合物链的含硅酮预聚物 |
| US9271828B2 (en) | 2007-03-28 | 2016-03-01 | Revision Optics, Inc. | Corneal implant retaining devices and methods of use |
| US9549848B2 (en) | 2007-03-28 | 2017-01-24 | Revision Optics, Inc. | Corneal implant inserters and methods of use |
| US8162953B2 (en) | 2007-03-28 | 2012-04-24 | Revision Optics, Inc. | Insertion system for corneal implants |
| WO2008124256A1 (en) * | 2007-04-06 | 2008-10-16 | Johsnon & Johnson Vision Care, Inc. | Methods of degassing ophthalmic lens monomer mixtures |
| US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US9539143B2 (en) | 2008-04-04 | 2017-01-10 | Revision Optics, Inc. | Methods of correcting vision |
| WO2009124268A2 (en) | 2008-04-04 | 2009-10-08 | Revision Optics, Inc. | Corneal inlay design and methods of correcting vision |
| US7939579B1 (en) | 2008-07-09 | 2011-05-10 | Contamac Limited | Hydrogels and methods of manufacture |
| US8440738B2 (en) | 2008-07-09 | 2013-05-14 | Timothy Higgs | Silicone hydrogels and methods of manufacture |
| EP2326944B1 (en) | 2008-09-19 | 2020-08-19 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
| KR101422900B1 (ko) * | 2008-12-18 | 2014-07-30 | 노파르티스 아게 | 실리콘 히드로겔 콘택트 렌즈의 제조 방법 |
| JP6023589B2 (ja) * | 2009-10-01 | 2016-11-09 | クーパーヴィジョン インターナショナル ホウルディング カンパニー リミテッド パートナーシップ | シリコーンヒドロゲルコンタクトレンズおよびシリコーンヒドロゲルコンタクトレンズの製造方法 |
| WO2012016097A2 (en) | 2010-07-30 | 2012-02-02 | Novartis Ag | Amphiphilic polysiloxane prepolymers and uses thereof |
| US8480227B2 (en) | 2010-07-30 | 2013-07-09 | Novartis Ag | Silicone hydrogel lenses with water-rich surfaces |
| US8469948B2 (en) | 2010-08-23 | 2013-06-25 | Revision Optics, Inc. | Methods and devices for forming corneal channels |
| WO2012047961A1 (en) | 2010-10-06 | 2012-04-12 | Novartis Ag | Polymerizable chain-extended polysiloxanes with pendant hydrophilic groups |
| AU2012223584B8 (en) | 2011-02-28 | 2014-08-14 | Coopervision International Limited | Dimensionally stable silicone hydrogel contact lenses |
| CN103764724B (zh) | 2011-02-28 | 2016-04-06 | 库柏维景国际控股公司 | 硅酮水凝胶隐形眼镜以及相关组合物和方法 |
| WO2012118674A2 (en) | 2011-02-28 | 2012-09-07 | Coopervision International Holding Company, Lp | Silicone hydrogel contact lenses |
| BR112013021486B1 (pt) | 2011-02-28 | 2021-06-22 | Coopervision International Holding Company, Lp | Método para fabricação de uma lente de contato de hidrogel, lente de contato de hidrogel e lote e embalagem da dita lente |
| WO2012118675A2 (en) | 2011-02-28 | 2012-09-07 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses |
| MX2013009217A (es) | 2011-02-28 | 2014-09-08 | Coopervision Int Holding Co Lp | Lentes de contacto de hidrogel de silicona que tienen niveles aceptables de perdida de energia. |
| WO2012118672A2 (en) | 2011-02-28 | 2012-09-07 | Coopervision International Holding Company, Lp | Silicone hydrogel contact lenses |
| WO2013055746A1 (en) | 2011-10-12 | 2013-04-18 | Novartis Ag | Method for making uv-absorbing ophthalmic lenses by coating |
| JP5505394B2 (ja) * | 2011-10-20 | 2014-05-28 | 信越化学工業株式会社 | シリコーンゴムの親水性付与方法 |
| KR101762932B1 (ko) | 2011-10-21 | 2017-08-04 | 리비젼 옵틱스, 인크. | 각막 이식물 저장 및 전달 디바이스 |
| US9974646B2 (en) | 2012-09-05 | 2018-05-22 | University Of Miami | Keratoprosthesis, and system and method of corneal repair using same |
| EP2932314B1 (en) | 2012-12-17 | 2017-02-01 | Novartis AG | Method for making improved uv-absorbing ophthalmic lenses |
| US9248928B2 (en) * | 2012-12-21 | 2016-02-02 | Coopervision International Holding Company, Lp | Methods of manufacturing contact lenses for delivery of beneficial agents |
| US9010933B2 (en) * | 2013-02-12 | 2015-04-21 | Shin-Etsu Silicones Of America, Inc. | Silicone contact lens and method for manufacturing thereof |
| WO2014152017A1 (en) | 2013-03-21 | 2014-09-25 | Shifamed Holdings, Llc | Accommodating intraocular lens |
| US9486311B2 (en) | 2013-02-14 | 2016-11-08 | Shifamed Holdings, Llc | Hydrophilic AIOL with bonding |
| US10195018B2 (en) | 2013-03-21 | 2019-02-05 | Shifamed Holdings, Llc | Accommodating intraocular lens |
| SG11201603699SA (en) | 2013-12-17 | 2016-07-28 | Novartis Ag | A silicone hydrogel lens with a crosslinked hydrophilic coating |
| JP6356635B2 (ja) * | 2014-06-12 | 2018-07-11 | 信越化学工業株式会社 | 眼科デバイス製造用モノマー |
| JP6173260B2 (ja) | 2014-06-12 | 2017-08-02 | 信越化学工業株式会社 | 眼科デバイス製造用モノマー |
| CA3008944C (en) | 2014-08-26 | 2021-11-16 | Shifamed Holdings, Llc | Accommodating intraocular lens |
| HUE046948T2 (hu) | 2014-08-26 | 2020-03-30 | Novartis Ag | Eljárás stabil bevonat felvitelére szilikon hidrogél kontaktlencsékre |
| WO2016144404A1 (en) | 2015-03-12 | 2016-09-15 | Revision Optics, Inc. | Methods of correcting vision |
| JP2019501238A (ja) * | 2015-11-11 | 2019-01-17 | ソルベイ スペシャルティ ポリマーズ イタリー エス．ピー．エー． | 新規なヒドロキシ末端（ペル）フルオロポリエーテル−ウレタンポリマー及びクリアコート組成物中でのその使用 |
| US11141263B2 (en) | 2015-11-18 | 2021-10-12 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lens |
| MY184638A (en) | 2015-12-15 | 2021-04-13 | Alcon Inc | Method for applying stable coating on silicone hydrogel contact lenses |
| US20190194455A1 (en) | 2016-08-31 | 2019-06-27 | Solvay Specialty Polymers Italy S.P.A. | Polyamides comprising (per)fluoropolyether and poly(organo siloxane) units |
| WO2019152023A1 (en) * | 2018-01-31 | 2019-08-08 | KeraMed, Inc. | Antimicrobial polymer for use in ophthalmic implants |
| US10307369B2 (en) * | 2016-09-08 | 2019-06-04 | Yichieh Shiuey | Antimicrobial polymer for use in ophthalmic implants |
| US10350056B2 (en) | 2016-12-23 | 2019-07-16 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lenses and methods for making and using same |
| AU2018277037B2 (en) | 2017-05-30 | 2024-04-18 | Shifamed Holdings, Llc | Surface treatments for accommodating intraocular lenses and associated methods and devices |
| EP4205702A1 (en) | 2017-06-07 | 2023-07-05 | Shifamed Holdings, LLC | Adjustable optical power intraocular lenses |
| CN117492231A (zh) | 2017-12-13 | 2024-02-02 | 爱尔康公司 | 周抛和月抛水梯度接触镜片 |
| JP7270486B2 (ja) | 2018-08-02 | 2023-05-10 | 信越化学工業株式会社 | 伸縮性膜及びその形成方法 |
| JP6777212B1 (ja) * | 2019-09-05 | 2020-10-28 | 信越化学工業株式会社 | パーフルオロポリエーテル基を有するシロキサンアクリレート |
| US20240241292A1 (en) * | 2023-01-09 | 2024-07-18 | Visco Vision Inc. | Composition for contact lens and contact lens |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440918A (en) * | 1982-01-18 | 1984-04-03 | Minnesota Mining And Manufacturing Company | Contact lens containing a fluorinated telechelic polyether |
| US4818801A (en) * | 1982-01-18 | 1989-04-04 | Minnesota Mining And Manufacturing Company | Ophthalmic device comprising a polymer of a telechelic perfluoropolyether |
| ES2068373T3 (es) * | 1989-01-11 | 1995-04-16 | Ciba Geigy Ag | Macromeros vinilicos que contienen segmentos de perfluoropolialquileter y polialquileter, polimeros, copolimeros y dispositivos oftalmicos elaborados a partir de los mismos. |
| US5334681A (en) * | 1989-06-20 | 1994-08-02 | Ciba-Geigy Corporation | Fluorine and/or silicone containing poly(alkylene-oxide)-block copolymer hydrogels and contact lenses thereof |
| US5079319A (en) * | 1989-10-25 | 1992-01-07 | Ciba-Geigy Corporation | Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof |
| US5010141A (en) * | 1989-10-25 | 1991-04-23 | Ciba-Geigy Corporation | Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof |
| JP2947915B2 (ja) * | 1990-10-31 | 1999-09-13 | ノバルティス アクチエンゲゼルシャフト | 酸素透過性高分子材料の製造方法 |
| DK0493320T3 (da) * | 1990-12-20 | 1996-08-26 | Ciba Geigy Ag | Fluor- og/eller silikone-holdige poly(alkylenoxid)-blokcopolymerer og kontaktlinser deraf |
| JPH04247268A (ja) * | 1991-02-01 | 1992-09-03 | Olympus Optical Co Ltd | 超音波振動装置 |
| US5314981A (en) * | 1992-03-27 | 1994-05-24 | Shin-Etsu Chemical Co., Ltd. | Room temperature curable organopolysiloxane composition and cured product of the same |
| US5300613A (en) * | 1992-06-02 | 1994-04-05 | Shin-Etsu Chemical Co., Ltd. | Fluorine-containing organosilicon compounds |
| DE69314384T2 (de) * | 1992-06-02 | 1998-03-05 | Shinetsu Chemical Co | Fluorenthaltende Organopolysiloxanzusammensetzung |
| JP3195662B2 (ja) * | 1992-08-24 | 2001-08-06 | 株式会社メニコン | 眼用レンズ材料 |
| US5264522A (en) * | 1992-09-10 | 1993-11-23 | Shin-Etsu Chemical Co., Ltd. | Heat-curable fluorosilicone rubber composition and cured product thereof |
| EP0725113B1 (en) * | 1995-01-23 | 2000-09-27 | Shin-Etsu Chemical Co., Ltd. | Fluorinated amide silicone compounds and curable siloxane compositions |
| EP0745604A3 (en) * | 1995-05-29 | 1998-07-29 | Shin-Etsu Chemical Co., Ltd. | Room temperature curable fluoropolymer composition; and fluorine-containing organosilicon compounds, a method of producing the same, and room temperature curable silicone composition containing the same |
-
1995
- 1995-08-15 TW TW84108480A patent/TW393498B/zh not_active IP Right Cessation
-
1996
- 1996-03-22 CZ CZ973108A patent/CZ310897A3/cs unknown
- 1996-03-22 AT AT96908111T patent/ATE188041T1/de active
- 1996-03-22 US US08/776,985 patent/US5945498A/en not_active Expired - Lifetime
- 1996-03-22 KR KR1019970706981A patent/KR19980703577A/ko not_active Application Discontinuation
- 1996-03-22 CN CNB961929901A patent/CN1135403C/zh not_active Expired - Lifetime
- 1996-03-22 PL PL32264396A patent/PL322643A1/xx unknown
- 1996-03-22 HU HU9801570A patent/HUP9801570A3/hu unknown
- 1996-03-22 EP EP19960908111 patent/EP0820601B1/en not_active Expired - Lifetime
- 1996-03-22 PT PT96908111T patent/PT820601E/pt unknown
- 1996-03-22 DK DK96908111T patent/DK0820601T3/da active
- 1996-03-22 AU AU51475/96A patent/AU703193B2/en not_active Expired
- 1996-03-22 DE DE69605780T patent/DE69605780T2/de not_active Expired - Lifetime
- 1996-03-22 CA CA 2213357 patent/CA2213357C/en not_active Expired - Lifetime
- 1996-03-22 MX MX9707554A patent/MX9707554A/es unknown
- 1996-03-22 ES ES96908111T patent/ES2142574T3/es not_active Expired - Lifetime
- 1996-03-22 JP JP52992596A patent/JP3967377B2/ja not_active Expired - Lifetime
- 1996-03-22 WO PCT/EP1996/001255 patent/WO1996031791A1/en not_active Application Discontinuation
- 1996-03-22 BR BR9604817A patent/BR9604817A/pt not_active IP Right Cessation
- 1996-03-22 NZ NZ30431896A patent/NZ304318A/xx unknown
- 1996-03-28 IL IL11769796A patent/IL117697A/xx not_active IP Right Cessation
- 1996-04-03 ZA ZA962655A patent/ZA962655B/xx unknown
-
1997
- 1997-10-03 NO NO19974584A patent/NO324788B1/no not_active IP Right Cessation
-
2000
- 2000-02-29 GR GR20000400492T patent/GR3032791T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ310897A3 (cs) | 1998-03-18 |
| DK0820601T3 (da) | 2000-05-22 |
| IL117697A0 (en) | 1996-07-23 |
| PL322643A1 (en) | 1998-02-16 |
| CN1180415A (zh) | 1998-04-29 |
| AU5147596A (en) | 1996-10-23 |
| MX9707554A (es) | 1997-12-31 |
| ZA962655B (en) | 1996-12-21 |
| AU703193B2 (en) | 1999-03-18 |
| EP0820601B1 (en) | 1999-12-22 |
| IL117697A (en) | 2001-01-11 |
| KR19980703577A (ko) | 1998-11-05 |
| CA2213357A1 (en) | 1996-10-10 |
| US5945498A (en) | 1999-08-31 |
| ATE188041T1 (de) | 2000-01-15 |
| GR3032791T3 (en) | 2000-06-30 |
| DE69605780T2 (de) | 2000-07-20 |
| HUP9801570A2 (hu) | 1998-11-30 |
| ES2142574T3 (es) | 2000-04-16 |
| EP0820601A1 (en) | 1998-01-28 |
| JPH11502894A (ja) | 1999-03-09 |
| JP3967377B2 (ja) | 2007-08-29 |
| CN1135403C (zh) | 2004-01-21 |
| TW393498B (en) | 2000-06-11 |
| HUP9801570A3 (en) | 1999-03-01 |
| CA2213357C (en) | 2007-05-08 |
| NO974584L (no) | 1997-11-26 |
| WO1996031791A1 (en) | 1996-10-10 |
| BR9604817A (pt) | 1998-06-09 |
| NO974584D0 (no) | 1997-10-03 |
| DE69605780D1 (de) | 2000-01-27 |
| NZ304318A (en) | 1999-03-29 |
| PT820601E (pt) | 2000-05-31 |
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