NO324725B1 - MORT-1-protein, DNA-sekvens som koder for MORT-1 og antistoffer spesifikke for MORT-1, samt fremgangsmate for fremstilling, farmasoytiske sammensetninger og anvendelser. - Google Patents

MORT-1-protein, DNA-sekvens som koder for MORT-1 og antistoffer spesifikke for MORT-1, samt fremgangsmate for fremstilling, farmasoytiske sammensetninger og anvendelser. Download PDF

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Publication number
NO324725B1
NO324725B1 NO19972716A NO972716A NO324725B1 NO 324725 B1 NO324725 B1 NO 324725B1 NO 19972716 A NO19972716 A NO 19972716A NO 972716 A NO972716 A NO 972716A NO 324725 B1 NO324725 B1 NO 324725B1
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Norway
Prior art keywords
protein
mort
fas
cells
proteins
Prior art date
Application number
NO19972716A
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English (en)
Norwegian (no)
Other versions
NO972716L (no
NO972716D0 (no
Inventor
David Wallach
Mark Boldin
Igor Mett
Eugene Varfolomeev
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11200294A external-priority patent/IL112002A0/xx
Priority claimed from IL112692A external-priority patent/IL112692A/en
Priority claimed from IL11461595A external-priority patent/IL114615A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of NO972716D0 publication Critical patent/NO972716D0/no
Publication of NO972716L publication Critical patent/NO972716L/no
Publication of NO324725B1 publication Critical patent/NO324725B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641Cysteine endopeptidases (3.4.22)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472Cysteine endopeptidases (3.4.22)
    • C12N9/6475Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transmitters (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Radar Systems Or Details Thereof (AREA)
NO19972716A 1994-12-15 1997-06-12 MORT-1-protein, DNA-sekvens som koder for MORT-1 og antistoffer spesifikke for MORT-1, samt fremgangsmate for fremstilling, farmasoytiske sammensetninger og anvendelser. NO324725B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL11200294A IL112002A0 (en) 1994-05-11 1994-12-15 Modulatiors of tnf/ngf superfamily receptors, their preparation and use
IL112692A IL112692A (en) 1995-02-19 1995-02-19 ANTIBODIES TO PROTEIN WHICH BINDS TO Fas-R
IL11461595A IL114615A0 (en) 1995-07-16 1995-07-16 Modulators of the function of fas receptors and other proteins
PCT/US1995/016542 WO1996018641A1 (en) 1994-12-15 1995-12-14 Modulators of the function of fas/apo1 receptors

Publications (3)

Publication Number Publication Date
NO972716D0 NO972716D0 (no) 1997-06-12
NO972716L NO972716L (no) 1997-07-11
NO324725B1 true NO324725B1 (no) 2007-12-03

Family

ID=27271687

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19972716A NO324725B1 (no) 1994-12-15 1997-06-12 MORT-1-protein, DNA-sekvens som koder for MORT-1 og antistoffer spesifikke for MORT-1, samt fremgangsmate for fremstilling, farmasoytiske sammensetninger og anvendelser.

Country Status (18)

Country Link
EP (1) EP0871645B1 (fi)
JP (1) JP3787355B2 (fi)
KR (1) KR100536394B1 (fi)
CN (1) CN1105725C (fi)
AT (1) ATE377073T1 (fi)
AU (1) AU706401B2 (fi)
CA (1) CA2207815C (fi)
CY (1) CY2586B2 (fi)
DE (1) DE69535634T2 (fi)
DK (1) DK0871645T3 (fi)
ES (1) ES2292172T3 (fi)
FI (1) FI121273B (fi)
HK (1) HK1007248A1 (fi)
MX (1) MX9704501A (fi)
NO (1) NO324725B1 (fi)
PT (1) PT871645E (fi)
UA (1) UA58489C2 (fi)
WO (1) WO1996018641A1 (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114615A0 (en) * 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
US6060238A (en) * 1995-02-13 2000-05-09 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6015665A (en) * 1995-02-13 2000-01-18 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US7097972B1 (en) 1995-02-13 2006-08-29 Regents Of The University Of Michigan Method and composition for regulating apoptosis
AU755662B2 (en) * 1995-02-22 2002-12-19 Yeda Research And Development Co. Ltd. Modulators of regulatory proteins
WO1996025941A1 (en) * 1995-02-22 1996-08-29 Yeda Research And Development Co. Ltd. Modulators of regulatory proteins
US7807783B1 (en) 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US6747138B1 (en) 1995-04-03 2004-06-08 Regents Of The University Of Michigan Methods and compositions for regulating Fas-associated apoptosis
US6399327B1 (en) 1995-07-16 2002-06-04 Yeda Research And Development Co. Ltd. Modulators of the function of FAS receptors and other proteins
US6911526B2 (en) * 1996-07-22 2005-06-28 The Trustees Of Columbia University In The City Of New York Compounds that inhibit the interaction between signal-transducing proteins and the GLGF (PDZ/DHR) domain and uses thereof
EP0842665A3 (en) * 1996-11-14 2002-12-18 Smithkline Beecham Corporation Interleukin-1 beta converting enzyme like apoptotic proteases and their agonists
US5969102A (en) * 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
PT977846E (pt) * 1997-04-25 2002-11-29 Wyeth Corp Isoformas de morti neuronal
AU7988698A (en) * 1997-06-26 1999-01-19 Chiron Corporation Human fadd-interacting protein (fip)
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
US6015712A (en) * 1999-07-19 2000-01-18 Isis Pharmaceuticals Inc. Antisense modulation of FADD expression
ATE542545T1 (de) 2001-05-24 2012-02-15 Zymogenetics Inc Taci-immunoglobulin-fusionsproteine
US6743630B2 (en) 2002-03-06 2004-06-01 The Trustees Of Columbia University In The City Of New York Method of preparing a protein array based on biochemical protein-protein interaction
WO2007019573A2 (en) 2005-08-09 2007-02-15 Zymogenetics, Inc. Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
EA016083B1 (ru) 2005-08-09 2012-02-28 Займоджинетикс, Инк. СПОСОБ ЛЕЧЕНИЯ НЕХОДЖКИНСКОЙ ЛИМФОМЫ С ПОМОЩЬЮ СЛИТОЙ МОЛЕКУЛЫ TACI-Ig
CN101489573B (zh) 2006-05-15 2013-05-22 阿雷斯贸易股份有限公司 用TACI-Ig融合分子治疗自身免疫疾病的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO178777C (no) * 1994-05-09 1996-05-29 Kvaerner Eng Varmeveksler
US7807783B1 (en) * 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US5674734A (en) * 1995-05-18 1997-10-07 President And Fellows Of Harvard College Cell death protein

Also Published As

Publication number Publication date
DK0871645T3 (da) 2007-12-03
HK1007248A1 (en) 1999-04-09
CA2207815A1 (en) 1996-06-20
NO972716L (no) 1997-07-11
ES2292172T3 (es) 2008-03-01
WO1996018641A1 (en) 1996-06-20
ATE377073T1 (de) 2007-11-15
CN1105725C (zh) 2003-04-16
EP0871645A4 (en) 1999-11-24
AU4602296A (en) 1996-07-03
FI121273B (fi) 2010-09-15
PT871645E (pt) 2007-11-14
KR100536394B1 (ko) 2006-04-21
AU706401B2 (en) 1999-06-17
EP0871645B1 (en) 2007-10-31
UA58489C2 (uk) 2003-08-15
FI972457A (fi) 1997-06-10
CA2207815C (en) 2011-03-29
CN1169729A (zh) 1998-01-07
JPH10510712A (ja) 1998-10-20
DE69535634T2 (de) 2008-08-28
EP0871645A1 (en) 1998-10-21
FI972457A0 (fi) 1997-06-10
DE69535634D1 (de) 2007-12-13
NO972716D0 (no) 1997-06-12
CY2586B2 (en) 2009-11-04
JP3787355B2 (ja) 2006-06-21
MX9704501A (es) 1997-10-31

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