NO323724B1 - Substituerte piperazin- og piperidin-forbindelser, anvendelse av slike forbindelser for fremstilling av et medikament for behandling av smerte, slag eller epilepsi samt farmasoytisk blanding omfattende slike forbindelser. - Google Patents
Substituerte piperazin- og piperidin-forbindelser, anvendelse av slike forbindelser for fremstilling av et medikament for behandling av smerte, slag eller epilepsi samt farmasoytisk blanding omfattende slike forbindelser. Download PDFInfo
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- NO323724B1 NO323724B1 NO20022947A NO20022947A NO323724B1 NO 323724 B1 NO323724 B1 NO 323724B1 NO 20022947 A NO20022947 A NO 20022947A NO 20022947 A NO20022947 A NO 20022947A NO 323724 B1 NO323724 B1 NO 323724B1
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Classifications
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17283199P | 1999-12-20 | 1999-12-20 | |
US09/476,927 US6387897B1 (en) | 1998-06-30 | 1999-12-30 | Preferentially substituted calcium channel blockers |
PCT/CA2000/001557 WO2001045709A1 (en) | 1999-12-20 | 2000-12-20 | Substituted piperazine and piperidine calcium channel blockers |
Publications (3)
Publication Number | Publication Date |
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NO20022947D0 NO20022947D0 (no) | 2002-06-19 |
NO20022947L NO20022947L (no) | 2002-08-09 |
NO323724B1 true NO323724B1 (no) | 2007-06-25 |
Family
ID=26868504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20022947A NO323724B1 (no) | 1999-12-20 | 2002-06-19 | Substituerte piperazin- og piperidin-forbindelser, anvendelse av slike forbindelser for fremstilling av et medikament for behandling av smerte, slag eller epilepsi samt farmasoytisk blanding omfattende slike forbindelser. |
Country Status (18)
Country | Link |
---|---|
US (2) | US6387897B1 (de) |
EP (1) | EP1244451B1 (de) |
JP (1) | JP2003518064A (de) |
KR (1) | KR100823889B1 (de) |
CN (1) | CN100477992C (de) |
AT (1) | ATE333878T1 (de) |
AU (1) | AU784206B2 (de) |
BR (1) | BR0016530A (de) |
CA (1) | CA2394327C (de) |
DE (1) | DE60029634T2 (de) |
DK (1) | DK1244451T3 (de) |
ES (1) | ES2269220T3 (de) |
HK (1) | HK1049969B (de) |
IL (1) | IL150117A0 (de) |
MX (1) | MXPA02006138A (de) |
NO (1) | NO323724B1 (de) |
PT (1) | PT1244451E (de) |
WO (1) | WO2001045709A1 (de) |
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US6943168B2 (en) * | 1998-06-30 | 2005-09-13 | Neuromed Technologies Inc. | Calcium channel inhibitors comprising benzhydril spaced from piperazine |
US6387897B1 (en) * | 1998-06-30 | 2002-05-14 | Neuromed Technologies, Inc. | Preferentially substituted calcium channel blockers |
US20040259866A1 (en) * | 1998-06-30 | 2004-12-23 | Snutch Terrance P. | Calcium channel blockers comprising two benzhydril moieties |
US6951862B2 (en) * | 1998-06-30 | 2005-10-04 | Neuromed Technologies, Inc. | Calcium channel blockers comprising two benzhydril moieties |
WO2004089922A2 (en) * | 1998-06-30 | 2004-10-21 | Neuromed Technologies, Inc. | Calcium channel inhibitors comprising benzhydril spaced from piperazine |
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JP4428053B2 (ja) * | 2002-02-05 | 2010-03-10 | 味の素株式会社 | ガバペンチン若しくはプレガバリンおよびn型カルシウムチャンネル拮抗剤を含有する医薬組成物 |
US20030199523A1 (en) * | 2002-02-28 | 2003-10-23 | Snutch Terrance P. | Heterocyclic calcium in channel blockers |
US20040204404A1 (en) * | 2002-09-30 | 2004-10-14 | Robert Zelle | Human N-type calcium channel blockers |
EP1611116A2 (de) * | 2003-04-08 | 2006-01-04 | Neuromed Technologies, Inc. | Calciumkanalinhibitoren, die benzhydril in einem gewissen abstand von piperazin enthalten |
WO2004093813A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders |
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AU2004243511A1 (en) * | 2003-05-30 | 2004-12-09 | Neuromed Technologies, Inc | 3-aminomethyl-pyrrolidines as N-type calcium channel blockers |
WO2005015159A2 (en) * | 2003-08-08 | 2005-02-17 | The Regents Of The University Of California. | Methods for modulating a drug-related effect or behavior |
US7524846B2 (en) * | 2003-10-14 | 2009-04-28 | Wyeth | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use |
US7507760B2 (en) * | 2004-01-22 | 2009-03-24 | Neuromed Pharmaceuticals Ltd. | N-type calcium channel blockers |
KR20070044803A (ko) * | 2004-04-09 | 2007-04-30 | 뉴로메드 파머큐티칼즈 리미티드 | 칼슘 채널 차단제로서 디아릴아민 유도체 |
US20050227999A1 (en) * | 2004-04-09 | 2005-10-13 | Neuromed Technologies Inc. | Diarylamine derivatives as calcium channel blockers |
GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
AU2005279600A1 (en) | 2004-08-30 | 2006-03-09 | Neuromed Pharmaceuticals Ltd. | Urea derivatives as calcium channel blockers |
TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
US7511077B2 (en) | 2005-02-09 | 2009-03-31 | Neuromed Pharmaceuticals Ltd. | Diamine calcium channel blockers |
JP2008534630A (ja) * | 2005-04-08 | 2008-08-28 | ニューロメッド ファーマシューティカルズ リミテッド | 疼痛の軽減のためのn型カルシウムチャネルブロッカーを含む組み合わせ治療の方法 |
US20080306087A1 (en) * | 2005-08-08 | 2008-12-11 | Astrazeneca Ab | Therapeutic Agents |
US8299211B2 (en) * | 2005-09-30 | 2012-10-30 | The Board Of Trustees Of The University Of Illinois | Peptides and regulation of calcium channels |
WO2007041360A2 (en) * | 2005-09-30 | 2007-04-12 | The Board Of Trustees Of The University Of Illinois | Peptides and calcium regulation in mammalian cells |
US8247442B2 (en) * | 2006-03-29 | 2012-08-21 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use |
TW200812963A (en) * | 2006-04-13 | 2008-03-16 | Euro Celtique Sa | Benzenesulfonamide compounds and the use thereof |
US8791264B2 (en) * | 2006-04-13 | 2014-07-29 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
CA2651811A1 (en) * | 2006-05-11 | 2007-11-22 | Neuromed Pharmaceuticals Ltd. | Method for increasing the bioavailability of benzhydryl piperazine containing compounds |
EP2061780A4 (de) * | 2006-09-14 | 2010-12-22 | Zalicus Pharmaceuticals Ltd | Diarylpiperidinverbindungen als kalziumkanalblocker |
EP2074105A4 (de) * | 2006-10-13 | 2010-10-06 | Neuromed Pharmaceuticals Ltd | Cyclopropylpiperazinverbindungen als calciumkanalblocker |
UY30639A1 (es) * | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
US8399486B2 (en) * | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
WO2009040659A2 (en) * | 2007-09-28 | 2009-04-02 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
JP2010540629A (ja) * | 2007-10-04 | 2010-12-24 | メルク・シャープ・エンド・ドーム・コーポレイション | カルシウムチャネル遮断薬としての置換アリールスルホン誘導体 |
CN101821242B (zh) * | 2007-10-17 | 2013-07-24 | 库多斯药物有限公司 | 4-[3-(4-环丙烷羰基-哌嗪-1-羰基)-4-氟-苄基]-2h-酞嗪-1-酮 |
US20090270413A1 (en) * | 2008-04-28 | 2009-10-29 | Galemmo Jr Robert | Di-t-butylphenyl piperazines as calcium channel blockers |
AU2009296888A1 (en) * | 2008-09-29 | 2010-04-01 | Merck Sharp & Dohme Corp. | Substituted aryl sulfone derivatives as calcium channel blockers |
LT2346495T (lt) | 2008-10-07 | 2016-10-10 | Astrazeneca Uk Limited | Farmacinė kompozicija 514 |
US20100113472A1 (en) * | 2008-11-03 | 2010-05-06 | Chemocentryx, Inc. | Compounds for the treatment of osteoporosis and cancers |
US8629149B2 (en) | 2009-09-04 | 2014-01-14 | Zalicus Pharmaceuticals Ltd. | Oxopiperazine derivatives for the treatment of pain and epilepsy |
RU2013118021A (ru) | 2010-09-20 | 2014-10-27 | Кареус Терапьютикс, Са | Способы и композиции для лечения сахарного диабета и дислипидемии |
BR112013022788A2 (pt) | 2011-03-08 | 2016-12-06 | Zalicus Pharmaceuticals Ltd | "composição farmacêutica compreendendo uma dispersão sólida de 1-(4-benzidrilpiperazin-1-il)-3,3-difenilpropan-1-ona" |
US8409560B2 (en) | 2011-03-08 | 2013-04-02 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
US10208023B2 (en) | 2013-03-01 | 2019-02-19 | Mark G. DeGiacomo | Heterocyclic inhibitors of the sodium channel |
US10168144B2 (en) | 2016-03-25 | 2019-01-01 | Sony Corporation | Optical apparatus for 3D data collection |
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-
1999
- 1999-12-30 US US09/476,927 patent/US6387897B1/en not_active Expired - Lifetime
-
2000
- 2000-12-20 MX MXPA02006138A patent/MXPA02006138A/es active IP Right Grant
- 2000-12-20 KR KR1020027007951A patent/KR100823889B1/ko not_active IP Right Cessation
- 2000-12-20 JP JP2001546648A patent/JP2003518064A/ja active Pending
- 2000-12-20 CN CNB008174369A patent/CN100477992C/zh not_active Expired - Fee Related
- 2000-12-20 EP EP00988531A patent/EP1244451B1/de not_active Expired - Lifetime
- 2000-12-20 AU AU24956/01A patent/AU784206B2/en not_active Ceased
- 2000-12-20 DK DK00988531T patent/DK1244451T3/da active
- 2000-12-20 AT AT00988531T patent/ATE333878T1/de active
- 2000-12-20 DE DE60029634T patent/DE60029634T2/de not_active Expired - Lifetime
- 2000-12-20 ES ES00988531T patent/ES2269220T3/es not_active Expired - Lifetime
- 2000-12-20 IL IL15011700A patent/IL150117A0/xx active IP Right Grant
- 2000-12-20 BR BR0016530-1A patent/BR0016530A/pt not_active Application Discontinuation
- 2000-12-20 PT PT00988531T patent/PT1244451E/pt unknown
- 2000-12-20 CA CA2394327A patent/CA2394327C/en not_active Expired - Fee Related
- 2000-12-20 WO PCT/CA2000/001557 patent/WO2001045709A1/en active IP Right Grant
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2002
- 2002-01-29 US US10/060,900 patent/US6617322B2/en not_active Expired - Fee Related
- 2002-06-19 NO NO20022947A patent/NO323724B1/no unknown
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2003
- 2003-03-28 HK HK03102253.5A patent/HK1049969B/zh not_active IP Right Cessation
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AU2495601A (en) | 2001-07-03 |
US20030045530A1 (en) | 2003-03-06 |
DK1244451T3 (da) | 2006-10-30 |
CA2394327A1 (en) | 2001-06-28 |
US6617322B2 (en) | 2003-09-09 |
DE60029634T2 (de) | 2007-07-05 |
KR100823889B1 (ko) | 2008-04-22 |
NO20022947D0 (no) | 2002-06-19 |
DE60029634D1 (de) | 2006-09-07 |
JP2003518064A (ja) | 2003-06-03 |
WO2001045709A1 (en) | 2001-06-28 |
IL150117A0 (en) | 2002-12-01 |
CN100477992C (zh) | 2009-04-15 |
BR0016530A (pt) | 2002-09-24 |
EP1244451B1 (de) | 2006-07-26 |
ATE333878T1 (de) | 2006-08-15 |
CA2394327C (en) | 2012-01-24 |
KR20020075874A (ko) | 2002-10-07 |
EP1244451A1 (de) | 2002-10-02 |
ES2269220T3 (es) | 2007-04-01 |
US6387897B1 (en) | 2002-05-14 |
NO20022947L (no) | 2002-08-09 |
HK1049969B (zh) | 2006-12-29 |
AU784206B2 (en) | 2006-02-23 |
MXPA02006138A (es) | 2002-12-05 |
CN1411374A (zh) | 2003-04-16 |
HK1049969A1 (en) | 2003-06-06 |
PT1244451E (pt) | 2006-10-31 |
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