NO322535B1 - 2-Alkyliden-19-nor-vitamin D-forbindelser samt mellomprodukter for fremstilling derav - Google Patents
2-Alkyliden-19-nor-vitamin D-forbindelser samt mellomprodukter for fremstilling derav Download PDFInfo
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- NO322535B1 NO322535B1 NO19994398A NO994398A NO322535B1 NO 322535 B1 NO322535 B1 NO 322535B1 NO 19994398 A NO19994398 A NO 19994398A NO 994398 A NO994398 A NO 994398A NO 322535 B1 NO322535 B1 NO 322535B1
- Authority
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- Norway
- Prior art keywords
- group
- vitamin
- hydrogen
- compounds
- methylene
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/819,693 US5843928A (en) | 1997-03-17 | 1997-03-17 | 2-alkylidene-19-nor-vitamin D compounds |
| PCT/US1998/002976 WO1998041501A1 (en) | 1997-03-17 | 1998-02-11 | 2-alkylidene-19-nor-vitamin d compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994398D0 NO994398D0 (no) | 1999-09-10 |
| NO994398L NO994398L (no) | 1999-09-10 |
| NO322535B1 true NO322535B1 (no) | 2006-10-23 |
Family
ID=25228793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994398A NO322535B1 (no) | 1997-03-17 | 1999-09-10 | 2-Alkyliden-19-nor-vitamin D-forbindelser samt mellomprodukter for fremstilling derav |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5843928A (da) |
| EP (1) | EP0970047B1 (da) |
| JP (2) | JP3786713B2 (da) |
| KR (1) | KR100380914B1 (da) |
| AT (1) | ATE223890T1 (da) |
| AU (1) | AU714253B2 (da) |
| CA (1) | CA2283829C (da) |
| DE (1) | DE69807852T2 (da) |
| DK (1) | DK0970047T3 (da) |
| ES (1) | ES2179451T3 (da) |
| NO (1) | NO322535B1 (da) |
| NZ (1) | NZ337503A (da) |
| PT (1) | PT970047E (da) |
| WO (1) | WO1998041501A1 (da) |
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| US8940916B2 (en) * | 2012-05-30 | 2015-01-27 | Wisconsin Alumni Research Foundation | Crystallization of (20R)-2-methylene-19-nor-24-difluoro-1α,25-dihydroxyvitamin D3 |
| US8884039B2 (en) | 2012-05-30 | 2014-11-11 | Wisconsin Alumni Research Foundation | Crystallization of (20R) and (20S) analogs of 2-methylene-19-nor-24-dimethyl-1α,25-dihydroxyvitamin D3 |
| US9040728B2 (en) | 2012-05-30 | 2015-05-26 | Wisconsin Alumni Research Foundation | Crystallization of (20R) 19-nor-24-difluoro-1α,25-dihydroxyvitamin D3 |
| US8785422B2 (en) | 2012-06-06 | 2014-07-22 | Wisconsin Alumni Research Foundation | A-ring modified 19-nor-vitamin D analogs and their uses |
| NZ703347A (en) | 2012-06-29 | 2016-05-27 | Wisconsin Alumni Res Found | Use of 2-methylene-19-nor-(20s)-1α,25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism |
| EP2746252A1 (en) | 2012-12-21 | 2014-06-25 | Wisconsin Alumni Research Foundation (WARF) | Crystallization of 1alpha-hydroxy-2-methylene- 18,19-dinor-homopregnacalciferol |
| US9416102B2 (en) * | 2013-01-23 | 2016-08-16 | Wisconsin Alumni Research Foundation | (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| AU2016268399B2 (en) | 2015-05-26 | 2020-10-15 | Wisconsin Alumni Research Foundation | 1alpha,25-dihydroxy-24,24-difluoro-19-nor-vitamin D3 analogs and their pharmaceutical uses |
| WO2017184262A1 (en) | 2016-04-18 | 2017-10-26 | Wisconsin Alumni Research Foundation | Use of 2amd and 2md to treat fibrosis |
| US10105375B2 (en) | 2016-08-30 | 2018-10-23 | Wisconsin Alumni Research Foundation | Combination of low dose 2-methylene-19-nor-(20S)1α, 25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| NZ232734A (en) * | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| AU650751B2 (en) * | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP3213092B2 (ja) * | 1991-11-01 | 2001-09-25 | 中外製薬株式会社 | ２β位に置換基を有するビタミンＤ誘導体 |
| DE69400495T2 (de) * | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| WO1996001811A1 (en) * | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
-
1997
- 1997-03-17 US US08/819,693 patent/US5843928A/en not_active Expired - Lifetime
-
1998
- 1998-02-11 AU AU62801/98A patent/AU714253B2/en not_active Expired
- 1998-02-11 KR KR10-1999-7008407A patent/KR100380914B1/ko not_active IP Right Cessation
- 1998-02-11 DE DE69807852T patent/DE69807852T2/de not_active Expired - Lifetime
- 1998-02-11 WO PCT/US1998/002976 patent/WO1998041501A1/en active IP Right Grant
- 1998-02-11 NZ NZ337503A patent/NZ337503A/xx not_active IP Right Cessation
- 1998-02-11 ES ES98905102T patent/ES2179451T3/es not_active Expired - Lifetime
- 1998-02-11 JP JP54050198A patent/JP3786713B2/ja not_active Expired - Lifetime
- 1998-02-11 AT AT98905102T patent/ATE223890T1/de active
- 1998-02-11 DK DK98905102T patent/DK0970047T3/da active
- 1998-02-11 CA CA002283829A patent/CA2283829C/en not_active Expired - Lifetime
- 1998-02-11 PT PT98905102T patent/PT970047E/pt unknown
- 1998-02-11 EP EP98905102A patent/EP0970047B1/en not_active Expired - Lifetime
- 1998-09-10 US US09/151,113 patent/US5936133A/en not_active Expired - Lifetime
-
1999
- 1999-09-10 NO NO19994398A patent/NO322535B1/no not_active IP Right Cessation
-
2005
- 2005-11-02 JP JP2005319365A patent/JP4035144B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6280198A (en) | 1998-10-12 |
| EP0970047B1 (en) | 2002-09-11 |
| US5843928A (en) | 1998-12-01 |
| ATE223890T1 (de) | 2002-09-15 |
| JP2001504135A (ja) | 2001-03-27 |
| CA2283829C (en) | 2006-07-11 |
| KR20000076306A (ko) | 2000-12-26 |
| JP2006117680A (ja) | 2006-05-11 |
| NZ337503A (en) | 2000-09-29 |
| WO1998041501A1 (en) | 1998-09-24 |
| US5936133A (en) | 1999-08-10 |
| DK0970047T3 (da) | 2002-11-11 |
| JP4035144B2 (ja) | 2008-01-16 |
| EP0970047A1 (en) | 2000-01-12 |
| DE69807852D1 (de) | 2002-10-17 |
| NO994398D0 (no) | 1999-09-10 |
| AU714253B2 (en) | 1999-12-23 |
| CA2283829A1 (en) | 1998-09-24 |
| NO994398L (no) | 1999-09-10 |
| JP3786713B2 (ja) | 2006-06-14 |
| KR100380914B1 (ko) | 2003-04-21 |
| ES2179451T3 (es) | 2003-01-16 |
| PT970047E (pt) | 2003-01-31 |
| DE69807852T2 (de) | 2009-09-24 |
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| RE | Reestablishment of rights (par. 72 patents act) | ||
| MK1K | Patent expired |