NO321186B1 - Monoklonale anti-alfa-V-integrin-antistoffer, antistoffragmenter av disse, hybridomcellelinje som produserer dem, aminosyresekvenser som utgjor dem, DNA-sekvenser som koder for aminosyresekvensene, farmasoytisk preparat som omfatter antistoffene og antistoffragmentene, fremgangsmate for fremstilling av antistoffene og antistoffragmentene og anvendelse av antistoffene og antistoffragmentene for fremstilling av legemidler og diagnostiske forbindelser. - Google Patents
Monoklonale anti-alfa-V-integrin-antistoffer, antistoffragmenter av disse, hybridomcellelinje som produserer dem, aminosyresekvenser som utgjor dem, DNA-sekvenser som koder for aminosyresekvensene, farmasoytisk preparat som omfatter antistoffene og antistoffragmentene, fremgangsmate for fremstilling av antistoffene og antistoffragmentene og anvendelse av antistoffene og antistoffragmentene for fremstilling av legemidler og diagnostiske forbindelser. Download PDFInfo
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- NO321186B1 NO321186B1 NO19955167A NO955167A NO321186B1 NO 321186 B1 NO321186 B1 NO 321186B1 NO 19955167 A NO19955167 A NO 19955167A NO 955167 A NO955167 A NO 955167A NO 321186 B1 NO321186 B1 NO 321186B1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94120165 | 1994-12-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO955167D0 NO955167D0 (no) | 1995-12-19 |
| NO955167L NO955167L (no) | 1996-06-21 |
| NO321186B1 true NO321186B1 (no) | 2006-04-03 |
Family
ID=8216547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19955167A NO321186B1 (no) | 1994-12-20 | 1995-12-19 | Monoklonale anti-alfa-V-integrin-antistoffer, antistoffragmenter av disse, hybridomcellelinje som produserer dem, aminosyresekvenser som utgjor dem, DNA-sekvenser som koder for aminosyresekvensene, farmasoytisk preparat som omfatter antistoffene og antistoffragmentene, fremgangsmate for fremstilling av antistoffene og antistoffragmentene og anvendelse av antistoffene og antistoffragmentene for fremstilling av legemidler og diagnostiske forbindelser. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5985278A (es) |
| EP (1) | EP0719859B1 (es) |
| JP (1) | JP3898245B2 (es) |
| KR (1) | KR100450368B1 (es) |
| CN (1) | CN1117763C (es) |
| AR (1) | AR001778A1 (es) |
| AT (1) | ATE244306T1 (es) |
| AU (1) | AU710234B2 (es) |
| BR (1) | BR9505980B1 (es) |
| CA (1) | CA2165573C (es) |
| CO (1) | CO4480042A1 (es) |
| CZ (1) | CZ290477B6 (es) |
| DE (1) | DE69531187T2 (es) |
| DK (1) | DK0719859T3 (es) |
| ES (1) | ES2202336T3 (es) |
| FI (1) | FI118536B (es) |
| HU (1) | HU221061B1 (es) |
| NO (1) | NO321186B1 (es) |
| PL (1) | PL182961B1 (es) |
| PT (1) | PT719859E (es) |
| RU (1) | RU2205223C2 (es) |
| SI (1) | SI0719859T1 (es) |
| SK (1) | SK284932B6 (es) |
| TR (1) | TR199501614A2 (es) |
| UA (1) | UA40621C2 (es) |
| ZA (1) | ZA9510806B (es) |
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| WO1998009651A1 (fr) * | 1996-09-03 | 1998-03-12 | Chugai Seiyaku Kabushiki Kaisha | COMPLEXES D'ANTICORPS ANTI-INTEGRINE α3 |
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| CN1267224A (zh) * | 1997-08-08 | 2000-09-20 | 加利福尼亚大学董事会 | 用αVβ6的拮抗剂治疗急性肺损伤和纤维化 |
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| US6160099A (en) * | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
| US6521593B1 (en) * | 1999-02-01 | 2003-02-18 | Childrens Hospital Los Angeles | Methods for inhibiting brain tumor growth |
| US7153944B2 (en) * | 2000-07-31 | 2006-12-26 | The General Hospital Corporation | High affinity integrin polypeptides and uses thereof |
| US7064180B2 (en) | 2000-07-31 | 2006-06-20 | The General Hospital Corporation | High affinity integrin polypeptides and uses thereof |
| US7323552B2 (en) * | 2000-07-31 | 2008-01-29 | The General Hospital Corporation | Variant integrin polypeptides and uses thereof |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| JP2004536786A (ja) * | 2001-03-02 | 2004-12-09 | メディミューン，インコーポレイテッド | インテグリンαｖβ３拮抗薬を他の予防薬もしくは治療薬と組み合わせて投与することによる炎症性疾患または自己免疫疾患の予防または治療方法 |
| RU2316337C2 (ru) | 2001-04-24 | 2008-02-10 | Мерк Патент Гмбх | КОМБИНИРОВАННАЯ ТЕРАПИЯ, ИСПОЛЬЗУЮЩАЯ АНТИАНГИОГЕННЫЕ СРЕДСТВА И TNF-α |
| US7829087B2 (en) * | 2001-07-09 | 2010-11-09 | Elan Pharmaceuticals, Inc. | Methods of treating cognitive impairment |
| WO2003006893A2 (en) * | 2001-07-09 | 2003-01-23 | Elan Pharmaceuticals, Inc. | Methods of inhibiting amyloid toxicity |
| CA2478317A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate |
| JP2005533001A (ja) * | 2002-03-04 | 2005-11-04 | メディミューン，インコーポレーテッド | インテグリンαｖβ３アンタゴニストを他の物質と併用投与する癌の予防または治療方法 |
| RS52488B (en) | 2002-03-13 | 2013-02-28 | Biogen Idec Ma Inc. | ANTI-ALFAvBETA6 ANTITELA |
| UA90242C2 (ru) * | 2002-03-13 | 2010-04-26 | Байоджен Айдек Ма Инк. | МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, КОТОРОЕ СПЕЦИФИЧЕСКИ СВЯЗЫВАЕТСЯ С αVβ6 |
| EP1499352A4 (en) * | 2002-04-12 | 2006-10-11 | Medimmune Inc | ANTI-INTERLEUKIN-9 RECOMBINANT ANTIBODIES |
| WO2003087340A2 (en) * | 2002-04-12 | 2003-10-23 | Raven Biotechnologies, Inc. | Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof |
| US20040176272A1 (en) * | 2003-01-30 | 2004-09-09 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
| EP1613273B1 (en) | 2003-04-11 | 2012-06-13 | MedImmune, LLC | Recombinant il-9 antibodies and uses thereof |
| US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
| AU2005299355A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Llc | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
| CN104072614B (zh) | 2005-07-08 | 2017-04-26 | 生物基因Ma公司 | 抗-αvβ6 抗体及其用途 |
| MX2008011905A (es) * | 2006-03-21 | 2008-09-30 | Genentech Inc | Terapia de combinacion. |
| SG173364A1 (en) | 2006-07-10 | 2011-08-29 | Biogen Idec Inc | Compositions and methods for inhibiting growth of smad4-deficient cancers |
| AU2007272970C1 (en) | 2006-07-11 | 2013-01-10 | Roy C. Levitt | Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors |
| EP3669878A1 (en) | 2006-08-10 | 2020-06-24 | Roy C. Levitt | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| WO2008141274A1 (en) * | 2007-05-11 | 2008-11-20 | Centocor, Inc. | Anti-alpha v immunoliposome composition, methods and uses |
| US20090196913A1 (en) * | 2007-05-11 | 2009-08-06 | Ken Shi Kun Huang | Anti-Alpha-V Immunoliposome Composition, Methods, and Uses |
| AU2008277907B2 (en) | 2007-07-17 | 2013-08-22 | Merck Patent Gmbh | Engineered anti-alpha V- integrin hybrid antibodies |
| KR20100065162A (ko) | 2007-09-26 | 2010-06-15 | 제넨테크, 인크. | 신규한 항체 |
| MX2011006675A (es) | 2008-12-23 | 2011-07-12 | Merck Patent Gmbh | Biomarcadores para inhibidores con actividad anti-angiogenica. |
| DK2411411T3 (en) | 2009-03-25 | 2016-11-07 | Hoffmann La Roche | New anti-alpha5beta1 antibodies and uses thereof |
| BR112012011268A2 (pt) | 2009-11-13 | 2019-09-24 | Merck Patent Gmbh | anticorpos anti-integrina ligados a nanopartículas carregadas com agentes quimioterapêuticos |
| AU2011217848B8 (en) * | 2010-02-18 | 2015-09-24 | The Regents Of The University Of California | Integrin aVB8 neutralizing antibody |
| EP2608804A4 (en) * | 2010-08-27 | 2015-03-11 | Univ Miami | TREATMENT OF RENAL DISEASES |
| LT2672994T (lt) | 2011-02-11 | 2018-07-25 | Merck Patent Gmbh | Anti-alfa-v integrino antikūnas, skirtas prostatos vėžio gydymui |
| SG194567A1 (en) | 2011-04-21 | 2013-12-30 | Seattle Genetics Inc | Novel binder-drug conjugates (adcs) and their use |
| EP2744823B1 (en) * | 2011-08-17 | 2017-08-02 | The Regents of the University of California | Antibodies that bind integrin alpha-v beta-8 |
| WO2014144466A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| WO2014143739A2 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| JP6721507B2 (ja) | 2013-12-23 | 2020-07-15 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ｋｓｐ阻害剤との抗体薬物複合体（ａｄｃ） |
| MX2017003406A (es) | 2014-09-17 | 2017-06-19 | Merck Patent Gmbh | Metodo para tratar enfermedades de metastasis osea, medicamentos para las mismas, y metodo para predecir el resultado clinico para tratar enfermedades de metastasis osea. |
| BR112017005336A2 (pt) | 2014-09-17 | 2017-12-12 | Merck Patent Gmbh | método de tratamento de cânceres sólidos e/ou metástases dos mesmos, medicamentos com essa finalidade e método para prever o resultado clínico de tratamento de cânceres sólidos e/ou metástases dos mesmos |
| WO2016207089A1 (de) | 2015-06-22 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen |
| KR20180020225A (ko) | 2015-06-23 | 2018-02-27 | 바이엘 파마 악티엔게젤샤프트 | Ksp 억제제의 표적화된 접합체 |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| JP7034914B2 (ja) | 2015-11-23 | 2022-03-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 線維症および／または線維性疾患の治療のための抗α－ｖインテグリン抗体 |
| CN116059390A (zh) | 2016-03-24 | 2023-05-05 | 拜耳制药股份公司 | 具有酶促可裂解基团的细胞毒性活性物质的前药 |
| WO2017216028A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| EP3510407A1 (en) | 2016-09-08 | 2019-07-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating nephrotic syndrome |
| IL291308B2 (en) | 2016-12-21 | 2024-07-01 | Bayer Pharma AG | Drug-antibody conjugates with enzymatically cleavable groups |
| EP3558386A1 (de) | 2016-12-21 | 2019-10-30 | Bayer Aktiengesellschaft | Prodrugs von cytotoxischen wirkstoffen mit enzymatisch spaltbaren gruppen |
| CA3047522A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Specific antibody drug conjugates (adcs) having ksp inhibitors |
| KR101961715B1 (ko) | 2018-07-18 | 2019-03-25 | (주) 삼진정밀 | 고효율 수처리장치 |
| US20200121788A1 (en) | 2018-10-19 | 2020-04-23 | Merck Patent Gmbh | Abituzumab for the treatment of colorectal cancer |
| KR101999620B1 (ko) | 2019-03-26 | 2019-07-12 | 조용진 | 부상슬러지 및 침전슬러지의 동시처리장치 |
| EP3953389A1 (en) * | 2019-04-08 | 2022-02-16 | Biogen MA Inc. | Anti-integrin antibodies and uses thereof |
| CN117143241B (zh) * | 2023-10-26 | 2024-02-23 | 迈威(上海)生物科技股份有限公司 | 与人整合素蛋白itgav/itgb8特异性结合的单克隆抗体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE175241T1 (de) * | 1992-04-03 | 1999-01-15 | Genentech Inc | Antikörper gegen alpha v beta 3 integrin |
| US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
-
1995
- 1995-12-06 DK DK95119233T patent/DK0719859T3/da active
- 1995-12-06 AT AT95119233T patent/ATE244306T1/de active
- 1995-12-06 DE DE69531187T patent/DE69531187T2/de not_active Expired - Lifetime
- 1995-12-06 ES ES95119233T patent/ES2202336T3/es not_active Expired - Lifetime
- 1995-12-06 SI SI9530683T patent/SI0719859T1/xx unknown
- 1995-12-06 EP EP95119233A patent/EP0719859B1/en not_active Expired - Lifetime
- 1995-12-06 PT PT95119233T patent/PT719859E/pt unknown
- 1995-12-13 AU AU40421/95A patent/AU710234B2/en not_active Ceased
- 1995-12-13 CZ CZ19953288A patent/CZ290477B6/cs not_active IP Right Cessation
- 1995-12-18 CA CA2165573A patent/CA2165573C/en not_active Expired - Fee Related
- 1995-12-18 JP JP32887795A patent/JP3898245B2/ja not_active Expired - Fee Related
- 1995-12-19 HU HU9503638A patent/HU221061B1/hu not_active IP Right Cessation
- 1995-12-19 NO NO19955167A patent/NO321186B1/no not_active IP Right Cessation
- 1995-12-19 SK SK1592-95A patent/SK284932B6/sk not_active IP Right Cessation
- 1995-12-19 ZA ZA9510806A patent/ZA9510806B/xx unknown
- 1995-12-19 CN CN95120901A patent/CN1117763C/zh not_active Expired - Fee Related
- 1995-12-19 RU RU95121105/13A patent/RU2205223C2/ru not_active IP Right Cessation
- 1995-12-19 UA UA95125376A patent/UA40621C2/uk unknown
- 1995-12-19 PL PL95311926A patent/PL182961B1/pl unknown
- 1995-12-19 US US08/574,699 patent/US5985278A/en not_active Expired - Lifetime
- 1995-12-19 FI FI956112A patent/FI118536B/fi not_active IP Right Cessation
- 1995-12-20 KR KR1019950052440A patent/KR100450368B1/ko not_active IP Right Cessation
- 1995-12-20 TR TR95/01614A patent/TR199501614A2/xx unknown
- 1995-12-20 BR BRPI9505980-6A patent/BR9505980B1/pt not_active IP Right Cessation
- 1995-12-20 AR AR33473095A patent/AR001778A1/es active IP Right Grant
- 1995-12-20 CO CO95060553A patent/CO4480042A1/es unknown
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Legal Events
| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |