NO319532B1 - <Beta>karbolinforbindelser,anvendelser av dem og farmasoytiske forbindelser som inneholder dem. - Google Patents
<Beta>karbolinforbindelser,anvendelser av dem og farmasoytiske forbindelser som inneholder dem. Download PDFInfo
- Publication number
- NO319532B1 NO319532B1 NO20006268A NO20006268A NO319532B1 NO 319532 B1 NO319532 B1 NO 319532B1 NO 20006268 A NO20006268 A NO 20006268A NO 20006268 A NO20006268 A NO 20006268A NO 319532 B1 NO319532 B1 NO 319532B1
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- pharmaceutically acceptable
- hydrogen
- compound according
- imidazolyl group
- Prior art date
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US9729798A | 1998-06-12 | 1998-06-12 | |
US8918098P | 1998-06-12 | 1998-06-12 | |
PCT/US1999/012874 WO1999064420A1 (en) | 1998-06-12 | 1999-06-08 | β-CARBOLINE COMPOUNDS |
Publications (3)
Publication Number | Publication Date |
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NO20006268D0 NO20006268D0 (no) | 2000-12-11 |
NO20006268L NO20006268L (no) | 2001-01-29 |
NO319532B1 true NO319532B1 (no) | 2005-08-29 |
Family
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Family Applications (1)
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NO20006268A NO319532B1 (no) | 1998-06-12 | 2000-12-11 | <Beta>karbolinforbindelser,anvendelser av dem og farmasoytiske forbindelser som inneholder dem. |
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US (1) | US6586445B1 (de) |
EP (1) | EP1086101B1 (de) |
JP (1) | JP2002517500A (de) |
KR (1) | KR20010071461A (de) |
CN (1) | CN1169808C (de) |
AR (1) | AR019153A1 (de) |
AT (1) | ATE229954T1 (de) |
AU (1) | AU761020B2 (de) |
CA (1) | CA2335339A1 (de) |
CZ (1) | CZ20004580A3 (de) |
DE (1) | DE69904595T2 (de) |
DK (1) | DK1086101T3 (de) |
ES (1) | ES2188184T3 (de) |
HK (1) | HK1032049A1 (de) |
HU (1) | HUP0302962A2 (de) |
IL (1) | IL140197A0 (de) |
NO (1) | NO319532B1 (de) |
NZ (1) | NZ508765A (de) |
PL (1) | PL345589A1 (de) |
RU (1) | RU2233841C2 (de) |
TW (1) | TWI236477B (de) |
WO (1) | WO1999064420A1 (de) |
Families Citing this family (49)
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FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
US6696418B1 (en) | 1999-09-01 | 2004-02-24 | Pfizer Inc. | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor |
FR2812546B1 (fr) * | 2000-08-01 | 2008-11-21 | Sod Conseils Rech Applic | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
TWI283577B (en) * | 1999-10-11 | 2007-07-11 | Sod Conseils Rech Applic | Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof |
US6495589B2 (en) | 2000-04-28 | 2002-12-17 | Pfizer Inc. | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor |
US6720330B2 (en) | 2000-11-17 | 2004-04-13 | Pfizer Inc. | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor |
FR2818978B1 (fr) * | 2000-12-28 | 2003-02-28 | Sod Conseils Rech Applic | Modulateurs de canaux sodiques derives de 2-piperidylimidazoles |
GB0108337D0 (en) | 2001-04-03 | 2001-05-23 | Novartis Ag | Organic compounds |
TWI248438B (en) * | 2001-04-10 | 2006-02-01 | Sod Conseils Rech Applic | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
CZ20033123A3 (cs) * | 2001-06-25 | 2004-11-10 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Farmaceutické prostředky, které inhibují proliferaci adenomů hypofýzy |
DE10136842A1 (de) * | 2001-07-23 | 2003-02-13 | Schering Ag | GABA¶A¶-Rezeptor-Modulatoren mit NMDA-antagonistischer Aktivität |
US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
PA8586801A1 (es) | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
BRPI0407052A (pt) | 2003-01-27 | 2006-01-17 | Pfizer | Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização |
DE602004026289D1 (de) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
CN101837127A (zh) | 2003-05-05 | 2010-09-22 | 前体生物药物股份公司 | 谷氨酰胺酰基和谷氨酸环化酶效应物的应用 |
WO2004113300A1 (ja) | 2003-06-23 | 2004-12-29 | Ono Pharmaceutical Co., Ltd. | 新規三環性複素環化合物 |
WO2005039548A2 (en) | 2003-10-15 | 2005-05-06 | Probiodrug Ag | Use of effectors of glutaminyl and glutamate cyclases |
DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
AU2005210004B2 (en) | 2004-02-05 | 2010-10-28 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
ATE541835T1 (de) * | 2004-02-05 | 2012-02-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
JP2007534738A (ja) | 2004-04-26 | 2007-11-29 | ファイザー・インク | Hivインテグラーゼ酵素の阻害剤 |
WO2005103003A2 (en) | 2004-04-26 | 2005-11-03 | Pfizer Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
EP1829874B1 (de) | 2004-12-22 | 2014-02-12 | Ono Pharmaceutical Co., Ltd. | Tricyclische verbindung und deren verwendung |
WO2006089053A2 (en) | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
MY144968A (en) * | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
JP5035865B2 (ja) * | 2005-09-26 | 2012-09-26 | 国立大学法人高知大学 | Helicobacterpylori菌株の増殖・運動抑制方法 |
WO2007062175A2 (en) * | 2005-11-21 | 2007-05-31 | Amgen Inc. | Spiro-substituted tricyclic heterocycles cxcr3 antagonists |
US7879859B2 (en) * | 2005-11-21 | 2011-02-01 | Merck Sharp & Dohme Corp. | Diagnosis and treatment of type 2 diabetes and other disorders |
CN101346375B (zh) * | 2005-11-23 | 2013-04-10 | 阿罗斯药物有限责任公司 | 调节门离子通道用组合物和方法 |
US20080004306A1 (en) * | 2006-04-10 | 2008-01-03 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
CA2693214A1 (en) * | 2007-07-19 | 2009-01-22 | Merck Sharp & Dohme Corp. | Beta carboline derivatives as antidiabetic compounds |
SG10201703086VA (en) * | 2008-10-17 | 2017-05-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their use as therapeutic agents |
WO2010051177A1 (en) * | 2008-10-29 | 2010-05-06 | Merck Sharp & Dohme Corp. | Triazole beta carboline derivatives as antidiabetic compounds |
TW201028414A (en) | 2009-01-16 | 2010-08-01 | Merck Sharp & Dohme | Oxadiazole beta carboline derivatives as antidiabetic compounds |
CN102844029A (zh) * | 2009-12-28 | 2012-12-26 | 奥迪欧医药设备有限公司 | 用于治疗听力损伤和眩晕的β-咔啉 |
CN102695414A (zh) | 2010-01-15 | 2012-09-26 | 默沙东公司 | 作为抗糖尿病化合物的噁二唑β-咔啉衍生物 |
KR101256588B1 (ko) * | 2010-02-17 | 2013-04-19 | 부산대학교 산학협력단 | 베타-카르볼린 알칼로이드를 함유하는 멜라닌 생성 촉진용 조성물 |
KR101784284B1 (ko) * | 2011-03-28 | 2017-10-11 | 에스제이티 몰레큘라 리서치, 에스.엘. | 대사증후군 치료 화합물 |
CN105837569B (zh) * | 2016-04-29 | 2017-12-26 | 华南农业大学 | 一种骆驼蓬碱噁唑啉类化合物及其制备方法和应用 |
CN107118212B (zh) * | 2017-05-26 | 2019-12-03 | 广西师范大学 | 1-吡啶-6-甲氧基-9-(3-碘苄)-β-咔啉、合成和应用 |
CN107163041B (zh) * | 2017-05-26 | 2019-06-21 | 广西师范大学 | 一种β-咔啉化合物及其合成方法和应用 |
CN106995440B (zh) * | 2017-05-26 | 2019-09-03 | 广西师范大学 | 1-吡啶-6-甲氧基-9-(2,3,4,5-四氟苄基)β-咔啉化合物及其合成方法和应用 |
CN107141285B (zh) * | 2017-05-26 | 2019-12-03 | 广西师范大学 | 1-吡啶-6-甲氧基-9-甲基苄-β-咔啉及其合成和应用 |
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US5378803A (en) * | 1987-12-11 | 1995-01-03 | Sterling Winthrop Inc. | Azole-fused peptides and processes for preparation thereof |
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1999
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2000
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2001
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ES2188184T3 (es) | 2003-06-16 |
RU2233841C2 (ru) | 2004-08-10 |
IL140197A0 (en) | 2002-02-10 |
DE69904595D1 (de) | 2003-01-30 |
CN1169808C (zh) | 2004-10-06 |
DK1086101T3 (da) | 2003-03-31 |
AR019153A1 (es) | 2001-12-26 |
CA2335339A1 (en) | 1999-12-16 |
ATE229954T1 (de) | 2003-01-15 |
NO20006268D0 (no) | 2000-12-11 |
DE69904595T2 (de) | 2003-11-27 |
US6586445B1 (en) | 2003-07-01 |
EP1086101B1 (de) | 2002-12-18 |
WO1999064420A1 (en) | 1999-12-16 |
PL345589A1 (en) | 2001-12-17 |
JP2002517500A (ja) | 2002-06-18 |
HK1032049A1 (en) | 2001-07-06 |
NZ508765A (en) | 2003-10-31 |
AU4553699A (en) | 1999-12-30 |
AU761020B2 (en) | 2003-05-29 |
EP1086101A1 (de) | 2001-03-28 |
NO20006268L (no) | 2001-01-29 |
CZ20004580A3 (cs) | 2001-12-12 |
HUP0302962A2 (hu) | 2003-12-29 |
CN1308632A (zh) | 2001-08-15 |
TWI236477B (en) | 2005-07-21 |
KR20010071461A (ko) | 2001-07-28 |
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