NO319216B1 - Doseringsformer for avgivelse av et aktivt middel, fremgangsmate til fremstilling av samme, samt fremgangsmater til avgivelse av aktive midler. - Google Patents
Doseringsformer for avgivelse av et aktivt middel, fremgangsmate til fremstilling av samme, samt fremgangsmater til avgivelse av aktive midler. Download PDFInfo
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- NO319216B1 NO319216B1 NO19973840A NO973840A NO319216B1 NO 319216 B1 NO319216 B1 NO 319216B1 NO 19973840 A NO19973840 A NO 19973840A NO 973840 A NO973840 A NO 973840A NO 319216 B1 NO319216 B1 NO 319216B1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/394,074 US5534263A (en) | 1995-02-24 | 1995-02-24 | Active agent dosage form comprising a matrix and at least two insoluble bands |
PCT/US1996/001848 WO1996025922A2 (en) | 1995-02-24 | 1996-02-09 | Banded prolonged release active agent dosage form |
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NO973840D0 NO973840D0 (no) | 1997-08-21 |
NO973840L NO973840L (no) | 1997-10-22 |
NO319216B1 true NO319216B1 (no) | 2005-07-04 |
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NO19973840A NO319216B1 (no) | 1995-02-24 | 1997-08-21 | Doseringsformer for avgivelse av et aktivt middel, fremgangsmate til fremstilling av samme, samt fremgangsmater til avgivelse av aktive midler. |
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US (4) | US5534263A (sv) |
EP (1) | EP0810856B1 (sv) |
JP (1) | JP3955320B2 (sv) |
KR (1) | KR100465268B1 (sv) |
CN (1) | CN1142771C (sv) |
AT (1) | ATE200421T1 (sv) |
AU (1) | AU703681B2 (sv) |
DE (1) | DE69612481T2 (sv) |
DK (1) | DK0810856T3 (sv) |
ES (1) | ES2155931T3 (sv) |
FI (1) | FI973452A (sv) |
GR (1) | GR3035743T3 (sv) |
HK (1) | HK1005794A1 (sv) |
NO (1) | NO319216B1 (sv) |
NZ (1) | NZ303809A (sv) |
PT (1) | PT810856E (sv) |
WO (1) | WO1996025922A2 (sv) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5534263A (en) * | 1995-02-24 | 1996-07-09 | Alza Corporation | Active agent dosage form comprising a matrix and at least two insoluble bands |
SE9603667D0 (sv) * | 1996-10-08 | 1996-10-08 | Astra Ab | Pharmaceutical compositions |
US5759579A (en) * | 1996-12-05 | 1998-06-02 | American Home Products Corporation | Pharmaceutical suspension systems |
SG108292A1 (en) * | 1997-06-11 | 2005-01-28 | Procter & Gamble | Film-coated tablet for improved upper gastrointestinal tract safety |
EP1003476B1 (en) * | 1997-08-11 | 2004-12-22 | ALZA Corporation | Prolonged release active agent dosage form adapted for gastric retention |
IN186245B (sv) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
WO1999018938A1 (en) * | 1997-10-09 | 1999-04-22 | Perio Products Ltd. | Delayed total release gastrointestinal drug delivery system |
US6099859A (en) * | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
US6365183B1 (en) | 1998-05-07 | 2002-04-02 | Alza Corporation | Method of fabricating a banded prolonged release active agent dosage form |
EP1413296A1 (en) * | 1998-05-07 | 2004-04-28 | ALZA Corporation | Method of fabricating a banded prolonged release active agent dosage form |
US6099862A (en) | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
US20090297597A1 (en) * | 1998-11-02 | 2009-12-03 | Gary Liversidge | Modified Release Ticlopidine Compositions |
US20070122481A1 (en) * | 1998-11-02 | 2007-05-31 | Elan Corporation Plc | Modified Release Compositions Comprising a Fluorocytidine Derivative for the Treatment of Cancer |
US20060240105A1 (en) * | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
PT1126826E (pt) | 1998-11-02 | 2008-11-25 | Elan Pharma Int Ltd | Composição de metilfenidato de libertação modificada multiparticulada |
US20090149479A1 (en) * | 1998-11-02 | 2009-06-11 | Elan Pharma International Limited | Dosing regimen |
US6635281B2 (en) | 1998-12-23 | 2003-10-21 | Alza Corporation | Gastric retaining oral liquid dosage form |
AU2199500A (en) * | 1998-12-23 | 2000-07-31 | Alza Corporation | Gastric retention dosage form having multiple layers |
US6342249B1 (en) | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
US6797283B1 (en) | 1998-12-23 | 2004-09-28 | Alza Corporation | Gastric retention dosage form having multiple layers |
US6498153B1 (en) | 1998-12-31 | 2002-12-24 | Akzo Nobel N.V. | Extended release growth promoting two component composition |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
KR101476574B1 (ko) | 1999-10-29 | 2014-12-24 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
DE10003757A1 (de) * | 2000-01-28 | 2001-08-02 | Knoll Ag | Ibuprofen-Wirkstoffzubereitung |
US7056531B1 (en) | 2000-05-04 | 2006-06-06 | Nature's Way Products, Inc. | Sustained release compositions for orally administered substances and methods |
MXPA03003895A (es) | 2000-10-30 | 2003-07-28 | Euro Celtique Sa | Formulaciones de hidrocodona de liberacion controlada. |
US20060034922A1 (en) * | 2000-11-03 | 2006-02-16 | Andrx Labs, Llc | Controlled release metformin compositions |
US6866866B1 (en) * | 2000-11-03 | 2005-03-15 | Andrx Labs, Llc | Controlled release metformin compositions |
US6790459B1 (en) | 2000-11-03 | 2004-09-14 | Andrx Labs, Llc | Methods for treating diabetes via administration of controlled release metformin |
US20030070584A1 (en) | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
US20030072731A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing starch or dextrin |
WO2003004009A1 (en) * | 2001-07-02 | 2003-01-16 | Geneva Pharmaceuticals, Inc. | Pharmaceutical composition |
US8309118B2 (en) | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
ITMI20012481A1 (it) | 2001-11-23 | 2003-05-23 | Univ Parma | Sistemi modulari per il rilascio controllato di sostanza a controllo spaziale e temporale |
US20040052848A1 (en) * | 2002-05-23 | 2004-03-18 | Xiu-Xiu Cheng | Biguanide formulations |
EP1536843B1 (en) * | 2002-07-02 | 2010-12-22 | Board Of Regents, The University Of Texas System | Radiolabeled compounds and liposomes and their methods of making and using the same |
US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
US7429619B2 (en) * | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
US20080220074A1 (en) * | 2002-10-04 | 2008-09-11 | Elan Corporation Plc | Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same |
JP3811127B2 (ja) * | 2003-01-30 | 2006-08-16 | 株式会社東芝 | 情報記録装置及び情報記録方法 |
US8153159B2 (en) * | 2003-09-18 | 2012-04-10 | Cephalon, Inc. | Modafinil modified release pharmaceutical compositions |
EP1667652B1 (en) * | 2003-09-26 | 2007-05-30 | ALZA Corporation | Improved controlled release dosage form including a banded engine |
NZ546183A (en) * | 2003-09-26 | 2011-04-29 | Alza Corp | Controlled release formulations exhibiting an ascending rate of release |
ATE504288T1 (de) * | 2003-09-26 | 2011-04-15 | Alza Corp | Oros-push-stick für die kontrollierte abgabe von wirkstoffen |
JP4919801B2 (ja) * | 2003-09-26 | 2012-04-18 | アルザ・コーポレーシヨン | 高い薬剤配合量を提供する薬剤コーティング及びそれを提供する方法 |
JP5563731B2 (ja) * | 2003-09-26 | 2014-07-30 | アルザ・コーポレーシヨン | オピオイドおよび非オピオイド鎮痛薬の制御放出製剤 |
AU2004285533A1 (en) * | 2003-10-31 | 2005-05-12 | Alza Corporation | Compositions and dosage forms for enhanced absorption |
US7387793B2 (en) | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
US6992359B2 (en) * | 2004-02-26 | 2006-01-31 | Grandis, Inc. | Spin transfer magnetic element with free layers having high perpendicular anisotropy and in-plane equilibrium magnetization |
US20110140217A1 (en) * | 2004-02-26 | 2011-06-16 | Grandis, Inc. | Spin transfer magnetic element with free layers having high perpendicular anisotropy and in-plane equilibrium magnetization |
SE0401031D0 (sv) | 2004-04-22 | 2004-04-22 | Duocort Ab | A new glucocorticoid replacement therapy |
US20060024368A1 (en) * | 2004-07-30 | 2006-02-02 | Reza Fassihi | Compressed composite delivery system for release-rate modulation of bioactives |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
WO2006063078A2 (en) * | 2004-12-08 | 2006-06-15 | Elan Corporation, Plc | Topiramate pharmaceuticals composition |
US20070298098A1 (en) * | 2005-02-16 | 2007-12-27 | Elan Pharma International Limited | Controlled Release Compositions Comprising Levetiracetam |
KR20080007586A (ko) * | 2005-04-12 | 2008-01-22 | 엘란 파마 인터내셔널 리미티드 | 세균감염증의 치료를 위한 세팔로스포린 함유 조절 방출조성물 |
WO2006113568A2 (en) * | 2005-04-19 | 2006-10-26 | Alza Corporation | Controlled delivery dosage form of tramadol and gabapentin |
US20100136106A1 (en) * | 2005-06-08 | 2010-06-03 | Gary Liversidge | Modified Release Famciclovir Compositions |
AU2006261893A1 (en) * | 2005-06-23 | 2007-01-04 | Combinatorx, Incorporated | Improved dosage forms for movement disorder treatment |
US20090214643A1 (en) * | 2005-07-19 | 2009-08-27 | Franklin Amie E | Improved pharmacokinetic profile of beta-adrenergic inverse agonists for the treatment of pulmonary airway diseases |
EP1933811A2 (en) * | 2005-09-30 | 2008-06-25 | Alza Corporation | Banded controlled release nanoparticle active agent formulation dosage forms and methods |
PL116330U1 (en) | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
US9011930B2 (en) * | 2006-05-01 | 2015-04-21 | Zycal Bioceuticals Healthcare Company, Inc. | Nutritional supplement and use thereof |
US20080131492A1 (en) * | 2006-06-23 | 2008-06-05 | Spherics, Inc. | Dosage forms for movement disorder treatment |
US9101544B2 (en) | 2006-08-30 | 2015-08-11 | Jagotec Ag | Controlled release nisoldipine compositions |
EP2063867A2 (en) * | 2006-12-22 | 2009-06-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
US20110031569A1 (en) * | 2009-08-10 | 2011-02-10 | Grandis, Inc. | Method and system for providing magnetic tunneling junction elements having improved performance through capping layer induced perpendicular anisotropy and memories using such magnetic elements |
US8913350B2 (en) * | 2009-08-10 | 2014-12-16 | Grandis, Inc. | Method and system for providing magnetic tunneling junction elements having improved performance through capping layer induced perpendicular anisotropy and memories using such magnetic elements |
US10446209B2 (en) | 2009-08-10 | 2019-10-15 | Samsung Semiconductor Inc. | Method and system for providing magnetic tunneling junction elements having improved performance through capping layer induced perpendicular anisotropy and memories using such magnetic elements |
US9130151B2 (en) | 2010-01-11 | 2015-09-08 | Samsung Electronics Co., Ltd. | Method and system for providing magnetic tunneling junctions usable in spin transfer torque magnetic memories |
US8254162B2 (en) | 2010-01-11 | 2012-08-28 | Grandis, Inc. | Method and system for providing magnetic tunneling junctions usable in spin transfer torque magnetic memories |
US8546896B2 (en) | 2010-07-16 | 2013-10-01 | Grandis, Inc. | Magnetic tunneling junction elements having magnetic substructures(s) with a perpendicular anisotropy and memories using such magnetic elements |
US20120045510A1 (en) * | 2010-08-18 | 2012-02-23 | Joel Waldman | Tablet sleeve for improved performance |
WO2012080833A2 (en) | 2010-12-13 | 2012-06-21 | Purdue Pharma L.P. | Controlled release dosage forms |
US8766383B2 (en) | 2011-07-07 | 2014-07-01 | Samsung Electronics Co., Ltd. | Method and system for providing a magnetic junction using half metallic ferromagnets |
US9580896B2 (en) | 2014-07-05 | 2017-02-28 | John David Hopkins | Apparatus and method for prolonged active agent in aqueous systems |
US9839212B2 (en) | 2015-04-16 | 2017-12-12 | Bio-Lab, Inc. | Multicomponent and multilayer compacted tablets |
EP3487485A2 (en) | 2016-07-19 | 2019-05-29 | Johnson & Johnson Consumer Inc. | Tablets having discontinuous coated regions |
US10583089B2 (en) | 2016-07-19 | 2020-03-10 | Johnson & Johnson Consumer Inc. | Tablets having discontinuous coated regions |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4290426A (en) * | 1978-05-04 | 1981-09-22 | Alza Corporation | Dispenser for dispensing beneficial agent |
US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
US4503031A (en) * | 1982-12-17 | 1985-03-05 | Glassman Jacob A | Super-fast-starting-sustained release tablet |
IT1188212B (it) * | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
US4803076A (en) * | 1986-09-04 | 1989-02-07 | Pfizer Inc. | Controlled release device for an active substance |
US4824677A (en) * | 1986-12-18 | 1989-04-25 | The Unjohn Company | Grooved tablet for fractional dosing of sustained release medication |
US4792448A (en) * | 1987-06-11 | 1988-12-20 | Pfizer Inc. | Generic zero order controlled drug delivery system |
US5023088A (en) * | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
US4915950A (en) * | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
IT1237904B (it) * | 1989-12-14 | 1993-06-18 | Ubaldo Conte | Compresse a rilascio a velocita' controllata delle sostanze attive |
US5326570A (en) * | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
US5266332A (en) * | 1991-12-06 | 1993-11-30 | Alza Corporation | Method for administering anti-Parkinson drug |
US5629008A (en) | 1992-06-02 | 1997-05-13 | C.R. Bard, Inc. | Method and device for long-term delivery of drugs |
US5256440A (en) * | 1992-06-22 | 1993-10-26 | Merck & Co., Inc. | Process for producing a tablet core aperture |
IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
IT1264517B1 (it) * | 1993-05-31 | 1996-09-24 | Ekita Investments Nv | Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati |
IT1265240B1 (it) * | 1993-11-30 | 1996-10-31 | Ekita Investments Nv | Compressa farmaceutica a rilascio controllato, di forma lenticolare |
US5464633A (en) * | 1994-05-24 | 1995-11-07 | Jagotec Ag | Pharmaceutical tablets releasing the active substance after a definite period of time |
US5534263A (en) | 1995-02-24 | 1996-07-09 | Alza Corporation | Active agent dosage form comprising a matrix and at least two insoluble bands |
IT1282650B1 (it) * | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
WO1999018938A1 (en) * | 1997-10-09 | 1999-04-22 | Perio Products Ltd. | Delayed total release gastrointestinal drug delivery system |
US6337091B1 (en) * | 1997-10-27 | 2002-01-08 | Temple University - Of The Commonwealth System Of Higher Education | Matrix for controlled delivery of highly soluble pharmaceutical agents |
-
1995
- 1995-02-24 US US08/394,074 patent/US5534263A/en not_active Expired - Lifetime
-
1996
- 1996-02-09 DE DE69612481T patent/DE69612481T2/de not_active Expired - Fee Related
- 1996-02-09 KR KR1019970705869A patent/KR100465268B1/ko not_active IP Right Cessation
- 1996-02-09 CN CNB961920998A patent/CN1142771C/zh not_active Expired - Fee Related
- 1996-02-09 NZ NZ303809A patent/NZ303809A/en unknown
- 1996-02-09 ES ES96907041T patent/ES2155931T3/es not_active Expired - Lifetime
- 1996-02-09 AT AT96907041T patent/ATE200421T1/de not_active IP Right Cessation
- 1996-02-09 WO PCT/US1996/001848 patent/WO1996025922A2/en active IP Right Grant
- 1996-02-09 AU AU50226/96A patent/AU703681B2/en not_active Ceased
- 1996-02-09 JP JP52572496A patent/JP3955320B2/ja not_active Expired - Fee Related
- 1996-02-09 PT PT96907041T patent/PT810856E/pt unknown
- 1996-02-09 EP EP96907041A patent/EP0810856B1/en not_active Expired - Lifetime
- 1996-02-09 DK DK96907041T patent/DK0810856T3/da active
- 1996-06-27 US US08/671,226 patent/US5667804A/en not_active Expired - Lifetime
-
1997
- 1997-08-21 NO NO19973840A patent/NO319216B1/no not_active IP Right Cessation
- 1997-08-22 FI FI973452A patent/FI973452A/sv not_active Application Discontinuation
-
1998
- 1998-05-25 HK HK98104481A patent/HK1005794A1/xx not_active IP Right Cessation
- 1998-09-08 US US09/149,042 patent/US6020000A/en not_active Expired - Lifetime
-
2000
- 2000-08-31 US US09/652,655 patent/US6316028B1/en not_active Expired - Lifetime
-
2001
- 2001-04-12 GR GR20010400304T patent/GR3035743T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU5022696A (en) | 1996-09-11 |
KR19980702469A (ko) | 1998-07-15 |
HK1005794A1 (en) | 1999-01-29 |
WO1996025922A3 (en) | 1996-10-03 |
KR100465268B1 (ko) | 2005-04-06 |
CN1175901A (zh) | 1998-03-11 |
EP0810856B1 (en) | 2001-04-11 |
ATE200421T1 (de) | 2001-04-15 |
DK0810856T3 (da) | 2001-05-07 |
PT810856E (pt) | 2001-09-28 |
JP3955320B2 (ja) | 2007-08-08 |
EP0810856A2 (en) | 1997-12-10 |
DE69612481D1 (de) | 2001-05-17 |
AU703681B2 (en) | 1999-04-01 |
JPH11500728A (ja) | 1999-01-19 |
NO973840L (no) | 1997-10-22 |
MX9706484A (es) | 1997-11-29 |
NZ303809A (en) | 1999-04-29 |
US5534263A (en) | 1996-07-09 |
WO1996025922A2 (en) | 1996-08-29 |
CN1142771C (zh) | 2004-03-24 |
US6316028B1 (en) | 2001-11-13 |
FI973452A0 (sv) | 1997-08-22 |
GR3035743T3 (en) | 2001-07-31 |
US5667804A (en) | 1997-09-16 |
ES2155931T3 (es) | 2001-06-01 |
US6020000A (en) | 2000-02-01 |
NO973840D0 (no) | 1997-08-21 |
FI973452A (sv) | 1997-08-22 |
DE69612481T2 (de) | 2001-07-26 |
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