NO317552B1 - Nye substituerte purinylderivater med immunomodulerende aktivitet - Google Patents

Nye substituerte purinylderivater med immunomodulerende aktivitet Download PDF

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Publication number
NO317552B1
NO317552B1 NO19965394A NO965394A NO317552B1 NO 317552 B1 NO317552 B1 NO 317552B1 NO 19965394 A NO19965394 A NO 19965394A NO 965394 A NO965394 A NO 965394A NO 317552 B1 NO317552 B1 NO 317552B1
Authority
NO
Norway
Prior art keywords
compound
arginine
dimethylaminopurin
pentoxycarbonyl
stated
Prior art date
Application number
NO19965394A
Other languages
English (en)
Norwegian (no)
Other versions
NO965394D0 (no
NO965394L (no
Inventor
Christopher Penney
Boulos Zacharie
Lyne Gagnon
Giorgio Attardo
Thimothy Connolly
Yves St-Denis
Salam Kadhim
Guy Ely
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of NO965394D0 publication Critical patent/NO965394D0/no
Publication of NO965394L publication Critical patent/NO965394L/no
Publication of NO317552B1 publication Critical patent/NO317552B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19965394A 1994-06-22 1996-12-13 Nye substituerte purinylderivater med immunomodulerende aktivitet NO317552B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26402894A 1994-06-22 1994-06-22
PCT/CA1995/000356 WO1995035297A1 (en) 1994-06-22 1995-06-21 Novel substituted purinyl derivatives with immunomodulating activity

Publications (3)

Publication Number Publication Date
NO965394D0 NO965394D0 (no) 1996-12-13
NO965394L NO965394L (no) 1997-02-21
NO317552B1 true NO317552B1 (no) 2004-11-15

Family

ID=23004250

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19965394A NO317552B1 (no) 1994-06-22 1996-12-13 Nye substituerte purinylderivater med immunomodulerende aktivitet

Country Status (16)

Country Link
US (2) US6110923A (pl)
EP (1) EP0766683A1 (pl)
JP (1) JP4151765B2 (pl)
CN (1) CN1051083C (pl)
AU (1) AU2666795A (pl)
BR (1) BR9508115A (pl)
FI (1) FI965040L (pl)
HU (1) HUT77780A (pl)
IL (1) IL114266A0 (pl)
MX (1) MX9700211A (pl)
NO (1) NO317552B1 (pl)
NZ (1) NZ287827A (pl)
PL (1) PL184342B1 (pl)
RU (1) RU2191189C2 (pl)
WO (1) WO1995035297A1 (pl)
ZA (1) ZA955131B (pl)

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US20070129334A1 (en) * 2001-10-30 2007-06-07 Conforma Therapeutics Corporation Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
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CN100345545C (zh) * 2003-06-18 2007-10-31 中国科学院上海药物研究所 6－氨基－α(R)－羟基－9H－嘌呤－9－丁酸乙酯的免疫抑制作用
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JP2009542645A (ja) * 2006-07-05 2009-12-03 アストラゼネカ・アクチエボラーグ Ｔｌｒ７のモジュレーターとして作用する８−オキソアデニン誘導体
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
EP2132209B8 (en) * 2007-03-19 2014-04-16 AstraZeneca AB 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators
JP5329444B2 (ja) * 2007-03-19 2013-10-30 アストラゼネカ・アクチエボラーグ Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
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Also Published As

Publication number Publication date
HUT77780A (hu) 1998-08-28
NZ287827A (en) 1999-02-25
RU2191189C2 (ru) 2002-10-20
PL317902A1 (en) 1997-04-28
NO965394D0 (no) 1996-12-13
HU9603492D0 (en) 1997-02-28
MX9700211A (es) 1998-01-31
BR9508115A (pt) 1998-11-03
US6110923A (en) 2000-08-29
CN1157618A (zh) 1997-08-20
AU2666795A (en) 1996-01-15
CN1051083C (zh) 2000-04-05
FI965040A0 (fi) 1996-12-16
ZA955131B (en) 1997-03-24
US5994361A (en) 1999-11-30
JPH10501533A (ja) 1998-02-10
FI965040A7 (fi) 1997-02-21
JP4151765B2 (ja) 2008-09-17
FI965040L (fi) 1997-02-21
WO1995035297A1 (en) 1995-12-28
PL184342B1 (pl) 2002-10-31
IL114266A0 (en) 1995-10-31
EP0766683A1 (en) 1997-04-09
NO965394L (no) 1997-02-21

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