NO316172B1 - 5,6-dihydropyron-derivater og farmasöytisk blanding - Google Patents

5,6-dihydropyron-derivater og farmasöytisk blanding Download PDF

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Publication number
NO316172B1
NO316172B1 NO19962017A NO962017A NO316172B1 NO 316172 B1 NO316172 B1 NO 316172B1 NO 19962017 A NO19962017 A NO 19962017A NO 962017 A NO962017 A NO 962017A NO 316172 B1 NO316172 B1 NO 316172B1
Authority
NO
Norway
Prior art keywords
mmol
hydroxy
dihydro
pyran
prepared
Prior art date
Application number
NO19962017A
Other languages
English (en)
Norwegian (no)
Other versions
NO962017L (no
NO962017D0 (no
Inventor
Edmund Lee Ellsworth
Elizabeth Lunney
Bradley Dean Tait
Original Assignee
Parke Davis & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,820 external-priority patent/US5840751A/en
Application filed by Parke Davis & Co filed Critical Parke Davis & Co
Publication of NO962017D0 publication Critical patent/NO962017D0/no
Publication of NO962017L publication Critical patent/NO962017L/no
Publication of NO316172B1 publication Critical patent/NO316172B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO19962017A 1993-11-19 1996-05-15 5,6-dihydropyron-derivater og farmasöytisk blanding NO316172B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15544393A 1993-11-19 1993-11-19
US08/319,820 US5840751A (en) 1993-11-19 1994-10-12 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
PCT/US1994/012269 WO1995014012A1 (en) 1993-11-19 1994-10-26 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Publications (3)

Publication Number Publication Date
NO962017D0 NO962017D0 (no) 1996-05-15
NO962017L NO962017L (no) 1996-07-08
NO316172B1 true NO316172B1 (no) 2003-12-22

Family

ID=26852338

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19962017A NO316172B1 (no) 1993-11-19 1996-05-15 5,6-dihydropyron-derivater og farmasöytisk blanding

Country Status (18)

Country Link
EP (1) EP0729464A1 (da)
JP (1) JP3684426B2 (da)
AT (1) ATE263761T1 (da)
AU (1) AU689158B2 (da)
CA (1) CA2176043A1 (da)
DE (1) DE69433705T2 (da)
DK (1) DK1142887T3 (da)
ES (1) ES2219457T3 (da)
FI (1) FI962022A (da)
HR (1) HRP940935B1 (da)
HU (1) HUT77668A (da)
IL (1) IL111674A0 (da)
NO (1) NO316172B1 (da)
NZ (1) NZ275961A (da)
PT (1) PT1142887E (da)
RU (1) RU2140917C1 (da)
SI (1) SI1142887T1 (da)
WO (1) WO1995014012A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69636130T2 (de) * 1995-08-11 2006-12-07 Zenon Environmental Inc., Oakville Permeatsammelsystem
US5834506A (en) * 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
EP1015441B1 (en) * 1997-09-11 2004-05-12 PHARMACIA & UPJOHN COMPANY Process to produce 4-hydroxy-2-oxo-pyrane derivatives useful as protease inhibitors
WO2000015634A2 (en) * 1998-09-11 2000-03-23 Warner-Lambert Company Hiv protease inhibitors
US6288235B1 (en) 1999-04-14 2001-09-11 Ortho-Mcneil Pharmaceutical, Inc. Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries
DE10030094A1 (de) * 2000-06-19 2001-12-20 Bayer Ag Phenylsubstituierte 5,6-Dihydro-pyron-Derivate
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7141681B2 (en) 2001-02-22 2006-11-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Continuous process for preparing dihydropyrones
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
DE10108470A1 (de) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Verfahren zur Herstellung optisch aktiver Dihydropyrone
DE10108471C1 (de) 2001-02-22 2002-11-21 Boehringer Ingelheim Pharma Kontinuierliches Verfahren zur Herstellung von 5,6-Dihydro-4-hydroxy-2-pyronen
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
DOP2003000641A (es) 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
AP2313A (en) 2004-08-18 2011-10-31 Pfizer Inhibitors of hepatitis C virus RNA-dependent RNA ploymerase, and compositions and treatments using the same.
DE102005059469A1 (de) 2005-12-13 2007-06-14 Bayer Cropscience Ag Insektizide Zusammensetzungen mit verbesserter Wirkung
DE102006007882A1 (de) 2006-02-21 2007-08-30 Bayer Cropscience Ag Cycloalkyl-phenylsubstituierte cyclische Ketoenole
EP2032551B9 (en) * 2006-06-16 2012-02-29 Pharma Mar, S.A. Antitumoral dihydropyran-2-one compounds
MX2011009188A (es) 2009-03-11 2011-09-26 Bayer Cropscience Ag Cetoenoles sustituidos con haloalquilmetilenoxi-fenilo.
DE102010008644A1 (de) 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie
RU2461555C1 (ru) * 2011-07-07 2012-09-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" Способ получения 5-арил-3-фенил-2-оксаспиро[5,6]додец-3-ен-1-онов, проявляющих анальгетическую активность
MX355158B (es) 2012-01-26 2018-04-06 Bayer Ip Gmbh Cetaenoles sustituidos con fenilo para controlar parasitos en peces.
AR093634A1 (es) 2012-11-28 2015-06-17 Sumitomo Chemical Co Compuestos de dihidropirona y herbicidas que los comprenden
SE539512C2 (sv) * 2015-12-02 2017-10-03 Ultupharma Ab Compounds and methods of treating bacterial infections
CN115916752A (zh) * 2020-06-26 2023-04-04 日本农药株式会社 芳基四氢吡啶衍生物或其盐类、和含有该化合物的杀虫剂及其使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses

Also Published As

Publication number Publication date
IL111674A0 (en) 1995-01-24
EP0729464A1 (en) 1996-09-04
HRP940935A2 (en) 1997-04-30
HRP940935B1 (en) 2004-08-31
FI962022A (fi) 1996-07-12
AU689158B2 (en) 1998-03-26
DE69433705D1 (de) 2004-05-13
JP3684426B2 (ja) 2005-08-17
PT1142887E (pt) 2004-08-31
NZ275961A (en) 2001-11-30
DE69433705T2 (de) 2005-03-10
JPH09505294A (ja) 1997-05-27
CA2176043A1 (en) 1995-05-26
ATE263761T1 (de) 2004-04-15
NO962017L (no) 1996-07-08
SI1142887T1 (en) 2004-08-31
HU9601348D0 (en) 1996-07-29
HUT77668A (hu) 1998-07-28
AU8125694A (en) 1995-06-06
NO962017D0 (no) 1996-05-15
ES2219457T3 (es) 2004-12-01
RU2140917C1 (ru) 1999-11-10
DK1142887T3 (da) 2004-06-21
WO1995014012A1 (en) 1995-05-26
FI962022A0 (fi) 1996-05-13

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NO316172B1 (no) 5,6-dihydropyron-derivater og farmasöytisk blanding
EP1142887B1 (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
AU680064B2 (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
KR100447557B1 (ko) 프로테아제억제제및항바이러스제로서의5,6-디히드로피론유도체
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