NO315406B1 - Blanding som omfatter lamell¶re polymeriske partikler samt fremstilling derav - Google Patents
Blanding som omfatter lamell¶re polymeriske partikler samt fremstilling derav Download PDFInfo
- Publication number
- NO315406B1 NO315406B1 NO19976018A NO976018A NO315406B1 NO 315406 B1 NO315406 B1 NO 315406B1 NO 19976018 A NO19976018 A NO 19976018A NO 976018 A NO976018 A NO 976018A NO 315406 B1 NO315406 B1 NO 315406B1
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- polymer
- particles
- active agent
- mixture according
- lamellar
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
- Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
- Y10S977/897—Polymerization
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/917—Vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Materials For Medical Uses (AREA)
- Graft Or Block Polymers (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9514285.7A GB9514285D0 (en) | 1995-07-13 | 1995-07-13 | Polymeric lamellar substrate particles for drug delivery |
PCT/GB1996/001695 WO1997002810A2 (en) | 1995-07-13 | 1996-07-15 | Polymeric lamellar substrate particles for drug delivery |
Publications (3)
Publication Number | Publication Date |
---|---|
NO976018D0 NO976018D0 (no) | 1997-12-22 |
NO976018L NO976018L (no) | 1997-12-22 |
NO315406B1 true NO315406B1 (no) | 2003-09-01 |
Family
ID=10777561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19976018A NO315406B1 (no) | 1995-07-13 | 1997-12-22 | Blanding som omfatter lamell¶re polymeriske partikler samt fremstilling derav |
Country Status (13)
Country | Link |
---|---|
US (1) | US6001395A (de) |
EP (1) | EP0837673B1 (de) |
JP (1) | JPH11508912A (de) |
AT (1) | ATE214918T1 (de) |
AU (1) | AU709031B2 (de) |
CA (1) | CA2223884A1 (de) |
DE (1) | DE69620182T2 (de) |
DK (1) | DK0837673T3 (de) |
ES (1) | ES2175109T3 (de) |
GB (1) | GB9514285D0 (de) |
NO (1) | NO315406B1 (de) |
PT (1) | PT837673E (de) |
WO (1) | WO1997002810A2 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6884435B1 (en) | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
EP1275380A1 (de) * | 1997-01-30 | 2003-01-15 | Chiron Corporation | Verwendung von Mikropartikeln mit adsorbiertem Antigen zur Stimulierung der Immunabwehr |
WO1998033487A1 (en) * | 1997-01-30 | 1998-08-06 | Chiron Corporation | Use of microparticles with adsorbed antigen to stimulate immune responses |
US7135191B2 (en) * | 1997-09-04 | 2006-11-14 | Zsolt Istvan Hertelendy | Urogenital or anorectal transmucosal vaccine delivery system |
GB9722682D0 (en) * | 1997-10-27 | 1997-12-24 | Scherer Ltd R P | Pharmaceutical products |
US20030059471A1 (en) * | 1997-12-15 | 2003-03-27 | Compton Bruce Jon | Oral delivery formulation |
US7393630B2 (en) | 1997-12-16 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Use of microparticles combined with submicron oil-in-water emulsions |
EP1042001B1 (de) | 1997-12-16 | 2002-04-03 | Chiron Corporation | Verwendung von mikropartikeln mit submikron öl/wasser emulsionen |
SE9801288D0 (sv) * | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
ES2260923T3 (es) * | 1998-07-29 | 2006-11-01 | Chiron Corporation | Micorparticulas con superficies adsorbentes, procedimientos de fabricacion y uso de las mismas. |
ATE295151T1 (de) | 1998-10-01 | 2005-05-15 | Powderject Res Ltd | Sprühbeschichtete mikropartikel für nadellose spritzen |
FR2786098B1 (fr) | 1998-11-20 | 2003-05-30 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication |
US6365173B1 (en) | 1999-01-14 | 2002-04-02 | Efrat Biopolymers Ltd. | Stereocomplex polymeric carriers for drug delivery |
WO2000050050A1 (en) * | 1999-02-23 | 2000-08-31 | Isis Pharmaceuticals, Inc. | Multiparticulate formulation |
US8206749B1 (en) | 1999-02-26 | 2012-06-26 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
GB9905136D0 (en) | 1999-03-06 | 1999-04-28 | Danbiosyst Uk | Surface modification of lamellar particles |
US20050214227A1 (en) * | 1999-03-08 | 2005-09-29 | Powderject Research Limited | Microparticle formulations for sustained-release of bioactive compounds |
US7713739B1 (en) | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
FR2801226B1 (fr) | 1999-11-23 | 2002-01-25 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation |
FR2814952B1 (fr) | 2000-10-06 | 2004-01-02 | Flamel Tech Sa | Suspension colloidale de particules submicromiques de vectorisation de principes actifs et leur mode de preparation |
AU2001290678A1 (en) * | 2000-09-08 | 2002-03-22 | Powderject Research Limited | Alginate particle formulation |
ATE350015T1 (de) | 2000-09-28 | 2007-01-15 | Novartis Vaccines & Diagnostic | Mikropartikelzusammensetzungen und verfahren zu ihrer herstellung |
US7266687B2 (en) * | 2001-02-16 | 2007-09-04 | Motorola, Inc. | Method and apparatus for storing and distributing encryption keys |
CA2476626A1 (en) * | 2002-02-20 | 2003-08-28 | Chiron Corporation | Microparticles with adsorbed polypeptide-containing molecules |
CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
US7285289B2 (en) * | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
JP2003342196A (ja) * | 2002-05-31 | 2003-12-03 | Mukku:Kk | 静脈注射用組成物、その製造法およびその製剤 |
FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
US7649023B2 (en) | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
JP2006525354A (ja) * | 2003-05-01 | 2006-11-09 | アルキメデス・ディヴェロップメント・リミテッド | Lh−rhアナログロイプロイドの経鼻投与 |
ES2596553T3 (es) | 2003-06-02 | 2017-01-10 | Glaxosmithkline Biologicals Sa | Composiciones inmunogénicas a base de micropartículas que comprenden toxoide adsorbido y un antígeno que contiene un polisacárido |
FR2859909B1 (fr) | 2003-09-22 | 2007-09-07 | Biomerieux Sa | Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation |
US20060263350A1 (en) * | 2003-09-26 | 2006-11-23 | Fairfield Clinical Trials Llc | Combination antihistamine medication |
CA2564588A1 (en) * | 2004-05-12 | 2005-12-01 | Surmodics, Inc. | Natural biodegradable polysaccharide coatings for medical articles |
WO2007040557A1 (en) * | 2005-09-21 | 2007-04-12 | Surmodics, Inc. | Coatings and articles including natural biodegradable polysaccharides |
US20070071792A1 (en) * | 2005-09-21 | 2007-03-29 | Varner Signe E | In VIVO formed matrices including natural biodegradale polysaccharides and ophthalmic uses thereof |
WO2008051245A2 (en) | 2005-12-02 | 2008-05-02 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
US8460362B2 (en) * | 2006-07-20 | 2013-06-11 | Orbusneich Medical, Inc. | Bioabsorbable polymeric medical device |
CN103494661B (zh) * | 2006-07-20 | 2016-03-30 | 奥巴斯尼茨医学公司 | 可生物吸收的聚合物医疗器械 |
CN103122132B (zh) | 2006-07-20 | 2016-03-16 | 奥巴斯尼茨医学公司 | 用于医疗器械的可生物吸收聚合物组合物 |
EP2073754A4 (de) * | 2006-10-20 | 2012-09-26 | Orbusneich Medical Inc | Bioresorbierbare polymerzusammensetzung und hintergrund für eine medizinische vorrichtung |
US7959942B2 (en) * | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
WO2008070118A1 (en) * | 2006-12-05 | 2008-06-12 | Landec Corporation | Drug delivery |
US20090263346A1 (en) * | 2006-12-05 | 2009-10-22 | David Taft | Systems and methods for delivery of drugs |
US20100004124A1 (en) * | 2006-12-05 | 2010-01-07 | David Taft | Systems and methods for delivery of materials for agriculture and aquaculture |
US20090246155A1 (en) * | 2006-12-05 | 2009-10-01 | Landec Corporation | Compositions and methods for personal care |
US8399007B2 (en) * | 2006-12-05 | 2013-03-19 | Landec Corporation | Method for formulating a controlled-release pharmaceutical formulation |
US20080154241A1 (en) * | 2006-12-07 | 2008-06-26 | Burkstrand Michael J | Latent stabilization of bioactive agents releasable from implantable medical articles |
US20110130822A1 (en) * | 2007-07-20 | 2011-06-02 | Orbusneich Medical, Inc. | Bioabsorbable Polymeric Compositions and Medical Devices |
US20100094405A1 (en) * | 2008-10-10 | 2010-04-15 | Orbusneich Medical, Inc. | Bioabsorbable Polymeric Medical Device |
US8062739B2 (en) * | 2007-08-31 | 2011-11-22 | Zimmer, Inc. | Hydrogels with gradient |
US8114883B2 (en) * | 2007-12-04 | 2012-02-14 | Landec Corporation | Polymer formulations for delivery of bioactive materials |
ES2498091T3 (es) | 2008-04-28 | 2014-09-24 | Novartis Ag | Procedimiento para producir nanopartículas |
CA2723192A1 (en) | 2008-05-07 | 2009-11-12 | Surmodics, Inc. | Delivery of nucleic acid complexes from particles |
EP2349077A4 (de) * | 2008-10-11 | 2015-01-21 | Orbusneich Medical Inc | Bioresorbierbare polymerzusammensetzungen und medizinische vorrichtungen |
US8901092B2 (en) | 2010-12-29 | 2014-12-02 | Surmodics, Inc. | Functionalized polysaccharides for active agent delivery |
AU2014236938B2 (en) * | 2013-03-14 | 2018-12-20 | Allergan, Inc. | Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process |
US11555177B2 (en) | 2016-07-13 | 2023-01-17 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4492720A (en) * | 1983-11-15 | 1985-01-08 | Benjamin Mosier | Method of preparing microspheres for intravascular delivery |
DK0724432T3 (da) * | 1993-10-22 | 2003-01-27 | Genentech Inc | Fremgangsmåder og præparater til mikroindkapsling af antigener til brug som vacciner |
GB9412273D0 (en) * | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
US5827531A (en) * | 1994-12-02 | 1998-10-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microcapsules and methods for making |
-
1995
- 1995-07-13 GB GBGB9514285.7A patent/GB9514285D0/en active Pending
-
1996
- 1996-07-15 WO PCT/GB1996/001695 patent/WO1997002810A2/en active IP Right Grant
- 1996-07-15 AT AT96924088T patent/ATE214918T1/de not_active IP Right Cessation
- 1996-07-15 JP JP9505622A patent/JPH11508912A/ja not_active Ceased
- 1996-07-15 CA CA002223884A patent/CA2223884A1/en not_active Abandoned
- 1996-07-15 DK DK96924088T patent/DK0837673T3/da active
- 1996-07-15 AU AU64665/96A patent/AU709031B2/en not_active Ceased
- 1996-07-15 PT PT96924088T patent/PT837673E/pt unknown
- 1996-07-15 ES ES96924088T patent/ES2175109T3/es not_active Expired - Lifetime
- 1996-07-15 DE DE69620182T patent/DE69620182T2/de not_active Expired - Fee Related
- 1996-07-15 US US08/983,156 patent/US6001395A/en not_active Expired - Fee Related
- 1996-07-15 EP EP96924088A patent/EP0837673B1/de not_active Expired - Lifetime
-
1997
- 1997-12-22 NO NO19976018A patent/NO315406B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
US6001395A (en) | 1999-12-14 |
NO976018D0 (no) | 1997-12-22 |
DE69620182D1 (de) | 2002-05-02 |
WO1997002810A3 (en) | 1997-02-20 |
ATE214918T1 (de) | 2002-04-15 |
DK0837673T3 (da) | 2002-07-22 |
EP0837673B1 (de) | 2002-03-27 |
WO1997002810A2 (en) | 1997-01-30 |
JPH11508912A (ja) | 1999-08-03 |
PT837673E (pt) | 2002-09-30 |
CA2223884A1 (en) | 1997-01-30 |
EP0837673A2 (de) | 1998-04-29 |
GB9514285D0 (en) | 1995-09-13 |
ES2175109T3 (es) | 2002-11-16 |
NO976018L (no) | 1997-12-22 |
AU709031B2 (en) | 1999-08-19 |
DE69620182T2 (de) | 2003-01-16 |
AU6466596A (en) | 1997-02-10 |
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