NO313457B1 - Hydroksamsyrederivater - Google Patents
Hydroksamsyrederivater Download PDFInfo
- Publication number
- NO313457B1 NO313457B1 NO19991559A NO991559A NO313457B1 NO 313457 B1 NO313457 B1 NO 313457B1 NO 19991559 A NO19991559 A NO 19991559A NO 991559 A NO991559 A NO 991559A NO 313457 B1 NO313457 B1 NO 313457B1
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- hydroxy
- methylamide
- diamide
- hydroxyl
- Prior art date
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- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title description 9
- 239000002253 acid Substances 0.000 title description 8
- 150000001875 compounds Chemical class 0.000 claims description 61
- 238000011282 treatment Methods 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- -1 phenyl-C1.4-alkyl Chemical group 0.000 claims description 10
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
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- 239000003814 drug Substances 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
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- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims description 2
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
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- 239000002884 skin cream Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 208000018464 vernal keratoconjunctivitis Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9620572.9A GB9620572D0 (en) | 1996-10-02 | 1996-10-02 | Organic compounds |
| GBGB9706667.4A GB9706667D0 (en) | 1997-04-02 | 1997-04-02 | Organic compounds |
| PCT/EP1997/005376 WO1998014424A1 (en) | 1996-10-02 | 1997-09-30 | Hydroxamic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO991559D0 NO991559D0 (no) | 1999-03-30 |
| NO991559L NO991559L (no) | 1999-03-30 |
| NO313457B1 true NO313457B1 (no) | 2002-10-07 |
Family
ID=26310147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991559A NO313457B1 (no) | 1996-10-02 | 1999-03-30 | Hydroksamsyrederivater |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0929517B1 (da) |
| JP (1) | JP3444898B2 (da) |
| KR (1) | KR20000048811A (da) |
| CN (1) | CN1101807C (da) |
| AR (1) | AR009103A1 (da) |
| AT (1) | ATE219050T1 (da) |
| AU (1) | AU726065B2 (da) |
| BR (1) | BR9712255A (da) |
| CA (1) | CA2267415A1 (da) |
| CO (1) | CO4900034A1 (da) |
| CZ (1) | CZ113999A3 (da) |
| DE (1) | DE69713354T2 (da) |
| DK (1) | DK0929517T3 (da) |
| ES (1) | ES2178759T3 (da) |
| HU (1) | HUP9903892A3 (da) |
| ID (1) | ID22212A (da) |
| IL (1) | IL129166A0 (da) |
| MY (1) | MY127926A (da) |
| NO (1) | NO313457B1 (da) |
| NZ (1) | NZ334908A (da) |
| PE (1) | PE2099A1 (da) |
| PL (1) | PL188518B1 (da) |
| PT (1) | PT929517E (da) |
| RU (1) | RU2196131C2 (da) |
| SI (1) | SI0929517T1 (da) |
| SK (1) | SK43099A3 (da) |
| TR (1) | TR199900725T2 (da) |
| WO (1) | WO1998014424A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056353A2 (en) * | 2002-12-20 | 2004-07-08 | Novartis Ag | Device and method for delivering mmp inhibitors |
| EP2287326A1 (en) | 2003-08-08 | 2011-02-23 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| EP1737499A4 (en) | 2004-03-09 | 2009-07-22 | Arriva Pharmaceuticals Inc | TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE BY INHALATION OF LOW DOSES OF A PROTEASE HEMMER |
| CN1951912B (zh) * | 2005-10-18 | 2010-05-05 | 上海五洲药业股份有限公司 | 手性脂环烃异羟肟酸衍生物的制备方法 |
| GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
| PL3445744T3 (pl) * | 2016-04-18 | 2022-02-07 | Vivoryon Therapeutics Ag | Nowe inhibitory mepryny alfa i beta |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
| PT822186E (pt) * | 1994-01-20 | 2000-08-31 | British Biotech Pharm | L-tert-leucina-2-piridilamida |
| EP0905126B1 (en) * | 1994-01-22 | 2002-12-04 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| GB9416897D0 (en) * | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
| GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
-
1997
- 1997-09-30 EP EP97909339A patent/EP0929517B1/en not_active Expired - Lifetime
- 1997-09-30 KR KR1019990702806A patent/KR20000048811A/ko not_active Ceased
- 1997-09-30 BR BR9712255A patent/BR9712255A/pt not_active Application Discontinuation
- 1997-09-30 PE PE1997000874A patent/PE2099A1/es not_active Application Discontinuation
- 1997-09-30 SK SK430-99A patent/SK43099A3/sk unknown
- 1997-09-30 IL IL12916697A patent/IL129166A0/xx not_active IP Right Cessation
- 1997-09-30 DE DE69713354T patent/DE69713354T2/de not_active Expired - Lifetime
- 1997-09-30 SI SI9730357T patent/SI0929517T1/xx unknown
- 1997-09-30 PL PL97332477A patent/PL188518B1/pl not_active IP Right Cessation
- 1997-09-30 PT PT97909339T patent/PT929517E/pt unknown
- 1997-09-30 ID IDW990143D patent/ID22212A/id unknown
- 1997-09-30 HU HU9903892A patent/HUP9903892A3/hu unknown
- 1997-09-30 CA CA002267415A patent/CA2267415A1/en not_active Abandoned
- 1997-09-30 NZ NZ334908A patent/NZ334908A/xx unknown
- 1997-09-30 WO PCT/EP1997/005376 patent/WO1998014424A1/en not_active Ceased
- 1997-09-30 CN CN97198511A patent/CN1101807C/zh not_active Expired - Fee Related
- 1997-09-30 ES ES97909339T patent/ES2178759T3/es not_active Expired - Lifetime
- 1997-09-30 AR ARP970104491A patent/AR009103A1/es unknown
- 1997-09-30 JP JP51623698A patent/JP3444898B2/ja not_active Expired - Fee Related
- 1997-09-30 DK DK97909339T patent/DK0929517T3/da active
- 1997-09-30 RU RU99108792/04A patent/RU2196131C2/ru not_active IP Right Cessation
- 1997-09-30 AT AT97909339T patent/ATE219050T1/de not_active IP Right Cessation
- 1997-09-30 AU AU47068/97A patent/AU726065B2/en not_active Ceased
- 1997-09-30 TR TR1999/00725T patent/TR199900725T2/xx unknown
- 1997-09-30 CZ CZ991139A patent/CZ113999A3/cs unknown
- 1997-10-01 CO CO97057298A patent/CO4900034A1/es unknown
- 1997-10-01 MY MYPI97004587A patent/MY127926A/en unknown
-
1999
- 1999-03-30 NO NO19991559A patent/NO313457B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |