AR009103A1 - Un derivado del acido hidroxamico, un procedimiento para fabricarlo, una composicion farmaceutica que lo comprende y compuestos utiles como intermedios - Google Patents
Un derivado del acido hidroxamico, un procedimiento para fabricarlo, una composicion farmaceutica que lo comprende y compuestos utiles como intermediosInfo
- Publication number
- AR009103A1 AR009103A1 ARP970104491A ARP970104491A AR009103A1 AR 009103 A1 AR009103 A1 AR 009103A1 AR P970104491 A ARP970104491 A AR P970104491A AR P970104491 A ARP970104491 A AR P970104491A AR 009103 A1 AR009103 A1 AR 009103A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- amino
- alkyl
- hydroxy
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Un derivado del ácido hidroxámico que es una (7-N-hidroxi) diamida de ácido 3-imino-4-oxo-6 (oximetil)-heptan-1,7-dioico, en forma libre o de salfarmacéuticamente aceptable. Prefentemente el derivado responde a la formula (1), donde R1 es unsusti tuyente de la formula A-(O-(CR5H)n) m-O-CH2- en lacual n es 1, 2, 3 o 4, m es 0, 1, 2 o 3 ; cada R5 es independientemente H, alquilo (opcionalmente hidroxi-, alcoxi C1-6-, amino-alquilamino C1-6 arilo(opcionalmente hidroxi-alcoxi C1-6-,amino-, a lquilamino C1-6, halo- o ciano- sustituido) C6-14 o (arilo) C6-a4 alquilo C1-6; A es hidrogeno, alquilo C1-10,arilo C6-14, arilo C6-14 (alquilo C1-6) (arilo C6-14) carbonilo o (alquilo C1-10) carbonilo; R2 es alquilo C3-12, alqueniloC3-12, cicloa lquilo (opcionalmentehidroxi-alcoxi C1-6-, amino- o alquilamino C1-6-sustituido) C3-7 arilo C5-14 o arilo C5-14 (alquilo C1-6) donde los grupos arilo están opcionalmentesustituidos por hidroxi, alquilo C1-6-, alcoxi C1-6-, amino-,halo-, o ciano-; R3 es alquilo, (opcionalmente hidroxi- o alcoxi C1-6- amino alquilamino C1-6-,tiol-, alquilmercapto C1-6-, o hidroxi protegido-, amino-, o tiol-sustituido) C1-10, arilo (opcionalmente hidroxi-, ariloxi C6-14- o alcoxi C1-6-, amino-alquilamino C1-6- amino-alquilamino C1-6-, halo- o ciano-sustituido) C6-14 o indolilmetilo; R4 es metilo, piridilo o un sustituyente de la formula X-Y,donde X es morfolino, piridilo o arilo; e Y es alquileno C1-12, donde hasta cuatro de lasunidades de metilen o (-CH2-) están reemplazadas opcionalmente con-CO-, -NH-, -SO2- u O-; en forma libre o de sal farmacéuticamente aceptable. Los derivados son utiles como fármacos como por ejemplo para la supresion de laliberacion del TNF ypara el tratamiento de e nfermedades autoinmunes e inflamatorias, como por ejemplo, esclerosis multiple y artritis reumatoide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9620572.9A GB9620572D0 (en) | 1996-10-02 | 1996-10-02 | Organic compounds |
GBGB9706667.4A GB9706667D0 (en) | 1997-04-02 | 1997-04-02 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR009103A1 true AR009103A1 (es) | 2000-03-08 |
Family
ID=26310147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970104491A AR009103A1 (es) | 1996-10-02 | 1997-09-30 | Un derivado del acido hidroxamico, un procedimiento para fabricarlo, una composicion farmaceutica que lo comprende y compuestos utiles como intermedios |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP0929517B1 (es) |
JP (1) | JP3444898B2 (es) |
KR (1) | KR20000048811A (es) |
CN (1) | CN1101807C (es) |
AR (1) | AR009103A1 (es) |
AT (1) | ATE219050T1 (es) |
AU (1) | AU726065B2 (es) |
BR (1) | BR9712255A (es) |
CA (1) | CA2267415A1 (es) |
CO (1) | CO4900034A1 (es) |
CZ (1) | CZ113999A3 (es) |
DE (1) | DE69713354T2 (es) |
DK (1) | DK0929517T3 (es) |
ES (1) | ES2178759T3 (es) |
HK (1) | HK1021637A1 (es) |
HU (1) | HUP9903892A3 (es) |
ID (1) | ID22212A (es) |
IL (1) | IL129166A0 (es) |
MY (1) | MY127926A (es) |
NO (1) | NO313457B1 (es) |
NZ (1) | NZ334908A (es) |
PE (1) | PE2099A1 (es) |
PL (1) | PL188518B1 (es) |
PT (1) | PT929517E (es) |
RU (1) | RU2196131C2 (es) |
SI (1) | SI0929517T1 (es) |
SK (1) | SK43099A3 (es) |
TR (1) | TR199900725T2 (es) |
WO (1) | WO1998014424A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003294917A1 (en) * | 2002-12-20 | 2004-07-14 | Novartis Ag | Device and method for delivering mmp inhibitors |
AU2004263900A1 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
CA2559062A1 (en) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
CN1951912B (zh) * | 2005-10-18 | 2010-05-05 | 上海五洲药业股份有限公司 | 手性脂环烃异羟肟酸衍生物的制备方法 |
GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
RU2021110237A (ru) * | 2016-04-18 | 2021-05-06 | Виворион Терапьютикс Аг | Новые ингибиторы меприна альфа и бета |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
ES2144819T3 (es) * | 1994-01-20 | 2000-06-16 | British Biotech Pharm | L-terc-leucina-2-piridilamida. |
DE69512891T2 (de) * | 1994-01-22 | 2000-02-24 | British Biotech Pharmaceuticals Ltd., Cowley | Metalloproteinaseinhibitoren |
GB9416897D0 (en) * | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
-
1997
- 1997-09-30 JP JP51623698A patent/JP3444898B2/ja not_active Expired - Fee Related
- 1997-09-30 AR ARP970104491A patent/AR009103A1/es unknown
- 1997-09-30 DK DK97909339T patent/DK0929517T3/da active
- 1997-09-30 RU RU99108792/04A patent/RU2196131C2/ru not_active IP Right Cessation
- 1997-09-30 PT PT97909339T patent/PT929517E/pt unknown
- 1997-09-30 IL IL12916697A patent/IL129166A0/xx not_active IP Right Cessation
- 1997-09-30 WO PCT/EP1997/005376 patent/WO1998014424A1/en not_active Application Discontinuation
- 1997-09-30 SI SI9730357T patent/SI0929517T1/xx unknown
- 1997-09-30 CN CN97198511A patent/CN1101807C/zh not_active Expired - Fee Related
- 1997-09-30 BR BR9712255A patent/BR9712255A/pt not_active Application Discontinuation
- 1997-09-30 CZ CZ991139A patent/CZ113999A3/cs unknown
- 1997-09-30 PE PE1997000874A patent/PE2099A1/es not_active Application Discontinuation
- 1997-09-30 AU AU47068/97A patent/AU726065B2/en not_active Ceased
- 1997-09-30 KR KR1019990702806A patent/KR20000048811A/ko not_active Application Discontinuation
- 1997-09-30 ID IDW990143D patent/ID22212A/id unknown
- 1997-09-30 AT AT97909339T patent/ATE219050T1/de not_active IP Right Cessation
- 1997-09-30 CA CA002267415A patent/CA2267415A1/en not_active Abandoned
- 1997-09-30 DE DE69713354T patent/DE69713354T2/de not_active Expired - Lifetime
- 1997-09-30 HU HU9903892A patent/HUP9903892A3/hu unknown
- 1997-09-30 NZ NZ334908A patent/NZ334908A/xx unknown
- 1997-09-30 TR TR1999/00725T patent/TR199900725T2/xx unknown
- 1997-09-30 ES ES97909339T patent/ES2178759T3/es not_active Expired - Lifetime
- 1997-09-30 PL PL97332477A patent/PL188518B1/pl not_active IP Right Cessation
- 1997-09-30 SK SK430-99A patent/SK43099A3/sk unknown
- 1997-09-30 EP EP97909339A patent/EP0929517B1/en not_active Expired - Lifetime
- 1997-10-01 CO CO97057298A patent/CO4900034A1/es unknown
- 1997-10-01 MY MYPI97004587A patent/MY127926A/en unknown
-
1999
- 1999-03-30 NO NO19991559A patent/NO313457B1/no not_active IP Right Cessation
-
2000
- 2000-01-20 HK HK00100370A patent/HK1021637A1/xx not_active IP Right Cessation
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