RU2021110237A - Новые ингибиторы меприна альфа и бета - Google Patents

Новые ингибиторы меприна альфа и бета Download PDF

Info

Publication number
RU2021110237A
RU2021110237A RU2021110237A RU2021110237A RU2021110237A RU 2021110237 A RU2021110237 A RU 2021110237A RU 2021110237 A RU2021110237 A RU 2021110237A RU 2021110237 A RU2021110237 A RU 2021110237A RU 2021110237 A RU2021110237 A RU 2021110237A
Authority
RU
Russia
Prior art keywords
compound according
group
alkyl
optionally
methoxyphenyl
Prior art date
Application number
RU2021110237A
Other languages
English (en)
Inventor
Михаэль ВЕРМАНН
Мирко Буххольц
Ганс-Ульрих ДЕМУТ
Даниэль РАМСБЕК
Дагмар ШЛЕНЦИГ
Штефан Шиллинг
Original Assignee
Виворион Терапьютикс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Виворион Терапьютикс Аг filed Critical Виворион Терапьютикс Аг
Publication of RU2021110237A publication Critical patent/RU2021110237A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/18—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Peptides Or Proteins (AREA)

Claims (35)

1. Соединение, имеющее приведенную ниже формулу I, его индивидуальные энантиомеры, его индивидуальные диастереомеры, его гидраты, его сольваты, его кристаллические формы, его индивидуальные таутомеры или его фармацевтически приемлемая соль,
Figure 00000001
,
где:
n = 1 или 2;
R1 выбран из группы, состоящей из H и алкила; где указанный алкил может быть соединен вместе с R3 с образованием кольца;
R3 выбран из группы, состоящей из Н, алкила, арила, арилалкила, гетероарила и гетероарилалкила, каждый из которых необязательно может иметь заместители; где указанный алкил может быть соединен вместе с R1 с образованием кольца;
R2 выбран из группы, состоящей из арила, арилалкила, гетероарила и гетероарилалкила, каждый из которых необязательно может иметь заместители;
R4 представляет собой H или алкил; и
X представляет собой –CH2 -.
2. Соединение по п. 1, имеющее приведенную ниже формулу V:
Figure 00000002
где:
R1 соединен вместе с R3 с образованием гетероциклического кольца.
3. Соединение по п. 1, где R3 и R4 представляют собой H.
4. Соединение по п. 1, где R2 выбран из группы, состоящей из арила, алкоксиарила, карбоксиарила, цианоарила, галоарила, гидроксиарила, алкоксигетероарила, цианогетероарила, галогетероарила, гетероариларила, гидроксигетероарила и карбоксигетероарила, каждый из которых необязательно может иметь заместители.
5. Соединение по п. 1, где R2 имеет приведенную ниже формулу,
Figure 00000003
,
где:
(i) по меньшей мере один из RP и Rm, предпочтительно Rm, представляет собой функциональную группу, имеющую кислотный атом водорода, и необязательно выбран из -COOH, -SO3H, -P(O)(OH)2, -C(O)-NH-OH, –OH и тетразол-5-ила; или
(ii) RP и Rm представляют собой алкокси-группы, которые соединены между собой, формируя часть 5-8-членного гетероцикла; или
(iii) по меньшей мере один из RP и Rm выбран из группы, состоящей из C1–6 алкила, C1–6 алкокси-группы, фтор(C1–6 алкила), фтор(C1–6 алкокси), фтора, хлора, брома, иода и циано-группы;
где R2 необязательно может иметь дополнительные заместители.
6. Соединение по п. 1, где R2 выбран из группы, состоящей из 1,3-бензодиоксол-5-ила, 3-карбоксифенила, 1,3-бензодиоксол-5-ила, 3-карбоксифенила, 4-карбоксифенила, 3-карбокси-4-метоксифенила, 3,5-дихлор-4-гидроксифенила, 4-хлорфенила, 4-цианофенила, 4-фторфенила, 2,6-дифтор-4-метоксифенила, 3-фтор-4-метоксифенила, 3-метоксифенила, 4-метоксифенила, 4-хлорфенила и 4-метилфенила.
7. Соединение по п. 1, где R2 представляет собой 3-карбоксифенил, и R4 представляет собой H.
8. Соединение по п. 1, которое выбрано из группы, состоящей из:
Figure 00000004
Figure 00000005
Figure 00000006
Figure 00000007
Figure 00000008
Figure 00000009
Figure 00000010
Figure 00000011
Figure 00000012
Figure 00000013
Figure 00000014
Figure 00000015
Figure 00000016
Figure 00000017
Figure 00000018
Figure 00000019
.
9. Фармацевтическая композиция, содержащая
соединение по любому из пп. 1-8, его индивидуальные энантиомеры, его индивидуальные диастереомеры, его гидраты, его сольваты, его кристаллические формы, его индивидуальные таутомеры или его фармацевтически приемлемую соль; и фармацевтически приемлемое вспомогательное вещество.
10. Способ лечения или профилактики тела человека или животного хирургическим или терапевтическим способом, включающий введение терапевтически эффективного количества соединения по любому из пп. 1-8 или фармацевтической композиции по п. 9 субъекту, нуждающемуся в этом.
11. Способ лечения или профилактики заболевания или патологического состояния, выбранного из болезни Альцгеймера, нефрита, повреждения почки, ишемии почки, ишемического острого тубулярного некроза, острой почечной недостаточности, воспаления мочевого пузыря, воспалительного заболевания кишечника (ВЗК), болезни Крона, язвенного колита, хронического воспаления, колита, фиброза, фиброзных состояний, келоидов, легочной гипертензии, интерстициального заболевания легкого и рака, в особенности рака толстой и прямой кишок, включающий введение терапевтически эффективного количества соединения по любому из пп. 1-8 или фармацевтической композиции по п. 9 субъекту, нуждающемуся в этом.
RU2021110237A 2016-04-18 2017-04-18 Новые ингибиторы меприна альфа и бета RU2021110237A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16165804 2016-04-18
EP16165804.2 2016-04-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2018140207A Division RU2746850C2 (ru) 2016-04-18 2017-04-18 Новые ингибиторы меприна альфа и бета

Publications (1)

Publication Number Publication Date
RU2021110237A true RU2021110237A (ru) 2021-05-06

Family

ID=55808391

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2018140207A RU2746850C2 (ru) 2016-04-18 2017-04-18 Новые ингибиторы меприна альфа и бета
RU2021110237A RU2021110237A (ru) 2016-04-18 2017-04-18 Новые ингибиторы меприна альфа и бета

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU2018140207A RU2746850C2 (ru) 2016-04-18 2017-04-18 Новые ингибиторы меприна альфа и бета

Country Status (12)

Country Link
US (2) US10975019B2 (ru)
EP (2) EP3445744B1 (ru)
JP (3) JP2019519477A (ru)
KR (2) KR102511732B1 (ru)
CN (2) CN114507175A (ru)
AU (2) AU2017253625B2 (ru)
CA (1) CA3021152A1 (ru)
DK (1) DK3445744T3 (ru)
ES (1) ES2903079T3 (ru)
PL (1) PL3445744T3 (ru)
RU (2) RU2746850C2 (ru)
WO (1) WO2017182433A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019519477A (ja) * 2016-04-18 2019-07-11 フラウンホファー ゲセルシャフト ツール フェールデルンク ダー アンゲヴァンテン フォルシュンク エー．ファオ． メプリンアルファ及びベータの新規な阻害剤
EP3750878A1 (en) 2019-06-14 2020-12-16 Vivoryon Therapeutics AG Heteroaromatic inhibitors of astacin proteinases

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9712255A (pt) * 1996-10-02 1999-08-24 Novartis Ag Derivados do cido hidrox-mico
AU735366B2 (en) * 1997-09-29 2001-07-05 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
US6583299B1 (en) * 1999-05-20 2003-06-24 G.D. Searle & Co. α-amino-β-sulfonyl hydroxamic acid compounds
US20010049449A1 (en) * 1999-12-23 2001-12-06 Becker Daniel P. Aromatic sulfonyl alpha-cycloamino hydroxamates and their use as MMP inhibitors
WO2001094358A1 (de) * 2000-06-08 2001-12-13 Jomaa Pharmaka Gmbh Phosphororganische hydroamsäurederivate als herbizide
AU2003267991B2 (en) * 2002-07-11 2009-10-08 Vicuron Pharmaceuticals, Inc. N-hydroxyamide derivatives possessing antibacterial activity
MXPA05007394A (es) * 2003-01-08 2005-09-12 Chiron Corp Agentes antibacterianos.
US7662856B2 (en) * 2003-08-29 2010-02-16 The University Of Houston System Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxlyamine
WO2005073180A1 (ja) * 2003-12-25 2005-08-11 Kureha Corporation ヒドロキサム酸誘導体、及び該誘導体を含むａｇｅ生成阻害剤
WO2006013209A2 (en) * 2004-08-02 2006-02-09 Genmedica Therapeutics Sl Compounds for inhibiting copper-containing amine oxidases and uses thereof
WO2007003594A1 (en) * 2005-07-01 2007-01-11 Solvay Pharmaceuticals Gmbh Screening methods for inhibitors of the metalloprotease meprin
US20070066646A1 (en) * 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof
US20080161320A1 (en) * 2006-09-11 2008-07-03 Xiong Cai Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
US8119692B2 (en) * 2007-04-02 2012-02-21 Panthera Biopharma Llc Hydroxamic acid derivatives of 4-phenyl 4-hydroxy, 4-phenyl 4-alkoxy and 4-phenyl 4-arylalkoxy butyric acid useful as therapeutic agents for treating anthrax poisoning
JP5539864B2 (ja) * 2007-06-12 2014-07-02 アカオゲン，インコーポレーテッド 抗菌剤
WO2009036057A1 (en) * 2007-09-10 2009-03-19 Curis, Inc. Antiproliferative agents containing a zinc binding moiety
TW200920357A (en) * 2007-09-10 2009-05-16 Curis Inc HSP90 inhibitors containing a zinc binding moiety
WO2015024021A2 (en) * 2013-08-16 2015-02-19 Duke University Antibacterial compounds
WO2015112441A1 (en) * 2014-01-22 2015-07-30 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
CN105237478A (zh) * 2015-11-06 2016-01-13 吉首大学 一类甲硝唑-酰胺衍生物尿素酶抑制剂及其合成和用途
JP2019519477A (ja) * 2016-04-18 2019-07-11 フラウンホファー ゲセルシャフト ツール フェールデルンク ダー アンゲヴァンテン フォルシュンク エー．ファオ． メプリンアルファ及びベータの新規な阻害剤

Also Published As

Publication number Publication date
EP3967679A1 (en) 2022-03-16
RU2018140207A3 (ru) 2020-05-19
AU2021257905B2 (en) 2023-03-02
EP3445744A1 (en) 2019-02-27
AU2017253625A1 (en) 2018-11-22
RU2746850C2 (ru) 2021-04-21
PL3445744T3 (pl) 2022-02-07
CN114507175A (zh) 2022-05-17
US20210198189A1 (en) 2021-07-01
RU2018140207A (ru) 2020-05-19
ES2903079T3 (es) 2022-03-31
AU2017253625B2 (en) 2021-08-12
JP2023129525A (ja) 2023-09-14
KR20220003139A (ko) 2022-01-07
KR102511732B1 (ko) 2023-03-17
US20190127317A1 (en) 2019-05-02
CN109195947A (zh) 2019-01-11
CA3021152A1 (en) 2017-10-26
WO2017182433A1 (en) 2017-10-26
JP2019519477A (ja) 2019-07-11
EP3445744B1 (en) 2021-10-06
KR102410199B1 (ko) 2022-06-17
KR20180135002A (ko) 2018-12-19
US10975019B2 (en) 2021-04-13
DK3445744T3 (da) 2021-12-13
CN109195947B (zh) 2022-03-04
JP2021102645A (ja) 2021-07-15
AU2021257905A1 (en) 2021-11-18
JP7179114B2 (ja) 2022-11-28

Similar Documents

Publication Publication Date Title
RU2018120242A (ru) Хинолиновые соединения, способы их получения и их применения в качестве лекарственного средства, ингибирующего транспортер уратов
RU2020110780A (ru) Ингибитор fgfr и его медицинское применение
JP2017524704A5 (ru)
RU2013114771A (ru) Диамиды азетидинила как ингибиторы моноацилглицерол липазы
RU2021110237A (ru) Новые ингибиторы меприна альфа и бета
AR095427A1 (es) Compuestos aromáticos sustituidos para el tratamiento de la fibrosis pulmonar, la fibrosis hepática, la fibrosis de la piel y la fibrosis cardíaca
MX2020007532A (es) Inhibidores de sarcomero cardiaco.
AR083180A1 (es) Amidas de oxopiperazina-azetidina y amidas oxodiazepina-azetidina como inhibidores de monoacilglicerol lipasa
AR083542A1 (es) Piperidin-4-il-azetidin diamidas como inhibidores de monoacilglicerol lipasa
RU2017125025A (ru) Конденсированные кольцевые гетероарильные соединения и их применение в качестве ингибиторов trk
JP2017506666A5 (ru)
RU2011147200A (ru) Азетидинилдиамиды в качестве ингибиторов моноациглицерин-липазы
IL259947A (en) The troirylhydroxypyrimidinones as apj receptor agonists
JP2018533593A5 (ru)
JP2017509689A5 (ru)
RU2018136888A (ru) Нафтиридины в качестве антагонистов интегрина
RU2019121871A (ru) Новые производные фенилпропионовой кислоты и их применение
PE20060823A1 (es) Compuestos de arilsulfonamida como moduladores de receptores cck1/cck2
JP2019529359A5 (ru)
BRPI0712268A2 (pt) composição para diagnóstico de doença relacionada à amilóide
RU2014122344A (ru) Аминопиримидиновые ингибиторы киназ
AR107030A1 (es) Inhibidores aza-bencimidazol de pad4
AR120244A1 (es) INHIBICIÓN DE INTEGRINA a4b7 HUMANA
JP2020521766A5 (ru)
RU2014114120A (ru) Производные бензойной кислоты в качестве ингибиторов эукариотического фактора инициации трансляции 4е