NO312995B1 - Pyrimidin- eller pyridinderivater samt anvendelse av slike derivater for fremstilling av legemidler for behandling avcerebrovaskul¶r sykdom - Google Patents
Pyrimidin- eller pyridinderivater samt anvendelse av slike derivater for fremstilling av legemidler for behandling avcerebrovaskul¶r sykdom Download PDFInfo
- Publication number
- NO312995B1 NO312995B1 NO19971050A NO971050A NO312995B1 NO 312995 B1 NO312995 B1 NO 312995B1 NO 19971050 A NO19971050 A NO 19971050A NO 971050 A NO971050 A NO 971050A NO 312995 B1 NO312995 B1 NO 312995B1
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- fluorophenyl
- compound
- pyrimidine
- alkyl
- Prior art date
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- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 29
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 239000003814 drug Substances 0.000 title description 16
- 229940079593 drug Drugs 0.000 title description 11
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 11
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- PUYGGMIXGXNYFR-UHFFFAOYSA-N 4-(4-fluorophenyl)-2-methyl-6-(6-piperidin-1-ylhexoxy)pyrimidine Chemical compound C=1C(C=2C=CC(F)=CC=2)=NC(C)=NC=1OCCCCCCN1CCCCC1 PUYGGMIXGXNYFR-UHFFFAOYSA-N 0.000 claims description 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 2
- XJUJSZXMVWAXCP-UHFFFAOYSA-N 4-(4-fluorophenyl)-2-methyl-6-(3-piperidin-1-ylpropoxy)pyridine Chemical compound N=1C(C)=CC(C=2C=CC(F)=CC=2)=CC=1OCCCN1CCCCC1 XJUJSZXMVWAXCP-UHFFFAOYSA-N 0.000 claims description 2
- LKYPFVJBVDQZJD-UHFFFAOYSA-N 4-(4-fluorophenyl)-2-methyl-6-(5-piperidin-1-ylpentoxy)pyridine Chemical compound N=1C(C)=CC(C=2C=CC(F)=CC=2)=CC=1OCCCCCN1CCCCC1 LKYPFVJBVDQZJD-UHFFFAOYSA-N 0.000 claims description 2
- SZSHJTJCJOWMHM-UHFFFAOYSA-N 4-(4-fluorophenyl)-2-methyl-6-(5-piperidin-1-ylpentoxy)pyrimidine Chemical compound C=1C(C=2C=CC(F)=CC=2)=NC(C)=NC=1OCCCCCN1CCCCC1 SZSHJTJCJOWMHM-UHFFFAOYSA-N 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
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Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21621494 | 1994-09-09 | ||
PCT/JP1995/001792 WO1996007641A1 (fr) | 1994-09-09 | 1995-09-08 | Derive heterocyclique et medicament |
Publications (3)
Publication Number | Publication Date |
---|---|
NO971050D0 NO971050D0 (no) | 1997-03-07 |
NO971050L NO971050L (no) | 1997-05-09 |
NO312995B1 true NO312995B1 (no) | 2002-07-29 |
Family
ID=16685068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19971050A NO312995B1 (no) | 1994-09-09 | 1997-03-07 | Pyrimidin- eller pyridinderivater samt anvendelse av slike derivater for fremstilling av legemidler for behandling avcerebrovaskul¶r sykdom |
Country Status (19)
Country | Link |
---|---|
US (2) | US5945426A (de) |
EP (1) | EP0781766B1 (de) |
JP (2) | JP3036079B2 (de) |
KR (1) | KR100358245B1 (de) |
CN (1) | CN1118454C (de) |
AT (1) | ATE263154T1 (de) |
BR (1) | BR9508900A (de) |
CA (1) | CA2199518A1 (de) |
DE (1) | DE69532811T2 (de) |
DK (1) | DK0781766T3 (de) |
ES (1) | ES2218552T3 (de) |
FI (1) | FI970967A0 (de) |
HU (1) | HU221855B1 (de) |
MX (1) | MX9701765A (de) |
NO (1) | NO312995B1 (de) |
NZ (1) | NZ292269A (de) |
PT (1) | PT781766E (de) |
RU (1) | RU2128996C1 (de) |
WO (1) | WO1996007641A1 (de) |
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IT1300056B1 (it) * | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci |
EP1108430A1 (de) * | 1998-08-25 | 2001-06-20 | Nippon Shinyaku Co., Ltd. | Kalzium-kanal antagonisten |
US20040077709A1 (en) * | 1999-05-31 | 2004-04-22 | Daiichi Pharmaceutical Co., Ltd. | Neuronal death inhibitors |
GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
GB0021494D0 (en) | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
EP1318146B1 (de) * | 2000-09-08 | 2005-02-23 | Nippon Shinyaku Co., Ltd. | Verfahren zur produktion von pyrimidinderivaten und geeignete zwischenprodukte |
WO2002024663A2 (en) * | 2000-09-19 | 2002-03-28 | Sumitomo Chemical Company, Limited | Pyrimidine compounds and their use |
GB0112810D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0112802D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0119477D0 (en) | 2001-08-09 | 2001-10-03 | Glaxo Group Ltd | Pyrimidine derivatives |
EP1546128B1 (de) | 2002-08-19 | 2006-05-03 | Glaxo Group Limited | Pyrimidinderivate als selektive cox-2-inhibitoren |
GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
ATE374766T1 (de) | 2003-01-14 | 2007-10-15 | Arena Pharm Inc | 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie |
WO2004087712A1 (en) * | 2003-03-31 | 2004-10-14 | Council Of Scientific And Industrial Research | NEW PYRIMIDINE LINKED PYRROLO[2,1-c][1,4]BENZODIAZEPINES AS POTENTIAL ANTITUMOUR AGENTS |
AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
AU2004257267B2 (en) | 2003-07-14 | 2009-12-03 | Arena Pharmaceuticals,Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US6966680B2 (en) * | 2003-11-28 | 2005-11-22 | Edward Kratz | Decorative lighting display with changeable shades and bulbs |
PT1756084E (pt) * | 2004-06-04 | 2009-02-17 | Arena Pharm Inc | Composto seleccionado de compostos de fórmula (i) e seus sais, solvatos, hidratos e n-óxidos farmaceuticamente aceitáveis |
DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
CA2619093A1 (en) * | 2005-09-16 | 2007-03-29 | Arena Pharmaceuticals, Inc. | Modulators of metabolism and the treatment of disorders related thereto |
TW200811147A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
TW200811140A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
EP1941879A1 (de) * | 2007-01-05 | 2008-07-09 | PAION Deutschland GmbH | Nervenschutzmittel zur Behandlung von neuronalen Schäden. |
EP2008653A1 (de) | 2007-06-28 | 2008-12-31 | Charité-Universitätsmedizin Berlin | Serotonerge Verbindungen zur Behandlung neuronaler Krankheiten |
DE102007051090A1 (de) | 2007-06-28 | 2009-01-08 | Charité - Universitätsmedizin Berlin | SSRI zur Behandlung neuronaler Krankheiten |
JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
CA3002551A1 (en) | 2015-06-22 | 2016-12-29 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders |
CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
EP3953762B1 (de) * | 2019-04-09 | 2022-09-14 | Gentex Corporation | Niedrig dimerisierende elektrochrome viologenverbindungen und vorrichtungen |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US3167553A (en) * | 1963-05-08 | 1965-01-26 | Searle & Co | 2-amino-4-ethereal-5-methyl-6-phenylpyrimidines |
BE756127A (fr) * | 1969-09-12 | 1971-03-15 | Hoechst Ag | Ethers heterocycliques et leur preparation |
JPS4921148B1 (de) * | 1970-12-28 | 1974-05-30 | ||
BE789099A (fr) * | 1971-09-22 | 1973-03-21 | Boehringer Sohn Ingelheim | Nouveaux derives de la pyridine et procede pour les fabriquer |
US3937712A (en) * | 1971-09-22 | 1976-02-10 | Boehringer Ingelheim Gmbh | (5-nitro-2-furyl)-pyridines |
US4115575A (en) * | 1973-02-20 | 1978-09-19 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)-pyrazines |
US4698340A (en) * | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
US4727073A (en) * | 1984-10-01 | 1988-02-23 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives and composition of the same |
CA2090027A1 (en) * | 1990-08-31 | 1992-03-01 | Shoichi Chokai | Pyrimidine derivatives and drugs |
US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
IL117659A (en) * | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
-
1995
- 1995-09-08 JP JP8509379A patent/JP3036079B2/ja not_active Expired - Fee Related
- 1995-09-08 WO PCT/JP1995/001792 patent/WO1996007641A1/ja active IP Right Grant
- 1995-09-08 US US08/809,004 patent/US5945426A/en not_active Expired - Fee Related
- 1995-09-08 DK DK95930725T patent/DK0781766T3/da active
- 1995-09-08 PT PT95930725T patent/PT781766E/pt unknown
- 1995-09-08 KR KR1019970701494A patent/KR100358245B1/ko not_active IP Right Cessation
- 1995-09-08 CA CA002199518A patent/CA2199518A1/en not_active Abandoned
- 1995-09-08 NZ NZ292269A patent/NZ292269A/en unknown
- 1995-09-08 DE DE69532811T patent/DE69532811T2/de not_active Expired - Fee Related
- 1995-09-08 ES ES95930725T patent/ES2218552T3/es not_active Expired - Lifetime
- 1995-09-08 BR BR9508900A patent/BR9508900A/pt not_active IP Right Cessation
- 1995-09-08 HU HU9800853A patent/HU221855B1/hu not_active IP Right Cessation
- 1995-09-08 EP EP95930725A patent/EP0781766B1/de not_active Expired - Lifetime
- 1995-09-08 MX MX9701765A patent/MX9701765A/es not_active IP Right Cessation
- 1995-09-08 CN CN95195014A patent/CN1118454C/zh not_active Expired - Fee Related
- 1995-09-08 RU RU97105769A patent/RU2128996C1/ru not_active IP Right Cessation
- 1995-09-08 AT AT95930725T patent/ATE263154T1/de not_active IP Right Cessation
-
1997
- 1997-03-07 FI FI970967A patent/FI970967A0/fi unknown
- 1997-03-07 NO NO19971050A patent/NO312995B1/no unknown
-
1999
- 1999-06-16 US US09/334,253 patent/US6191149B1/en not_active Expired - Fee Related
- 1999-11-26 JP JP33560399A patent/JP3312616B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP3036079B2 (ja) | 2000-04-24 |
ES2218552T3 (es) | 2004-11-16 |
WO1996007641A1 (fr) | 1996-03-14 |
CA2199518A1 (en) | 1996-03-14 |
FI970967A (fi) | 1997-03-07 |
JP3312616B2 (ja) | 2002-08-12 |
KR100358245B1 (ko) | 2003-11-28 |
PT781766E (pt) | 2004-07-30 |
DE69532811T2 (de) | 2005-03-17 |
NO971050D0 (no) | 1997-03-07 |
RU2128996C1 (ru) | 1999-04-20 |
US5945426A (en) | 1999-08-31 |
US6191149B1 (en) | 2001-02-20 |
CN1157609A (zh) | 1997-08-20 |
EP0781766A4 (de) | 1998-01-14 |
BR9508900A (pt) | 1997-12-30 |
HUT77779A (hu) | 1998-08-28 |
AU701395B2 (en) | 1999-01-28 |
DE69532811D1 (de) | 2004-05-06 |
NO971050L (no) | 1997-05-09 |
ATE263154T1 (de) | 2004-04-15 |
HU221855B1 (hu) | 2003-02-28 |
KR970705545A (ko) | 1997-10-09 |
EP0781766B1 (de) | 2004-03-31 |
FI970967A0 (fi) | 1997-03-07 |
CN1118454C (zh) | 2003-08-20 |
NZ292269A (en) | 1998-09-24 |
AU3399695A (en) | 1996-03-27 |
JP2000136184A (ja) | 2000-05-16 |
MX9701765A (es) | 1997-06-28 |
EP0781766A1 (de) | 1997-07-02 |
DK0781766T3 (da) | 2004-07-26 |
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