NO311868B1 - Anvendelse av 2,6-dialkyl-4-silylfenoler for fremstilling av et medikament for nedsettelse av serumkolesterolnivåer - Google Patents
Anvendelse av 2,6-dialkyl-4-silylfenoler for fremstilling av et medikament for nedsettelse av serumkolesterolnivåer Download PDFInfo
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- NO311868B1 NO311868B1 NO19962415A NO962415A NO311868B1 NO 311868 B1 NO311868 B1 NO 311868B1 NO 19962415 A NO19962415 A NO 19962415A NO 962415 A NO962415 A NO 962415A NO 311868 B1 NO311868 B1 NO 311868B1
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- Prior art keywords
- cholesterol
- compound
- formula
- cholesterol levels
- compound according
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- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16528193A | 1993-12-10 | 1993-12-10 | |
| PCT/US1994/012702 WO1995015760A1 (en) | 1993-12-10 | 1994-11-03 | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO962415D0 NO962415D0 (no) | 1996-06-07 |
| NO962415L NO962415L (no) | 1996-06-07 |
| NO311868B1 true NO311868B1 (no) | 2002-02-11 |
Family
ID=22598245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19962415A NO311868B1 (no) | 1993-12-10 | 1996-06-07 | Anvendelse av 2,6-dialkyl-4-silylfenoler for fremstilling av et medikament for nedsettelse av serumkolesterolnivåer |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP0732928B1 (es) |
| JP (1) | JPH09511222A (es) |
| CN (1) | CN1092517C (es) |
| AT (2) | ATE285238T1 (es) |
| AU (1) | AU681731B2 (es) |
| CA (1) | CA2177968C (es) |
| DE (2) | DE69434198T2 (es) |
| DK (2) | DK0732928T3 (es) |
| ES (2) | ES2233937T3 (es) |
| HU (1) | HU220761B1 (es) |
| IL (1) | IL111905A (es) |
| NO (1) | NO311868B1 (es) |
| NZ (1) | NZ276285A (es) |
| PT (2) | PT732928E (es) |
| WO (1) | WO1995015760A1 (es) |
| ZA (1) | ZA949663B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| BR9809793A (pt) | 1997-05-14 | 2000-06-27 | Atherogenics Inc | Monoésteres de probucol para o tratamento de doença inflamatória e cardiovascular |
| CA2293461C (en) * | 1997-06-24 | 2004-02-24 | Hoechst Marion Roussel, Inc. | Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents |
| US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
| WO1998058937A1 (en) * | 1997-06-25 | 1998-12-30 | Hoechst Marion Roussel, Inc. | 2,6-DI-t-BUTYL-4-[ (DIMETHYL-4-METHOXYPHENYLSILYL) -METHYLOXY]PHENOL AND 2,6-DI-t-BUTYL-4-[ (DIMETHYL-2-METHOXY-PHENYLSILYL) -METHYLOXY]PHENOL |
| KR20010020611A (ko) | 1997-07-01 | 2001-03-15 | 아테로제닉스, 인코포레이티드 | 항산화제에 의한 과증식질병 치료의 향상 |
| US6887712B1 (en) | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| MXPA01004683A (es) * | 1998-11-09 | 2002-09-18 | Atherogenics Inc | Metodos y composiciones para disminuir los niveles de colesterol en el plasma. |
| US6821738B2 (en) | 1999-01-20 | 2004-11-23 | The Board Of Regents For Oklahoma State University | Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents |
| WO2002040021A2 (en) | 2000-11-17 | 2002-05-23 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| EP1465854A4 (en) | 2001-12-19 | 2005-06-08 | Atherogenics Inc | CHALCONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES |
| CA2492433A1 (en) | 2002-07-12 | 2004-01-22 | Artherogenics, Inc. | Organic amine salts of poorly soluble probucol esters and ethers |
| US7173129B2 (en) | 2003-06-06 | 2007-02-06 | Athero Genics, Inc. | Sulfonamide-substituted chalcone derivatives and their use to treat diseases |
| EP1677804A1 (en) * | 2003-10-17 | 2006-07-12 | Amylin Pharmaceuticals, Inc. | Silyl phenols for promoting vascular health |
| WO2005112914A2 (en) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
| US8252840B2 (en) | 2007-03-26 | 2012-08-28 | Salutria Pharmaceuticals Llc | Methods of derivatives of probucol for the treatment of type II diabetes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE349046B (es) * | 1966-12-23 | 1972-09-18 | C Guevne | |
| FR2230376A1 (en) * | 1973-05-24 | 1974-12-20 | Gueyne Jean | Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity |
| FR2308372A2 (fr) * | 1975-04-21 | 1976-11-19 | Cortial | Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif |
| US4670421A (en) * | 1982-07-12 | 1987-06-02 | American Cyanamid Company | Antiatherosclerotic silanes |
| US4900757A (en) * | 1988-12-08 | 1990-02-13 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane |
| US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
| NZ238807A (en) * | 1990-07-05 | 1994-03-25 | Merrell Dow Pharma | Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions |
-
1994
- 1994-11-03 DK DK95901141T patent/DK0732928T3/da active
- 1994-11-03 PT PT95901141T patent/PT732928E/pt unknown
- 1994-11-03 DK DK04016883T patent/DK1468692T3/da active
- 1994-11-03 DE DE69434198T patent/DE69434198T2/de not_active Expired - Fee Related
- 1994-11-03 CA CA002177968A patent/CA2177968C/en not_active Expired - Fee Related
- 1994-11-03 JP JP7516186A patent/JPH09511222A/ja not_active Ceased
- 1994-11-03 AU AU10499/95A patent/AU681731B2/en not_active Ceased
- 1994-11-03 CN CN94194438A patent/CN1092517C/zh not_active Expired - Fee Related
- 1994-11-03 EP EP95901141A patent/EP0732928B1/en not_active Expired - Lifetime
- 1994-11-03 AT AT95901141T patent/ATE285238T1/de not_active IP Right Cessation
- 1994-11-03 WO PCT/US1994/012702 patent/WO1995015760A1/en active IP Right Grant
- 1994-11-03 EP EP04016884A patent/EP1468693A3/en not_active Withdrawn
- 1994-11-03 ES ES95901141T patent/ES2233937T3/es not_active Expired - Lifetime
- 1994-11-03 DE DE69434720T patent/DE69434720T2/de not_active Expired - Lifetime
- 1994-11-03 NZ NZ276285A patent/NZ276285A/en not_active IP Right Cessation
- 1994-11-03 AT AT04016883T patent/ATE324113T1/de not_active IP Right Cessation
- 1994-11-03 HU HU9601590A patent/HU220761B1/hu not_active IP Right Cessation
- 1994-11-03 PT PT04016883T patent/PT1468692E/pt unknown
- 1994-11-03 EP EP04016883A patent/EP1468692B1/en not_active Expired - Lifetime
- 1994-11-03 ES ES04016883T patent/ES2263094T3/es not_active Expired - Lifetime
- 1994-12-05 ZA ZA949663A patent/ZA949663B/xx unknown
- 1994-12-07 IL IL11190594A patent/IL111905A/en not_active IP Right Cessation
-
1996
- 1996-06-07 NO NO19962415A patent/NO311868B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4900757A (en) | Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane | |
| US5532400A (en) | 2,6-di-alkyl-4-silyl-phenols as antiatheroscelerotic agents | |
| US5677291A (en) | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols | |
| NO311868B1 (no) | Anvendelse av 2,6-dialkyl-4-silylfenoler for fremstilling av et medikament for nedsettelse av serumkolesterolnivåer | |
| NO179914B (no) | Analogifremgangsmåte ved fremstilling av terapeutisk aktive bis[4-(2,6-dialkyl)fenolÅsilanderivater | |
| US5304668A (en) | Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents | |
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| US4954528A (en) | Hypocholesterolemic use of bis(3,5-di-tertiary-butly-4-hydroxyphenylthio)methane | |
| EP0462556B1 (en) | Hypotriglyceridemic use of certain bis(3,5-di-alkyl-4-hydroxphenylthio)methanes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |