NO311637B1 - Topiske oftalmiske formuleringer inneholdende doxepinderivater for behandling av öyenallergisykdommer - Google Patents
Topiske oftalmiske formuleringer inneholdende doxepinderivater for behandling av öyenallergisykdommer Download PDFInfo
- Publication number
- NO311637B1 NO311637B1 NO19970517A NO970517A NO311637B1 NO 311637 B1 NO311637 B1 NO 311637B1 NO 19970517 A NO19970517 A NO 19970517A NO 970517 A NO970517 A NO 970517A NO 311637 B1 NO311637 B1 NO 311637B1
- Authority
- NO
- Norway
- Prior art keywords
- dimethylaminopropylidene
- dihydrodibenz
- oxepin
- acetic acid
- treatment
- Prior art date
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000580 secretagogue effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/469,729 US5641805A (en) | 1995-06-06 | 1995-06-06 | Topical ophthalmic formulations for treating allergic eye diseases |
| PCT/US1996/006289 WO1996039147A2 (fr) | 1995-06-06 | 1996-05-03 | Compositions ophtalmiques topiques contenant des derives de doxepine destinees au traitement d'affections allergiques des yeux |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO970517D0 NO970517D0 (no) | 1997-02-05 |
| NO970517L NO970517L (no) | 1997-04-03 |
| NO311637B1 true NO311637B1 (no) | 2001-12-27 |
Family
ID=23864859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19970517A NO311637B1 (no) | 1995-06-06 | 1997-02-05 | Topiske oftalmiske formuleringer inneholdende doxepinderivater for behandling av öyenallergisykdommer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5641805A (fr) |
| EP (1) | EP0799044B1 (fr) |
| JP (1) | JP3068858B2 (fr) |
| KR (1) | KR100202155B1 (fr) |
| CN (1) | CN1082367C (fr) |
| AT (1) | ATE220906T1 (fr) |
| AU (1) | AU698854B2 (fr) |
| CA (1) | CA2195094C (fr) |
| DE (2) | DE69622527T2 (fr) |
| DK (1) | DK0799044T3 (fr) |
| ES (1) | ES2179198T3 (fr) |
| FI (1) | FI970489A0 (fr) |
| LU (1) | LU90969I2 (fr) |
| MX (1) | MX9701013A (fr) |
| MY (1) | MY116651A (fr) |
| NL (1) | NL300101I2 (fr) |
| NO (1) | NO311637B1 (fr) |
| PT (1) | PT799044E (fr) |
| TW (1) | TW438588B (fr) |
| WO (1) | WO1996039147A2 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859000A (en) * | 1995-06-07 | 1999-01-12 | University Of Utah Research Foundation | Method for reducing mast cell mediated allergic reactions |
| KR100598723B1 (ko) * | 1998-07-14 | 2006-07-11 | 알콘 매뉴팩츄어링, 리미티드 | 비알레르기성 안염증 질환 치료 및 안혈관신생 예방용약제를 제조하기 위한11-(3-디메틸아미노프로필리덴)-6,11-디하이드로디벤즈[β,ε]옥세핀-2-아세트산의 용도 |
| US6174914B1 (en) | 1999-06-15 | 2001-01-16 | Alcon Laboratories, Inc. | Method of inhibiting cytokine release from human ocular cells |
| CA2374002A1 (fr) | 1999-06-18 | 2000-12-28 | Alcon Laboratories, Inc. | Stabilisateur de mastocytes a usage ophtalmique topique, pour traiter les affections allergiques des yeux |
| ATE291913T1 (de) | 2000-01-25 | 2005-04-15 | Alcon Inc | Antiallergische ophthalmische zubereitungen, geeignet zur anwendung mit kontaktlinsen |
| CN1173697C (zh) | 2000-05-19 | 2004-11-03 | 爱尔康公司 | 用于治疗过敏性疾病的苯胺二硫化物衍生物 |
| CN1172666C (zh) | 2000-05-19 | 2004-10-27 | 爱尔康公司 | 用于治疗过敏性疾病的含有苯甲酰胺二硫化物衍生物的组合物 |
| AU5567501A (en) | 2000-05-19 | 2001-12-03 | Alcon Universal Ltd | Disulfide derivatives useful for treating allergic diseases |
| AU2002316887A1 (en) * | 2001-05-03 | 2002-11-18 | Novartis Ag | Anti-ige antibody to treat ocular allergies |
| TWI231759B (en) * | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| US7977376B2 (en) | 2001-06-27 | 2011-07-12 | Novartis Ag | Olopatadine formulations for topical nasal administration |
| BR0214643A (pt) * | 2001-12-05 | 2004-11-03 | Alcon Inc | Aplicação de um antagonista h1, e um esteróide seguro para tratar rinite |
| US20050209312A1 (en) * | 2004-03-19 | 2005-09-22 | Bausch & Lomb Incorporated | Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative |
| US20050288283A1 (en) * | 2004-06-28 | 2005-12-29 | Alcon, Inc. | Topical formulations for treating allergic diseases |
| CN103860540A (zh) * | 2004-11-24 | 2014-06-18 | 爱尔康公司 | 奥洛他定在治疗鼻子过敏或发炎状态的制剂制备中的用途 |
| ES2437077T3 (es) * | 2005-07-08 | 2014-01-08 | Senju Pharmaceutical Co., Ltd. | Preparado oftálmico de absorción percutánea que comprende olopatadina |
| DK3150209T3 (da) | 2006-03-31 | 2019-10-28 | Vistakon Pharmaceuticals Llc | Okulære allergibehandlinger |
| US20080139531A1 (en) * | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
| ES2781090T3 (es) | 2007-02-07 | 2020-08-28 | Novartis Ag | Formulaciones de olopatadina para administración nasal tópica |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| JP2010523695A (ja) * | 2007-04-11 | 2010-07-15 | アルコン リサーチ， リミテッド | アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのＴＮＦαのインヒビターおよび抗ヒスタミン薬の使用 |
| US20100227917A1 (en) * | 2007-09-06 | 2010-09-09 | Masashi Nakakura | EYE DROP CONTAINING DIBENZ[b,e]OXEPIN DERIVATIVE |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
| IT1397503B1 (it) | 2009-04-21 | 2013-01-16 | F S I Fabbrica Italiana Sint | Processo per la preparazione di olopatadina |
| MX2012000539A (es) * | 2009-07-17 | 2012-02-28 | Alcon Res Ltd | Regimen de rocio nasal de olopatadina para niños. |
| WO2011027322A1 (fr) | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Forme galénique à libération prolongée contenant de l'olopatadine pour une administration orale |
| MX2012003693A (es) * | 2009-10-01 | 2012-04-19 | Alcon Res Ltd | Composiciones de olopatadine y usos de las mismas. |
| TW201206936A (en) | 2010-07-19 | 2012-02-16 | Alcon Res Ltd | Methods and compositions for the treatment of allergy |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| CN103202833A (zh) * | 2012-12-25 | 2013-07-17 | 常州市亚邦医药研究所有限公司 | 一种奥洛他定或其盐的药用组合物及其制备方法 |
| US20150119455A1 (en) * | 2013-10-31 | 2015-04-30 | Nephron Pharmaceuticals Corporation | Formulation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4370324A (en) * | 1980-09-17 | 1983-01-25 | Bernstein Joel E | Method and composition for treating and preventing irritation of the eyes |
| US4923892A (en) * | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
| GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| JPS6310784A (ja) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
-
1995
- 1995-06-06 US US08/469,729 patent/US5641805A/en not_active Expired - Lifetime
-
1996
- 1996-05-03 CA CA002195094A patent/CA2195094C/fr not_active Expired - Lifetime
- 1996-05-03 WO PCT/US1996/006289 patent/WO1996039147A2/fr active IP Right Grant
- 1996-05-03 DE DE69622527T patent/DE69622527T2/de not_active Expired - Lifetime
- 1996-05-03 AT AT96915500T patent/ATE220906T1/de active
- 1996-05-03 CN CN96190605A patent/CN1082367C/zh not_active Ceased
- 1996-05-03 KR KR1019970700721A patent/KR100202155B1/ko active IP Right Review Request
- 1996-05-03 DE DE2002199034 patent/DE10299034I2/de active Active
- 1996-05-03 EP EP96915500A patent/EP0799044B1/fr not_active Expired - Lifetime
- 1996-05-03 DK DK96915500T patent/DK0799044T3/da active
- 1996-05-03 JP JP9500510A patent/JP3068858B2/ja not_active Expired - Lifetime
- 1996-05-03 PT PT96915500T patent/PT799044E/pt unknown
- 1996-05-03 AU AU57261/96A patent/AU698854B2/en not_active Expired
- 1996-05-03 ES ES96915500T patent/ES2179198T3/es not_active Expired - Lifetime
- 1996-05-03 MX MX9701013A patent/MX9701013A/es unknown
- 1996-05-14 MY MYPI96001818A patent/MY116651A/en unknown
- 1996-06-04 TW TW085106668A patent/TW438588B/zh not_active IP Right Cessation
-
1997
- 1997-02-05 FI FI970489A patent/FI970489A0/fi unknown
- 1997-02-05 NO NO19970517A patent/NO311637B1/no not_active IP Right Cessation
-
2002
- 2002-09-19 NL NL300101C patent/NL300101I2/nl unknown
- 2002-10-02 LU LU90969C patent/LU90969I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE10299034I2 (de) | 2005-07-07 |
| MX9701013A (es) | 1997-05-31 |
| KR100202155B1 (ko) | 1999-06-15 |
| DE69622527D1 (de) | 2002-08-29 |
| KR970704452A (ko) | 1997-09-06 |
| CA2195094A1 (fr) | 1996-12-12 |
| JP3068858B2 (ja) | 2000-07-24 |
| DE69622527T2 (de) | 2002-12-05 |
| MY116651A (en) | 2004-03-31 |
| DE10299034I1 (de) | 2003-01-23 |
| WO1996039147A3 (fr) | 1997-02-20 |
| DK0799044T3 (da) | 2002-10-14 |
| FI970489A (fi) | 1997-02-05 |
| NO970517L (no) | 1997-04-03 |
| AU698854B2 (en) | 1998-11-12 |
| US5641805A (en) | 1997-06-24 |
| WO1996039147A2 (fr) | 1996-12-12 |
| JPH09510235A (ja) | 1997-10-14 |
| NL300101I1 (nl) | 2002-12-02 |
| NL300101I2 (nl) | 2003-01-06 |
| AU5726196A (en) | 1996-12-24 |
| CA2195094C (fr) | 2002-02-26 |
| LU90969I2 (fr) | 2002-12-02 |
| TW438588B (en) | 2001-06-07 |
| NO970517D0 (no) | 1997-02-05 |
| FI970489A0 (fi) | 1997-02-05 |
| ES2179198T3 (es) | 2003-01-16 |
| CN1161000A (zh) | 1997-10-01 |
| PT799044E (pt) | 2002-11-29 |
| EP0799044A2 (fr) | 1997-10-08 |
| EP0799044B1 (fr) | 2002-07-24 |
| ATE220906T1 (de) | 2002-08-15 |
| CN1082367C (zh) | 2002-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |