NO311573B1 - Reversible proteasehemmere - Google Patents

Info

Publication number

NO311573B1

NO311573B1 NO19974403A NO974403A NO311573B1 NO 311573 B1 NO311573 B1 NO 311573B1 NO 19974403 A NO19974403 A NO 19974403A NO 974403 A NO974403 A NO 974403A NO 311573 B1 NO311573 B1 NO 311573B1

Authority

NO

Norway

Prior art keywords

phenyl

compound according

alkyl

naphthyl

morpholinylcarbonyl

Prior art date

1995-03-24

Links

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• 230000002441 reversible effect Effects 0.000 title description 11
• 239000000137 peptide hydrolase inhibitor Substances 0.000 title description 5
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title description 3
• -1 phenylacetyl Chemical group 0.000 claims description 153
• 150000001875 compounds Chemical class 0.000 claims description 100
• 239000000203 mixture Substances 0.000 claims description 92
• 239000000460 chlorine Substances 0.000 claims description 43
• 125000000217 alkyl group Chemical group 0.000 claims description 35
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
• 150000003254 radicals Chemical class 0.000 claims description 28
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 25
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 24
• 229910052739 hydrogen Inorganic materials 0.000 claims description 24
• 239000001257 hydrogen Substances 0.000 claims description 21
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 21
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 21
• 125000003118 aryl group Chemical group 0.000 claims description 20
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 18
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 12
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 12
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 12
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• 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims description 11
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