NO311524B1 - Aminoacetylmercaptoacetylamidderivater som er anvendbare som inhibitorer av enkefalinase og ACE, farmasöytisk preparat ogfremgangsmåte for fremstilling av forbindelsene - Google Patents
Aminoacetylmercaptoacetylamidderivater som er anvendbare som inhibitorer av enkefalinase og ACE, farmasöytisk preparat ogfremgangsmåte for fremstilling av forbindelsene Download PDFInfo
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- NO311524B1 NO311524B1 NO19942994A NO942994A NO311524B1 NO 311524 B1 NO311524 B1 NO 311524B1 NO 19942994 A NO19942994 A NO 19942994A NO 942994 A NO942994 A NO 942994A NO 311524 B1 NO311524 B1 NO 311524B1
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- Norway
- Prior art keywords
- oxo
- phenylpropyl
- mmol
- carboxylic acid
- acid
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- 230000000304 vasodilatating effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- NXSIJWJXMWBCBX-NWKQFZAZSA-N α-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 NXSIJWJXMWBCBX-NWKQFZAZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83602892A | 1992-02-14 | 1992-02-14 | |
| US98567892A | 1992-12-11 | 1992-12-11 | |
| PCT/US1993/000153 WO1993016103A1 (en) | 1992-02-14 | 1993-01-08 | Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO942994D0 NO942994D0 (no) | 1994-08-12 |
| NO942994L NO942994L (no) | 1994-10-13 |
| NO311524B1 true NO311524B1 (no) | 2001-12-03 |
Family
ID=27125838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19942994A NO311524B1 (no) | 1992-02-14 | 1994-08-12 | Aminoacetylmercaptoacetylamidderivater som er anvendbare som inhibitorer av enkefalinase og ACE, farmasöytisk preparat ogfremgangsmåte for fremstilling av forbindelsene |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US5424425A (uk) |
| EP (1) | EP0625987B1 (uk) |
| JP (1) | JP3460838B2 (uk) |
| KR (1) | KR100276029B1 (uk) |
| AT (1) | ATE164593T1 (uk) |
| AU (1) | AU668707B2 (uk) |
| CA (1) | CA2130116C (uk) |
| DE (1) | DE69317764T2 (uk) |
| DK (1) | DK0625987T3 (uk) |
| ES (1) | ES2117123T3 (uk) |
| FI (1) | FI106717B (uk) |
| HU (1) | HU220596B1 (uk) |
| IL (1) | IL104716A (uk) |
| MX (1) | MX9300777A (uk) |
| NO (1) | NO311524B1 (uk) |
| NZ (1) | NZ246811A (uk) |
| TW (1) | TW225534B (uk) |
| WO (1) | WO1993016103A1 (uk) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2130116C (en) * | 1992-02-14 | 1998-04-07 | Gary A. Flynn | Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5646276A (en) * | 1992-05-13 | 1997-07-08 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
| US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
| NZ267161A (en) * | 1993-06-11 | 1996-12-20 | Eisai Co Ltd | Dipeptidic benzazepine derivative with ace inhibiting activity |
| US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
| PT750631E (pt) * | 1994-02-14 | 2000-07-31 | Merrell Pharma Inc | Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace |
| WO1995021840A1 (en) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase |
| CN1142831A (zh) * | 1994-02-14 | 1997-02-12 | 默里尔药物公司 | 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物 |
| DE69514912T2 (de) * | 1994-03-24 | 2000-10-05 | Merrell Pharmaceuticals Inc., Cincinnati | Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten |
| US5616775A (en) * | 1994-05-05 | 1997-04-01 | Bristol-Myers Squibb Co. | Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring |
| US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
| US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
| US6699869B1 (en) | 1995-03-24 | 2004-03-02 | Myriad Genetics Inc. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
| US6020331A (en) * | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
| US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
| US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
| US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
| US6117896A (en) | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
| US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| JP2002503674A (ja) * | 1998-02-12 | 2002-02-05 | モレキュメティックス リミテッド | βシート模倣物およびその使用に関する方法 |
| JP4588877B2 (ja) | 1998-06-17 | 2010-12-01 | ブリストル−マイヤーズ スクイブ カンパニー | Ａｄｐ−受容体抗血小板物質と抗高血圧薬の組合せ投与による脳梗塞の予防 |
| CA2358955A1 (en) * | 1998-12-31 | 2000-07-13 | Aventis Pharmaceuticals Inc. | N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase |
| CA2358939A1 (en) * | 1998-12-31 | 2000-07-13 | Joseph P. Burkhart | 3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase |
| US6486193B2 (en) | 1998-12-31 | 2002-11-26 | Aventis Pharmaceuticals Inc. | 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| AU2003219809A1 (en) | 2002-02-14 | 2003-09-04 | Myriad Genetics, Inc. | Beta-sheet mimetics and composition and methods relating thereto |
| DE10229180A1 (de) * | 2002-06-28 | 2004-01-29 | Aventis Pharma Deutschland Gmbh | Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3334095A (en) * | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
| US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
| GB1525845A (en) * | 1976-07-30 | 1978-09-20 | Ucb Sa | 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones |
| IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
| EP0042100A1 (de) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
| US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
| US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
| US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
| IL78634A0 (en) * | 1985-04-30 | 1986-08-31 | Lilly Co Eli | 7-substituted bicyclic pyrazolidinones |
| ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
| CA1337654C (en) * | 1986-06-13 | 1995-11-28 | Gary A. Flynn | Fused tricyclic lactams as antihypertensive agents |
| US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
| GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
| US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
| WO1993005809A1 (en) * | 1991-09-16 | 1993-04-01 | Schering Corporation | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation |
| CA2078759C (en) * | 1991-09-27 | 2003-09-16 | Alan M. Warshawsky | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace |
| CA2130116C (en) * | 1992-02-14 | 1998-04-07 | Gary A. Flynn | Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
| US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
-
1993
- 1993-01-08 CA CA002130116A patent/CA2130116C/en not_active Expired - Fee Related
- 1993-01-08 HU HU9402355A patent/HU220596B1/hu not_active IP Right Cessation
- 1993-01-08 NZ NZ246811A patent/NZ246811A/en unknown
- 1993-01-08 DE DE69317764T patent/DE69317764T2/de not_active Expired - Fee Related
- 1993-01-08 ES ES93903024T patent/ES2117123T3/es not_active Expired - Lifetime
- 1993-01-08 KR KR1019940702796A patent/KR100276029B1/ko not_active IP Right Cessation
- 1993-01-08 JP JP51405693A patent/JP3460838B2/ja not_active Expired - Fee Related
- 1993-01-08 AU AU34391/93A patent/AU668707B2/en not_active Ceased
- 1993-01-08 AT AT93903024T patent/ATE164593T1/de not_active IP Right Cessation
- 1993-01-08 DK DK93903024T patent/DK0625987T3/da active
- 1993-01-08 EP EP93903024A patent/EP0625987B1/en not_active Expired - Lifetime
- 1993-01-08 WO PCT/US1993/000153 patent/WO1993016103A1/en active IP Right Grant
- 1993-02-09 TW TW082100886A patent/TW225534B/zh active
- 1993-02-12 IL IL104716A patent/IL104716A/xx not_active IP Right Cessation
- 1993-02-12 MX MX9300777A patent/MX9300777A/es unknown
- 1993-09-10 US US08/119,924 patent/US5424425A/en not_active Expired - Lifetime
-
1994
- 1994-08-12 FI FI943728A patent/FI106717B/fi not_active IP Right Cessation
- 1994-08-12 NO NO19942994A patent/NO311524B1/no not_active IP Right Cessation
-
1995
- 1995-03-01 US US08/397,294 patent/US5529995A/en not_active Expired - Fee Related
- 1995-03-01 US US08/396,999 patent/US5488048A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW225534B (uk) | 1994-06-21 |
| AU3439193A (en) | 1993-09-03 |
| KR100276029B1 (ko) | 2000-12-15 |
| IL104716A (en) | 1997-09-30 |
| HUT71105A (en) | 1995-11-28 |
| US5529995A (en) | 1996-06-25 |
| JPH07503955A (ja) | 1995-04-27 |
| WO1993016103A1 (en) | 1993-08-19 |
| ES2117123T3 (es) | 1998-08-01 |
| US5488048A (en) | 1996-01-30 |
| KR950700323A (ko) | 1995-01-16 |
| DE69317764T2 (de) | 1998-07-30 |
| HU220596B1 (hu) | 2002-03-28 |
| FI106717B (fi) | 2001-03-30 |
| FI943728A0 (fi) | 1994-08-12 |
| AU668707B2 (en) | 1996-05-16 |
| ATE164593T1 (de) | 1998-04-15 |
| IL104716A0 (en) | 1993-06-10 |
| EP0625987B1 (en) | 1998-04-01 |
| HU9402355D0 (en) | 1994-10-28 |
| DK0625987T3 (da) | 1999-01-11 |
| CA2130116A1 (en) | 1993-08-19 |
| US5424425A (en) | 1995-06-13 |
| CA2130116C (en) | 1998-04-07 |
| FI943728A (fi) | 1994-08-12 |
| NO942994L (no) | 1994-10-13 |
| MX9300777A (es) | 1993-08-01 |
| EP0625987A1 (en) | 1994-11-30 |
| JP3460838B2 (ja) | 2003-10-27 |
| NO942994D0 (no) | 1994-08-12 |
| DE69317764D1 (de) | 1998-05-07 |
| NZ246811A (en) | 1996-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |