NO310240B1 - Tripeptidforbindelser med antitrombotisk aktivitet, farmasöytisk formulering inneholdende slike forbindelser, oganvendelse derav - Google Patents

Tripeptidforbindelser med antitrombotisk aktivitet, farmasöytisk formulering inneholdende slike forbindelser, oganvendelse derav Download PDF

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Publication number
NO310240B1
NO310240B1 NO19943402A NO943402A NO310240B1 NO 310240 B1 NO310240 B1 NO 310240B1 NO 19943402 A NO19943402 A NO 19943402A NO 943402 A NO943402 A NO 943402A NO 310240 B1 NO310240 B1 NO 310240B1
Authority
NO
Norway
Prior art keywords
acid
compound
compounds
arg
added
Prior art date
Application number
NO19943402A
Other languages
English (en)
Norwegian (no)
Other versions
NO943402D0 (no
NO943402L (no
Inventor
Paul David Gesellchen
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO943402D0 publication Critical patent/NO943402D0/no
Publication of NO943402L publication Critical patent/NO943402L/no
Publication of NO310240B1 publication Critical patent/NO310240B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO19943402A 1993-09-14 1994-09-13 Tripeptidforbindelser med antitrombotisk aktivitet, farmasöytisk formulering inneholdende slike forbindelser, oganvendelse derav NO310240B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/121,134 US5430023A (en) 1990-09-28 1993-09-14 Tripeptide antithrombotic agents

Publications (3)

Publication Number Publication Date
NO943402D0 NO943402D0 (no) 1994-09-13
NO943402L NO943402L (no) 1995-03-15
NO310240B1 true NO310240B1 (no) 2001-06-11

Family

ID=22394776

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19943402A NO310240B1 (no) 1993-09-14 1994-09-13 Tripeptidforbindelser med antitrombotisk aktivitet, farmasöytisk formulering inneholdende slike forbindelser, oganvendelse derav

Country Status (31)

Country Link
US (1) US5430023A (sv)
EP (1) EP0643073B1 (sv)
JP (1) JPH07149791A (sv)
KR (1) KR100312388B1 (sv)
CN (1) CN1055698C (sv)
AT (1) ATE160574T1 (sv)
AU (1) AU674773B2 (sv)
BR (1) BR9403542A (sv)
CA (1) CA2131982C (sv)
CO (1) CO4290364A1 (sv)
CY (1) CY2072B1 (sv)
CZ (1) CZ286139B6 (sv)
DE (1) DE69407006T2 (sv)
DK (1) DK0643073T3 (sv)
ES (1) ES2110186T3 (sv)
FI (1) FI944231A (sv)
GR (1) GR3026115T3 (sv)
HU (1) HU220620B1 (sv)
IL (1) IL110933A (sv)
MY (1) MY112879A (sv)
NO (1) NO310240B1 (sv)
NZ (1) NZ264438A (sv)
PE (1) PE43695A1 (sv)
PH (1) PH31655A (sv)
PL (1) PL176448B1 (sv)
RU (1) RU2105010C1 (sv)
SI (1) SI0643073T1 (sv)
TW (1) TW275622B (sv)
UA (1) UA32556C2 (sv)
YU (1) YU54194A (sv)
ZA (1) ZA947015B (sv)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760235A (en) * 1992-03-04 1998-06-02 Gyogyszerkutato Intezet Kft. Anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for preparation thereof
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
JPH09509943A (ja) * 1994-03-04 1997-10-07 イーライ・リリー・アンド・カンパニー 抗血栓剤
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5691356A (en) * 1994-03-21 1997-11-25 Bristol-Myers Squibb Company Disubstituted heterocyclic thrombin inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US6046169A (en) * 1995-06-07 2000-04-04 Cor Therapeutics, Inc. Inhibitors of factor XA
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6245743B1 (en) 1996-06-05 2001-06-12 Cor Therapeutics, Inc. Inhibitors of factor Xa
JP3539607B2 (ja) * 1997-02-19 2004-07-07 シャープ株式会社 空気調和機の運転制御システム
JP2001525823A (ja) 1997-05-15 2001-12-11 イーライ・リリー・アンド・カンパニー 抗血栓化合物
US6903075B1 (en) 1997-05-29 2005-06-07 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
WO1999064395A1 (en) * 1998-06-11 1999-12-16 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
SE9802973D0 (sv) * 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
US6172081B1 (en) 1999-06-24 2001-01-09 Novartis Ag Tetrahydroisoquinoline 3-carboxamide derivatives
JP4373792B2 (ja) * 2002-02-11 2009-11-25 ゴールド−ティー テック インコーポレイテッド 血栓形成を予防する方法
US7205315B2 (en) 2003-09-27 2007-04-17 Sanofi-Aventis Deutschland Gmbh Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases
CN102391360B (zh) * 2011-11-02 2013-07-03 东南大学 一种抗血栓和血小板聚集的小肽
KR102388531B1 (ko) * 2021-07-07 2022-04-21 이재호 특장차용 스마트 유압 시스템

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
DE3827415A1 (de) * 1988-08-12 1990-02-15 Behringwerke Ag Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
MY112879A (en) 2001-10-31
HUT67849A (en) 1995-05-29
YU54194A (sh) 1997-01-08
US5430023A (en) 1995-07-04
RU2105010C1 (ru) 1998-02-20
CZ286139B6 (cs) 2000-01-12
BR9403542A (pt) 1995-06-20
KR100312388B1 (ko) 2001-12-28
CN1055698C (zh) 2000-08-23
PL305009A1 (en) 1995-03-20
IL110933A0 (en) 1994-11-28
NZ264438A (en) 1996-06-25
ZA947015B (en) 1996-03-12
FI944231A (sv) 1995-03-15
UA32556C2 (uk) 2001-02-15
HU220620B1 (hu) 2002-03-28
DE69407006T2 (de) 1998-04-16
KR950008534A (ko) 1995-04-19
PE43695A1 (es) 1995-12-09
TW275622B (sv) 1996-05-11
NO943402D0 (no) 1994-09-13
JPH07149791A (ja) 1995-06-13
HU9402626D0 (en) 1994-11-28
ATE160574T1 (de) 1997-12-15
GR3026115T3 (en) 1998-05-29
SI0643073T1 (en) 1998-08-31
PH31655A (en) 1999-01-12
CO4290364A1 (es) 1996-04-17
DE69407006D1 (de) 1998-01-08
EP0643073B1 (en) 1997-11-26
IL110933A (en) 1998-12-27
ES2110186T3 (es) 1998-02-01
RU94034734A (ru) 1996-07-20
DK0643073T3 (da) 1997-12-29
CN1106819A (zh) 1995-08-16
NO943402L (no) 1995-03-15
AU7294894A (en) 1995-03-30
AU674773B2 (en) 1997-01-09
FI944231A0 (sv) 1994-09-13
EP0643073A1 (en) 1995-03-15
CA2131982A1 (en) 1995-03-15
CA2131982C (en) 2003-07-29
CY2072B1 (en) 1998-09-11
PL176448B1 (pl) 1999-05-31
CZ222094A3 (en) 1995-03-15

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