NO308845B1 - Nye benzylpyrimidiner - Google Patents
Nye benzylpyrimidinerInfo
- Publication number
- NO308845B1 NO308845B1 NO972393A NO972393A NO308845B1 NO 308845 B1 NO308845 B1 NO 308845B1 NO 972393 A NO972393 A NO 972393A NO 972393 A NO972393 A NO 972393A NO 308845 B1 NO308845 B1 NO 308845B1
- Authority
- NO
- Norway
- Prior art keywords
- pct
- date
- heteroaryl
- sec
- aryl
- Prior art date
Links
- OOLOAWZLPBDRJQ-UHFFFAOYSA-N 2-benzylpyrimidine Chemical class N=1C=CC=NC=1CC1=CC=CC=C1 OOLOAWZLPBDRJQ-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- -1 ethylene, vinylene Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH353694 | 1994-11-24 | ||
| CH270495 | 1995-09-25 | ||
| PCT/EP1995/004451 WO1996016046A2 (en) | 1994-11-24 | 1995-11-13 | Novel benzyl pyrimidines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO972393D0 NO972393D0 (no) | 1997-05-26 |
| NO972393L NO972393L (no) | 1997-05-29 |
| NO308845B1 true NO308845B1 (no) | 2000-11-06 |
Family
ID=25691190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO972393A NO308845B1 (no) | 1994-11-24 | 1997-05-26 | Nye benzylpyrimidiner |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5763450A (ja) |
| EP (1) | EP0793656B1 (ja) |
| JP (1) | JP3117721B2 (ja) |
| KR (1) | KR100417508B1 (ja) |
| CN (1) | CN1136198C (ja) |
| AT (1) | ATE235471T1 (ja) |
| AU (1) | AU704911B2 (ja) |
| BR (1) | BR9509768A (ja) |
| CA (1) | CA2205406C (ja) |
| CZ (1) | CZ157597A3 (ja) |
| DE (1) | DE69530104T2 (ja) |
| DK (1) | DK0793656T3 (ja) |
| ES (1) | ES2193205T3 (ja) |
| FI (1) | FI972194A0 (ja) |
| HU (1) | HUT77372A (ja) |
| MX (1) | MX9703687A (ja) |
| NO (1) | NO308845B1 (ja) |
| NZ (1) | NZ296532A (ja) |
| PL (1) | PL320458A1 (ja) |
| PT (1) | PT793656E (ja) |
| WO (1) | WO1996016046A2 (ja) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
| PT966464E (pt) * | 1997-03-03 | 2003-09-30 | Basilea Pharmaceutica Ag | 2,4-diaminopirimidinas substituidas |
| WO1998039328A1 (en) * | 1997-03-03 | 1998-09-11 | F.Hoffmann-La Roche Ag | Substituted 2,4-diaminopyrimidines |
| WO1999000359A1 (fr) * | 1997-06-27 | 1999-01-07 | Fujisawa Pharmaceutical Co., Ltd. | Derives de noyau aromatique |
| US6893815B1 (en) * | 1997-06-30 | 2005-05-17 | Isis Pharmaceuticals, Inc. | Nucleobase heterocyclic combinatorialization |
| JP4370002B2 (ja) * | 1997-08-08 | 2009-11-25 | 富山化学工業株式会社 | キノロンカルボン酸誘導体またはその塩 |
| CA2309882A1 (en) * | 1997-12-22 | 1999-07-01 | Pharmacia & Upjohn Company | 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents |
| JP3346766B2 (ja) * | 1998-04-06 | 2002-11-18 | 富山化学工業株式会社 | キノロンカルボン酸誘導体またはその塩 |
| AU4483000A (en) * | 1999-04-23 | 2000-11-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) |
| EP1230224B1 (de) * | 1999-11-04 | 2004-12-29 | Basilea Pharmaceutica AG | Substituierte 5-benzyl-2,4-diaminopyrimidine |
| US7612065B2 (en) | 2000-04-21 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-JUN N-terminal kinases (JNK) |
| PE20011349A1 (es) | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales |
| AU2001278480A1 (en) * | 2000-07-24 | 2002-02-05 | Bayer Crop Science Ag | Biphenyl carboxamides |
| HUP0301189A3 (en) * | 2000-07-24 | 2003-11-28 | Bayer Cropscience Ag | Pyrazolyl biphenyl carboxamides, intermediates, preparation and use thereof for controlling undesired microorganisms |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| BR0213233A (pt) | 2001-10-12 | 2005-01-04 | Warner Lambert Co | Alcinos inibidores de metaloproteinase de matriz |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| EP1403271B1 (en) * | 2002-09-25 | 2005-11-16 | Degussa AG | Method of producing 5-formyl-2-furylboronic acid |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| CN101296907B (zh) * | 2005-09-01 | 2013-03-27 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类 |
| US8268825B2 (en) | 2005-09-26 | 2012-09-18 | The Board Of Regents For Oklahoma State University | Method for the treatment of anthrax infections |
| JP5128603B2 (ja) * | 2006-10-04 | 2013-01-23 | エフ．ホフマン−ラ ロシュ アーゲー | フェノキシジアミノピリミジン誘導体の合成方法 |
| AU2008251723A1 (en) | 2007-04-20 | 2008-11-20 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| US8853228B2 (en) * | 2007-06-04 | 2014-10-07 | University Of Connecticut | Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase |
| US20090136473A1 (en) | 2007-11-21 | 2009-05-28 | Decode Genetics Ehf | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| GB0815962D0 (en) * | 2008-09-02 | 2008-10-08 | Merlion Pharmaceuticals Pte Ltd | Hybrid antibacterial compounds and their use |
| KR20110099687A (ko) | 2008-10-29 | 2011-09-08 | 데시페라 파마슈티칼스, 엘엘씨. | 항-암과 항-증식성 활성을 나타내는 시클로프로판 아미드와 유사체 |
| CA2772916C (en) | 2009-09-02 | 2019-01-15 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| CN102040591B (zh) * | 2009-10-15 | 2013-12-11 | 山东轩竹医药科技有限公司 | 7-苯基喹诺酮类化合物 |
| EA201390341A1 (ru) * | 2010-09-01 | 2013-08-30 | Новартис Аг | Адсорбция иммунопотенциаторов на нерастворимых солях металлов |
| KR20140026392A (ko) | 2011-03-02 | 2014-03-05 | 노파르티스 아게 | 저용량의 항원 및/또는 보조제를 갖는 조합 백신 |
| US9375471B2 (en) | 2012-03-08 | 2016-06-28 | Glaxosmithkline Biologicals Sa | Adjuvanted formulations of booster vaccines |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CA3089630A1 (en) | 2018-01-31 | 2019-08-08 | Deciphera Pharmaceuticals, Llc | Combination therapy for the treatment of mastocytosis |
| SG11202007198WA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
| TW202122082A (zh) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| EP4013412A1 (en) | 2019-08-12 | 2022-06-22 | Deciphera Pharmaceuticals, LLC | Ripretinib for treating gastrointestinal stromal tumors |
| EP4084779B1 (en) | 2019-12-30 | 2024-10-09 | Deciphera Pharmaceuticals, LLC | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| EP4084778B1 (en) | 2019-12-30 | 2023-11-01 | Deciphera Pharmaceuticals, LLC | Amorphous kinase inhibitor formulations and methods of use thereof |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
| US4039543A (en) * | 1974-12-24 | 1977-08-02 | Hoffmann-La Roche Inc. | Benzylpyrimidines |
| CA2095518A1 (en) * | 1990-11-14 | 1992-05-15 | Jeffrey M. Blaney | Specific inhibition of dihydrofolate reductase and compounds therefor |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
-
1995
- 1995-11-13 AU AU41161/96A patent/AU704911B2/en not_active Ceased
- 1995-11-13 BR BR9509768A patent/BR9509768A/pt not_active Application Discontinuation
- 1995-11-13 ES ES95939267T patent/ES2193205T3/es not_active Expired - Lifetime
- 1995-11-13 HU HU9701973A patent/HUT77372A/hu unknown
- 1995-11-13 CZ CZ971575A patent/CZ157597A3/cs unknown
- 1995-11-13 AT AT95939267T patent/ATE235471T1/de not_active IP Right Cessation
- 1995-11-13 DE DE69530104T patent/DE69530104T2/de not_active Expired - Lifetime
- 1995-11-13 US US08/836,857 patent/US5763450A/en not_active Expired - Lifetime
- 1995-11-13 WO PCT/EP1995/004451 patent/WO1996016046A2/en active IP Right Grant
- 1995-11-13 JP JP08516521A patent/JP3117721B2/ja not_active Expired - Lifetime
- 1995-11-13 CA CA002205406A patent/CA2205406C/en not_active Expired - Fee Related
- 1995-11-13 DK DK95939267T patent/DK0793656T3/da active
- 1995-11-13 PL PL95320458A patent/PL320458A1/xx unknown
- 1995-11-13 MX MX9703687A patent/MX9703687A/es not_active IP Right Cessation
- 1995-11-13 KR KR1019970703472A patent/KR100417508B1/ko not_active IP Right Cessation
- 1995-11-13 PT PT95939267T patent/PT793656E/pt unknown
- 1995-11-13 CN CNB951963988A patent/CN1136198C/zh not_active Expired - Fee Related
- 1995-11-13 EP EP95939267A patent/EP0793656B1/en not_active Expired - Lifetime
- 1995-11-13 NZ NZ296532A patent/NZ296532A/en unknown
-
1997
- 1997-05-22 FI FI972194A patent/FI972194A0/fi not_active IP Right Cessation
- 1997-05-26 NO NO972393A patent/NO308845B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5763450A (en) | 1998-06-09 |
| JP3117721B2 (ja) | 2000-12-18 |
| CZ157597A3 (en) | 1997-09-17 |
| NZ296532A (en) | 2000-02-28 |
| CN1166831A (zh) | 1997-12-03 |
| FI972194A (fi) | 1997-05-22 |
| EP0793656A1 (en) | 1997-09-10 |
| EP0793656B1 (en) | 2003-03-26 |
| JPH11507009A (ja) | 1999-06-22 |
| BR9509768A (pt) | 1998-07-07 |
| ATE235471T1 (de) | 2003-04-15 |
| NO972393D0 (no) | 1997-05-26 |
| WO1996016046A3 (en) | 1996-07-25 |
| DE69530104D1 (de) | 2003-04-30 |
| KR100417508B1 (ko) | 2004-03-18 |
| ES2193205T3 (es) | 2003-11-01 |
| CN1136198C (zh) | 2004-01-28 |
| FI972194A0 (fi) | 1997-05-22 |
| CA2205406C (en) | 2008-02-05 |
| CA2205406A1 (en) | 1996-05-30 |
| PT793656E (pt) | 2003-07-31 |
| HUT77372A (hu) | 1998-03-30 |
| MX9703687A (es) | 1997-08-30 |
| PL320458A1 (en) | 1997-09-29 |
| DE69530104T2 (de) | 2003-12-24 |
| WO1996016046A2 (en) | 1996-05-30 |
| AU4116196A (en) | 1996-06-17 |
| DK0793656T3 (da) | 2003-07-21 |
| NO972393L (no) | 1997-05-29 |
| AU704911B2 (en) | 1999-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN MAY 2002 |