IE800236L - Esters. - Google Patents

Esters.

Info

Publication number
IE800236L
IE800236L IE800236A IE23680A IE800236L IE 800236 L IE800236 L IE 800236L IE 800236 A IE800236 A IE 800236A IE 23680 A IE23680 A IE 23680A IE 800236 L IE800236 L IE 800236L
Authority
IE
Ireland
Prior art keywords
cycloalkyl
hydrogen
methyl
esters
gb2041937a
Prior art date
Application number
IE800236A
Other versions
IE49385B1 (en
Original Assignee
Merz & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz & Co filed Critical Merz & Co
Publication of IE800236L publication Critical patent/IE800236L/en
Publication of IE49385B1 publication Critical patent/IE49385B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Novel compounds of the formula <IMAGE> wherein R is 3-pyridinyl or 2-(4- chlorophenoxy)-2-methyl-propyl; R<1> is hydrogen, C5-14 cycloalkyl, (C5-14 cycloalkyl)methyl, (C5-14 cycloalkyl)carbonyl, (C5-14 cycloalkyl)acetyl, 1-adamantyl, 1- adamantylmethyl, 1-adamantylcarbonyl, 1-adamantylacetyl, cumyl, p-chlorobenzoyl, piperidino or 2- pyrimidinyl; and R<2> is hydrogen, -(CH2)4-, halogen, C1-6 alkyl, cycloalkyl, methoxy, ethoxy, trifluoromethyl or nitro; provided that R<2> is C1-6 cycloalkyl or -(CH2)4- when R<1> is hydrogen; or a pharmaceutically acceptable acid addition salts thereof may be used in the treatment of hyperlipidemias. [GB2041937A]
IE236/80A 1979-02-08 1980-02-07 Nicotinic and 2-(4-chlorophenoxy)-2-methylpropanoic acid derivatives IE49385B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2904757 1979-02-08

Publications (2)

Publication Number Publication Date
IE800236L true IE800236L (en) 1980-08-08
IE49385B1 IE49385B1 (en) 1985-10-02

Family

ID=6062456

Family Applications (1)

Application Number Title Priority Date Filing Date
IE236/80A IE49385B1 (en) 1979-02-08 1980-02-07 Nicotinic and 2-(4-chlorophenoxy)-2-methylpropanoic acid derivatives

Country Status (22)

Country Link
JP (1) JPS55129245A (en)
AR (1) AR228251A1 (en)
AT (1) AT374797B (en)
AU (1) AU532208B2 (en)
BE (1) BE881626A (en)
CA (1) CA1135689A (en)
CH (1) CH644092A5 (en)
DK (1) DK152360C (en)
ES (1) ES488345A0 (en)
FR (1) FR2448532A1 (en)
GB (1) GB2041937B (en)
GR (1) GR73905B (en)
HU (1) HU182099B (en)
IE (1) IE49385B1 (en)
IL (1) IL59337A (en)
IT (1) IT1141197B (en)
MX (1) MX6377E (en)
NL (1) NL8000826A (en)
PL (1) PL123379B1 (en)
SE (1) SE450381B (en)
SG (1) SG51185G (en)
YU (1) YU33880A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2221681A (en) * 1988-01-22 1990-02-14 Kh Nii Endokrinolog I Khim Undecylic ether n-chlorophenoxyisobutyric acid and a pharmaceutical preparation for treating hyperlipemia based on it

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3175M (en) * 1963-06-25 1965-03-08 Analyses Et De Rech S Biolog M New chemical compounds with peripheral vasodilating action.
DE2352012A1 (en) * 1972-11-01 1974-05-09 Ciba Geigy Ag NEW ALIPHATICALLY SUBSTITUTED ARYLCHALCOGENO-HYDROCARBON DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
ES438246A1 (en) * 1975-06-04 1977-01-16 Alter Sa Process for purifying the mixed ester, ethylene glycol 1-(2-p-chlorophenoxy)-2-methylpropionate nicotinate
JPS57102866A (en) * 1980-12-19 1982-06-26 Kyorin Pharmaceut Co Ltd Nicotinic acid derivative and its preparation

Also Published As

Publication number Publication date
JPS55129245A (en) 1980-10-06
ES8101552A1 (en) 1980-12-16
AU5535580A (en) 1980-08-14
SE450381B (en) 1987-06-22
FR2448532B1 (en) 1984-12-14
GB2041937B (en) 1983-04-13
DK53680A (en) 1980-08-09
IT8019782A0 (en) 1980-02-08
ATA70380A (en) 1983-10-15
AT374797B (en) 1984-05-25
PL123379B1 (en) 1982-10-30
GB2041937A (en) 1980-09-17
DK152360B (en) 1988-02-22
SE8000962L (en) 1980-08-09
GR73905B (en) 1984-05-21
AU532208B2 (en) 1983-09-22
PL221888A1 (en) 1980-10-20
HU182099B (en) 1983-12-28
FR2448532A1 (en) 1980-09-05
IT1141197B (en) 1986-10-01
CH644092A5 (en) 1984-07-13
MX6377E (en) 1985-05-23
ES488345A0 (en) 1980-12-16
YU33880A (en) 1983-06-30
JPS6126993B2 (en) 1986-06-23
NL8000826A (en) 1980-08-12
IL59337A (en) 1984-10-31
BE881626A (en) 1980-08-08
DK152360C (en) 1988-08-01
AR228251A1 (en) 1983-02-15
IE49385B1 (en) 1985-10-02
CA1135689A (en) 1982-11-16
SG51185G (en) 1986-01-24

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Legal Events

Date Code Title Description
MM4A Patent lapsed