GB2221681A - Undecylic ether n-chlorophenoxyisobutyric acid and a pharmaceutical preparation for treating hyperlipemia based on it - Google Patents

Undecylic ether n-chlorophenoxyisobutyric acid and a pharmaceutical preparation for treating hyperlipemia based on it

Info

Publication number
GB2221681A
GB2221681A GB8920466A GB8920466A GB2221681A GB 2221681 A GB2221681 A GB 2221681A GB 8920466 A GB8920466 A GB 8920466A GB 8920466 A GB8920466 A GB 8920466A GB 2221681 A GB2221681 A GB 2221681A
Authority
GB
United Kingdom
Prior art keywords
undecylic
ether
pharmaceutical preparation
treating hyperlipemia
chlorophenoxyisobutyric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8920466A
Other versions
GB8920466D0 (en
Inventor
Volovelsky Lev Natanovich
Natarov Valery Vladimirovich
Checkman Ivan Sergeevich
Tumanov Viktor Andreevich
Zapadnjuk Vitaly Ignatievich
Popova Nadezhda Vasilievna
Shneur Vera Nikolaevna
Korotkov Sergei Alexandrovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH NII ENDOKRINOLOG I KHIM
KI MED I
Original Assignee
KH NII ENDOKRINOLOG I KHIM
KI MED I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KH NII ENDOKRINOLOG I KHIM, KI MED I filed Critical KH NII ENDOKRINOLOG I KHIM
Publication of GB8920466D0 publication Critical patent/GB8920466D0/en
Publication of GB2221681A publication Critical patent/GB2221681A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a new substance-undecylic ether n-chlorophenoxyisobutyric acid and to a pharmaceutical preparation based on it. The undecylic ether n-chlorophenoxyisobutyric acid has formula (I). The claimed combination is an active component of a pharmaceutical preparation for treating hyperlipemia. The claimed preparation is used medically for treating hyperlipemia, in particular arteriosclerosis and a number of vascular diseases.
GB8920466A 1988-01-22 1988-01-22 Undecylic ether n-chlorophenoxyisobutyric acid and a pharmaceutical preparation for treating hyperlipemia based on it Withdrawn GB2221681A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SU1988/000019 WO1989006643A1 (en) 1988-01-22 1988-01-22 UNDECYLIC ETHER n-CHLOROPHENOXYISOBUTYRIC ACID AND A PHARMACEUTICAL PREPARATION FOR TREATING HYPERLIPEMIA BASED ON IT

Publications (2)

Publication Number Publication Date
GB8920466D0 GB8920466D0 (en) 1989-11-01
GB2221681A true GB2221681A (en) 1990-02-14

Family

ID=21617183

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8920466A Withdrawn GB2221681A (en) 1988-01-22 1988-01-22 Undecylic ether n-chlorophenoxyisobutyric acid and a pharmaceutical preparation for treating hyperlipemia based on it

Country Status (6)

Country Link
JP (1) JPH02502998A (en)
DE (1) DE3891219T1 (en)
FR (1) FR2630736B1 (en)
GB (1) GB2221681A (en)
SE (1) SE8903047L (en)
WO (1) WO1989006643A1 (en)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2356655A1 (en) * 1972-11-16 1974-05-22 Funai Pharmaceutical Ind Ltd SUBSTITUTED PHENOXY-ALPHA-METHYLPROPIONIC ACID DERIVATIVES AND METHOD FOR PREPARING THE SAME
DE2461069A1 (en) * 1973-12-27 1975-07-17 Siegfried Ag NEW CHOLESTEROL-LOWERING COMPOUNDS
FR2287215A1 (en) * 1974-10-08 1976-05-07 Nippon Kayaku Kk COMPOSITION OF TABLETS
FR2318621A1 (en) * 1975-07-24 1977-02-18 Takeda Chemical Industries Ltd L-ASCORBIC ACID GRANULES AND TABLETS AND METHOD FOR PREPARING THEM
DE2934300A1 (en) * 1978-08-28 1980-03-06 Ppg Industries Inc TRICHLORPHENOXY ALKANIC CARBON ACIDS, METHOD FOR THE PRODUCTION THEREOF AND CONTAINERS THEREOF FOR THE TREATMENT OF PLANTS
FR2442827A1 (en) * 1978-12-01 1980-06-27 Kaken Chemical Co NOVEL SUBSTITUTED OXY-CYCLOHEXYLACETIC ACIDS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
US4248889A (en) * 1978-10-30 1981-02-03 Sankyo Company Limited 3,5-Dihydroxypentanoic ester derivatives having antihyperlipaemic activity
CH644092A5 (en) * 1979-02-08 1984-07-13 Merz & Co SUBSTITUTED PHENYLESTERS OF NICOTINIC ACID AND 2 (P-CHLORPHENOXY) ISOBUTTERIC ACID.
GB2142822A (en) * 1983-06-29 1985-01-30 Alec Stanley Walter Shaw Nicotine lozenges
EP0142979A2 (en) * 1983-11-15 1985-05-29 Sterwin Ag. Improvements in the production of halocyclopropyl-substituted phenoxyalkanoic acids and esters
AT378952B (en) * 1981-12-14 1985-10-25 Arcana Chem Pharm METHOD FOR PRODUCING PHENOXYISOBUTTERS | UREESTERS
FR2598146A1 (en) * 1986-04-30 1987-11-06 Rech Ind NEW PROCESS FOR THE PREPARATION OF FIBRATES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717669A (en) * 1968-06-18 1973-02-20 American Home Prod 2-phenoxyalkanoic acid esters
FR2085634A1 (en) * 1970-04-14 1971-12-31 Synthelabo 2-(parachlorophenoxy)-2-methyl propionic esters - hypolipemics and hypocholesterolemics
EP0032631A3 (en) * 1980-01-16 1981-11-11 Fbc Limited Herbicidal phenoxyalkanoic acid derivatives, their preparation, compositions containing them, and their use

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2356655A1 (en) * 1972-11-16 1974-05-22 Funai Pharmaceutical Ind Ltd SUBSTITUTED PHENOXY-ALPHA-METHYLPROPIONIC ACID DERIVATIVES AND METHOD FOR PREPARING THE SAME
DE2461069A1 (en) * 1973-12-27 1975-07-17 Siegfried Ag NEW CHOLESTEROL-LOWERING COMPOUNDS
FR2287215A1 (en) * 1974-10-08 1976-05-07 Nippon Kayaku Kk COMPOSITION OF TABLETS
FR2318621A1 (en) * 1975-07-24 1977-02-18 Takeda Chemical Industries Ltd L-ASCORBIC ACID GRANULES AND TABLETS AND METHOD FOR PREPARING THEM
DE2934300A1 (en) * 1978-08-28 1980-03-06 Ppg Industries Inc TRICHLORPHENOXY ALKANIC CARBON ACIDS, METHOD FOR THE PRODUCTION THEREOF AND CONTAINERS THEREOF FOR THE TREATMENT OF PLANTS
US4248889A (en) * 1978-10-30 1981-02-03 Sankyo Company Limited 3,5-Dihydroxypentanoic ester derivatives having antihyperlipaemic activity
FR2442827A1 (en) * 1978-12-01 1980-06-27 Kaken Chemical Co NOVEL SUBSTITUTED OXY-CYCLOHEXYLACETIC ACIDS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
CH644092A5 (en) * 1979-02-08 1984-07-13 Merz & Co SUBSTITUTED PHENYLESTERS OF NICOTINIC ACID AND 2 (P-CHLORPHENOXY) ISOBUTTERIC ACID.
AT378952B (en) * 1981-12-14 1985-10-25 Arcana Chem Pharm METHOD FOR PRODUCING PHENOXYISOBUTTERS | UREESTERS
GB2142822A (en) * 1983-06-29 1985-01-30 Alec Stanley Walter Shaw Nicotine lozenges
EP0142979A2 (en) * 1983-11-15 1985-05-29 Sterwin Ag. Improvements in the production of halocyclopropyl-substituted phenoxyalkanoic acids and esters
FR2598146A1 (en) * 1986-04-30 1987-11-06 Rech Ind NEW PROCESS FOR THE PREPARATION OF FIBRATES

Also Published As

Publication number Publication date
GB8920466D0 (en) 1989-11-01
FR2630736A1 (en) 1989-11-03
FR2630736B1 (en) 1990-08-24
JPH02502998A (en) 1990-09-20
SE8903047D0 (en) 1989-09-15
WO1989006643A1 (en) 1989-07-27
SE8903047L (en) 1989-09-15
DE3891219T1 (en) 1990-02-01

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)