NO306096B1 - Fremgangsmåte for fremstilling av et kolonisk tilförselssystem - Google Patents
Fremgangsmåte for fremstilling av et kolonisk tilförselssystem Download PDFInfo
- Publication number
- NO306096B1 NO306096B1 NO924227A NO924227A NO306096B1 NO 306096 B1 NO306096 B1 NO 306096B1 NO 924227 A NO924227 A NO 924227A NO 924227 A NO924227 A NO 924227A NO 306096 B1 NO306096 B1 NO 306096B1
- Authority
- NO
- Norway
- Prior art keywords
- drug
- stated
- polymer
- colon
- indomethacin
- Prior art date
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- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 150000002341 glycosylamines Chemical class 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 229910001510 metal chloride Inorganic materials 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 210000003249 myenteric plexus Anatomy 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000011224 negative regulation of urine volume Effects 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229940126578 oral vaccine Drugs 0.000 description 1
- 229960004570 oxprenolol Drugs 0.000 description 1
- PLIKAWJENQZMHA-UHFFFAOYSA-N p-hydroxyphenylamine Natural products NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 229920003175 pectinic acid Polymers 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000013047 polymeric layer Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229940124513 senna glycoside Drugs 0.000 description 1
- IPQVTOJGNYVQEO-KGFNBKMBSA-N sennoside A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC2=C1C(=O)C1=C(O)C=C(C(O)=O)C=C1[C@@H]2[C@H]1C2=CC(C(O)=O)=CC(O)=C2C(=O)C2=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C=CC=C21 IPQVTOJGNYVQEO-KGFNBKMBSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000009718 spray deposition Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000002294 steroidal antiinflammatory agent Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 108060007951 sulfatase Proteins 0.000 description 1
- URNFTLVCQLRCMN-UHFFFAOYSA-N sulisatin Chemical compound CC1=CC=CC2=C1NC(=O)C2(C=1C=CC(OS(O)(=O)=O)=CC=1)C1=CC=C(OS(O)(=O)=O)C=C1 URNFTLVCQLRCMN-UHFFFAOYSA-N 0.000 description 1
- 229950007465 sulisatin Drugs 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Percussion Or Vibration Massage (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Surgical Instruments (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Memory System Of A Hierarchy Structure (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51871490A | 1990-05-04 | 1990-05-04 | |
| PCT/US1991/003014 WO1991016881A1 (fr) | 1990-05-04 | 1991-05-02 | Systeme de liberation de medicament colique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO924227D0 NO924227D0 (no) | 1992-11-03 |
| NO924227L NO924227L (no) | 1992-12-30 |
| NO306096B1 true NO306096B1 (no) | 1999-09-20 |
Family
ID=24065163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO924227A NO306096B1 (no) | 1990-05-04 | 1992-11-03 | Fremgangsmåte for fremstilling av et kolonisk tilförselssystem |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0527942B1 (fr) |
| JP (1) | JPH05508631A (fr) |
| KR (1) | KR100194161B1 (fr) |
| AT (1) | ATE185267T1 (fr) |
| AU (1) | AU660147B2 (fr) |
| BR (1) | BR9106419A (fr) |
| CA (1) | CA2082156A1 (fr) |
| DE (2) | DE527942T1 (fr) |
| DK (1) | DK0527942T3 (fr) |
| ES (1) | ES2048133T3 (fr) |
| FI (1) | FI924984A (fr) |
| GR (2) | GR940300025T1 (fr) |
| HU (1) | HU210497B (fr) |
| MC (1) | MC2288A1 (fr) |
| NO (1) | NO306096B1 (fr) |
| RU (1) | RU2113221C1 (fr) |
| WO (1) | WO1991016881A1 (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4209160A1 (de) * | 1992-03-20 | 1993-09-30 | Bauer Kurt Heinz Prof Dr | Vernetzte Polysaccharide, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US5656290A (en) * | 1993-02-26 | 1997-08-12 | The Procter & Gamble Company | Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery |
| CA2176719C (fr) * | 1993-11-17 | 2007-09-18 | Geoffrey Anisson | Procede de diffusion d'acides gras |
| AU695906B2 (en) * | 1993-11-17 | 1998-08-27 | Commonwealth Scientific And Industrial Research Organisation | Fatty acid delivery system |
| DE4340057A1 (de) * | 1993-11-24 | 1995-06-01 | Falk Pharma Gmbh | Budesonid-Arzneimittel zur Verbesserung der enteralen Flüssigkeitsresorption, insbesondere nach postoperativen Zuständen |
| CN1072964C (zh) * | 1994-04-22 | 2001-10-17 | 山之内制药株式会社 | 结肠特异性释药系统 |
| US5849327A (en) * | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
| US5811388A (en) * | 1995-06-07 | 1998-09-22 | Cibus Pharmaceutical, Inc. | Delivery of drugs to the lower GI tract |
| US5656294A (en) * | 1995-06-07 | 1997-08-12 | Cibus Pharmaceutical, Inc. | Colonic delivery of drugs |
| GB9516268D0 (en) | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
| AU710109B2 (en) * | 1996-01-16 | 1999-09-16 | Ap Pharma, Inc. | Topical delivery of drugs to the lower gastrointestinal tract |
| FR2752843B1 (fr) * | 1996-08-30 | 1998-10-16 | Sod Conseils Rech Applic | Copolymeres reticules a base de polymeres polycarboxyliques et leur utilisation comme support de composition pharmaceutique |
| WO1998026767A2 (fr) * | 1996-12-17 | 1998-06-25 | Poli Industria Chimica S.P.A. | Formulations a liberation lente et specifique d'un site, pour l'administration de mesalazine |
| US6229009B1 (en) | 1997-08-29 | 2001-05-08 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Polycarboxylic based cross-linked copolymers |
| CA2317411C (fr) * | 1998-01-30 | 2005-06-28 | Scios Inc. | Apport a liberation lente de peptide ou de proteine |
| KR20000011247A (ko) * | 1998-07-23 | 2000-02-25 | 김윤 | 다당류를이용한대장선택성약물전달조성물및약학제제 |
| IT1303735B1 (it) * | 1998-11-11 | 2001-02-23 | Falorni Italia Farmaceutici S | Acidi ialuronici reticolati e loro usi medici. |
| IT1303738B1 (it) * | 1998-11-11 | 2001-02-23 | Aquisitio S P A | Processo di reticolazione di polisaccaridi carbossilati. |
| ATE314091T1 (de) | 1999-06-09 | 2006-01-15 | Mochida Pharm Co Ltd | System für wirkstofffreisetzung im unteren verdauungstrakt |
| FR2799196B1 (fr) * | 1999-10-04 | 2002-02-08 | Sod Conseils Rech Applic | Copolymeres reticules a base de copolymeres polycarboxyliques non reticules |
| JP2006516396A (ja) * | 2003-01-31 | 2006-07-06 | デーエスエム アイピー アセッツ ベー． ヴェー． | カロテノイドを含む新規な組成物 |
| US7670624B2 (en) | 2004-01-29 | 2010-03-02 | Astella Pharma Inc. | Gastrointestinal-specific multiple drug release system |
| GB0607534D0 (en) * | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| KR101122845B1 (ko) | 2009-07-30 | 2012-03-21 | 부산대학교 산학협력단 | 경구용 염증성 장질환 치료제 |
| US10588857B2 (en) | 2012-03-29 | 2020-03-17 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
| BR112015023124A2 (pt) | 2013-03-14 | 2017-07-18 | Therabiome Llc | liberação de organismos probióticos e/ou agentes terapêuticos almejada para o trato gastrintestinal |
| US10420796B2 (en) | 2015-01-16 | 2019-09-24 | Seikagaku Corporation | Crosslinked chondroitin sulfate, composition containing same, and treatment agent for eye disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7504049L (sv) * | 1975-04-09 | 1976-10-10 | Haessle Ab | Colonpreparation |
| DE2717707C3 (de) * | 1977-04-21 | 1979-11-22 | Chephasaar Chemisch-Pharmazeutische Fabrik Gmbh, 6670 St Ingbert | Karamellisierte Lactulose |
| US4668517A (en) * | 1985-04-04 | 1987-05-26 | Norwich Eaton Pharmaceuticals, Inc. | Furazolidone dosage form |
| ZA881301B (en) * | 1987-02-27 | 1989-10-25 | Lilly Co Eli | Sustained release matrix formulations |
| DK110188D0 (da) * | 1988-03-02 | 1988-03-02 | Claus Selch Larsen | High molecular weight prodrug derivatives of antiinflammatory drugs |
| US4857331A (en) * | 1988-03-31 | 1989-08-15 | Warner-Lambert Company | Sugarless pectin delivery system |
| IT1219942B (it) * | 1988-05-13 | 1990-05-24 | Fidia Farmaceutici | Esteri polisaccaridici |
| DE4006521A1 (de) * | 1990-03-02 | 1991-09-05 | Bayer Ag | Zuckerhaltige polymere zur umhuellung und einbettung von arzneistoffen |
-
1991
- 1991-05-02 RU SU92016384A patent/RU2113221C1/ru active
- 1991-05-02 DE DE91910743T patent/DE527942T1/de active Pending
- 1991-05-02 CA CA002082156A patent/CA2082156A1/fr not_active Abandoned
- 1991-05-02 AT AT91910743T patent/ATE185267T1/de not_active IP Right Cessation
- 1991-05-02 DK DK91910743T patent/DK0527942T3/da active
- 1991-05-02 BR BR919106419A patent/BR9106419A/pt not_active Application Discontinuation
- 1991-05-02 AU AU80877/91A patent/AU660147B2/en not_active Ceased
- 1991-05-02 HU HU9203451A patent/HU210497B/hu not_active IP Right Cessation
- 1991-05-02 MC MC91@@D patent/MC2288A1/fr unknown
- 1991-05-02 JP JP91510595A patent/JPH05508631A/ja active Pending
- 1991-05-02 ES ES91910743T patent/ES2048133T3/es not_active Expired - Lifetime
- 1991-05-02 EP EP91910743A patent/EP0527942B1/fr not_active Revoked
- 1991-05-02 WO PCT/US1991/003014 patent/WO1991016881A1/fr not_active Application Discontinuation
- 1991-05-02 DE DE69131688T patent/DE69131688T2/de not_active Revoked
-
1992
- 1992-11-03 NO NO924227A patent/NO306096B1/no not_active IP Right Cessation
- 1992-11-04 KR KR1019920702750A patent/KR100194161B1/ko not_active IP Right Cessation
- 1992-11-04 FI FI924984A patent/FI924984A/fi unknown
-
1994
- 1994-05-31 GR GR940300025T patent/GR940300025T1/el unknown
-
1999
- 1999-11-18 GR GR990403000T patent/GR3031906T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO924227L (no) | 1992-12-30 |
| DK0527942T3 (da) | 2000-03-27 |
| ATE185267T1 (de) | 1999-10-15 |
| DE69131688D1 (de) | 1999-11-11 |
| MC2288A1 (fr) | 1993-07-14 |
| HU9203451D0 (en) | 1993-05-28 |
| EP0527942A1 (fr) | 1993-02-24 |
| RU2113221C1 (ru) | 1998-06-20 |
| ES2048133T3 (es) | 2000-01-16 |
| ES2048133T1 (es) | 1994-03-16 |
| FI924984A0 (fi) | 1992-11-04 |
| JPH05508631A (ja) | 1993-12-02 |
| GR940300025T1 (fr) | 1994-05-31 |
| HU210497B (en) | 1995-04-28 |
| AU8087791A (en) | 1991-11-27 |
| NO924227D0 (no) | 1992-11-03 |
| FI924984A (fi) | 1992-11-04 |
| DE69131688T2 (de) | 2000-05-25 |
| CA2082156A1 (fr) | 1991-11-05 |
| KR100194161B1 (ko) | 1999-06-15 |
| DE527942T1 (de) | 1994-03-03 |
| EP0527942B1 (fr) | 1999-10-06 |
| HUT64210A (en) | 1993-12-28 |
| WO1991016881A1 (fr) | 1991-11-14 |
| GR3031906T3 (en) | 2000-02-29 |
| EP0527942A4 (en) | 1993-10-13 |
| BR9106419A (pt) | 1993-05-04 |
| AU660147B2 (en) | 1995-06-15 |
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