NO304313B1 - Forbindelser med en sulfamoyl- og amidinogruppe, og farmas°ytiske blandinger som inneholder dem - Google Patents
Forbindelser med en sulfamoyl- og amidinogruppe, og farmas°ytiske blandinger som inneholder demInfo
- Publication number
- NO304313B1 NO304313B1 NO940503A NO940503A NO304313B1 NO 304313 B1 NO304313 B1 NO 304313B1 NO 940503 A NO940503 A NO 940503A NO 940503 A NO940503 A NO 940503A NO 304313 B1 NO304313 B1 NO 304313B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- compounds
- alkylamino
- alkylene
- linked
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- -1 piperidino, morpholino, piperazinyl Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9301686A FR2701480B1 (fr) | 1993-02-15 | 1993-02-15 | Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
Publications (3)
Publication Number | Publication Date |
---|---|
NO940503D0 NO940503D0 (no) | 1994-02-14 |
NO940503L NO940503L (de) | 1994-08-16 |
NO304313B1 true NO304313B1 (no) | 1998-11-30 |
Family
ID=9444071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO940503A NO304313B1 (no) | 1993-02-15 | 1994-02-14 | Forbindelser med en sulfamoyl- og amidinogruppe, og farmas°ytiske blandinger som inneholder dem |
Country Status (23)
Country | Link |
---|---|
US (2) | US5506258A (de) |
EP (1) | EP0614911B1 (de) |
JP (1) | JP2994546B2 (de) |
KR (1) | KR940019682A (de) |
CN (1) | CN1104634A (de) |
AT (1) | ATE179430T1 (de) |
AU (1) | AU673398B2 (de) |
CA (1) | CA2115631A1 (de) |
DE (1) | DE69418083T2 (de) |
DK (1) | DK0614911T3 (de) |
ES (1) | ES2132351T3 (de) |
FI (1) | FI940680A (de) |
FR (1) | FR2701480B1 (de) |
GR (1) | GR3030243T3 (de) |
HU (1) | HUT66960A (de) |
IL (1) | IL108649A (de) |
MX (1) | MX9401191A (de) |
NO (1) | NO304313B1 (de) |
NZ (1) | NZ250878A (de) |
PH (1) | PH30887A (de) |
RU (1) | RU2126382C1 (de) |
TW (1) | TW372233B (de) |
ZA (1) | ZA941029B (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516653A (en) | 1993-12-28 | 1996-05-14 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof |
US5545549A (en) * | 1994-02-03 | 1996-08-13 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof |
US5602024A (en) | 1994-12-02 | 1997-02-11 | Synaptic Pharmaceutical Corporation | DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof |
US5989920A (en) * | 1994-12-02 | 1999-11-23 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5 |
US5668151A (en) * | 1995-06-07 | 1997-09-16 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: piperidine derivatives |
BR9611479B1 (pt) | 1995-11-13 | 2009-01-13 | Ácidos alfa-iminoidroxÂmicos e carboxÍlicos n-substituÍdos cÍclicos e heterocÍclicos. | |
AU7692996A (en) * | 1995-12-01 | 1997-06-27 | Ciba-Geigy Ag | Receptor antagonists |
WO1997019682A1 (en) | 1995-12-01 | 1997-06-05 | Synaptic Pharmaceutical Corporation | Aryl sulfonamide and sulfamide derivatives and uses thereof |
AU7692896A (en) * | 1995-12-01 | 1997-06-27 | Novartis Ag | Quinazolin-2,4-diazirines as NPY receptor antagonist |
US6433185B1 (en) | 1996-01-11 | 2002-08-13 | Sanofi-Synthelabo | N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them |
FR2743562B1 (fr) | 1996-01-11 | 1998-04-03 | Sanofi Sa | Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant |
DE69724941T2 (de) * | 1996-03-21 | 2004-07-15 | Banyu Pharmaceutical Co., Ltd. | Aminopyridin-derivate |
ES2176776T3 (es) | 1996-08-23 | 2002-12-01 | Agouron Pharma | Ligandos del neuropeptido-y. |
FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
US6245817B1 (en) | 1997-02-14 | 2001-06-12 | Bayer Corporation | NPY5 receptor antagonists and methods for using same |
US6048900A (en) | 1998-02-13 | 2000-04-11 | Bayer Corporation | Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists |
EP0910565A1 (de) * | 1997-02-14 | 1999-04-28 | Bayer Corporation | Amidderivate als selektive neuropeptid-y-rezeptoren |
DE19719817A1 (de) * | 1997-05-13 | 1998-11-19 | Hoechst Ag | Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren |
US6713265B1 (en) | 1997-06-04 | 2004-03-30 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) |
US5889016A (en) * | 1997-06-26 | 1999-03-30 | Bristol-Myers Squibb Company | Dihydropyrimidone derivatives as NPY antagonists |
PE20000127A1 (es) * | 1997-12-22 | 2000-03-14 | Novartis Ag | Derivado de bencenosulfonamida |
GB2344050A (en) * | 1998-11-26 | 2000-05-31 | Ferring Bv | Agents useful in the treatment of reproductive disorders. |
FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
FR2822827B1 (fr) * | 2001-03-28 | 2003-05-16 | Sanofi Synthelabo | Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant |
AU2002314744A1 (en) * | 2001-04-17 | 2002-10-28 | Sepracor, Inc. | Thiazole and other heterocyclic ligands and use thereof |
GB0130219D0 (en) * | 2001-12-18 | 2002-02-06 | Pfizer Ltd | Compounds for the treatment of sexual dysfunction |
FR2840897B1 (fr) | 2002-06-14 | 2004-09-10 | Fournier Lab Sa | Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique |
EA008921B1 (ru) * | 2003-03-25 | 2007-08-31 | Лаборатуар Фурнье С.А. | Производные бензолсульфонамидов, способ их получения и их применение для лечения боли |
ZA200508439B (en) | 2003-05-05 | 2007-03-28 | Probiodrug Ag | Medical use of inhibitors of glutaminyl and glutamate cyclases |
DE10344936A1 (de) * | 2003-09-27 | 2005-04-21 | Aventis Pharma Gmbh | Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen |
ZA200603165B (en) | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
EP1713780B1 (de) | 2004-02-05 | 2012-01-18 | Probiodrug AG | Neue inhibitoren von glutaminylcyclase |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
JP5674463B2 (ja) * | 2007-06-05 | 2015-02-25 | サノフイ | 置換されたベンゾイルアミノ−インダン−2−カルボン酸及び関連化合物 |
JPWO2009110510A1 (ja) | 2008-03-06 | 2011-07-14 | Msd株式会社 | アルキルアミノピリジン誘導体 |
FR2949674A1 (fr) * | 2009-09-10 | 2011-03-11 | Oreal | Utilisation d'un antagoniste du neuropeptide y pour augmenter le volume et/ou la coloration naturelle des levres |
SG178953A1 (en) | 2009-09-11 | 2012-04-27 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
WO2019079243A1 (en) * | 2017-10-17 | 2019-04-25 | Albert Einstein College Of Medicine, Inc. | MITOFUSIN ACTIVATORS AND USES THEREOF |
EP4324329A3 (de) | 2018-01-17 | 2024-04-17 | Migal Galilee Research Institute Ltd. | Neue methionin-stoffwechselweghemmer |
BR112020014559A2 (pt) | 2018-01-17 | 2020-12-08 | Migal - Galilee Research Institute Ltd. | Inibidores inovadores da via metabólica da metionina |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT84171B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem |
PT84170B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas |
DE3939797A1 (de) * | 1989-12-01 | 1991-06-06 | Basf Ag | Neue vom neuropeptid y abgeleitete peptide |
AU1354292A (en) * | 1991-03-18 | 1992-10-21 | Pentapharm Ag | Parasubstituted phenylalanine derivates |
JP3283114B2 (ja) * | 1992-09-07 | 2002-05-20 | クミアイ化学工業株式会社 | 縮合ヘテロ環誘導体及び農園芸用殺菌剤 |
-
1993
- 1993-02-15 FR FR9301686A patent/FR2701480B1/fr not_active Expired - Fee Related
-
1994
- 1994-02-09 PH PH47736A patent/PH30887A/en unknown
- 1994-02-14 FI FI940680A patent/FI940680A/fi unknown
- 1994-02-14 US US08/195,281 patent/US5506258A/en not_active Expired - Fee Related
- 1994-02-14 CA CA002115631A patent/CA2115631A1/en not_active Abandoned
- 1994-02-14 NO NO940503A patent/NO304313B1/no unknown
- 1994-02-14 RU RU94004977A patent/RU2126382C1/ru active
- 1994-02-14 HU HU9400414A patent/HUT66960A/hu unknown
- 1994-02-15 ZA ZA941029A patent/ZA941029B/xx unknown
- 1994-02-15 EP EP94400331A patent/EP0614911B1/de not_active Expired - Lifetime
- 1994-02-15 CN CN94102694A patent/CN1104634A/zh active Pending
- 1994-02-15 DE DE69418083T patent/DE69418083T2/de not_active Expired - Fee Related
- 1994-02-15 TW TW083101254A patent/TW372233B/zh active
- 1994-02-15 ES ES94400331T patent/ES2132351T3/es not_active Expired - Lifetime
- 1994-02-15 KR KR1019940002676A patent/KR940019682A/ko not_active Application Discontinuation
- 1994-02-15 DK DK94400331T patent/DK0614911T3/da active
- 1994-02-15 JP JP6018511A patent/JP2994546B2/ja not_active Expired - Lifetime
- 1994-02-15 AT AT94400331T patent/ATE179430T1/de not_active IP Right Cessation
- 1994-02-15 IL IL10864994A patent/IL108649A/en not_active IP Right Cessation
- 1994-02-15 AU AU55165/94A patent/AU673398B2/en not_active Ceased
- 1994-02-15 MX MX9401191A patent/MX9401191A/es not_active IP Right Cessation
- 1994-02-15 NZ NZ250878A patent/NZ250878A/en unknown
-
1996
- 1996-01-04 US US08/582,887 patent/US5674890A/en not_active Expired - Fee Related
-
1999
- 1999-05-19 GR GR990401334T patent/GR3030243T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5674890A (en) | 1997-10-07 |
HUT66960A (en) | 1995-01-30 |
IL108649A (en) | 1998-09-24 |
CN1104634A (zh) | 1995-07-05 |
HU9400414D0 (en) | 1994-05-30 |
TW372233B (en) | 1999-10-21 |
FR2701480A1 (fr) | 1994-08-19 |
ZA941029B (en) | 1995-08-15 |
PH30887A (en) | 1997-12-23 |
EP0614911A1 (de) | 1994-09-14 |
KR940019682A (ko) | 1994-09-14 |
IL108649A0 (en) | 1994-05-30 |
AU673398B2 (en) | 1996-11-07 |
AU5516594A (en) | 1994-08-18 |
DE69418083T2 (de) | 1999-11-25 |
NO940503D0 (no) | 1994-02-14 |
DE69418083D1 (de) | 1999-06-02 |
MX9401191A (es) | 1994-08-31 |
FI940680A0 (fi) | 1994-02-14 |
RU2126382C1 (ru) | 1999-02-20 |
JP2994546B2 (ja) | 1999-12-27 |
ES2132351T3 (es) | 1999-08-16 |
ATE179430T1 (de) | 1999-05-15 |
NZ250878A (en) | 1996-02-27 |
NO940503L (de) | 1994-08-16 |
FR2701480B1 (fr) | 1995-05-24 |
FI940680A (fi) | 1994-08-16 |
CA2115631A1 (en) | 1994-08-16 |
DK0614911T3 (da) | 1999-11-08 |
EP0614911B1 (de) | 1999-04-28 |
JPH06293794A (ja) | 1994-10-21 |
GR3030243T3 (en) | 1999-08-31 |
US5506258A (en) | 1996-04-09 |
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