NO304313B1 - Forbindelser med en sulfamoyl- og amidinogruppe, og farmas°ytiske blandinger som inneholder dem - Google Patents

Forbindelser med en sulfamoyl- og amidinogruppe, og farmas°ytiske blandinger som inneholder dem

Info

Publication number
NO304313B1
NO304313B1 NO940503A NO940503A NO304313B1 NO 304313 B1 NO304313 B1 NO 304313B1 NO 940503 A NO940503 A NO 940503A NO 940503 A NO940503 A NO 940503A NO 304313 B1 NO304313 B1 NO 304313B1
Authority
NO
Norway
Prior art keywords
alkyl
compounds
alkylamino
alkylene
linked
Prior art date
Application number
NO940503A
Other languages
English (en)
Norwegian (no)
Other versions
NO940503D0 (no
NO940503L (de
Inventor
Bernard Christophe
Loic Foulon
Alain Pellet
Claudine Serradeil-Le Gal
Gurard Valette
Original Assignee
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Elf filed Critical Sanofi Elf
Publication of NO940503D0 publication Critical patent/NO940503D0/no
Publication of NO940503L publication Critical patent/NO940503L/no
Publication of NO304313B1 publication Critical patent/NO304313B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO940503A 1993-02-15 1994-02-14 Forbindelser med en sulfamoyl- og amidinogruppe, og farmas°ytiske blandinger som inneholder dem NO304313B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301686A FR2701480B1 (fr) 1993-02-15 1993-02-15 Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Publications (3)

Publication Number Publication Date
NO940503D0 NO940503D0 (no) 1994-02-14
NO940503L NO940503L (de) 1994-08-16
NO304313B1 true NO304313B1 (no) 1998-11-30

Family

ID=9444071

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940503A NO304313B1 (no) 1993-02-15 1994-02-14 Forbindelser med en sulfamoyl- og amidinogruppe, og farmas°ytiske blandinger som inneholder dem

Country Status (23)

Country Link
US (2) US5506258A (de)
EP (1) EP0614911B1 (de)
JP (1) JP2994546B2 (de)
KR (1) KR940019682A (de)
CN (1) CN1104634A (de)
AT (1) ATE179430T1 (de)
AU (1) AU673398B2 (de)
CA (1) CA2115631A1 (de)
DE (1) DE69418083T2 (de)
DK (1) DK0614911T3 (de)
ES (1) ES2132351T3 (de)
FI (1) FI940680A (de)
FR (1) FR2701480B1 (de)
GR (1) GR3030243T3 (de)
HU (1) HUT66960A (de)
IL (1) IL108649A (de)
MX (1) MX9401191A (de)
NO (1) NO304313B1 (de)
NZ (1) NZ250878A (de)
PH (1) PH30887A (de)
RU (1) RU2126382C1 (de)
TW (1) TW372233B (de)
ZA (1) ZA941029B (de)

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US5516653A (en) 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en) * 1994-02-03 1996-08-13 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5602024A (en) 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5989920A (en) * 1994-12-02 1999-11-23 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5668151A (en) * 1995-06-07 1997-09-16 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: piperidine derivatives
BR9611479B1 (pt) 1995-11-13 2009-01-13 Ácidos alfa-iminoidroxÂmicos e carboxÍlicos n-substituÍdos cÍclicos e heterocÍclicos.
AU7692996A (en) * 1995-12-01 1997-06-27 Ciba-Geigy Ag Receptor antagonists
WO1997019682A1 (en) 1995-12-01 1997-06-05 Synaptic Pharmaceutical Corporation Aryl sulfonamide and sulfamide derivatives and uses thereof
AU7692896A (en) * 1995-12-01 1997-06-27 Novartis Ag Quinazolin-2,4-diazirines as NPY receptor antagonist
US6433185B1 (en) 1996-01-11 2002-08-13 Sanofi-Synthelabo N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them
FR2743562B1 (fr) 1996-01-11 1998-04-03 Sanofi Sa Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant
DE69724941T2 (de) * 1996-03-21 2004-07-15 Banyu Pharmaceutical Co., Ltd. Aminopyridin-derivate
ES2176776T3 (es) 1996-08-23 2002-12-01 Agouron Pharma Ligandos del neuropeptido-y.
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
US6245817B1 (en) 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
US6048900A (en) 1998-02-13 2000-04-11 Bayer Corporation Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
EP0910565A1 (de) * 1997-02-14 1999-04-28 Bayer Corporation Amidderivate als selektive neuropeptid-y-rezeptoren
DE19719817A1 (de) * 1997-05-13 1998-11-19 Hoechst Ag Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren
US6713265B1 (en) 1997-06-04 2004-03-30 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
US5889016A (en) * 1997-06-26 1999-03-30 Bristol-Myers Squibb Company Dihydropyrimidone derivatives as NPY antagonists
PE20000127A1 (es) * 1997-12-22 2000-03-14 Novartis Ag Derivado de bencenosulfonamida
GB2344050A (en) * 1998-11-26 2000-05-31 Ferring Bv Agents useful in the treatment of reproductive disorders.
FR2819254B1 (fr) * 2001-01-08 2003-04-18 Fournier Lab Sa Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
AU2002314744A1 (en) * 2001-04-17 2002-10-28 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
FR2840897B1 (fr) 2002-06-14 2004-09-10 Fournier Lab Sa Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
EA008921B1 (ru) * 2003-03-25 2007-08-31 Лаборатуар Фурнье С.А. Производные бензолсульфонамидов, способ их получения и их применение для лечения боли
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
DE10344936A1 (de) * 2003-09-27 2005-04-21 Aventis Pharma Gmbh Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen
ZA200603165B (en) 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1713780B1 (de) 2004-02-05 2012-01-18 Probiodrug AG Neue inhibitoren von glutaminylcyclase
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
EP2142514B1 (de) 2007-04-18 2014-12-24 Probiodrug AG Thioharnstoffderivate als glutaminylcyclaseinhibitoren
JP5674463B2 (ja) * 2007-06-05 2015-02-25 サノフイ 置換されたベンゾイルアミノ−インダン−2−カルボン酸及び関連化合物
JPWO2009110510A1 (ja) 2008-03-06 2011-07-14 Msd株式会社 アルキルアミノピリジン誘導体
FR2949674A1 (fr) * 2009-09-10 2011-03-11 Oreal Utilisation d'un antagoniste du neuropeptide y pour augmenter le volume et/ou la coloration naturelle des levres
SG178953A1 (en) 2009-09-11 2012-04-27 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
WO2019079243A1 (en) * 2017-10-17 2019-04-25 Albert Einstein College Of Medicine, Inc. MITOFUSIN ACTIVATORS AND USES THEREOF
EP4324329A3 (de) 2018-01-17 2024-04-17 Migal Galilee Research Institute Ltd. Neue methionin-stoffwechselweghemmer
BR112020014559A2 (pt) 2018-01-17 2020-12-08 Migal - Galilee Research Institute Ltd. Inibidores inovadores da via metabólica da metionina

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
PT84171B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
DE3939797A1 (de) * 1989-12-01 1991-06-06 Basf Ag Neue vom neuropeptid y abgeleitete peptide
AU1354292A (en) * 1991-03-18 1992-10-21 Pentapharm Ag Parasubstituted phenylalanine derivates
JP3283114B2 (ja) * 1992-09-07 2002-05-20 クミアイ化学工業株式会社 縮合ヘテロ環誘導体及び農園芸用殺菌剤

Also Published As

Publication number Publication date
US5674890A (en) 1997-10-07
HUT66960A (en) 1995-01-30
IL108649A (en) 1998-09-24
CN1104634A (zh) 1995-07-05
HU9400414D0 (en) 1994-05-30
TW372233B (en) 1999-10-21
FR2701480A1 (fr) 1994-08-19
ZA941029B (en) 1995-08-15
PH30887A (en) 1997-12-23
EP0614911A1 (de) 1994-09-14
KR940019682A (ko) 1994-09-14
IL108649A0 (en) 1994-05-30
AU673398B2 (en) 1996-11-07
AU5516594A (en) 1994-08-18
DE69418083T2 (de) 1999-11-25
NO940503D0 (no) 1994-02-14
DE69418083D1 (de) 1999-06-02
MX9401191A (es) 1994-08-31
FI940680A0 (fi) 1994-02-14
RU2126382C1 (ru) 1999-02-20
JP2994546B2 (ja) 1999-12-27
ES2132351T3 (es) 1999-08-16
ATE179430T1 (de) 1999-05-15
NZ250878A (en) 1996-02-27
NO940503L (de) 1994-08-16
FR2701480B1 (fr) 1995-05-24
FI940680A (fi) 1994-08-16
CA2115631A1 (en) 1994-08-16
DK0614911T3 (da) 1999-11-08
EP0614911B1 (de) 1999-04-28
JPH06293794A (ja) 1994-10-21
GR3030243T3 (en) 1999-08-31
US5506258A (en) 1996-04-09

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