NO302950B1 - Fremgangsmåte for fremstilling av aprotininanaloger - Google Patents
Fremgangsmåte for fremstilling av aprotininanaloger Download PDFInfo
- Publication number
- NO302950B1 NO302950B1 NO904622A NO904622A NO302950B1 NO 302950 B1 NO302950 B1 NO 302950B1 NO 904622 A NO904622 A NO 904622A NO 904622 A NO904622 A NO 904622A NO 302950 B1 NO302950 B1 NO 302950B1
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- Prior art keywords
- aprotinin
- arg
- 42ser
- kfn
- amino acid
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- VBEGHXKAFSLLGE-UHFFFAOYSA-N n-phenylnitramide Chemical compound [O-][N+](=O)NC1=CC=CC=C1 VBEGHXKAFSLLGE-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK225488A DK225488D0 (da) | 1988-04-26 | 1988-04-26 | Polypeptid |
| PCT/DK1989/000096 WO1989010374A1 (en) | 1988-04-26 | 1989-04-25 | Aprotinin analogues and a process for the production thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO904622D0 NO904622D0 (no) | 1990-10-25 |
| NO904622L NO904622L (no) | 1990-12-18 |
| NO302950B1 true NO302950B1 (no) | 1998-05-11 |
Family
ID=8111114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO904622A NO302950B1 (no) | 1988-04-26 | 1990-10-25 | Fremgangsmåte for fremstilling av aprotininanaloger |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5373090A (xx) |
| EP (1) | EP0339942B1 (xx) |
| JP (1) | JP2810743B2 (xx) |
| AT (1) | ATE103295T1 (xx) |
| AU (1) | AU619553B2 (xx) |
| DE (1) | DE68914022T2 (xx) |
| DK (1) | DK225488D0 (xx) |
| ES (1) | ES2061983T3 (xx) |
| FI (1) | FI93964C (xx) |
| IE (1) | IE64230B1 (xx) |
| NO (1) | NO302950B1 (xx) |
| NZ (1) | NZ228896A (xx) |
| WO (1) | WO1989010374A1 (xx) |
| ZA (1) | ZA893075B (xx) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US7413537B2 (en) | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
| DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
| IL99585A0 (en) * | 1990-10-01 | 1992-08-18 | Novo Nordisk As | Aprotinin analogues,their production and pharmaceutical compositions containing them |
| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
| IL104314A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
| JPH07509229A (ja) * | 1992-07-13 | 1995-10-12 | コルバス・インターナショナル、インコーポレイテッド | ウシ膵トリプシン阻害因子から誘導される因子Ｘａの阻害因子 |
| CA2145517A1 (en) * | 1992-09-25 | 1994-04-14 | Ignace Lasters | Bovine pancreatic trypsin inhibitor derived inhibitors of factor viia - tissue factor complex |
| CA2180954C (en) | 1994-01-11 | 2007-03-20 | William Markland | Inhibitors of human plasmin derived from the kunitz domains |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| ZA963619B (en) | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
| US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| DE19629982A1 (de) * | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin-Varianten mit verbesserten Eigenschaften |
| DE19725014A1 (de) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
| SI2386310T1 (sl) | 2002-08-28 | 2019-03-29 | Dyax Corp. | Metode za ohranjanje organov in tkiv |
| US20040209243A1 (en) * | 2003-01-07 | 2004-10-21 | Andrew Nixon | Kunitz domain library |
| US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| WO2005021557A2 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US20060218667A1 (en) * | 2004-10-12 | 2006-09-28 | Vojdani Fakhrieh S | Plant-produced recombinant aprotinin and aprotinin variants |
| CN101102819A (zh) | 2004-12-23 | 2008-01-09 | Csl百灵有限公司 | 血栓的形成和/或稳定化的预防 |
| WO2009026334A2 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| CN102307594A (zh) * | 2009-01-06 | 2012-01-04 | 戴埃克斯有限公司 | 用激肽释放酶抑制剂治疗粘膜炎 |
| HUE039605T2 (hu) | 2010-01-06 | 2019-01-28 | Dyax Corp | Plazma kallikreint kötõ proteinek |
| KR102320178B1 (ko) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
| WO2015148790A1 (en) | 2014-03-27 | 2015-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| NZ744233A (en) | 2015-12-11 | 2023-11-24 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
| GB2188322A (en) * | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
| GB2188933A (en) * | 1986-04-10 | 1987-10-14 | Bayer Ag | Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby |
| DE3724570A1 (de) * | 1987-06-27 | 1989-01-05 | Bayer Ag | Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist |
| GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
-
1988
- 1988-04-26 DK DK225488A patent/DK225488D0/da unknown
-
1989
- 1989-04-25 AU AU35603/89A patent/AU619553B2/en not_active Ceased
- 1989-04-25 EP EP89304122A patent/EP0339942B1/en not_active Expired - Lifetime
- 1989-04-25 WO PCT/DK1989/000096 patent/WO1989010374A1/en active IP Right Grant
- 1989-04-25 US US07/598,737 patent/US5373090A/en not_active Expired - Lifetime
- 1989-04-25 ES ES89304122T patent/ES2061983T3/es not_active Expired - Lifetime
- 1989-04-25 IE IE133489A patent/IE64230B1/en not_active IP Right Cessation
- 1989-04-25 AT AT89304122T patent/ATE103295T1/de not_active IP Right Cessation
- 1989-04-25 JP JP1505101A patent/JP2810743B2/ja not_active Expired - Fee Related
- 1989-04-25 DE DE68914022T patent/DE68914022T2/de not_active Expired - Fee Related
- 1989-04-26 NZ NZ228896A patent/NZ228896A/xx unknown
- 1989-04-26 ZA ZA893075A patent/ZA893075B/xx unknown
-
1990
- 1990-10-25 FI FI905275A patent/FI93964C/fi not_active IP Right Cessation
- 1990-10-25 NO NO904622A patent/NO302950B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5373090A (en) | 1994-12-13 |
| DE68914022T2 (de) | 1994-07-07 |
| IE64230B1 (en) | 1995-07-26 |
| JPH03504009A (ja) | 1991-09-05 |
| AU619553B2 (en) | 1992-01-30 |
| DE68914022D1 (de) | 1994-04-28 |
| NZ228896A (en) | 1991-08-27 |
| EP0339942B1 (en) | 1994-03-23 |
| FI905275A0 (fi) | 1990-10-25 |
| JP2810743B2 (ja) | 1998-10-15 |
| EP0339942A3 (en) | 1990-05-30 |
| ZA893075B (en) | 1989-12-27 |
| NO904622D0 (no) | 1990-10-25 |
| WO1989010374A1 (en) | 1989-11-02 |
| DK225488D0 (da) | 1988-04-26 |
| NO904622L (no) | 1990-12-18 |
| FI93964C (fi) | 1995-06-26 |
| IE891334L (en) | 1989-10-26 |
| AU3560389A (en) | 1989-11-24 |
| FI93964B (fi) | 1995-03-15 |
| ATE103295T1 (de) | 1994-04-15 |
| ES2061983T3 (es) | 1994-12-16 |
| EP0339942A2 (en) | 1989-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN OCTOBER 2002 |