NO302232B1 - Fremgangsmate for fremstilling av N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,7,10-tetraazasyklododekan- og N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotetradekanderivater og deres metallkomplekser - Google Patents

Fremgangsmate for fremstilling av N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,7,10-tetraazasyklododekan- og N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotetradekanderivater og deres metallkomplekser

Info

Publication number
NO302232B1
NO302232B1 NO19944691A NO944691A NO302232B1 NO 302232 B1 NO302232 B1 NO 302232B1 NO 19944691 A NO19944691 A NO 19944691A NO 944691 A NO944691 A NO 944691A NO 302232 B1 NO302232 B1 NO 302232B1
Authority
NO
Norway
Prior art keywords
carboxyalkyl
hydroxyalkyl
tri
beta
tetraazacyclododecane
Prior art date
Application number
NO19944691A
Other languages
English (en)
Norwegian (no)
Other versions
NO944691D0 (no
NO944691L (no
Inventor
Ulf Tilstam
Helmut Boerner
Klaus Nickisch
Heinz Gries
Johannes Platzek
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of NO944691D0 publication Critical patent/NO944691D0/no
Publication of NO944691L publication Critical patent/NO944691L/no
Publication of NO302232B1 publication Critical patent/NO302232B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19944691A 1992-06-04 1994-12-05 Fremgangsmate for fremstilling av N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,7,10-tetraazasyklododekan- og N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotetradekanderivater og deres metallkomplekser NO302232B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218744A DE4218744C2 (de) 1992-06-04 1992-06-04 Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
PCT/EP1993/001362 WO1993024469A1 (de) 1992-06-04 1993-05-28 VERFAHREN ZUR HERSTELLUNG VON N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECAN- UND N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECAN-DERIVATEN UND DEREN METALLKOMPLEXE

Publications (3)

Publication Number Publication Date
NO944691D0 NO944691D0 (no) 1994-12-05
NO944691L NO944691L (no) 1994-12-05
NO302232B1 true NO302232B1 (no) 1998-02-09

Family

ID=6460555

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19944691A NO302232B1 (no) 1992-06-04 1994-12-05 Fremgangsmate for fremstilling av N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,7,10-tetraazasyklododekan- og N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotetradekanderivater og deres metallkomplekser

Country Status (16)

Country Link
US (1) US5386028A (cs)
EP (1) EP0643705B1 (cs)
JP (1) JP3565843B2 (cs)
KR (1) KR100269081B1 (cs)
AT (1) ATE178321T1 (cs)
CA (1) CA2137243C (cs)
CZ (1) CZ282873B6 (cs)
DE (2) DE4218744C2 (cs)
DK (1) DK0643705T3 (cs)
ES (1) ES2131582T3 (cs)
GR (1) GR3030604T3 (cs)
HU (1) HU213951B (cs)
IL (1) IL105807A (cs)
NO (1) NO302232B1 (cs)
SK (1) SK281901B6 (cs)
WO (1) WO1993024469A1 (cs)

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PT2896405T (pt) 2011-04-21 2020-03-31 Bayer Ip Gmbh Preparação de gadobutrol de pureza elevada
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KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
CN113968823A (zh) 2015-06-19 2022-01-25 麻省理工学院 烯基取代的2,5-哌嗪二酮和其在组合物中用于向个体或细胞递送药剂的用途
AU2017333698B2 (en) 2016-09-27 2020-12-24 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
EP3820853A4 (en) * 2018-07-10 2022-08-17 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF 2,2',2''-(10-((2R,3S)-1,3,4-TRIHYDROXY BUTAN-2-YL)-1,4,7,10-TETRAAZACYCLODODECANE-1 ACID ,4,7-TRIYL) TRIACETIC AND ITS COMPLEXES
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
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Also Published As

Publication number Publication date
EP0643705A1 (de) 1995-03-22
ES2131582T3 (es) 1999-08-01
IL105807A0 (en) 1993-09-22
IL105807A (en) 1998-12-06
ATE178321T1 (de) 1999-04-15
DK0643705T3 (da) 1999-10-25
CZ301594A3 (en) 1995-08-16
SK281901B6 (sk) 2001-09-11
SK148794A3 (en) 1995-07-11
HU9403464D0 (en) 1995-03-28
DE4218744A1 (de) 1993-12-09
CZ282873B6 (cs) 1997-11-12
WO1993024469A1 (de) 1993-12-09
GR3030604T3 (en) 1999-10-29
JPH07507067A (ja) 1995-08-03
CA2137243C (en) 2005-09-20
EP0643705B1 (de) 1999-03-31
NO944691D0 (no) 1994-12-05
US5386028A (en) 1995-01-31
HU213951B (en) 1997-11-28
NO944691L (no) 1994-12-05
DE4218744C2 (de) 1997-11-06
CA2137243A1 (en) 1993-12-09
JP3565843B2 (ja) 2004-09-15
DE59309488D1 (de) 1999-05-06
HUT71263A (en) 1995-11-28
KR100269081B1 (ko) 2000-10-16
KR950701918A (ko) 1995-05-17

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Legal Events

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CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

MK1K Patent expired