DK0643705T3 - Fremgangsmåde til fremstilling af N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- og N-beta-hydroxyal - Google Patents

Fremgangsmåde til fremstilling af N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- og N-beta-hydroxyal

Info

Publication number
DK0643705T3
DK0643705T3 DK93912835T DK93912835T DK0643705T3 DK 0643705 T3 DK0643705 T3 DK 0643705T3 DK 93912835 T DK93912835 T DK 93912835T DK 93912835 T DK93912835 T DK 93912835T DK 0643705 T3 DK0643705 T3 DK 0643705T3
Authority
DK
Denmark
Prior art keywords
beta
carboxyalkyl
hydroxyalkyl
tri
tetraazacyclododecane
Prior art date
Application number
DK93912835T
Other languages
Danish (da)
English (en)
Inventor
Heinz Gries
Johannes Platzek
Ulf Tilstam
Helmut Birner
Klaus Nickisch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0643705T3 publication Critical patent/DK0643705T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK93912835T 1992-06-04 1993-05-28 Fremgangsmåde til fremstilling af N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- og N-beta-hydroxyal DK0643705T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218744A DE4218744C2 (de) 1992-06-04 1992-06-04 Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
PCT/EP1993/001362 WO1993024469A1 (de) 1992-06-04 1993-05-28 VERFAHREN ZUR HERSTELLUNG VON N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECAN- UND N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECAN-DERIVATEN UND DEREN METALLKOMPLEXE

Publications (1)

Publication Number Publication Date
DK0643705T3 true DK0643705T3 (da) 1999-10-25

Family

ID=6460555

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912835T DK0643705T3 (da) 1992-06-04 1993-05-28 Fremgangsmåde til fremstilling af N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- og N-beta-hydroxyal

Country Status (16)

Country Link
US (1) US5386028A (cs)
EP (1) EP0643705B1 (cs)
JP (1) JP3565843B2 (cs)
KR (1) KR100269081B1 (cs)
AT (1) ATE178321T1 (cs)
CA (1) CA2137243C (cs)
CZ (1) CZ282873B6 (cs)
DE (2) DE4218744C2 (cs)
DK (1) DK0643705T3 (cs)
ES (1) ES2131582T3 (cs)
GR (1) GR3030604T3 (cs)
HU (1) HU213951B (cs)
IL (1) IL105807A (cs)
NO (1) NO302232B1 (cs)
SK (1) SK281901B6 (cs)
WO (1) WO1993024469A1 (cs)

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IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
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WO2012135025A2 (en) 2011-03-28 2012-10-04 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
EP2699556A1 (en) 2011-04-21 2014-02-26 Bayer Intellectual Property GmbH Preparation of high-purity gadobutrol
PE20150041A1 (es) 2011-10-27 2015-01-28 Massachusetts Inst Technology Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco
WO2015117911A1 (en) * 2014-02-06 2015-08-13 Agfa Healthcare Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
AU2016278970B2 (en) 2015-06-19 2020-10-29 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
HUE050553T2 (hu) 2016-09-27 2020-12-28 Bayer Pharma AG Eljárás A módosulatú kalkobutrol kristályos alakjának elõállítására
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
WO2020012372A1 (en) * 2018-07-10 2020-01-16 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
EP4565570A1 (en) * 2022-08-01 2025-06-11 Portland State University High relaxivity contrast agents and stereoselective preparation
CN118702638B (zh) * 2024-06-13 2025-09-23 上海凌凯科技股份有限公司 1,4,7,10-四氮十二烷衍生物、制备方法及其在合成钆络合物中的应用

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Also Published As

Publication number Publication date
JPH07507067A (ja) 1995-08-03
DE4218744A1 (de) 1993-12-09
WO1993024469A1 (de) 1993-12-09
ES2131582T3 (es) 1999-08-01
NO302232B1 (no) 1998-02-09
US5386028A (en) 1995-01-31
NO944691D0 (no) 1994-12-05
EP0643705B1 (de) 1999-03-31
SK281901B6 (sk) 2001-09-11
HU9403464D0 (en) 1995-03-28
JP3565843B2 (ja) 2004-09-15
DE4218744C2 (de) 1997-11-06
CZ301594A3 (en) 1995-08-16
KR950701918A (ko) 1995-05-17
ATE178321T1 (de) 1999-04-15
SK148794A3 (en) 1995-07-11
KR100269081B1 (ko) 2000-10-16
NO944691L (no) 1994-12-05
IL105807A (en) 1998-12-06
CA2137243A1 (en) 1993-12-09
CZ282873B6 (cs) 1997-11-12
DE59309488D1 (de) 1999-05-06
EP0643705A1 (de) 1995-03-22
GR3030604T3 (en) 1999-10-29
CA2137243C (en) 2005-09-20
IL105807A0 (en) 1993-09-22
HUT71263A (en) 1995-11-28
HU213951B (en) 1997-11-28

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