NO300594B1 - Analogifremgangsmåte for fremstilling av polypeptid og fremgangsmåte for fremstilling av T-celler med spesifisitet mot polypeptidet - Google Patents
Analogifremgangsmåte for fremstilling av polypeptid og fremgangsmåte for fremstilling av T-celler med spesifisitet mot polypeptidet Download PDFInfo
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- NO300594B1 NO300594B1 NO904919A NO904919A NO300594B1 NO 300594 B1 NO300594 B1 NO 300594B1 NO 904919 A NO904919 A NO 904919A NO 904919 A NO904919 A NO 904919A NO 300594 B1 NO300594 B1 NO 300594B1
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- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Mycobacteriaceae (F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/965—Chemistry: molecular biology and microbiology involving idiotype or anti-idiotype antibody
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO964483A NO304233B1 (no) | 1989-03-14 | 1996-10-22 | Polypeptid og sett for diagnostisering av insulinavhengig diabetes mellitus samt fremstilling av slikt materiale |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32286489A | 1989-03-14 | 1989-03-14 | |
US07/371,249 US5114844A (en) | 1989-03-14 | 1989-06-26 | Diagnosis and treatment of insulin dependent diabetes mellitus |
PCT/US1990/001397 WO1990010449A1 (en) | 1989-03-14 | 1990-03-14 | Diagnosis and treatment of insulin dependent diabetes mellitus |
Publications (3)
Publication Number | Publication Date |
---|---|
NO904919D0 NO904919D0 (no) | 1990-11-13 |
NO904919L NO904919L (no) | 1991-01-14 |
NO300594B1 true NO300594B1 (no) | 1997-06-23 |
Family
ID=26983648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO904919A NO300594B1 (no) | 1989-03-14 | 1990-11-13 | Analogifremgangsmåte for fremstilling av polypeptid og fremgangsmåte for fremstilling av T-celler med spesifisitet mot polypeptidet |
Country Status (10)
Country | Link |
---|---|
US (2) | US5114844A (fi) |
EP (1) | EP0417271B1 (fi) |
JP (3) | JP3165148B2 (fi) |
AT (1) | ATE174689T1 (fi) |
AU (1) | AU639456B2 (fi) |
CA (1) | CA2029861C (fi) |
DE (1) | DE69032833T2 (fi) |
FI (1) | FI103976B (fi) |
NO (1) | NO300594B1 (fi) |
WO (1) | WO1990010449A1 (fi) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5645998A (en) | 1988-12-13 | 1997-07-08 | University Of Florida Research Foundation | Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus |
US5762937A (en) * | 1988-12-13 | 1998-06-09 | University Of Florida Research Foundation, Inc. | Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus |
US6001360A (en) * | 1988-12-13 | 1999-12-14 | University Of Florida | Method and compositions for early detection and treatment of insulin dependent diabetes mellitus |
US5780034A (en) * | 1989-03-14 | 1998-07-14 | Yeda Research And Development Co. Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus using heat shock protein determinents |
US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
GB8919321D0 (en) * | 1989-08-25 | 1989-10-11 | Univ London | Treatment of chronic inflammatory conditions |
US5427940A (en) * | 1991-06-03 | 1995-06-27 | Board Of Regents, The University Of Texas System | Engineered cells producing insulin in response to glucose |
GB9007194D0 (en) * | 1990-03-30 | 1990-05-30 | Wellcome Found | Live vaccines |
US5512447A (en) * | 1990-09-07 | 1996-04-30 | The Regents Of The University Of California | Methods for the diagnosis and treatment of diabetes |
DE69133393T2 (de) | 1990-09-07 | 2005-06-16 | The Regents Of The University Of California, Oakland | Verfahren zur diagnose und behandlung von diabetes |
US5998366A (en) * | 1990-09-21 | 1999-12-07 | The Regents Of The University Of California | Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders |
US5674978A (en) | 1990-09-21 | 1997-10-07 | The Regents Of The University Of California | Peptides derived from glutamic acid decarboxylase |
US5620686A (en) * | 1990-09-28 | 1997-04-15 | British Technology Group Limited | Antigen-antibody conjugates |
CA2096975C (en) * | 1990-11-26 | 2003-04-22 | Carl Wu | Cell stress transcriptional factors |
US5767240A (en) * | 1991-04-22 | 1998-06-16 | The United States Of America As Represented By The Department Of Health And Human Services | Activity-dependent neurotrophic factor |
US6174862B1 (en) | 1991-04-22 | 2001-01-16 | Ramot University Authority For Applied Research And Industrial Development, Ltd. | Neurotrophic peptides of activity dependent neurotrophic factor |
CA2103159A1 (en) * | 1991-05-15 | 1992-11-16 | Ake Lernmark | Cloning and expression of human islet glutamic acid decarboxylase autoantigen |
WO1993009141A1 (en) * | 1991-11-01 | 1993-05-13 | Joslin Diabetes Center | Antigen associated with type i diabetes mellitus |
AT398495B (de) * | 1992-06-09 | 1994-12-27 | Wick Georg Dr | Diagnose oder vorhersage von atherosklerose |
IL102687A (en) * | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
WO1994003478A1 (en) * | 1992-07-31 | 1994-02-17 | Immulogic Pharmaceutical Corporation | Sensitive assay for antigens and antibodies and its use to identify rheumatoid arthritis antigen |
US5420108A (en) * | 1992-09-14 | 1995-05-30 | Shohet; Isaac H. | Method of controlling diabetes mellitus |
US5872094A (en) * | 1993-01-06 | 1999-02-16 | The General Hospital Corporation | Method for attaching cartilaginous tissue, cartilage matrix protein or link protein to a surface |
DK0700445T3 (da) * | 1993-06-04 | 2002-05-13 | Whitehead Biomedical Inst | Stressproteiner og anvendelser deraf |
US7008790B1 (en) | 1993-08-12 | 2006-03-07 | Classen Immunotherapies, Inc. | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae |
US5728385A (en) | 1993-08-12 | 1998-03-17 | Classen Immunotherapies, Inc. | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae |
JPH09505588A (ja) | 1993-11-23 | 1997-06-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 多くの細胞外生成物及びそれらの製造法並びに使用 |
US6752993B1 (en) | 1993-11-23 | 2004-06-22 | The Regents Of The University Of California | Abundant extracellular product vaccines and methods for their production and use |
US7300660B2 (en) | 1993-11-23 | 2007-11-27 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
US5863742A (en) * | 1994-03-10 | 1999-01-26 | Chiron Diagnostics Corporation | Inhibition of protease activity of human whole blood cell lysates |
ATE260295T1 (de) * | 1994-03-21 | 2004-03-15 | Univ Utrecht | Peptidfragmente von mikrobiellen stressproteinen und daraus hergestellte pharmazeutische zusammensetzungen für die behandlung und vorbeugung von entzündungserkrankungen |
US5869058A (en) * | 1994-05-25 | 1999-02-09 | Yeda Research And Development Co. Ltd. | Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines |
US6509165B1 (en) | 1994-07-08 | 2003-01-21 | Trustees Of Dartmouth College | Detection methods for type I diabetes |
EP0788512B1 (en) * | 1994-07-08 | 1999-03-24 | The Trustees Of Dartmouth College | Proinsulin peptide compounds for detecting and treating type i diabetes |
WO1996005223A1 (en) * | 1994-08-12 | 1996-02-22 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
GB9419553D0 (en) * | 1994-09-27 | 1994-11-16 | Univ Bristol | Polypeptides and their use in the treatment of auto-immune disease |
UA42040C2 (uk) * | 1994-12-21 | 2001-10-15 | Йеда Рісерч Енд Дівелопмент Ко. Лтд | Поліпептид, спосіб діагностики інсулінозалежного цукрового діабету (iddm), що розвинувся або що розвивається (варіанти), набір для діагностики iddm (варіанти), препарат для запобігання або лікування iddm, фармацевтична композиція для профілактики або лікування iddm |
US6180103B1 (en) | 1994-12-21 | 2001-01-30 | Yeda Research And Development Co., Ltd. | Peptide p277 analogs, and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes |
IL114407A0 (en) * | 1995-06-30 | 1995-10-31 | Yeda Res & Dev | Novel peptides and pharmaceutical compositions comprising them |
US20030190323A1 (en) * | 1995-07-05 | 2003-10-09 | Yeda Research And Development Co. Ltd. | Preparations and methods for the treatment of T cell mediated diseases |
US6488933B2 (en) | 1995-07-05 | 2002-12-03 | Yeda Research And Development Co. Ltd. | Preparations for the treatment of T cell mediated diseases |
IL114458A0 (en) * | 1995-07-05 | 1995-11-27 | Yeda Res & Dev | Therapeutic preparations for treatment of T cell mediated diseases |
US6013660A (en) * | 1996-10-02 | 2000-01-11 | The Regents Of The University Of California | Externally targeted prophylactic and chemotherapeutic method and agents |
US7157089B1 (en) | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
WO1998035705A1 (en) * | 1997-02-18 | 1998-08-20 | Whitehead Institute For Biomedical Research | Use of heat shock proteins to deliver moieties into cells |
CN100489105C (zh) | 1997-08-05 | 2009-05-20 | 恩温塔生物制药学公司 | 包含hpv抗原和应激蛋白或者其表达载体的组合物激发的抗hpv抗原免疫应答 |
US20020009448A1 (en) * | 1997-09-19 | 2002-01-24 | Leslie P. Weiner | T-cell vaccination for the treatment of multiple sclerosis |
WO1999037315A1 (en) * | 1998-01-27 | 1999-07-29 | Bai Jane Pei Fan | Chemical derivatives of autoantigens and autoimmune-suppressive peptides and pharmaceutical composition containing the same |
US7488476B2 (en) * | 1998-11-05 | 2009-02-10 | Hadasit Medical Research Services & Development Ltd. | B-cell epitope peptides of HSP 65, DNA encoding said peptides, antibodies directed against said peptides and the different uses thereof in the treatment of inflammatory and autoimmune diseases |
WO2000027870A1 (en) * | 1998-11-05 | 2000-05-18 | Hadasit Medical Research Services & Development Ltd. | Novel amino acid sequences, dna encoding the amino acid sequences, antibodies directed against such sequences and the different uses thereof |
US8158125B2 (en) * | 1998-11-05 | 2012-04-17 | Hadasit Medical Research Services & Development Ltd. | B-cell epitope peptides of HSP 65, novel amino acid sequences, DNA encoding the amino acid sequences of said peptides, antibodies directed against said peptides and different uses thereof in the treatment of inflammatory and autoimmune diseases |
US6497880B1 (en) | 1998-12-08 | 2002-12-24 | Stressgen Biotechnologies Corporation | Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus |
AU5926700A (en) * | 1999-07-08 | 2001-01-30 | Stressgen Biotechnologies Corporation | Induction of a th1-like response in vitro |
IL150113A0 (en) * | 1999-12-15 | 2002-12-01 | Peptor Ltd | Fragments and antagonists of heat shock protein 60 |
AU1814101A (en) | 2000-01-14 | 2001-07-24 | Massachusetts Institute Of Technology | In vivo CTL elicitation by heat shock protein fusion proteins maps to a discrete ATP binding domain and is CD4+ cell-independent |
IL153474A0 (en) * | 2000-06-26 | 2003-07-06 | Stressgen Biotechnologies Corp | Human papilloma virus treatment |
IL137460A0 (en) * | 2000-07-24 | 2001-07-24 | Yeda Res & Dev | Identifying antigen clusters for monitoring a global state of an immune system |
MXPA03006971A (es) * | 2001-02-05 | 2004-05-05 | Stressgen Biotechnologies Corp | Tratamiento del virus de hepatitis b. |
EP1575479A4 (en) | 2002-01-31 | 2006-10-25 | Develogen Israel Ltd | HSP-PEPTIDES AND ANALOGUES FOR MODULATING IMMUNE RESPONSES ON ANY PRESENTING CELLS |
US20050084967A1 (en) | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
CA2595520A1 (en) * | 2004-01-28 | 2005-08-11 | Develogen Israel Ltd. | Hsp therapy in conjunction with a low antigenicity diet |
US20050260770A1 (en) * | 2004-04-01 | 2005-11-24 | Cohen Irun R | Antigen array and diagnostic uses thereof |
EP1835933A4 (en) * | 2005-01-04 | 2015-01-07 | Yeda Res & Dev | HSP60, PEPTIDES HSP60 AND T-CELL VACCINES FOR IMMUNOMODULATION |
EP2402022B1 (en) | 2005-03-14 | 2014-10-29 | Yeda Research And Development Co., Ltd. | Compositions of HSP60 peptides and viral antigens for vaccination and diagnosis |
CN101277722A (zh) | 2005-08-06 | 2008-10-01 | 王庆华 | 用于预防和治疗ⅰ型糖尿病的组合物及方法 |
WO2007116409A2 (en) | 2006-04-11 | 2007-10-18 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved vaccines comprising multimeric hsp60 peptide carriers |
DE102006019127A1 (de) * | 2006-04-25 | 2007-10-31 | Carl Zeiss Meditec Ag | Multiwellenlängen-Lasersystem und Verfahren für ophthalmologische Anwendungen |
WO2009090650A2 (en) | 2008-01-16 | 2009-07-23 | Ben-Gurion University Of The Negev Research And Development Authority | Vaccine for alzheimer's disease |
JP2015508812A (ja) | 2012-03-01 | 2015-03-23 | イエダ リサーチ アンド ディベロプメント カンパニー リミテッド | 非自己免疫性糖尿病を抑制および処置するためのhsp60由来ペプチドおよびペプチド類似体 |
CN104203263A (zh) | 2012-03-01 | 2014-12-10 | 耶达研究与发展有限公司 | 利用HSP60衍生肽再生胰岛β细胞 |
EP3090064B1 (en) | 2013-12-31 | 2019-11-13 | Yeda Research and Development Co. Ltd. | Diagnosis of systemic lupus erythematosus using oligonucleotides antigens |
WO2016139659A1 (en) | 2015-03-01 | 2016-09-09 | Immunarray Ltd. | Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens |
KR101843000B1 (ko) * | 2016-12-07 | 2018-03-28 | 주식회사 에프앤디파트너스 | 피부 트러블별 미용 또는 치료 기능을 제공하는 개인 맞춤형 기능성 팩 및 그의 사용 방법 |
KR102292635B1 (ko) | 2019-07-26 | 2021-08-23 | (의)삼성의료재단 | 마스크 팩 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8701163A (nl) * | 1986-09-09 | 1988-04-05 | Nederlanden Staat | Gebruik van een peptide voor de bereiding van preparaten voor het verlichten, het behandelen en de diagnose van autoimmuunziekten, in het bijzonder arthritische toestanden, verbindingen die met dit peptide verwant zijn, alsmede farmaceutische en diagnostische preparaten en testkits. |
DE3782996T2 (de) * | 1986-09-23 | 1993-06-09 | Yeda Res & Dev | Zellmembranproteine, zubereitungen, die sie enthalten und verfahren zu ihrer herstellung. |
US4952395A (en) * | 1987-02-26 | 1990-08-28 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
NL8703107A (nl) * | 1987-12-22 | 1989-07-17 | Nederlanden Staat | Polypeptiden en derivaten daarvan, alsmede de toepassing daarvan in farmaceutische en diagnostische preparaten. |
IL85746A (en) * | 1988-03-15 | 1994-05-30 | Yeda Res & Dev | Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases |
US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
-
1989
- 1989-06-26 US US07/371,249 patent/US5114844A/en not_active Expired - Lifetime
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1990
- 1990-03-14 CA CA002029861A patent/CA2029861C/en not_active Expired - Lifetime
- 1990-03-14 AU AU55467/90A patent/AU639456B2/en not_active Expired
- 1990-03-14 AT AT90908064T patent/ATE174689T1/de not_active IP Right Cessation
- 1990-03-14 WO PCT/US1990/001397 patent/WO1990010449A1/en active IP Right Grant
- 1990-03-14 EP EP90908064A patent/EP0417271B1/en not_active Expired - Lifetime
- 1990-03-14 DE DE69032833T patent/DE69032833T2/de not_active Expired - Lifetime
- 1990-03-14 JP JP50811690A patent/JP3165148B2/ja not_active Expired - Fee Related
- 1990-11-13 NO NO904919A patent/NO300594B1/no not_active IP Right Cessation
- 1990-11-13 FI FI905614A patent/FI103976B/fi active IP Right Grant
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1993
- 1993-03-29 US US08/039,704 patent/US5671848A/en not_active Expired - Lifetime
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1999
- 1999-07-26 JP JP21116199A patent/JP3203323B2/ja not_active Expired - Lifetime
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Also Published As
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---|---|
FI905614A0 (fi) | 1990-11-13 |
FI103976B1 (fi) | 1999-10-29 |
US5671848A (en) | 1997-09-30 |
ATE174689T1 (de) | 1999-01-15 |
CA2029861C (en) | 2001-01-16 |
EP0417271A1 (en) | 1991-03-20 |
EP0417271B1 (en) | 1998-12-16 |
JPH04502920A (ja) | 1992-05-28 |
US5114844A (en) | 1992-05-19 |
CA2029861A1 (en) | 1990-09-15 |
DE69032833T2 (de) | 1999-05-12 |
NO904919D0 (no) | 1990-11-13 |
EP0417271A4 (en) | 1992-09-09 |
JP3203323B2 (ja) | 2001-08-27 |
AU639456B2 (en) | 1993-07-29 |
AU5546790A (en) | 1990-10-09 |
DE69032833D1 (de) | 1999-01-28 |
NO904919L (no) | 1991-01-14 |
JP2001010962A (ja) | 2001-01-16 |
WO1990010449A1 (en) | 1990-09-20 |
JP2000055916A (ja) | 2000-02-25 |
FI103976B (fi) | 1999-10-29 |
JP3165148B2 (ja) | 2001-05-14 |
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