NO20130484A1 - Fremgangsmate for bestemmelse av graden av infeksjon - Google Patents
Fremgangsmate for bestemmelse av graden av infeksjon Download PDFInfo
- Publication number
- NO20130484A1 NO20130484A1 NO20130484A NO20130484A NO20130484A1 NO 20130484 A1 NO20130484 A1 NO 20130484A1 NO 20130484 A NO20130484 A NO 20130484A NO 20130484 A NO20130484 A NO 20130484A NO 20130484 A1 NO20130484 A1 NO 20130484A1
- Authority
- NO
- Norway
- Prior art keywords
- infection
- degree
- indication
- sample
- mastitis
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 26
- 210000004027 cell Anatomy 0.000 claims abstract description 49
- 239000008267 milk Substances 0.000 claims abstract description 26
- 235000013336 milk Nutrition 0.000 claims abstract description 26
- 210000004080 milk Anatomy 0.000 claims abstract description 26
- 210000001082 somatic cell Anatomy 0.000 claims abstract description 20
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 claims abstract description 17
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000003550 marker Substances 0.000 claims abstract description 17
- 230000003458 metachromatic effect Effects 0.000 claims abstract description 11
- 238000001514 detection method Methods 0.000 claims abstract description 6
- 230000004069 differentiation Effects 0.000 claims abstract description 6
- 208000004396 mastitis Diseases 0.000 claims description 26
- 241000283690 Bos taurus Species 0.000 claims description 12
- 210000000265 leukocyte Anatomy 0.000 claims description 12
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- 238000010790 dilution Methods 0.000 claims description 5
- 239000012895 dilution Substances 0.000 claims description 5
- 210000004698 lymphocyte Anatomy 0.000 claims description 3
- 210000002540 macrophage Anatomy 0.000 claims description 3
- 210000001616 monocyte Anatomy 0.000 claims description 3
- 239000002245 particle Substances 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 10
- 238000000684 flow cytometry Methods 0.000 description 10
- 238000005259 measurement Methods 0.000 description 9
- 239000000975 dye Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 208000031462 Bovine Mastitis Diseases 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- 238000007405 data analysis Methods 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 208000031504 Asymptomatic Infections Diseases 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011325 microbead Substances 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000011120 smear test Methods 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/06—Quantitative determination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/365—Breast disorders, e.g. mastalgia, mastitits, Paget's disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/065615 WO2012052046A1 (en) | 2010-10-18 | 2010-10-18 | Method for determining a degree of infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20130484A1 true NO20130484A1 (no) | 2013-04-11 |
Family
ID=44144667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20130484A NO20130484A1 (no) | 2010-10-18 | 2013-04-11 | Fremgangsmate for bestemmelse av graden av infeksjon |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20130157306A1 (es) |
| EP (1) | EP2630487B1 (es) |
| JP (1) | JP5781617B2 (es) |
| KR (1) | KR101770447B1 (es) |
| AU (1) | AU2010362562B2 (es) |
| BR (1) | BR112013008965B1 (es) |
| CA (1) | CA2814559C (es) |
| ES (1) | ES2596678T3 (es) |
| MX (1) | MX342266B (es) |
| NO (1) | NO20130484A1 (es) |
| NZ (1) | NZ608803A (es) |
| PL (1) | PL2630487T3 (es) |
| WO (1) | WO2012052046A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017065708A1 (en) * | 2015-10-12 | 2017-04-20 | Nehir Biyoteknoloji Ar-Ge Hizm. Dan. Bils. Paz. San. Tic. Ltd. Sti | On-line automatic subclinical mastitis detection device based on optical scattering and an automatic milk sampling system comprising this device |
| EP3196644B1 (en) * | 2016-01-22 | 2019-11-27 | Mastatix, Ltd. | Method for diagnosing mastitis in a lactating animal |
| CN108717125B (zh) * | 2018-06-22 | 2021-05-11 | 北京农学院 | 奶牛早期乳腺炎症监测方法 |
| JP7405555B2 (ja) * | 2019-10-08 | 2023-12-26 | 株式会社アドバンテスト | 体細胞計、体細胞測定方法、プログラムおよび記録媒体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3327119A (en) * | 1964-03-26 | 1967-06-20 | Ibm | Method and apparatus for detecting cancer cells |
| JPH0635972B2 (ja) * | 1986-11-27 | 1994-05-11 | 東亜医用電子株式会社 | フロ−サイトメトリ−による白血球の分類方法 |
| JP2003310299A (ja) * | 2002-04-25 | 2003-11-05 | Sysmex Corp | 乳試料中に含まれる体細胞を測定するための乳試料処理方法及び試薬ならびに方法 |
| US6979550B1 (en) * | 2002-09-05 | 2005-12-27 | Rivas Ariel L | Method for diagnosis of, and determination of susceptibility to bovine mastitis |
| NZ571425A (en) * | 2006-03-24 | 2011-09-30 | Advanced Animal Diagnostics | Microfluidic chamber assembly for mastitis assay with wedge shaped chamber |
| GB2457094A (en) | 2008-02-04 | 2009-08-05 | Univ Dublin City | A cuvette assembly for holding milking samples |
| JPWO2010013757A1 (ja) * | 2008-07-31 | 2012-01-12 | 株式会社クラレ | 体細胞数の測定装置及びセンサ |
-
2010
- 2010-10-18 NZ NZ608803A patent/NZ608803A/en unknown
- 2010-10-18 EP EP10768012.6A patent/EP2630487B1/en not_active Revoked
- 2010-10-18 AU AU2010362562A patent/AU2010362562B2/en active Active
- 2010-10-18 JP JP2013533098A patent/JP5781617B2/ja active Active
- 2010-10-18 BR BR112013008965-2A patent/BR112013008965B1/pt active IP Right Grant
- 2010-10-18 WO PCT/EP2010/065615 patent/WO2012052046A1/en active Application Filing
- 2010-10-18 PL PL10768012T patent/PL2630487T3/pl unknown
- 2010-10-18 US US13/819,616 patent/US20130157306A1/en not_active Abandoned
- 2010-10-18 KR KR1020137012633A patent/KR101770447B1/ko active IP Right Grant
- 2010-10-18 MX MX2013004232A patent/MX342266B/es active IP Right Grant
- 2010-10-18 CA CA2814559A patent/CA2814559C/en active Active
- 2010-10-18 ES ES10768012.6T patent/ES2596678T3/es active Active
-
2013
- 2013-04-11 NO NO20130484A patent/NO20130484A1/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013008965B1 (pt) | 2021-08-03 |
| AU2010362562B2 (en) | 2014-05-15 |
| US20130157306A1 (en) | 2013-06-20 |
| ES2596678T3 (es) | 2017-01-11 |
| PL2630487T3 (pl) | 2017-01-31 |
| MX342266B (es) | 2016-09-23 |
| CA2814559C (en) | 2018-12-11 |
| BR112013008965A2 (pt) | 2020-06-30 |
| EP2630487A1 (en) | 2013-08-28 |
| MX2013004232A (es) | 2013-05-30 |
| NZ608803A (en) | 2014-11-28 |
| EP2630487B1 (en) | 2016-08-17 |
| KR101770447B1 (ko) | 2017-08-22 |
| JP5781617B2 (ja) | 2015-09-24 |
| WO2012052046A1 (en) | 2012-04-26 |
| JP2013543118A (ja) | 2013-11-28 |
| CA2814559A1 (en) | 2012-04-26 |
| KR20140020835A (ko) | 2014-02-19 |
| AU2010362562A1 (en) | 2013-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |