NO20090779L - 5,6-bisaryl-2-pyridin-karboksamidderivater, fremstilling og anvendelse derav i terapeutika som uretosin II receptorantagonister - Google Patents

5,6-bisaryl-2-pyridin-karboksamidderivater, fremstilling og anvendelse derav i terapeutika som uretosin II receptorantagonister

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Publication number
NO20090779L
NO20090779L NO20090779A NO20090779A NO20090779L NO 20090779 L NO20090779 L NO 20090779L NO 20090779 A NO20090779 A NO 20090779A NO 20090779 A NO20090779 A NO 20090779A NO 20090779 L NO20090779 L NO 20090779L
Authority
NO
Norway
Prior art keywords
preparation
urethosine
bisaryl
therapeutics
receptor antagonists
Prior art date
Application number
NO20090779A
Other languages
English (en)
Norwegian (no)
Inventor
Jean-Michel Altenburger
Valerie Fossey
Gilbert Lassalle
Frederic Petit
Jean Claude Verniers
Philip Janiak
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20090779L publication Critical patent/NO20090779L/no

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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NO20090779A 2006-08-11 2009-02-18 5,6-bisaryl-2-pyridin-karboksamidderivater, fremstilling og anvendelse derav i terapeutika som uretosin II receptorantagonister NO20090779L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0607283A FR2904827B1 (fr) 2006-08-11 2006-08-11 Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii
PCT/FR2007/001357 WO2008020124A1 (fr) 2006-08-11 2007-08-09 Dérivés de 5,6-bisaryl-2-pyridine-carboxamide, leur préparation et leur application en thérapeutique comme antagonistes des recepteurs a l'urotensine ii

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NO20090779L true NO20090779L (no) 2009-05-05

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NO20090779A NO20090779L (no) 2006-08-11 2009-02-18 5,6-bisaryl-2-pyridin-karboksamidderivater, fremstilling og anvendelse derav i terapeutika som uretosin II receptorantagonister

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US (2) US8110579B2 (zh)
EP (2) EP2439193B1 (zh)
JP (1) JP5230621B2 (zh)
KR (1) KR20090050075A (zh)
CN (1) CN101511789B (zh)
AR (1) AR062294A1 (zh)
AT (1) ATE553082T1 (zh)
AU (1) AU2007285659B2 (zh)
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CL (1) CL2007002329A1 (zh)
CO (1) CO6150147A2 (zh)
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DK (1) DK2059508T3 (zh)
EA (1) EA016352B1 (zh)
ES (1) ES2385614T3 (zh)
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FR2948119A1 (fr) 2009-07-16 2011-01-21 Sanofi Aventis Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii
FR2948120A1 (fr) * 2009-07-16 2011-01-21 Sanofi Aventis Derives de 5,6-bisaryl-2-pyrimidine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l’urotensine ii
AR079022A1 (es) * 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
EA201590693A1 (ru) * 2012-10-05 2015-08-31 Ригель Фармасьютикалс, Инк. Ингибиторы gdf-8
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
EP2961746B1 (en) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
WO2014144455A1 (en) 2013-03-15 2014-09-18 Epizyme, Inc. 1 -phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
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US9738651B2 (en) * 2013-03-15 2017-08-22 Epizyme, Inc. CARM1 inhibitors and uses thereof
MY182818A (en) * 2015-03-18 2021-02-05 Vectus Biosystems Ltd Compositions for the treatment of fibrosis and fibrosis-related conditions

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KR20090050075A (ko) 2009-05-19
FR2904827A1 (fr) 2008-02-15
RS52420B (en) 2013-02-28
US20120108611A1 (en) 2012-05-03
PL2059508T3 (pl) 2012-09-28
HRP20120559T1 (hr) 2012-07-31
CN101511789A (zh) 2009-08-19
TW200815393A (en) 2008-04-01
GT200900026A (es) 2009-11-24
CR10603A (es) 2009-07-03
TWI388551B (zh) 2013-03-11
US8110579B2 (en) 2012-02-07
AR062294A1 (es) 2008-10-29
US8552201B2 (en) 2013-10-08
ZA200900835B (en) 2010-06-30
EP2059508A1 (fr) 2009-05-20
HK1135903A1 (zh) 2010-06-18
MA30703B1 (fr) 2009-09-01
AU2007285659A1 (en) 2008-02-21
CL2007002329A1 (es) 2008-03-07
MY145644A (en) 2012-03-15
AU2007285659B2 (en) 2013-01-10
NZ574699A (en) 2011-10-28
EA016352B1 (ru) 2012-04-30
IL196797A (en) 2013-07-31
MX2009001582A (es) 2009-02-19
EP2439193B1 (fr) 2014-04-23
CA2659928A1 (fr) 2008-02-21
ATE553082T1 (de) 2012-04-15
EP2059508B1 (fr) 2012-04-11
CY1113129T1 (el) 2016-04-13
IL196797A0 (en) 2009-11-18
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CN101511789B (zh) 2012-05-23
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EA200970192A1 (ru) 2009-08-28
WO2008020124A1 (fr) 2008-02-21
SI2059508T1 (sl) 2012-08-31
TN2009000040A1 (en) 2010-08-19
PT2059508E (pt) 2012-07-03
UY30534A1 (es) 2008-03-31
PE20080421A1 (es) 2008-06-17
FR2904827B1 (fr) 2008-09-19
ES2385614T3 (es) 2012-07-27
JP2010500332A (ja) 2010-01-07
EP2439193A1 (fr) 2012-04-11
CO6150147A2 (es) 2010-04-20
JP5230621B2 (ja) 2013-07-10
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