NO20084997L - Pyrazolo[3,4-D]pyrimidinderivater nyttige for a behandle andedrettssykdommer - Google Patents
Pyrazolo[3,4-D]pyrimidinderivater nyttige for a behandle andedrettssykdommerInfo
- Publication number
- NO20084997L NO20084997L NO20084997A NO20084997A NO20084997L NO 20084997 L NO20084997 L NO 20084997L NO 20084997 A NO20084997 A NO 20084997A NO 20084997 A NO20084997 A NO 20084997A NO 20084997 L NO20084997 L NO 20084997L
- Authority
- NO
- Norway
- Prior art keywords
- pyrazolo
- respiratory diseases
- pyrimidine derivatives
- derivatives useful
- treating respiratory
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0610242.0A GB0610242D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
PCT/EP2007/004501 WO2007134828A1 (en) | 2006-05-23 | 2007-05-21 | Pyrazolo [3, 4-d] pyrimidine derivatives useful to treat respiratory disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20084997L true NO20084997L (no) | 2008-12-22 |
Family
ID=36687588
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20084997A NO20084997L (no) | 2006-05-23 | 2008-11-28 | Pyrazolo[3,4-D]pyrimidinderivater nyttige for a behandle andedrettssykdommer |
Country Status (24)
Country | Link |
---|---|
US (5) | US20090131457A1 (pt) |
EP (1) | EP2026811A1 (pt) |
JP (1) | JP2009537580A (pt) |
KR (1) | KR101106853B1 (pt) |
CN (1) | CN101443013A (pt) |
AR (2) | AR061057A1 (pt) |
AU (1) | AU2007253615B2 (pt) |
BR (1) | BRPI0712022A2 (pt) |
CA (1) | CA2650661A1 (pt) |
CL (1) | CL2007001455A1 (pt) |
CR (1) | CR10419A (pt) |
EC (1) | ECSP088902A (pt) |
GB (1) | GB0610242D0 (pt) |
GT (1) | GT200800256A (pt) |
IL (1) | IL195017A0 (pt) |
MA (1) | MA30433B1 (pt) |
MX (1) | MX2008014835A (pt) |
NO (1) | NO20084997L (pt) |
PE (1) | PE20080315A1 (pt) |
RU (1) | RU2008150619A (pt) |
TN (1) | TNSN08478A1 (pt) |
TW (1) | TW200806665A (pt) |
WO (1) | WO2007134828A1 (pt) |
ZA (1) | ZA200809097B (pt) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
NZ571182A (en) | 2006-04-04 | 2010-09-30 | Univ California | Pyrazolo[3,4-d]pyrimidines |
EP2173722B1 (en) * | 2007-07-26 | 2012-08-29 | Novartis AG | Pyrimidine derivatives useful for the treatment of inflammatory or allergic conditions |
US7928140B2 (en) | 2007-08-02 | 2011-04-19 | Amgen Inc. | Benzothiazole PI3 kinase modulators for cancer treatment |
WO2009046448A1 (en) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
EP2231661A1 (en) | 2007-12-19 | 2010-09-29 | Amgen, Inc. | Inhibitors of pi3 kinase |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
MY191407A (en) | 2008-01-04 | 2022-06-27 | Intellikine Llc | Certain chemical entities, compositions and methods |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
EP2111861A1 (en) * | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
US8415376B2 (en) | 2008-05-30 | 2013-04-09 | Amgen Inc. | Inhibitors of PI3 kinase |
US9096611B2 (en) * | 2008-07-08 | 2015-08-04 | Intellikine Llc | Kinase inhibitors and methods of use |
US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
US8220787B2 (en) * | 2008-09-19 | 2012-07-17 | Panasonic Corporation | Part mounting device |
JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン, エルエルシー | 複素環キナーゼ阻害剤 |
DK2358720T3 (en) | 2008-10-16 | 2016-06-06 | Univ California | Heteroarylkinaseinhibitorer fused-ring |
US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
WO2010114894A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted heterocyclic compounds |
WO2010129816A2 (en) | 2009-05-07 | 2010-11-11 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
WO2011041634A1 (en) * | 2009-10-02 | 2011-04-07 | Vertex Pharmaceuticals Incorporated | Pyrazole inhibitors of phosphatidylinositol 3-kinase |
WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
GB201004311D0 (en) | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
WO2011146313A1 (en) | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
EP2571357B1 (en) | 2010-05-21 | 2016-07-06 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
EP2637669A4 (en) | 2010-11-10 | 2014-04-02 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and their use |
DK2663309T3 (en) | 2011-01-10 | 2017-06-19 | Infinity Pharmaceuticals Inc | METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES |
US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
CN103946226A (zh) | 2011-07-19 | 2014-07-23 | 无限药品股份有限公司 | 杂环化合物及其应用 |
EP2734520B1 (en) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
SG11201400310WA (en) | 2011-08-29 | 2014-06-27 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
CA2846496C (en) | 2011-09-02 | 2020-07-14 | The Regents Of The University Of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
SG11201400277VA (en) | 2011-09-14 | 2014-05-29 | Proximagen Ltd | New enzyme inhibitor compounds |
GB201115853D0 (en) | 2011-09-14 | 2011-10-26 | Proximagen Ltd | New enzyme inhibitor compounds |
ES2650630T3 (es) | 2011-10-03 | 2018-01-19 | The University Of North Carolina At Chapel Hill | Compuestos de pirrolopirimidina para el tratamiento del cáncer |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP2852579A4 (en) | 2012-05-22 | 2015-12-30 | Univ North Carolina | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER |
KR20160027218A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
MX2015003874A (es) | 2012-09-26 | 2015-12-16 | Univ California | Modulacion de ire1. |
US9562047B2 (en) | 2012-10-17 | 2017-02-07 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
EP2925752A4 (en) | 2012-11-27 | 2016-06-01 | Univ North Carolina | PYRIMIDINE COMPOUNDS FOR CANCER TREATMENT |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
CN105209042B (zh) | 2013-03-22 | 2019-03-08 | 米伦纽姆医药公司 | 催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合 |
WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
BR112016007467B1 (pt) | 2013-10-04 | 2022-09-20 | Infinity Pharmaceuticals, Inc | Compostos heterocíclicos e usos dos mesmos |
JP6701088B2 (ja) | 2014-03-19 | 2020-05-27 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | Pi3k−ガンマ媒介障害の治療で使用するための複素環式化合物 |
WO2015157128A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Therapuetic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CZ308056B6 (cs) * | 2015-07-20 | 2019-11-27 | Ustav Experimentalni Botaniky Av Cr V V I | 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky |
EP3350183A1 (en) | 2015-09-14 | 2018-07-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
PL3442535T3 (pl) | 2016-04-15 | 2022-10-24 | Cancer Research Technology Limited | Związki heterocykliczne jako inhibitory kinazy ret |
KR20220054894A (ko) | 2016-04-15 | 2022-05-03 | 캔써 리서치 테크놀로지 리미티드 | Ret 키나아제 억제제로서의 헤테로사이클릭 화합물 |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2017223422A1 (en) | 2016-06-24 | 2017-12-28 | Infinity Pharmaceuticals, Inc. | Combination therapies |
JOP20180009A1 (ar) * | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR205429A1 (es) * | 1971-04-27 | 1976-05-07 | Ciba Geigy Ag | Procedimiento para la elaboracion de nuevos derivados de 4-amino - 3-(5-nitro- 2 -furil)-1-metil - 1h - pirazol-(3,4-ol)-pirimidina |
AR204665A1 (es) * | 1974-05-13 | 1976-02-20 | Lilly Co Eli | Procedimiento para preparar compuestos de 3-(5-nitroimidazol-2-il)pirazolo(3,4d)pirimidina |
US4044130A (en) * | 1974-07-03 | 1977-08-23 | Ciba-Geigy Corporation | Compositions for the control of microorganisms |
JPS5195094A (en) * | 1975-01-31 | 1976-08-20 | * ***** ****so*shi***** *o*u****** ********ne***u**** *** *** ****ne*** *************te***ku** | |
ATE283700T1 (de) * | 1999-06-08 | 2004-12-15 | Lorantis Ltd | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
PL354249A1 (en) * | 1999-09-17 | 2003-12-29 | Abbott Gmbhabbott Gmbh | Pyrazolopyrimidines as therapeutic agents |
EP1278748B1 (en) * | 2000-04-25 | 2011-03-23 | ICOS Corporation | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
JP4459619B2 (ja) * | 2001-10-02 | 2010-04-28 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 化合物 |
AU2003225933A1 (en) * | 2002-03-22 | 2003-10-13 | Cellular Genomics, Inc. | AN IMPROVED FORMULATION OF CERTAIN PYRAZOLO(3,4-d) PYRIMIDINES AS KINASE MODULATORS |
US7429596B2 (en) * | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
CA2553724A1 (en) * | 2004-02-03 | 2005-08-18 | Abbott Laboratories | Aminobenzoxazoles as therapeutic agents |
WO2006068760A2 (en) * | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
EA200870385A1 (ru) * | 2006-03-29 | 2009-04-28 | Фолдркс Фармасьютикалз, Инк. | Ингибирование токсичности альфа-синуклеина |
-
2006
- 2006-05-23 GB GBGB0610242.0A patent/GB0610242D0/en active Pending
-
2007
- 2007-05-21 MX MX2008014835A patent/MX2008014835A/es not_active Application Discontinuation
- 2007-05-21 WO PCT/EP2007/004501 patent/WO2007134828A1/en active Application Filing
- 2007-05-21 EP EP07725407A patent/EP2026811A1/en not_active Withdrawn
- 2007-05-21 JP JP2009511393A patent/JP2009537580A/ja active Pending
- 2007-05-21 US US12/227,314 patent/US20090131457A1/en not_active Abandoned
- 2007-05-21 RU RU2008150619/04A patent/RU2008150619A/ru not_active Application Discontinuation
- 2007-05-21 CA CA002650661A patent/CA2650661A1/en not_active Abandoned
- 2007-05-21 KR KR1020087028535A patent/KR101106853B1/ko active IP Right Grant
- 2007-05-21 PE PE2007000620A patent/PE20080315A1/es not_active Application Discontinuation
- 2007-05-21 BR BRPI0712022-2A patent/BRPI0712022A2/pt not_active Application Discontinuation
- 2007-05-21 AR ARP070102192A patent/AR061057A1/es not_active Application Discontinuation
- 2007-05-21 AU AU2007253615A patent/AU2007253615B2/en not_active Ceased
- 2007-05-21 CN CNA2007800173225A patent/CN101443013A/zh active Pending
- 2007-05-22 TW TW096118225A patent/TW200806665A/zh unknown
- 2007-05-22 CL CL200701455A patent/CL2007001455A1/es unknown
-
2008
- 2008-10-23 ZA ZA200809097A patent/ZA200809097B/xx unknown
- 2008-10-30 IL IL195017A patent/IL195017A0/en unknown
- 2008-10-30 CR CR10419A patent/CR10419A/es not_active Application Discontinuation
- 2008-11-21 TN TNP2008000478A patent/TNSN08478A1/en unknown
- 2008-11-21 GT GT200800256A patent/GT200800256A/es unknown
- 2008-11-21 EC EC2008008902A patent/ECSP088902A/es unknown
- 2008-11-26 MA MA31421A patent/MA30433B1/fr unknown
- 2008-11-28 NO NO20084997A patent/NO20084997L/no not_active Application Discontinuation
-
2013
- 2013-10-09 US US14/049,706 patent/US20140051698A1/en not_active Abandoned
-
2014
- 2014-04-25 US US14/261,890 patent/US8901134B2/en active Active
-
2016
- 2016-06-27 US US15/194,373 patent/US20160303132A1/en not_active Abandoned
-
2017
- 2017-11-10 AR ARP170103136A patent/AR110051A2/es unknown
-
2018
- 2018-01-10 US US15/867,425 patent/US20180125849A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20140235632A1 (en) | 2014-08-21 |
RU2008150619A (ru) | 2010-06-27 |
MX2008014835A (es) | 2008-12-01 |
AU2007253615B2 (en) | 2011-06-23 |
US20180125849A1 (en) | 2018-05-10 |
CR10419A (es) | 2011-07-19 |
AR061057A1 (es) | 2008-07-30 |
KR20090008392A (ko) | 2009-01-21 |
TW200806665A (en) | 2008-02-01 |
ECSP088902A (es) | 2008-12-30 |
EP2026811A1 (en) | 2009-02-25 |
BRPI0712022A2 (pt) | 2011-12-27 |
KR101106853B1 (ko) | 2012-01-19 |
GT200800256A (es) | 2009-05-28 |
CN101443013A (zh) | 2009-05-27 |
GB0610242D0 (en) | 2006-07-05 |
US20140051698A1 (en) | 2014-02-20 |
US8901134B2 (en) | 2014-12-02 |
TNSN08478A1 (en) | 2010-04-14 |
CA2650661A1 (en) | 2007-11-29 |
JP2009537580A (ja) | 2009-10-29 |
IL195017A0 (en) | 2009-08-03 |
AR110051A2 (es) | 2019-02-20 |
US20160303132A1 (en) | 2016-10-20 |
ZA200809097B (en) | 2009-11-25 |
PE20080315A1 (es) | 2008-06-11 |
MA30433B1 (fr) | 2009-05-04 |
CL2007001455A1 (es) | 2008-05-16 |
WO2007134828A1 (en) | 2007-11-29 |
AU2007253615A1 (en) | 2007-11-29 |
US20090131457A1 (en) | 2009-05-21 |
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