NO20082834L - 2-(fenyl eller heterosyklisk)-1H-fenantro[9,10-D]imidazoler som MPGES-1-inhibitorer - Google Patents

2-(fenyl eller heterosyklisk)-1H-fenantro[9,10-D]imidazoler som MPGES-1-inhibitorer

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Publication number
NO20082834L
NO20082834L NO20082834A NO20082834A NO20082834L NO 20082834 L NO20082834 L NO 20082834L NO 20082834 A NO20082834 A NO 20082834A NO 20082834 A NO20082834 A NO 20082834A NO 20082834 L NO20082834 L NO 20082834L
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Norway
Prior art keywords
mpges
inhibitors
phenanthro
imidazoles
heterocyclic
Prior art date
Application number
NO20082834A
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English (en)
Inventor
Richard Friesen
Marc Gagnon
Anh Chau
Bernard Cote
Yves Ducharme
Richard Frenette
Andre Giroux
Evelyn Martins
Hongping Yu
Tom Wu
Original Assignee
Merck Frosst Canada Ltd
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Application filed by Merck Frosst Canada Ltd filed Critical Merck Frosst Canada Ltd
Publication of NO20082834L publication Critical patent/NO20082834L/no

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
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  • Plural Heterocyclic Compounds (AREA)

Abstract

eller farmasøytisk akseptable salter derav. Disse forbindelsene er inhibitorer av enzymet mikrosomal prostaglandin E-syntase-1 (mPGES-1), og er derfor anvendbare til behandling av smerte og/eller betennelse fra mange forskjellige sykdommer eller tilstander, slik som osteoartritt, reumatoid artritt og akutt eller kronisk smerte. Fremgangsmåter for behandling av sykdommer eller tilstander formidlet av mPGES-l-enzymet, og farmasøytiske preparater, er også omfattet.
NO20082834A 2005-11-23 2008-06-20 2-(fenyl eller heterosyklisk)-1H-fenantro[9,10-D]imidazoler som MPGES-1-inhibitorer NO20082834L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/374,288 US7442716B2 (en) 2004-12-17 2005-11-23 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
PCT/CA2006/001904 WO2007059611A1 (en) 2005-11-23 2006-11-21 2-(phenyl or heterocyclic)-1h-phenantrho[9,10-d]imidazoles as mpges-1 inhibitors

Publications (1)

Publication Number Publication Date
NO20082834L true NO20082834L (no) 2008-08-21

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ID=38066869

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Application Number Title Priority Date Filing Date
NO20082834A NO20082834L (no) 2005-11-23 2008-06-20 2-(fenyl eller heterosyklisk)-1H-fenantro[9,10-D]imidazoler som MPGES-1-inhibitorer

Country Status (13)

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US (2) US7442716B2 (no)
EP (1) EP1954683B1 (no)
JP (1) JP5276445B2 (no)
KR (1) KR20080069208A (no)
CN (1) CN101370787B (no)
BR (1) BRPI0618881A2 (no)
CA (1) CA2629527C (no)
ES (1) ES2569399T3 (no)
NO (1) NO20082834L (no)
NZ (1) NZ568107A (no)
RU (1) RU2421448C2 (no)
WO (2) WO2007059611A1 (no)
ZA (1) ZA200803926B (no)

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