NO20081434L - 5-(fenylisoksazolyletoksy)-triazol-3-yl substituert pyridinsammensetninger for behandling av neurologisk, psykiatrisk eller smerteforstyrrelser - Google Patents

5-(fenylisoksazolyletoksy)-triazol-3-yl substituert pyridinsammensetninger for behandling av neurologisk, psykiatrisk eller smerteforstyrrelser

Info

Publication number
NO20081434L
NO20081434L NO20081434A NO20081434A NO20081434L NO 20081434 L NO20081434 L NO 20081434L NO 20081434 A NO20081434 A NO 20081434A NO 20081434 A NO20081434 A NO 20081434A NO 20081434 L NO20081434 L NO 20081434L
Authority
NO
Norway
Prior art keywords
phenylisoxazolylethoxy
psychiatric
triazol
neurological
treatment
Prior art date
Application number
NO20081434A
Other languages
English (en)
Norwegian (no)
Inventor
Abdelmalik Slassi
Per-Olov Bergstrom
Tao Xin
Louise Edwards
Methvin Isaac
Alexander Minidis
David Wensbo
Caroline Ericsson
Veronica Profir
Jalaj Arora
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20081434L publication Critical patent/NO20081434L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
NO20081434A 2005-09-29 2008-03-19 5-(fenylisoksazolyletoksy)-triazol-3-yl substituert pyridinsammensetninger for behandling av neurologisk, psykiatrisk eller smerteforstyrrelser NO20081434L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72152705P 2005-09-29 2005-09-29
PCT/US2006/036423 WO2007040982A1 (en) 2005-09-29 2006-09-20 5- (phenylisoxazolylethoxy) -triazol- 3 -yl substituted pyridine compounds for the treatment of neurological, psychiatric or pain disorders

Publications (1)

Publication Number Publication Date
NO20081434L true NO20081434L (no) 2008-05-19

Family

ID=37745801

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081434A NO20081434L (no) 2005-09-29 2008-03-19 5-(fenylisoksazolyletoksy)-triazol-3-yl substituert pyridinsammensetninger for behandling av neurologisk, psykiatrisk eller smerteforstyrrelser

Country Status (18)

Country Link
US (4) US20080227824A1 (zh)
EP (1) EP1934209A1 (zh)
JP (2) JP2009510064A (zh)
KR (1) KR20080050421A (zh)
CN (1) CN101273037A (zh)
AR (1) AR058807A1 (zh)
AU (1) AU2006297462A1 (zh)
BR (1) BRPI0616228A2 (zh)
CA (1) CA2623009A1 (zh)
EC (1) ECSP088283A (zh)
IL (1) IL189990A0 (zh)
NO (1) NO20081434L (zh)
RU (1) RU2008108219A (zh)
TW (1) TW200800976A (zh)
UA (1) UA92503C2 (zh)
UY (1) UY29796A1 (zh)
WO (1) WO2007040982A1 (zh)
ZA (1) ZA200802163B (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4637578B2 (ja) * 2002-08-09 2011-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体−５の調節因子としての１，２，４−オキサジアゾール類
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
UY29796A1 (es) * 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
TW200821305A (en) * 2006-10-05 2008-05-16 Astrazeneca Ab MGluR5 modulators
CL2008003085A1 (es) 2007-10-19 2009-10-09 Astrazeneca Ab Compuestos derivados de 4-metil-5-[1-(2-(3-metilfenil)-2h-tetrazol-5-il)etoxi]-4h-1,2,4-triazol-3-il moduladores del receptor mglur5; composiciones farmceuticas que los contienen; compuestos intermediarios; y su uso en la preparacion de un medicamento util en el tratamiento de desordenes neurologicos, psiquiatricos o gastrointestinales.
EA201000656A1 (ru) * 2007-10-26 2010-12-30 Астразенека Аб Аминопроизводные 1,2,4-триазола в качестве модуляторов mglur5
AR073007A1 (es) * 2008-08-12 2010-10-06 Astrazeneca Ab Derivados de oxazol utiles para tratar trastornos mediados por el receptor mglur5
AR073268A1 (es) * 2008-08-12 2010-10-28 Astrazeneca Ab Forma cristalina de 4-(5-[(1r)-1-[5-(3-clorofenil)isoxazol-3-il] etoxi]-4-metil-4h-1,2,4-triazol-3-il)piridina.
WO2010048095A2 (en) * 2008-10-22 2010-04-29 House Ear Institute Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
KR20110089868A (ko) * 2008-12-12 2011-08-09 아스트라제네카 아베 ４-［４-메틸-５-(ｃ1-10알킬티오／ｃ5-10아릴-ｃ1-6알킬티오)-４ｈ-１,２,４-트리아졸-3-일］피리딘을 제조하기 위한 신규 방법
WO2010071559A1 (en) * 2008-12-18 2010-06-24 Astrazeneca Ab Processes for the manufacture of 3-{4-methyl-5- [ (ir) -1- (2- (3-methylphenyl) -2h-tetrazol-5-yl) -ethoxy] -4h- [1,2, 4] triazol-3-yl} -pyridine, 4-methyl-3-methylthio-5- (3- pyridyl)-l,2,4-triazole, and (ir) -1- [2- (3-methylphenyl) -2h- tetrazol-5-yl] ethanol
BRPI0923053A2 (pt) * 2008-12-18 2017-06-06 Astrazeneca Ab processo para preparar um composto
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
WO2010139966A1 (en) * 2009-06-05 2010-12-09 Oslo University Hospital Hf Azole derivatives as wtn pathway inhibitors
JP5775094B2 (ja) 2009-12-29 2015-09-09 イーライ リリー アンド カンパニー 統合失調症の処置に有用な選択的ｍＧｌｕ５受容体増強因子としてのテトラヒドロトリアゾロピリジン化合物
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
US20120295942A1 (en) 2010-02-01 2012-11-22 Nicholas James Devereux Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
US8080568B1 (en) * 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
UA112418C2 (uk) * 2010-09-07 2016-09-12 Астеллас Фарма Інк. Терапевтичний болезаспокійливий засіб
WO2012076898A1 (en) 2010-12-08 2012-06-14 Oslo University Hospital Hf Triazole derivatives as wnt signaling pathway inhibitors
BR112013023813A2 (pt) 2011-03-18 2016-12-13 Novartis Ag combinações de ativadores do receptor acetilcolina nicotínico alfa 7 e antagonistas de mglur5 para uso em dopamina induzida por discinesia na doença de parkinson
KR20160120157A (ko) 2015-04-07 2016-10-17 주식회사 메드팩토 암 예방 또는 치료용 약학적 조성물 및 이를 이용한 방법
WO2016163754A1 (en) * 2015-04-07 2016-10-13 Medpacto Inc. Pharmaceutical composition for preventing or treating cancer and method using thereof
KR20220008828A (ko) * 2019-05-15 2022-01-21 클라에스 툴린 동물에서 통증의 예방 및/또는 치료에 사용하기 위한 4-[5-[(rac)-1-[5-(3-클로로페닐)-3-이속사졸릴]에톡시]-4-메틸-4H-1,2,4-트리아졸-3-일]피리딘
US20220387410A1 (en) 2019-11-05 2022-12-08 Claes Thulin 4-[5-[(rac)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine for use in prevention and/or treatment of surmenage in a mammal
WO2024088712A1 (en) 2022-10-28 2024-05-02 Orphelion Ab Mglur5 receptor antagonists for use in prevention and/or treatment of bone marrow lesions (bml) and/or osteoporosis, cartilage loss, osteosclerosis, osteitis in a mammal

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1210344T3 (da) 1999-08-19 2006-03-06 Nps Pharma Inc Heteropolycykliske forbindelser og anvendelser deraf som metabotrope glutamatreceptorantagonister
BR0207390A (pt) * 2001-02-21 2004-10-13 Nps Pharma Inc Compostos, composições farmacêuticas e métodos de tratatamento de doença associada a ativação e a ativação do grupo i mg1ur
JP4637578B2 (ja) * 2002-08-09 2011-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体−５の調節因子としての１，２，４−オキサジアゾール類
JP2006502134A (ja) 2002-08-09 2006-01-19 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体において活性を有する化合物
JP2006506340A (ja) 2002-08-09 2006-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール
WO2005060971A1 (en) 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of reflux-related diseases
ES2303969T3 (es) 2003-12-19 2008-09-01 Astrazeneca Ab 5-fluoro- y cloro-piridin-2-il-tetrazoles como ligandos del receptor metabotropico de glutamato de tipo 5.
WO2005077368A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
WO2005077345A1 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease
CN101018779A (zh) 2004-02-18 2007-08-15 阿斯利康(瑞典)有限公司 三唑化合物及其作为代谢型谷氨酸受体拮抗剂的应用
TW200531694A (en) 2004-02-18 2005-10-01 Astrazeneca Ab Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists
ATE402935T1 (de) 2004-02-18 2008-08-15 Astrazeneca Ab Kondensierte heterocyclische verbindungen und deren verwendung als antagonisten des metabotropen rezeptors zur behandlung von gastrointestinalen erkrankungen
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
UA82434C2 (uk) 2004-02-18 2008-04-10 Astrazeneca Ab Полігетероциклічні сполуки і їх застосування як антагоністів метаботропного рецептора глютамату, фармацевтична композиція на їх основі
CA2556263A1 (en) 2004-02-18 2005-09-01 Astrazeneca Ab Tetrazole compounds and their use as metabotropic glutamate receptor antagonists
UY29796A1 (es) * 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor

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IL189990A0 (en) 2008-08-07
ECSP088283A (es) 2008-04-28
JP2010013476A (ja) 2010-01-21
EP1934209A1 (en) 2008-06-25
WO2007040982A1 (en) 2007-04-12
CA2623009A1 (en) 2007-04-12
US20070270469A1 (en) 2007-11-22
AR058807A1 (es) 2008-02-27
AU2006297462A1 (en) 2007-04-12
BRPI0616228A2 (pt) 2011-06-14
TW200800976A (en) 2008-01-01
UA92503C2 (ru) 2010-11-10
US20070270468A1 (en) 2007-11-22
US20070129408A1 (en) 2007-06-07
US7476684B2 (en) 2009-01-13
JP2009510064A (ja) 2009-03-12
RU2008108219A (ru) 2009-11-10
KR20080050421A (ko) 2008-06-05
CN101273037A (zh) 2008-09-24
US20080227824A1 (en) 2008-09-18
UY29796A1 (es) 2007-04-30

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