NO20081084L - Arylpyridiner og fremgangsmater for deres anvendelse - Google Patents
Arylpyridiner og fremgangsmater for deres anvendelseInfo
- Publication number
- NO20081084L NO20081084L NO20081084A NO20081084A NO20081084L NO 20081084 L NO20081084 L NO 20081084L NO 20081084 A NO20081084 A NO 20081084A NO 20081084 A NO20081084 A NO 20081084A NO 20081084 L NO20081084 L NO 20081084L
- Authority
- NO
- Norway
- Prior art keywords
- methods
- aryl pyridines
- pyridines
- aryl
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70474205P | 2005-08-02 | 2005-08-02 | |
| PCT/US2006/030269 WO2007016674A2 (fr) | 2005-08-02 | 2006-07-31 | Aryl pyridines et procédés pour leur utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081084L true NO20081084L (no) | 2008-02-29 |
Family
ID=37517029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081084A NO20081084L (no) | 2005-08-02 | 2008-02-29 | Arylpyridiner og fremgangsmater for deres anvendelse |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8153804B2 (fr) |
| EP (1) | EP1919895A2 (fr) |
| JP (1) | JP2009503103A (fr) |
| KR (1) | KR20080040692A (fr) |
| CN (1) | CN101258142A (fr) |
| AU (1) | AU2006275403A1 (fr) |
| BR (1) | BRPI0614262A2 (fr) |
| CA (1) | CA2617413A1 (fr) |
| MX (1) | MX2008001538A (fr) |
| NO (1) | NO20081084L (fr) |
| WO (1) | WO2007016674A2 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4059932A1 (fr) | 2008-12-19 | 2022-09-21 | Vertex Pharmaceuticals Incorporated | Composés utiles en tant qu'inhibiteurs de kinase d'atr |
| WO2011143425A2 (fr) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Composés utilisables en tant qu'inhibiteurs de la kinase atr |
| JP5856151B2 (ja) * | 2010-05-12 | 2016-02-09 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼ阻害剤として有用な２−アミノピリジン誘導体 |
| AU2011253025A1 (en) | 2010-05-12 | 2012-11-29 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| KR20140014205A (ko) * | 2011-03-04 | 2014-02-05 | 렉시컨 파마슈티컬스 인코퍼레이티드 | Mst1 키나제 억제제 및 그의 사용 방법 |
| ES2751741T3 (es) | 2011-09-30 | 2020-04-01 | Vertex Pharma | Procedimiento para fabricar compuestos útiles como inhibidores de la quinasa ATR |
| US20130089626A1 (en) | 2011-09-30 | 2013-04-11 | Vertex Pharmaceuticals Incorporated | Treating Cancer with ATR Inhibitors |
| IN2014KN02410A (fr) | 2012-04-05 | 2015-05-01 | Vertex Pharma | |
| US8999632B2 (en) | 2012-10-04 | 2015-04-07 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
| WO2016161145A1 (fr) * | 2015-03-31 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs stk4 pour le traitement de malignités hématologiques |
| KR20180054657A (ko) | 2015-09-30 | 2018-05-24 | 버텍스 파마슈티칼스 인코포레이티드 | Dna 손상제 및 atr 저해제의 병용물을 사용한 암 치료 방법 |
| US11919902B2 (en) * | 2017-12-22 | 2024-03-05 | Hibercell, Inc. | Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| JP7268049B2 (ja) | 2018-03-08 | 2023-05-02 | インサイト・コーポレイション | ＰＩ３Ｋ－γ阻害剤としてのアミノピラジンジオール化合物 |
| WO2020010003A1 (fr) | 2018-07-02 | 2020-01-09 | Incyte Corporation | DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ |
| WO2020102150A1 (fr) | 2018-11-13 | 2020-05-22 | Incyte Corporation | Dérivés hétérocycliques utilisés comme inhibiteurs de pi3k |
| US11078204B2 (en) | 2018-11-13 | 2021-08-03 | Incyte Corporation | Heterocyclic derivatives as PI3K inhibitors |
| US11396502B2 (en) | 2018-11-13 | 2022-07-26 | Incyte Corporation | Substituted heterocyclic derivatives as PI3K inhibitors |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0412798A3 (en) * | 1989-08-08 | 1992-07-01 | Merck Sharp & Dohme Ltd. | Substituted pyridines, their preparation, formulations and use in dementia |
| US6069766A (en) * | 1990-02-09 | 2000-05-30 | Seagate Technology, Inc. | Miniature hard disc drive having low profile actuator arm voice coil and spindle motors |
| JPH0558997A (ja) | 1991-09-04 | 1993-03-09 | Mitsubishi Kasei Corp | チオカルバモイルアセトニトリル誘導体 |
| SE9401353D0 (sv) | 1994-04-21 | 1994-04-21 | Pharmacia Ab | Novel antitumour compounds with antimitotic activity |
| GB9525296D0 (en) | 1995-12-11 | 1996-02-07 | Merck Sharp & Dohme | Therapeutic agents |
| US5952349A (en) * | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
| NZ333513A (en) | 1996-07-10 | 2000-04-28 | Schering Corp | 1,4-di-substituted piperidines and medicaments useful as muscarinic antagonists |
| AU3880097A (en) | 1996-08-14 | 1998-03-06 | Warner-Lambert Company | Low molecular weight dendritic compounds as pharmaceutical agents |
| WO1998013361A1 (fr) * | 1996-09-26 | 1998-04-02 | Novartis Ag | Composition herbicide |
| DE19651099A1 (de) | 1996-12-09 | 1998-06-10 | Consortium Elektrochem Ind | Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung |
| WO1999055675A1 (fr) * | 1998-04-29 | 1999-11-04 | Axiva Gmbh | Procede pour la production catalytique de derives de bipyridyle substitues |
| JP4570057B2 (ja) | 1999-09-09 | 2010-10-27 | 三菱レイヨン株式会社 | アリールピリジン誘導体の製造法 |
| US6458789B1 (en) * | 1999-09-29 | 2002-10-01 | Lion Bioscience Ag | 2-aminopyridine derivatives and combinatorial libraries thereof |
| ATE420862T1 (de) * | 2000-06-12 | 2009-01-15 | Eisai R&D Man Co Ltd | 1,2-dihydropyridinverbindungen, verfahren zu deren herstellung und deren verwendung |
| JP2004504326A (ja) * | 2000-07-18 | 2004-02-12 | レオ・ファーマ・アクティーゼルスカブ | マトリックスメタロプロテイナーゼ阻害剤 |
| JP2002193938A (ja) * | 2000-12-01 | 2002-07-10 | Bayer Ag | ４−アリールピリジン誘導体 |
| MXPA03011391A (es) * | 2001-06-12 | 2004-07-01 | Neurogen Corp | 2,5-diarilpirazinas, 2,5-diarilpiridinas y 2,5-diarilpirimidinas como moudladores de receptor crf1. |
| US20030082191A1 (en) * | 2001-08-29 | 2003-05-01 | Poduslo Joseph F. | Treatment for central nervous system disorders |
| EP1506189A1 (fr) * | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Derives de pyrrole utilises en tant qu'inhibiteurs de erk2 et leurs utilisations |
| WO2004000318A2 (fr) * | 2002-06-21 | 2003-12-31 | Cellular Genomics, Inc. | Utilisation de certains monocycles a substitution amino en tant que modulateurs de l'activite des kinases |
| AU2003245669A1 (en) * | 2002-06-21 | 2004-01-06 | Cellular Genomics, Inc. | Certain aromatic monocycles as kinase modulators |
| EP1541687A4 (fr) | 2002-07-05 | 2006-01-04 | Japan Tobacco Inc | Genes de recuperation de sterilite apportes a un cytoplasme sterile male de type riz bt |
| AU2003247959B2 (en) * | 2002-07-09 | 2010-07-29 | Vertex Pharmaceuticals Incorporated | Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities |
| JP2004107271A (ja) | 2002-07-22 | 2004-04-08 | Mitsubishi Rayon Co Ltd | 水溶性アルキルホスフィン誘導体とその製造方法、ホスフィン配位子錯体並びにビアリール誘導体の製造方法 |
| KR20050074571A (ko) | 2002-11-11 | 2005-07-18 | 바이엘 헬스케어 아게 | Ｉｐ 수용체 길항제로서의 페닐 또는 헤테로아릴 아미노알칸 유도체 |
| JP2004182713A (ja) | 2002-12-03 | 2004-07-02 | Api Corporation | ハロアリール置換ピリジン誘導体の製造方法 |
| US20040142978A1 (en) * | 2002-12-12 | 2004-07-22 | Pharmacia Corporation | Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2 |
| WO2004058749A1 (fr) * | 2002-12-18 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Derives de benzisoxazole utiles en tant qu'inhibiteurs des proteine kinases |
| DE10315573A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| DE602004023838D1 (de) | 2003-04-24 | 2009-12-10 | Merck & Co Inc | Hemmer der akt aktivität |
| CA2522431A1 (fr) | 2003-04-24 | 2004-11-11 | Merck & Co., Inc. | Inhibiteurs de l'activite akt |
| JP2004359642A (ja) | 2003-06-06 | 2004-12-24 | Nippon Shokubai Co Ltd | マレイミド化合物およびその製造方法 |
-
2006
- 2006-07-31 JP JP2008525185A patent/JP2009503103A/ja active Pending
- 2006-07-31 MX MX2008001538A patent/MX2008001538A/es not_active Application Discontinuation
- 2006-07-31 AU AU2006275403A patent/AU2006275403A1/en not_active Abandoned
- 2006-07-31 WO PCT/US2006/030269 patent/WO2007016674A2/fr active Application Filing
- 2006-07-31 CN CNA2006800286110A patent/CN101258142A/zh active Pending
- 2006-07-31 EP EP06813280A patent/EP1919895A2/fr not_active Withdrawn
- 2006-07-31 CA CA002617413A patent/CA2617413A1/fr not_active Abandoned
- 2006-07-31 BR BRPI0614262-1A patent/BRPI0614262A2/pt not_active Application Discontinuation
- 2006-07-31 US US11/497,539 patent/US8153804B2/en active Active
- 2006-07-31 KR KR1020087002775A patent/KR20080040692A/ko not_active Application Discontinuation
-
2008
- 2008-02-29 NO NO20081084A patent/NO20081084L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007016674A3 (fr) | 2007-03-15 |
| WO2007016674A2 (fr) | 2007-02-08 |
| JP2009503103A (ja) | 2009-01-29 |
| CA2617413A1 (fr) | 2007-02-08 |
| CN101258142A (zh) | 2008-09-03 |
| KR20080040692A (ko) | 2008-05-08 |
| US8153804B2 (en) | 2012-04-10 |
| EP1919895A2 (fr) | 2008-05-14 |
| AU2006275403A1 (en) | 2007-02-08 |
| MX2008001538A (es) | 2008-04-04 |
| US20070032501A1 (en) | 2007-02-08 |
| BRPI0614262A2 (pt) | 2011-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |