NO20080498L - Fluorsubstituerte 2-okso-azepanderivater - Google Patents
Fluorsubstituerte 2-okso-azepanderivaterInfo
- Publication number
- NO20080498L NO20080498L NO20080498A NO20080498A NO20080498L NO 20080498 L NO20080498 L NO 20080498L NO 20080498 A NO20080498 A NO 20080498A NO 20080498 A NO20080498 A NO 20080498A NO 20080498 L NO20080498 L NO 20080498L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- halogen
- lower alkyl
- fluorine
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Oppfinnelsen angår forbindelser med den generelle formel I hvor R1 er lavere alkyl substituert med halogen eller er aryl eller heteroaryl, usubstituert eller substituert med halogen; R2 er heterosykloalkyl, aryl eller heteroaryl, som er usubstituert eller substituert med én eller flere substituenter, valgt fra gruppen bestående av halogen, lavere alkyloksy, lavere alkyl substituert med halogen, O-lavere alkyl substituert med halogen eller er substituert med C(O)-NR''2, (CR2)m-C(O)-R', heteroaryl eller S(O)2-lavere alkyl; R3/R3', R4/R4' og R5/R5' uavhengig av hverandre er hydrogen eller fluor, hvor minst én av R4/R4' eller R5/R5' alltid er fluor; R' er aryl eller hydroksy; R'' er hydrogen, sykloalkyl eller heterosykloalkyl; R er hydrogen eller lavere alkyl; m er 0, 1, 2 eller 3; samt farmasøytisk egnede syreaddisjonssalter, optisk rene enantiomerer, racemater eller diastereomere blandinger derav. Det er funnet at forbindelsene med den generelle formel I er ?-sekretaseinhibitorer og de beslektede forbindelsene kan være anvendelige ved behandling av Alzheimers sykdom eller vanlige kreftformer omfattende, men ikke begrenset til, karsinomer i livmorhalsen og brystkarsinomer og ondartede sykdommer i det hematopoetiske systemet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107455 | 2005-08-12 | ||
| PCT/EP2006/064935 WO2007020190A1 (en) | 2005-08-12 | 2006-08-02 | Fluoro substituted 2-oxo azepan derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080498L true NO20080498L (no) | 2008-03-07 |
Family
ID=37102441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080498A NO20080498L (no) | 2005-08-12 | 2008-01-28 | Fluorsubstituerte 2-okso-azepanderivater |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7501406B2 (no) |
| EP (1) | EP1915345B1 (no) |
| JP (1) | JP4885958B2 (no) |
| KR (1) | KR101020397B1 (no) |
| CN (1) | CN101238106B (no) |
| AR (1) | AR055370A1 (no) |
| AT (1) | ATE492536T1 (no) |
| AU (1) | AU2006281493A1 (no) |
| BR (1) | BRPI0614566A2 (no) |
| CA (1) | CA2619223A1 (no) |
| DE (1) | DE602006019103D1 (no) |
| ES (1) | ES2355581T3 (no) |
| IL (1) | IL189026A0 (no) |
| MX (1) | MX2008001833A (no) |
| NO (1) | NO20080498L (no) |
| RU (1) | RU2419611C2 (no) |
| TW (1) | TWI325421B (no) |
| WO (1) | WO2007020190A1 (no) |
| ZA (1) | ZA200800930B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010509235A (ja) * | 2006-11-03 | 2010-03-25 | ノースウェスタン ユニバーシティ | 多発性硬化症の治療 |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| GB201009603D0 (en) | 2010-06-08 | 2010-07-21 | Cambridge Entpr Ltd | Anti-inflammatory agent |
| WO2012014127A1 (en) | 2010-07-30 | 2012-02-02 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0110051A (pt) * | 2000-04-03 | 2004-12-07 | Bristol Myers Squibb Pharma Co | Composto, uso do composto, composição farmacêutica e método de tratamento do mal de alzheimer |
| EP1997495B1 (en) * | 2003-03-24 | 2013-01-02 | Axikin Pharmaceuticals, Inc. | 2-phenoxy- and 2-phenylsulfanyl-benzenesulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders |
| EP1680406A1 (en) * | 2003-10-29 | 2006-07-19 | Elan Pharmaceuticals, Inc. | N-substituted benzene sulfonamides |
| KR100880972B1 (ko) * | 2004-07-13 | 2009-02-03 | 에프. 호프만-라 로슈 아게 | 설폰아마이드 유도체 |
-
2006
- 2006-08-02 AT AT06792637T patent/ATE492536T1/de active
- 2006-08-02 BR BRPI0614566-3A patent/BRPI0614566A2/pt not_active IP Right Cessation
- 2006-08-02 WO PCT/EP2006/064935 patent/WO2007020190A1/en active Application Filing
- 2006-08-02 DE DE602006019103T patent/DE602006019103D1/de active Active
- 2006-08-02 AU AU2006281493A patent/AU2006281493A1/en not_active Abandoned
- 2006-08-02 MX MX2008001833A patent/MX2008001833A/es active IP Right Grant
- 2006-08-02 EP EP06792637A patent/EP1915345B1/en not_active Not-in-force
- 2006-08-02 JP JP2008525543A patent/JP4885958B2/ja not_active Expired - Fee Related
- 2006-08-02 CA CA002619223A patent/CA2619223A1/en not_active Abandoned
- 2006-08-02 ES ES06792637T patent/ES2355581T3/es active Active
- 2006-08-02 CN CN2006800285175A patent/CN101238106B/zh not_active Expired - Fee Related
- 2006-08-02 KR KR1020087003293A patent/KR101020397B1/ko not_active IP Right Cessation
- 2006-08-02 RU RU2008103452/04A patent/RU2419611C2/ru not_active IP Right Cessation
- 2006-08-08 US US11/500,662 patent/US7501406B2/en not_active Expired - Fee Related
- 2006-08-08 TW TW095129018A patent/TWI325421B/zh not_active IP Right Cessation
- 2006-08-10 AR ARP060103496A patent/AR055370A1/es not_active Application Discontinuation
-
2008
- 2008-01-24 IL IL189026A patent/IL189026A0/en unknown
- 2008-01-28 NO NO20080498A patent/NO20080498L/no not_active Application Discontinuation
- 2008-01-29 ZA ZA200800930A patent/ZA200800930B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7501406B2 (en) | 2009-03-10 |
| RU2419611C2 (ru) | 2011-05-27 |
| RU2008103452A (ru) | 2009-09-20 |
| EP1915345A1 (en) | 2008-04-30 |
| AR055370A1 (es) | 2007-08-22 |
| KR20080027936A (ko) | 2008-03-28 |
| BRPI0614566A2 (pt) | 2009-08-04 |
| ZA200800930B (en) | 2009-02-25 |
| AU2006281493A1 (en) | 2007-02-22 |
| US20070037789A1 (en) | 2007-02-15 |
| DE602006019103D1 (de) | 2011-02-03 |
| IL189026A0 (en) | 2008-08-07 |
| TW200734308A (en) | 2007-09-16 |
| WO2007020190A1 (en) | 2007-02-22 |
| ATE492536T1 (de) | 2011-01-15 |
| TWI325421B (en) | 2010-06-01 |
| JP4885958B2 (ja) | 2012-02-29 |
| CA2619223A1 (en) | 2007-02-22 |
| CN101238106B (zh) | 2011-02-16 |
| CN101238106A (zh) | 2008-08-06 |
| MX2008001833A (es) | 2008-04-09 |
| ES2355581T3 (es) | 2011-03-29 |
| JP2009504600A (ja) | 2009-02-05 |
| KR101020397B1 (ko) | 2011-03-08 |
| EP1915345B1 (en) | 2010-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |